salicylic acid has been researched along with Tinnitus in 37 studies
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).
Tinnitus: A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Memantine, an antiglutamatergic drug, has been proposed as a treatment for tinnitus." | 7.73 | Salicylate- and quinine-induced tinnitus and effects of memantine. ( Dalby-Brown, W; Ding, D; Fitzgerald, S; Hilczmayer, E; Lobarinas, E; Mirza, N; Salvi, R; Sun, W; Yang, G; Zhang, L, 2006) |
| "To elucidate the neurological mechanism of lidocaine's suppression to tinnitus." | 7.72 | [Study of neurological mechanism of lidocaine's suppression to tinnitus via microdialysis]. ( Dong, Y; Han, HW; Li, XP; Liu, GQ; Liu, JX, 2003) |
| "Memantine, an antiglutamatergic drug, has been proposed as a treatment for tinnitus." | 3.73 | Salicylate- and quinine-induced tinnitus and effects of memantine. ( Dalby-Brown, W; Ding, D; Fitzgerald, S; Hilczmayer, E; Lobarinas, E; Mirza, N; Salvi, R; Sun, W; Yang, G; Zhang, L, 2006) |
| "To elucidate the neurological mechanism of lidocaine's suppression to tinnitus." | 3.72 | [Study of neurological mechanism of lidocaine's suppression to tinnitus via microdialysis]. ( Dong, Y; Han, HW; Li, XP; Liu, GQ; Liu, JX, 2003) |
| "Using the extracellular recording method, the effects of lidocaine (a local anesthetic known to relieve tinnitus) on discharge of inferior colliculus (IC) neurons of the guinea pig were studied before and after salicylate (200 mg/kg) administration." | 3.69 | Effects of lidocaine on salicylate-induced discharge of neurons in the inferior colliculus of the guinea pig. ( Manabe, Y; Oka, H; Saito, H; Yoshida, S, 1997) |
| "Tinnitus is a perception of sound that can occur in the absence of an external stimulus." | 2.82 | Whole scalp resting state EEG of oscillatory brain activity shows no parametric relationship with psychoacoustic and psychosocial assessment of tinnitus: A repeated measures study. ( Hall, DA; Hoare, DJ; McNamara, AJ; Pierzycki, RH, 2016) |
| " GPIAS showed that rats with long-term administration of salicylate were experiencing tinnitus, and the mRNA and protein expression levels of TNF-α and NR2A were up-regulated in chronic treatment groups, and they returned to baseline 14 days after cessation of treatment." | 1.40 | Effects of salicylate on the inflammatory genes expression and synaptic ultrastructure in the cochlear nucleus of rats. ( Chen, JY; Hu, SS; Huang, ZW; Mei, L; Wu, H, 2014) |
| "A high unit dose (15 grain/975 mg) enteric coated aspirin preparation was studied in normal individuals and patients with arthritis to determine how readily well tolerated, therapeutic (150-300 micrograms/ml) salicylate (SA) levels could be achieved using a twice daily dosing regimen." | 1.27 | Aspirin dosing using 15 grain enteric coated tablets. ( Feigal, D; Jang, H; Pollet, S; White, RH; Yim, CW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.41) | 18.7374 |
| 1990's | 8 (21.62) | 18.2507 |
| 2000's | 8 (21.62) | 29.6817 |
| 2010's | 17 (45.95) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Yin, M | 1 |
| Xia, C | 1 |
| Wu, C | 1 |
| Ji, Y | 1 |
| Zhou, Y | 1 |
| Hwang, JH | 3 |
| Huang, DC | 1 |
| Lu, YC | 1 |
| Yang, WS | 1 |
| Liu, TC | 1 |
| Berger, JI | 1 |
