salubrinal and Paralysis

Polyglutamine expansion diseases are a group of hereditary neurodegenerative disorders that develop when a CAG repeat in the causative genes is unstably expanded above a certain threshold. The expansion of trinucleotide CAG repeats causes hereditary adult-onset neurodegenerative disorders, such as Huntington's disease, dentatorubral-pallidoluysian atrophy, spinobulbar muscular atrophy and multiple forms of spinocerebellar ataxia (SCA). The most common dominantly inherited SCA is the type 3 (SCA3), also known as Machado-Joseph disease (MJD), which is an autosomal dominant, progressive neurological disorder. The gene causatively associated with MJD is

Topics: Animals; Animals, Genetically Modified; Ataxin-3; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cinnamates; Endoplasmic Reticulum Stress; Guanabenz; Humans; Longevity; Methylene Blue; Motor Neurons; Mutation; Nerve Degeneration; Oxidative Stress; Paralysis; Phenotype; Protein Aggregates; Repressor Proteins; Small Molecule Libraries; Thiourea; Transgenes; Unfolded Protein Response