salsolinol has been researched along with Parkinson Disease in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.56) | 18.7374 |
| 1990's | 17 (47.22) | 18.2507 |
| 2000's | 4 (11.11) | 29.6817 |
| 2010's | 9 (25.00) | 24.3611 |
| 2020's | 4 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, X; Lang, W; Li, Q; Li, W; Sun, H; Wan, Z; Wang, H; Wang, Y; Wu, S | 1 |
| Copeland, RL; Csoka, AB; Getachew, B; Manaye, KF; Tizabi, Y | 1 |
| Deng, Y; Ke, M; Wu, H; Xie, B | 1 |
| Chye, SM; Koh, RY; Ling, APK; Ng, KY; Voon, KGL; Voon, SM; Yap, YJ | 1 |
| D'Acunto, CW; Gonzalez, G; Grúz, J; Kaňovský, P; Strnad, M | 1 |
| Bugajski, A; Gil, K; Kurnik-Łucka, M; Panula, P | 1 |
| Ali, S; Chen, X; Chen, Z; Deng, Y; Guo, M; Huang, Y; Liu, K; Sun, F; Zheng, X; Zhong, R | 1 |
| Ali, S; Chen, X; Chen, Z; Deng, Y; Guo, M; Qing, H; Zhang, Y; Zheng, X; Zhong, R | 1 |
| Brown, D; Reglödi, D; Tamas, A; Tizabi, Y | 1 |
| Deng, YL; Li, HM; Li, YJ; Meng, LY; Schläppi, M; Song, DW; Xie, BJ; Xin, N | 1 |
| Bugajski, A; Bujak-Gizycka, B; Gil, K; Kurnik, M; Madej, J; Thor, P | 1 |
| Deng, Y; Lin, F; Peng, L; Qing, H; Ullah, K; Wu, H; Xie, B | 1 |
| Deng, Y; Duan, J; Hou, Y; Su, Y; Wang, R; Ying, Z; Zhang, Y | 1 |
| Klingemann, I; Moser, A; Scholz, J | 1 |
| Epp, LM; Mravec, B | 1 |
| Deng, YL; Liu, XQ; Qing, H; Wang, R; Zheng, XL | 1 |
| Dostert, P; Nagatsu, T; Naoi, M; Yoshida, M | 1 |
| Allievi, C; Della Vedova, F; Dordain, G; Dostert, P; Durif, F; La Croix, R; Strolin Benedetti, M; Vernay, D | 1 |
| Dostert, P; Nagatsu, T; Naoi, M; Niwa, T; Takeda, N; Tatematsu, A; Yoshida, M; Yoshizumi, H | 1 |
| Dostert, P; Maruyama, W; Naoi, M; Narabayashi, H | 1 |
| Dostert, P; Hashizume, Y; Maruyama, W; Naoi, M | 1 |
| Antkiewicz-Michaluk, L; Krygowska-Wajs, A; Romańska, I; Szczudlik, A; Vetulani, J | 1 |
| Naoi, M | 1 |
| Benedetti, MS; Ibi, T; Maruyama, W; Nakao, N; Naoi, M; Sahashi, K | 1 |
| Gerlach, M; Koutsilieri, E; Riederer, P | 1 |
| Jaskowski, P; Kömpf, D; Moser, A; Siebecker, F; Vieregge, P | 1 |
| Häussermann, P; Kuhn, W; Müller, T; Przuntek, H; Rommelspacher, H; Sällström Baum, S; Woitalla, D | 1 |
| Deleu, D | 1 |
| Häussermann, P; Kuhn, W; Müller, T; Przuntek, H; Rommelspacher, H; Sällström Baum, S | 1 |
| Antkiewicz-Michaluk, L; Michaluk, J; Papla, I; Romańska, I; Vetulani, J | 1 |
| Dostert, P; Maruyama, W; Nagatsu, T; Nakahara, D; Naoi, M; Niwa, T; Takahashi, A; Takeda, N; Tatematsu, A; Yoshizumi, H | 1 |
| Kömpf, D; Moser, A | 1 |
| Camp, VM; Faraj, BA; Kutner, M | 1 |
| Camp, VM; Faraj, BA; Watts, RL | 1 |
| Dordain, G; Dostert, P; Strolin Benedetti, M; Vernay, D | 1 |
| Dostert, P; Strolin Benedetti, M | 1 |
6 review(s) available for salsolinol and Parkinson Disease
| Article | Year |
|---|---|
The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson's Disease.
