salvianolic-acid-B has been researched along with Thrombosis* in 1 studies
1 other study(ies) available for salvianolic-acid-B and Thrombosis
| Article | Year |
|---|---|
Protective effects and potential mechanism of salvianolic acid B on sodium laurate-induced thromboangiitis obliterans in rats.
The root of Salvia miltiorrhiza f. alba (RSMA) (Lamiaceae) is used for the treatment of patients with thromboangiitis obliterans (TAO) in traditional Chinese medicine. Previously, a mixture of phenolic acids extracted from RSMA has shown significant protective effects on TAO rats.. This study investigates the inhibitory effects of salvianolic acid B on TAO induced by sodium laurate injection in rats to explore the effective constituents of RSMA in TAO treatment.. TAO rats were developed using injected sodium laurate. After treatment with ligustrazine hydrochloride (15 mg/kg) and various doses of salvianolic acid B (10, 20, 40 mg/kg) by tail intravenous injection, levels of thromboxane B. Salvianolic acid B significantly decreased the expressions of TXB. Salvianolic acid B has a protective effect on TAO rats. The mechanism may involve inhibition of thrombosis and TAO-associated inflammatory responses, which may explain the success of RSMA treatment of TAO in humans in traditional Chinese medical practice. Hence, it may be a potential drug for TAO treatment in conventional medicine. Topics: Animals; Benzofurans; Humans; Inflammation; Lauric Acids; Male; Medicine, Chinese Traditional; Plant Roots; Rats; Rats, Wistar; Salvia miltiorrhiza; Thromboangiitis Obliterans; Thrombosis | 2020 |