salicylsalicylic acid has been researched along with HIV Coinfection in 3 studies
salicylsalicylic acid: structure
salsalate : A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Juluri, R | 1 |
| Gupta, S | 1 |
| Vuppalanchi, R | 1 |
| Hileman, CO | 1 |
| Carman, TL | 1 |
| Gripshover, BM | 1 |
| O'Riordan, M | 1 |
| Storer, NJ | 1 |
| Harrill, DE | 1 |
| White, CA | 1 |
| McComsey, GA | 1 |
| Gupta, SK | 1 |
| Johnson, RM | 1 |
| Saha, C | 1 |
| Mather, KJ | 1 |
| Greenwald, ML | 1 |
| Waltz, JS | 1 |
| Rehman, J | 1 |
| Dubé, MP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of the Use of Salsalate to Decrease Endothelial Cell Activation and Inflammation in HIV-infected Adults[NCT01046682] | Phase 2 | 40 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Flow mediated dilation (FMD) of the brachial artery was measured by ultrasound. This is a measure of endothelial dependent endothelial cell function. Flow mediated dilation is expressed as a percent change from baseline brachial artery diameter to brachial artery diameter after reactive hyperemia. Reactive hyperemia occurred after occluding the brachial artery with a blood pressure cuff for 5 minutes. (NCT01046682)
Timeframe: Entry and week 13 visits
| Intervention | % change from baseline (Median) |
|---|---|
| Salsalate | 0.99 |
| Usual Care | -0.07 |
1 trial available for salicylsalicylic acid and HIV Coinfection
| Article | Year |
|---|---|
Salsalate is poorly tolerated and fails to improve endothelial function in virologically suppressed HIV-infected adults.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brachial Artery; Dose-Response Relationship, Drug; Endothel | 2010 |
2 other studies available for salicylsalicylic acid and HIV Coinfection
| Article | Year |
|---|---|
Serum concentration-dependent hepatotoxicity in individuals receiving oral salsalate.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Dose-Respons | 2009 |
Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Brachial Artery; Cardiovascular Diseases; Endotheliu | 2008 |