| Coomber, B | 1 |
| Hill, S | 1 |
| Alexander, SPH | 1 |
| Owen, W | 1 |
| Palmer, AR | 1 |
| Wallace, MN | 1 |
| Chan, YC | 2 |
| Wang, MF | 1 |
| Sederholm, F | 1 |
| Swedberg, MD | 1 |
| Hu, SS | 1 |
| Mei, L | 1 |
| Chen, JY | 1 |
| Huang, ZW | 1 |
| Wu, H | 1 |
| Zhang, FY | 1 |
| Xue, YX | 1 |
| Liu, WJ | 1 |
| Yao, YL | 1 |
| Ma, J | 1 |
| Chen, L | 1 |
| Shang, XL | 1 |
| Chen, G | 1 |
| Feng, L | 1 |
| Liu, Z | 1 |
| Sun, Y | 1 |
| Chang, H | 1 |
| Cui, P | 1 |
| Chen, YC | 1 |
| Li, X | 1 |
| Liu, L | 1 |
| Wang, J | 1 |
| Lu, CQ | 1 |
| Yang, M | 1 |
| Jiao, Y | 1 |
| Zang, FC | 1 |
| Radziwon, K | 1 |
| Chen, GD | 3 |
| Sun, W | 2 |
| Krishnan Muthaiah, VP | 1 |
| Salvi, R | 2 |
| Teng, GJ | 1 |
| Chang, NC | 1 |
| Chen, JC | 1 |
| Ruel, J | 1 |
| Chabbert, C | 1 |
| Nouvian, R | 1 |
| Bendris, R | 1 |
| Eybalin, M | 1 |
| Leger, CL | 1 |
| Bourien, J | 1 |
| Mersel, M | 1 |
| Puel, JL | 1 |
| Knipper, M | 1 |
| Zimmermann, U | 1 |
| Müller, M | 1 |
| Zheng, Y | 1 |
| Stiles, L | 1 |
| Hamilton, E | 1 |
| Smith, PF | 1 |
| Darlington, CL | 1 |
| Wang, YM | 1 |
| Song, HY | 1 |
| Tong, Z | 1 |
| Qian, SJ | 1 |
| Guo, RX | 1 |
| Jing, ZJ | 1 |
| Shi, JR | 1 |
| Holt, AG | 1 |
| Bissig, D | 1 |
| Mirza, N | 2 |
| Rajah, G | 1 |
| Berkowitz, B | 1 |
| Caperton, KK | 1 |
| Thompson, AM | 1 |
| Stolzberg, D | 1 |
| Allman, BL | 1 |
| Salvi, RJ | 1 |
| Liu, J | 1 |
| Yu, P | 1 |
| Lin, Y | 1 |
| Zhou, N | 1 |
| Li, T | 1 |
| Ma, F | 1 |
| Mao, L | 1 |
| Liu, JX | 1 |
| Li, XP | 1 |
| Dong, Y | 1 |
| Han, HW | 1 |
| Liu, GQ | 1 |
| Lobarinas, E | 1 |
| Yang, G | 1 |
| Ding, D | 1 |
| Dalby-Brown, W | 1 |
| Hilczmayer, E | 1 |
| Fitzgerald, S | 1 |
| Zhang, L | 1 |
| Basta, D | 1 |
| Goetze, R | 1 |
| Ernst, A | 1 |
| Kauer, JS | 1 |
| Nemitz, JW | 1 |
| Sasaki, CT | 1 |
| Jastreboff, PJ | 1 |
| Manabe, Y | 1 |
| Yoshida, S | 1 |
| Saito, H | 1 |
| Oka, H | 1 |
| Ochi, K | 2 |
| Ohashi, T | 1 |
| Kato, I | 1 |
| Eggermont, JJ | 3 |
| Maune, S | 1 |
| Frese, KA | 1 |
| Mrowietz, U | 1 |
| Reker, U | 1 |
| Kenmochi, M | 1 |
| Bauer, CA | 1 |
| Brozoski, TJ | 1 |
| Holder, TM | 1 |
| Caspary, DM | 1 |
| Pollet, S | 1 |
| White, RH | 1 |
| Jang, H | 1 |
| Yim, CW | 1 |
| Feigal, D | 1 |
| Kuwano, A | 1 |
| Naitou, I | 1 |
| Miyamoto, N | 1 |
| Arai, K | 1 |
| Kawamata, T | 1 |
| Pierzycki, RH | 1 |
| McNamara, AJ | 1 |
| Hoare, DJ | 1 |
| Hall, DA | 1 |
| Burrus, TM | 1 |
| Miller, GM | 1 |
| Flynn, LP | 1 |
| Fulgham, JR | 1 |
| Lanzino, G | 1 |
| Kumar, A | 1 |
| Ahuja, CK | 1 |
| Khandelwal, N | 1 |
| Bakshi, JB | 1 |
| Chen, Z | 1 |
| Feng, H | 1 |
| Zhu, G | 1 |
| Wu, N | 1 |
| Lin, J | 1 |
| Agrawal, R | 1 |
| Flood, LM | 1 |
| Bradey, N | 1 |
| Matsushima, JI | 1 |
| Sakai, N | 1 |
| Uemi, N | 1 |
| Ifukube, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Systematic Evaluation of the Acoustic CR ® Neuromodulation Treatment for Tinnitus[NCT01541969] | Phase 2/Phase 3 | 100 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Non-invasive recording to measure rhythmic patterns of spontaneous brain activity at rest. An a priori hypothesis targeted normalized delta rhythm. Band powers were calculated as percent change in delta brainwave pattern relative to change in total (1-90 Hz) EEG band. Comparison made between 'visit 2' and 'visit 6'.