Topics: Animals; Apoptosis; Brain; Humans; Isoquinolines; Mice; Neurotoxins; Parkinson Disease; Rats | 2020 |
Salsolinol: an Unintelligible and Double-Faced Molecule-Lessons Learned from In Vivo and In Vitro Experiments.
Topics: Alcoholism; Animals; Brain; Humans; Isoquinolines; Parkinson Disease; Synaptic Transmission; Tetrahydroisoquinolines | 2018 |
Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic Parkinson's disease.
Topics: Acetaldehyde; Brain; Candida albicans; Candidiasis; Chronic Disease; Dopamine; Humans; Isoquinolines; Parkinson Disease | 2006 |
N-methyl-(R)salsolinol as a dopaminergic neurotoxin: from an animal model to an early marker of Parkinson's disease.
Topics: Animals; Biomarkers; Brain; Cell Line; Cell Survival; Dopamine; Humans; Isoquinolines; Male; Neurotoxins; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Wistar; Salsoline Alkaloids; Stereoisomerism; Tetrahydroisoquinolines | 1997 |
[Neurotoxin candidates as pathogenic agents of Parkinson's disease].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Chemistry; Disease Models, Animal; Humans; Isoquinolines; Neurotoxins; Parkinson Disease; Rats | 1997 |
Overview of the present state of MAO inhibitors.
Topics: Animals; Benzamides; Humans; Hydrazines; Isoquinolines; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Parkinson Disease; Phenethylamines; Piperidines; Selegiline; Structure-Activity Relationship | 1987 |
3 trial(s) available for salsolinol and Parkinson Disease
| Article | Year |
|---|---|
Stereospecific occurrence of a parkinsonism-inducing catechol isoquinoline, N-methyl(R)salsolinol, in the human intraventricular fluid.
Topics: Aged; Antiparkinson Agents; Body Fluids; Cerebral Ventricles; Female; Humans; Isoquinolines; Levodopa; Male; Middle Aged; Molecular Structure; Neurotoxins; Parkinson Disease; Stereoisomerism | 1996 |
Increase in salsolinol level in the cerebrospinal fluid of parkinsonian patients is related to dementia: advantage of a new high-performance liquid chromatography methodology.
Topics: Adult; Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Dementia; Female; Homovanillic Acid; Humans; Isoquinolines; Levodopa; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Tyrosine | 1997 |
Plasma levels of R- and S-salsolinol are not increased in "de-novo" Parkinsonian patients.
Topics: Adult; Aged; Aged, 80 and over; Dopamine; Female; Humans; Isoquinolines; Male; Methylation; Middle Aged; Parkinson Disease; Stereoisomerism | 1998 |
27 other study(ies) available for salsolinol and Parkinson Disease
| Article | Year |
|---|---|
Salsolinol Induces Parkinson's Disease Through Activating NLRP3-Dependent Pyroptosis and the Neuroprotective Effect of Acteoside.
Topics: Animals; Humans; Inflammasomes; Mice; Neuroblastoma; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Phenols; Pyroptosis | 2022 |
Dihydromyricetin Protects Against Salsolinol-Induced Toxicity in Dopaminergic Cell Line: Implication for Parkinson's Disease.
Topics: Cell Line, Tumor; Dopamine; Dopaminergic Neurons; gamma-Aminobutyric Acid; Humans; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease | 2023 |
High-fat diet causes increased endogenous neurotoxins and phenotype of Parkinson's disease in mice.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucose Intolerance; Isoquinolines; Malondialdehyde; Mice; Neurotoxins; Parkinson Disease; Salsoline Alkaloids | 2019 |
Cytokinin Plant Hormones Have Neuroprotective Activity in In Vitro Models of Parkinson's Disease.
