salicylsalicylic acid has been researched along with Arthritis, Rheumatoid in 11 studies
salicylsalicylic acid: structure
salsalate : A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a multicenter, double blind, parallel group study, 233 patients with classical or definite rheumatoid arthritis (RA) were randomized to 12 weeks of either salsalate (salicylsalicylic acid, nonacetylated salicylate) or aspirin following disease flare." | 9.06 | Does the acetyl group of aspirin contribute to the antiinflammatory efficacy of salicylic acid in the treatment of rheumatoid arthritis? The Multicenter Salsalate/Aspirin Comparison Study Group. ( , 1989) |
| " On oral challenges, she developed an urticarial reaction after tartrazine; urticarial and bronchospastic reactions after salicylsalicylic acid; and urticarial and bronchospastic reactions after choline magnesium trisalicylate." | 7.67 | Sensitivity to non-acetylated salicylates in a patient with asthma, nasal polyps, and rheumatoid arthritis. ( Chudwin, DS; Frey, C; Golden, HE; Luskin, AT; Richmond, GW; Strub, M, 1986) |
| "In a multicenter, double blind, parallel group study, 233 patients with classical or definite rheumatoid arthritis (RA) were randomized to 12 weeks of either salsalate (salicylsalicylic acid, nonacetylated salicylate) or aspirin following disease flare." | 5.06 | Does the acetyl group of aspirin contribute to the antiinflammatory efficacy of salicylic acid in the treatment of rheumatoid arthritis? The Multicenter Salsalate/Aspirin Comparison Study Group. ( , 1989) |
| " On oral challenges, she developed an urticarial reaction after tartrazine; urticarial and bronchospastic reactions after salicylsalicylic acid; and urticarial and bronchospastic reactions after choline magnesium trisalicylate." | 3.67 | Sensitivity to non-acetylated salicylates in a patient with asthma, nasal polyps, and rheumatoid arthritis. ( Chudwin, DS; Frey, C; Golden, HE; Luskin, AT; Richmond, GW; Strub, M, 1986) |
| "Salicylate availability from salsalate (SSA) and aspirin (ASA) was examined in six rheumatoid arthritis patients in a multiple-dose double-blind crossover study." | 3.66 | Availability of salicylate from salsalate and aspirin. ( Cassell, S; Dromgoole, SH; Furst, DE; Paulus, HE, 1983) |
| " The convenient twice-daily dosage regimen makes this drug particularly suitable for chronic use." | 2.65 | Salsalate for arthritis: a clinical evaluation. ( McPherson, TC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shay, K | 1 |
| McPherson, TC | 1 |
| Dromgoole, SH | 1 |
| Cassell, S | 1 |
| Furst, DE | 1 |
| Paulus, HE | 2 |
| Fazarinc, F | 1 |
| Steen, SN | 1 |
| Bombardier, C | 1 |
| Peloso, PM | 1 |
| Goldsmith, CH | 1 |
| Ré, ON | 1 |
| Ivorra, J | 1 |
| Batlle, E | 1 |
| Morales, C | 1 |
| Rosas, J | 1 |
| Roth, S | 1 |
| Bennett, R | 1 |
| Caldron, P | 1 |
| Hartman, R | 1 |
| Mitchell, C | 1 |
| Doucette, M | 1 |
| Ekholm, B | 1 |
| Goldlust, B | 1 |
| Lee, E | 1 |
| Wilson, R | 1 |
| Chudwin, DS | 1 |
| Strub, M | 1 |
| Golden, HE | 1 |
| Frey, C | 1 |
| Richmond, GW | 1 |
| Luskin, AT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease: A Mechanistic Approach[NCT01398943] | 60 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Brachial artery FMD induced by reactive hyperemia will be used to assess vascular endothelial function at baseline and several hours after each experimental intervention. (NCT01398943)
Timeframe: Post FMD was taken approximately 110 min after baseline
| Intervention | percentage of change in FMD (Mean) | |
|---|---|---|
| Placebo | AOC Treatment | |
| All Controls | 6.7 | 6.9 |
| All COPD Patients | 3.1 | 4.7 |
A measure of vascular stiffness at baseline and several hours after each experimental intervention. (NCT01398943)
Timeframe: Post PWV was taken approximately 90 min after baseline
| Intervention | m/sec (Mean) | |
|---|---|---|
| Placebo | AOC Treatment | |
| All Controls | 11 | 10 |
| All COPD Patients | 14 | 11 |
5 trials available for salicylsalicylic acid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Salsalate for arthritis: a clinical evaluation.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Ost | 1984 |
Long-term management of rheumatoid arthritis with disalcid.
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Long-Term Care; Male; Middle | 1980 |
Salsalate, a nonacetylated salicylate, is as efficacious as diclofenac in patients with rheumatoid arthritis. Salsalate-Diclofenac Study Group.
Topics: Aged; Arthritis, Rheumatoid; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged; Mul | 1995 |
Reduced risk of NSAID gastropathy (GI mucosal toxicity) with nonacetylated salicylate (salsalate): an endoscopic study.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blin | 1990 |
Does the acetyl group of aspirin contribute to the antiinflammatory efficacy of salicylic acid in the treatment of rheumatoid arthritis? The Multicenter Salsalate/Aspirin Comparison Study Group.
Topics: Acetylation; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Double-Blind Method; Female; Humans; Male; | 1989 |
6 other studies available for salicylsalicylic acid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Treatment of an edentulous patient with a dry mouth.
Topics: Adhesives; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Ag | 2000 |
Availability of salicylate from salsalate and aspirin.
Topics: Arthritis, Rheumatoid; Aspirin; Biological Availability; Chromatography, High Pressure Liquid; Doubl | 1983 |
Salicylsalicylic acid revisited: a multicentre study.
Topics: Adult; Aged; Analgesics; Arthritis; Arthritis, Rheumatoid; Evaluation Studies as Topic; Female; Huma | 1979 |
[Salsalate: is it more tolerated than other non-steroidal anti-inflammatory agents?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Male; Middle Aged; Salicylat | 1992 |
Aspirin versus nonacetylated salicylate.
Topics: Arthritis, Rheumatoid; Aspirin; Humans; Salicylates | 1989 |
Sensitivity to non-acetylated salicylates in a patient with asthma, nasal polyps, and rheumatoid arthritis.
Topics: Albuterol; Arthritis, Rheumatoid; Asthma; Bronchial Spasm; Choline; Drug Combinations; Drug Hypersen | 1986 |