~We used a Neuroscan system (SynAmps2 model 8050, Compumedics Neuroscan, Charlotte, NC, USA) and custom cap with 66 equidistant scalp electrodes (Easycap, GmbH, Germany). A central frontal electrode was used as ground and a nose-tip electrode as reference. Electrode impedances were maintained at 5 kΩ prior to recordings. Recording was done with an offline filter of 0.5 to 200 Hz pass-band and 1 kHz sampling rate. Recording was over a continuous 10-minute period. Participants were seated in a quiet, darkened soundproof booth and were instructed to relax, keep eyes open and fix gaze on a marker point." (NCT01541969)
Timeframe: Baseline (visit 2) and 12 weeks (visit 6)
| Intervention | Percent change (Mean) |
|---|---|
| CR Neuromodulation | 0.001 |
| Tinnitus Masking | 0.004 |
Change in the global score on a 25 item, multi-attribute questionnaire measure of the functional impact of tinnitus (0-100 scale). Change was computed as 'visit 2' - 'visit 6' and so a positive change score indicates a reduction of tinnitus symptoms. (NCT01541969)
Timeframe: Baseline (visit 2) and 12 weeks (visit 6)
| Intervention | units on a scale (Mean) |
|---|---|
| CR Neuromodulation | 2.38 |
| Tinnitus Masking | 4.45 |
Change in the global score on a 25 item, multi-attribute questionnaire measure of the functional impact of tinnitus (0-100 scale). Change was computed as 'visit 2' - 'visit 6' and so a positive change score indicates a reduction of tinnitus symptoms. (NCT01541969)
Timeframe: Baseline (visit 2) and 12 weeks (visit 6)
| Intervention | units on a scale (Mean) |
|---|---|
| CR Neuromodulation | 2.84 |
| Tinnitus Masking | 1.64 |
Change in the global score on a 27 item, multi-attribute questionnaire measure of the functional impact of tinnitus (0-100 scale). Change was computed as 'visit 2' - 'visit 10' and so a positive change score indicates a reduction of tinnitus symptoms. (NCT01541969)
Timeframe: Baseline (visit 2) and 36 weeks (visit 10)
| Intervention | units on a scale (Mean) |
|---|---|
| CR Neuromodulation | 5.41 |
| Tinnitus Masking | 6.01 |
Change in the global score on a 27 item, multi-attribute questionnaire measure of the functional impact of tinnitus (0-100 scale). Change was computed as 'visit 2' - 'visit 6' and so a positive change score indicates a reduction of tinnitus symptoms. (NCT01541969)
Timeframe: Baseline (visit 2) and 12 weeks (visit 6)
| Intervention | units on a scale (Mean) |
|---|---|
| CR Neuromodulation | 3.75 |
| Tinnitus Masking | 4.02 |
The WHOQOL-BREF is a 26-item, multi-attribute questionnaire measure of health related quality of life. Outcome was measured as a change on Question 1: 'How would you rate your quality of life (over the past 4 weeks)?' There are 5 response options (Very poor=1; Poor=2; Neither poor nor good=3; Good=4; Very good=5). Change was computed as 'visit 2' - 'visit 6' and so a positive change score indicates a reduction in self-perceived quality of life. (NCT01541969)
Timeframe: Baseline (visit 2) and 12 weeks (visit 6)
| Intervention | units on a scale (Mean) |
|---|---|
| CR Neuromodulation | -0.21 |
| Tinnitus Masking | -0.11 |
1 review available for salicylic acid and Tinnitus
| Article | Year |
|---|---|
Molecular aspects of tinnitus.