Topics: Acetylcysteine; Caspase 3; Caspase 7; Cell Death; Cell Differentiation; Cell Line, Tumor; Cytokinins; Glutamic Acid; Humans; Isoquinolines; Models, Biological; Neurons; Neuroprotective Agents; Oxidative Stress; Oxygen; Parkinson Disease; Plant Growth Regulators; Superoxides | 2021 |
Changes in salsolinol production and salsolinol synthase activity in Parkinson's disease model.
Topics: Animals; Brain; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dopamine; Humans; Isoquinolines; Lyases; Male; Nerve Tissue Proteins; Oxidative Stress; Parkinson Disease; Rats, Sprague-Dawley | 2018 |
Isolation and Sequencing of Salsolinol Synthase, an Enzyme Catalyzing Salsolinol Biosynthesis.
Topics: Animals; Brain; Dopamine; Dopaminergic Neurons; Isoquinolines; Neurotoxins; Nitric Oxide Synthase; Parkinson Disease; Rats; Tetrahydroisoquinolines | 2018 |
PACAP protects against salsolinol-induced toxicity in dopaminergic SH-SY5Y cells: implication for Parkinson's disease.
Topics: Apoptosis; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cyclic AMP Response Element-Binding Protein; Dopaminergic Neurons; Humans; Isoquinolines; Neuroprotective Agents; Parkinson Disease; Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide | 2013 |
Formation of a salsolinol-like compound, the neurotoxin, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, in a cellular model of hyperglycemia and a rat model of diabetes.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Dopaminergic Neurons; Glucose; Hydroxyl Radical; Hyperglycemia; Isoquinolines; Neurotoxins; Parkinson Disease; Rats; Tetrahydroisoquinolines | 2014 |
The influence of salsolinol on basic rat metabolism.
Topics: Adipose Tissue; Adult; Animals; Body Weight; Cholesterol; Disease Models, Animal; Eating; Enteric Nervous System; Gastric Emptying; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Intestinal Absorption; Isoquinolines; Male; Parkinson Disease; Rats; Rats, Wistar | 2012 |
Methylglyoxal increases dopamine level and leads to oxidative stress in SH-SY5Y cells.
Topics: Cell Line; Diabetes Mellitus, Type 2; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Gene Expression; Guanidines; Humans; Isoquinolines; Membrane Potential, Mitochondrial; Models, Neurological; Neurotoxins; Oxidative Stress; Parkinson Disease; Pyruvaldehyde; RNA, Messenger; Tyrosine 3-Monooxygenase | 2014 |
Increased vulnerability of parkin knock down PC12 cells to hydrogen peroxide toxicity: the role of salsolinol and NM-salsolinol.
Topics: Animals; Cell Death; Dose-Response Relationship, Drug; Gene Knockdown Techniques; Hydrogen Peroxide; Isoquinolines; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neurotoxins; Oxidants; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Ubiquitin-Protein Ligases | 2013 |
Increased systemic levels of norsalsolinol derivatives are induced by levodopa treatment and do not represent biological markers of Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Biomarkers; Chromatography, High Pressure Liquid; Female; Humans; Inactivation, Metabolic; Isoquinolines; Levodopa; Male; Middle Aged; Neurologic Examination; Neuropsychological Tests; Parkinson Disease; Prospective Studies; Reference Values; Salsoline Alkaloids | 2004 |
Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells.
Topics: Apoptosis; Catechols; Cell Line, Tumor; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Humans; Hydroxyl Radical; Iron; Iron Metabolism Disorders; Isoquinolines; Malondialdehyde; Models, Biological; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinson Disease; Salsoline Alkaloids; Up-Regulation | 2008 |
N-methylated tetrahydroisoquinolines as dopaminergic neurotoxins.
Topics: Animals; Brain; Cell Death; Culture Techniques; Dopamine; Humans; Isoquinolines; Methylation; Methyltransferases; Monoamine Oxidase; Nerve Degeneration; Parkinson Disease; Rats; Receptors, Dopamine; Substantia Nigra; Tetrahydroisoquinolines | 1993 |
Dopamine-derived tetrahydroisoquinolines and Parkinson's disease.
