salpichrolide-c and Breast-Neoplasms

salpichrolide-c has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for salpichrolide-c and Breast-Neoplasms

ArticleYear
Antiproliferative activity of withanolides against human breast cancer cell lines.
    Journal of natural products, 2010, May-28, Volume: 73, Issue:5

    The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 muM. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Combinatorial Chemistry Techniques; Drug Screening Assays, Antitumor; Female; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Structure-Activity Relationship; Withanolides

2010