salubrinal and Cardiomegaly

salubrinal has been researched along with Cardiomegaly* in 1 studies

Other Studies

1 other study(ies) available for salubrinal and Cardiomegaly

Article	Year
Salubrinal Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress Pathway. Molecules and cells, 2017, Volume: 40, Issue:1 Pathological hypertrophy of the heart is closely associated with endoplasmic reticulum stress (ERS), leading to maladaptations such as myocardial fibrosis, induction of apoptosis, and cardiac dysfunctions. Salubrinal is a known selective inhibitor of protein phosphatase 1 (PP1) complex involving dephosphorylation of phospho-eukaryotic translation initiation factor 2 subunit (p-eIF2)-α, the key signaling process in the ERS pathway. In this study, the effects of salubrinal were examined on cardiac hypertrophy using the mouse model of transverse aortic constriction (TAC) and cell model of neonatal rat ventricular myocytes (NRVMs). Treatment of TAC-induced mice with salubrinal (0.5 mg·kg Topics: Animals; Cardiomegaly; Cinnamates; Disease Models, Animal; Endoplasmic Reticulum Stress; Male; Mice; Mice, Inbred C57BL; Rats; Thiourea	2017

Article

Year

Salubrinal Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress Pathway.

Molecules and cells, 2017, Volume: 40, Issue:1

Pathological hypertrophy of the heart is closely associated with endoplasmic reticulum stress (ERS), leading to maladaptations such as myocardial fibrosis, induction of apoptosis, and cardiac dysfunctions. Salubrinal is a known selective inhibitor of protein phosphatase 1 (PP1) complex involving dephosphorylation of phospho-eukaryotic translation initiation factor 2 subunit (p-eIF2)-α, the key signaling process in the ERS pathway. In this study, the effects of salubrinal were examined on cardiac hypertrophy using the mouse model of transverse aortic constriction (TAC) and cell model of neonatal rat ventricular myocytes (NRVMs). Treatment of TAC-induced mice with salubrinal (0.5 mg·kg

Topics: Animals; Cardiomegaly; Cinnamates; Disease Models, Animal; Endoplasmic Reticulum Stress; Male; Mice; Mice, Inbred C57BL; Rats; Thiourea

2017