Topics: Aged; Aged, 80 and over; Female; Humans; Isoquinolines; Male; Middle Aged; Parkinson Disease; Reference Values; Salsoline Alkaloids | 1993 |
Presence of tetrahydroisoquinoline-related compounds, possible MPTP-like neurotoxins, in parkinsonian brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Biotransformation; Culture Techniques; Dopamine; Frontal Lobe; Gas Chromatography-Mass Spectrometry; Humans; Isoquinolines; Neurotoxins; Parkinson Disease; Structure-Activity Relationship; Tetrahydroisoquinolines | 1993 |
(R)salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Female; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Isoquinolines; Lymphocytes; Male; Methyltransferases; Middle Aged; Parkinson Disease; Statistics, Nonparametric; Substrate Specificity | 1998 |
N-methyl-(R)-salsolinol and its relevance to Parkinson's disease.
Topics: Disease Progression; Humans; Isoquinolines; Parkinson Disease | 1998 |
Salsolinol, catecholamine metabolites, and visual hallucinations in L-dopa treated patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Biomarkers; Catecholamines; Female; Hallucinations; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Isoquinolines; Levodopa; Male; Parkinson Disease; Reference Values; Regression Analysis; Tyrosine | 1996 |
Endogenous dopamine-derived neurotoxins and Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Dopamine; Humans; Isoquinolines; Methyltransferases; MPTP Poisoning; Nerve Tissue Proteins; Neurotoxins; Parkinson Disease; Parkinson Disease, Secondary; Rats; Salsoline Alkaloids; Substantia Nigra; Tetrahydroisoquinolines; Tyrosine 3-Monooxygenase | 1998 |
R- and S-salsolinol are not increased in cerebrospinal fluid of Parkinsonian patients.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Isoquinolines; Male; Middle Aged; Parkinson Disease; Reference Values; Stereoisomerism | 1999 |
Antidopaminergic effects of 1,2,3,4-tetrahydroisoquinoline and salsolinol.
Topics: Animals; Antiparkinson Agents; Apomorphine; Binding, Competitive; Brain Chemistry; Catalepsy; Dopamine; Dopamine Antagonists; Haloperidol; Homovanillic Acid; Isoquinolines; Male; Motor Activity; Neurotoxins; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Wistar; Tetrahydroisoquinolines; Tritium | 2000 |
Endogenous synthesis of N-methylsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in rat brain during in vivo microdialysis with salsolinol, as demonstrated by gas chromatography-mass spectrometry.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Gas Chromatography-Mass Spectrometry; Isoquinolines; Male; Methylation; Parkinson Disease; Perfusion; Rats; Rats, Wistar; Salsoline Alkaloids; Tetrahydroisoquinolines | 1992 |
Presence of methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, derivatives of the neurotoxin isoquinoline, in parkinsonian lumbar CSF.
Topics: Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Isoquinolines; Male; Middle Aged; Monoamine Oxidase; Parkinson Disease; Spinal Puncture; Tetrahydroisoquinolines | 1992 |
Interrelationship between activation of dopaminergic pathways and cerebrospinal fluid concentration of dopamine tetrahydroisoquinoline metabolite salsolinol in humans: preliminary findings.
Topics: Adrenal Medulla; Adult; Aged; Caudate Nucleus; Dopamine; Female; Follow-Up Studies; Humans; Isoquinolines; Male; Middle Aged; Neurologic Examination; Parkinson Disease | 1991 |
Effect of adrenal-caudate transplantation on CSF levels of salsolinol sulfate in patients with Parkinson's disease.
Topics: Adrenal Glands; Caudate Nucleus; Humans; Isoquinolines; Nerve Tissue; Parkinson Disease; Transplantation, Homologous | 1990 |
Enantiomeric composition of urinary salsolinol in parkinsonian patients after Madopar.
Topics: Aged; Aged, 80 and over; Benserazide; Drug Combinations; Female; Humans; Hydrazines; Isoquinolines; Levodopa; Male; Middle Aged; Parkinson Disease; Stereoisomerism | 1989 |