Topics: Animals; Auditory Cortex; Auditory Pathways; Brain Stem; Cochlea; Humans; Limbic System; Noise; Sali | 2010 |
2 trials available for salicylic acid and Tinnitus
| Article | Year |
|---|---|
Whole scalp resting state EEG of oscillatory brain activity shows no parametric relationship with psychoacoustic and psychosocial assessment of tinnitus: A repeated measures study.
Topics: Biomarkers; Brain; Electroencephalography; Humans; Oscillometry; Principal Component Analysis; Psych | 2016 |
Effects of greater occipital nerve block on tinnitus and dizziness.
Topics: Adult; Aged; Attention; Dizziness; Face; Head; Humans; Middle Aged; Movement; Nerve Block; Nervous S | 1999 |
34 other studies available for salicylic acid and Tinnitus
| Article | Year |
|---|---|
Aberrant expression of Nav1.6 in the cochlear nucleus correlates with salicylate-induced tinnitus in rats.
Topics: Animals; Behavior Rating Scale; Cochlear Nucleus; Glutamate Decarboxylase; Mice; NAV1.6 Voltage-Gate | 2020 |
Effects of Tumor Necrosis Factor Blocker on Salicylate-Induced Tinnitus in Mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cochlea; Disease Models, Animal; Etanercept; Kv Ch | 2017 |
Effects of the cannabinoid CB
Topics: Acoustic Stimulation; Alpha Rhythm; Animals; Arachidonic Acids; Auditory Cortex; Behavior, Animal; C | 2017 |
Effects of Spirulina on GABA Receptor Gene Expression in Salicylate-Induced Tinnitus.
Topics: Animals; Brain; Cochlea; Down-Regulation; Gene Expression; Mice; Receptors, GABA; Receptors, GABA-B; | 2018 |
Establishment of auditory discrimination and detection of tinnitus induced by salicylic acid and intense tone exposure in the rat.
Topics: Acoustic Stimulation; Animals; Anti-Infective Agents; Auditory Perception; Conditioning, Operant; Di | 2013 |
Effects of salicylate on the inflammatory genes expression and synaptic ultrastructure in the cochlear nucleus of rats.
Topics: Animals; Behavior, Animal; Cochlear Nucleus; Disease Models, Animal; Gene Expression Regulation; Inf | 2014 |
Changes in the numbers of ribbon synapses and expression of RIBEYE in salicylate-induced tinnitus.
Topics: Alcohol Oxidoreductases; Animals; Base Sequence; Blotting, Western; Co-Repressor Proteins; DNA Prime | 2014 |
Both central and peripheral auditory systems are involved in salicylate-induced tinnitus in rats: a behavioral study.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Cochlear Nerve; Conditioning, Operant; Drinking; Dr | 2014 |
Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network.
Topics: Amygdala; Animals; Auditory Cortex; Brain Mapping; Cerebellum; Cochlea; Disease Models, Animal; Geni | 2015 |
Expression of Antioxidant Genes in the Mouse Cochlea and Brain in Salicylate-Induced Tinnitus and Effect of Treatment with Spirulina platensis Water Extract.
Topics: Animals; Brain; Catalase; Cochlea; Gene Expression Regulation; Male; Mice; Plant Extracts; Salicylic | 2015 |
Salicylate enables cochlear arachidonic-acid-sensitive NMDA receptor responses.
Topics: Action Potentials; Animals; Animals, Newborn; Arachidonic Acid; Cochlea; Glutamic Acid; Guinea Pigs; | 2008 |
The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats.
Topics: Animals; Behavior, Animal; Benzoxazines; Conditioning, Operant; Cyclohexanols; Disease Models, Anima | 2010 |
[Effects of er-long-zuo-ci-wan on the spontaneous activities of auditory central nucleus in rat model of tinnitus induced by salicylate acid].
Topics: Animals; Auditory Cortex; Auditory Pathways; Drugs, Chinese Herbal; Male; Phytotherapy; Rats; Rats, | 2009 |
Evidence of key tinnitus-related brain regions documented by a unique combination of manganese-enhanced MRI and acoustic startle reflex testing.
Topics: Animals; Brain Mapping; Cochlear Nucleus; Disease Models, Animal; Inferior Colliculi; Magnetic Reson | 2010 |
Activation of serotonergic neurons during salicylate-induced tinnitus.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Gerbillinae; Immunohistochemistry; Neurons; P | 2010 |
Salicylate-induced peripheral auditory changes and tonotopic reorganization of auditory cortex.
Topics: Action Potentials; Animals; Auditory Cortex; Cyclooxygenase Inhibitors; Electrophysiology; Evoked Po | 2011 |
In vivo electrochemical monitoring of the change of cochlear perilymph ascorbate during salicylate-induced tinnitus.
Topics: Animals; Ascorbic Acid; Cochlea; Electrochemistry; Electrodes; Guinea Pigs; Male; Perilymph; Salicyl | 2012 |
[Study of neurological mechanism of lidocaine's suppression to tinnitus via microdialysis].
Topics: Animals; Hypothalamus; Lidocaine; Microdialysis; Random Allocation; Rats; Rats, Wistar; Salicylic Ac | 2003 |
Salicylate- and quinine-induced tinnitus and effects of memantine.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Auditory Cortex; Dose-Re | 2006 |
Effects of salicylate application on the spontaneous activity in brain slices of the mouse cochlear nucleus, medial geniculate body and primary auditory cortex.
Topics: Action Potentials; Animals; Auditory Cortex; Auditory Pathways; Cochlear Nucleus; Dose-Response Rela | 2008 |
Tinnitus aurium: fact ... or fancy.
Topics: Animals; Auditory Pathways; Brain Mapping; Brain Stem; Cochlea; Cochlear Nerve; Deoxyglucose; Diseas | 1982 |
Salicylate-induced abnormal activity in the inferior colliculus of rats.
Topics: Acoustic Stimulation; Animals; Calcium; Dose-Response Relationship, Drug; Free Radical Scavengers; I | 1995 |
Effects of lidocaine on salicylate-induced discharge of neurons in the inferior colliculus of the guinea pig.
Topics: Action Potentials; Anesthetics, Local; Animals; Auditory Pathways; Disease Models, Animal; Electroph | 1997 |
[Effects of salicylate and quinine on cat primary auditory cortex--spontaneous firing rate].
Topics: Animals; Auditory Cortex; Cats; Quinine; Salicylates; Salicylic Acid; Tinnitus | 1997 |
Effects of quinine on neural activity in cat primary auditory cortex.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Auditory Threshold; Cats; Cortical Synchronization; | 1997 |
[Toxic inner ear damage in topical treatment of psoriasis with salicylates].
Topics: Adult; Audiometry, Pure-Tone; Auditory Threshold; Female; Hearing Loss, Sensorineural; Humans; Kerat | 1997 |
Salicylate and quinine selectively increase spontaneous firing rates in secondary auditory cortex.
Topics: Acoustic Stimulation; Analgesics, Non-Narcotic; Animals; Auditory Cortex; Auditory Threshold; Cats; | 1998 |
Effects of chronic salicylate on GABAergic activity in rat inferior colliculus.
Topics: Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Inferior Colliculi; Kinetics; Mal | 2000 |
Aspirin dosing using 15 grain enteric coated tablets.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Female; Gastrointestinal Diseases; Humans; Male; Middle | 1985 |
Treatment of a Scalp Arteriovenous Malformation by a Combination of Embolization and Surgical Removal.
Topics: Adult; Blood Loss, Surgical; Cerebral Angiography; Cerebrovascular Circulation; Combined Modality Th | 2020 |
NeuroImages. Symptomatic left temporal arteriovenous traumatic fistula.
Topics: Adult; Angiography; Arteriovenous Fistula; Carotid Artery, External; Embolization, Therapeutic; Head | 2009 |
Cirsoid aneurysm of the right pre-auricular region: an unusual cause of tinnitus managed by endovascular glue embolisation.
Topics: Angiography; Arteriovenous Fistula; Embolization, Therapeutic; Enbucrilate; Ethiodized Oil; Female; | 2012 |
Anomalous intracranial venous drainage associated with basal ganglia calcification.
Topics: Basal Ganglia Diseases; Calcinosis; Cerebral Angiography; Cerebral Veins; Child; Dominance, Cerebral | 2007 |
Iatrogenic pulsatile tinnitus.
Topics: Adult; Arteriovenous Fistula; Humans; Iatrogenic Disease; Male; Myringoplasty; Scalp; Temporal Arter | 1993 |