Page last updated: 2024-10-17

salicylic acid and Neuralgia

salicylic acid has been researched along with Neuralgia in 24 studies

Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).

Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Research Excerpts

ExcerptRelevanceReference
" This was done by comparing skin and plasma levels of acetylsalicylic acid (ASA) and salicylic acid (SA) after topically administered ASA/diethyl ether (ADE) mixture in acute herpetic neuralgia (AHN) and postherpetic neuralgia (PHN)."9.08Skin and plasma levels of acetylsalicylic acid: a comparison between topical aspirin/diethyl ether mixture and oral aspirin in acute herpes zoster and postherpetic neuralgia. ( Bareggi, SR; De Benedittis, G; Pirola, R, 1998)
" This was done by comparing skin and plasma levels of acetylsalicylic acid (ASA) and salicylic acid (SA) after topically administered ASA/diethyl ether (ADE) mixture in acute herpetic neuralgia (AHN) and postherpetic neuralgia (PHN)."5.08Skin and plasma levels of acetylsalicylic acid: a comparison between topical aspirin/diethyl ether mixture and oral aspirin in acute herpes zoster and postherpetic neuralgia. ( Bareggi, SR; De Benedittis, G; Pirola, R, 1998)
"Most scalp neuralgias are supraorbital or occipital."2.50[Scalp neuralgia and headache elicited by cranial superficial anatomical causes: supraorbital neuralgia, occipital neuralgia, and post-craniotomy headache]. ( Shimizu, S, 2014)
"Occipital neuralgia is a benign extracranial cause of headache, and it may be confused with other more serious headache syndromes."2.40Occipital neuralgias: clinical recognition of a complicated headache. A case series and literature review. ( Gilberstadt, H; Kuhn, SC; Kuhn, WF, 1997)
"A 46-year-old female, known case of adiposis dolorosa since adolescence, noticed painful thickening of scalp in bilateral parieto-occipital areas and vertex 1 year back."1.36Adiposis dolorosa of scalp presenting with severe headache: an unusual case. ( Bhoyar, K; Dange, N; Kawale, J; Mahore, A, 2010)
"We believed that the loss of consciousness during lesser nerve block may be due to a subarachnoid injection."1.31Sudden unconsciousness during a lesser occipital nerve block in a patient with the occipital bone defect. ( Kim, P; Kitajima, T; Matsumoto, T; Okuda, Y; Shinohara, M, 2001)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19908 (33.33)18.7374
1990's7 (29.17)18.2507
2000's4 (16.67)29.6817
2010's5 (20.83)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
LUDECKE, T1
Bareggi, SR1
Pirola, R1
De Benedittis, G1
Wang, L1
Das, S1
Yang, H1
Shimizu, S1
Doh, EJ1
Yoon, HS1
Cho, S1
Park, HS1
Cohen, SP1
Peterlin, BL1
Fulton, L1
Neely, ET1
Kurihara, C1
Gupta, A1
Mali, J1
Fu, DC1
Jacobs, MB1
Plunkett, AR1
Verdun, AJ1
Stojanovic, MP1
Hanling, S1
Constantinescu, O1
White, RL1
McLean, BC1
Pasquina, PF1
Zhao, Z1
Klinger, M1
Villani, F1
Klinger, F1
Gaetani, P1
Rodriguez Y Baena, R1
Levi, D1
Kawale, J1
Mahore, A1
Dange, N1
Bhoyar, K1
Wang, H1
Chen, H1
Jiang, H1
Cerrato, P1
Bergui, M1
Imperiale, D1
Baima, C1
Grasso, M1
Giraudo, M1
Lentini, A1
Lopiano, L1
Bradac, GB1
Bergamasco, B1
MARTIN, BC1
FAGAN, PJ1
Oh, S1
Tok, S1
Allemann, J1
Prevost, A1
Schmid, UD1
Mathur, JG1
Rifat, SF1
Lombardo, JA1
Dubuisson, D1
Sulfaro, MA1
Gobetti, JP1
Brown, CR1
Kuhn, WF1
Kuhn, SC1
Gilberstadt, H1
Okuda, Y1
Matsumoto, T1
Shinohara, M1
Kitajima, T1
Kim, P1
Schultz, DR1
Thomas, AL1
Xie, Z1
Graff-Radford, SB1
Jaeger, B1
Reeves, JL1
Dalessio, DJ1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Heated vs. Pulsed Radiofrequency Treatment of the Genicular Nerves for Osteoarthritis Knee Pain[NCT04379895]60 participants (Anticipated)Interventional2020-06-30Not yet recruiting
A Comparison of Pain Control AND Quality of Life Improvement Between Occipital Nerve Block And Occipital Nerve Radiofrequency Ablation: A Double-Blind Single Center Prospective Study[NCT04124458]70 participants (Anticipated)Interventional2023-01-02Not yet recruiting
Pulsed vs Continuous Radiofrequency Neurotomy for Cervical Facet Joint Mediated Pain: a Single-blind Randomized Controlled Clinical Trial[NCT04124445]88 participants (Anticipated)Interventional2020-02-10Recruiting
Randomized, Double-blind, Comparative-effectiveness Study Comparing Corticosteroid Injections to Pulsed Radiofrequency for Occipital Neuralgia[NCT01670825]81 participants (Actual)Interventional2012-08-31Completed
Greater Occipital Nerve Pulsed Radiofrequency for the Treatment of Combined Migraine and Cervicogenic Headache (New Approach): Randomized Clinical Trial[NCT06121037]60 participants (Actual)Interventional2022-01-01Completed
Ultrasound Guided Platelet Rich Plasma Injections for Post Traumatic Greater Occipital Neuralgia: A Randomized Controlled Pilot Study[NCT04051203]Phase 135 participants (Anticipated)Interventional2019-02-01Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Average Occipital Pain 2 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 2 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 2 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection2.495
Corticosteroid Injection + Sham Pulsed Radiofrequency3.694

Change in Average Occipital Pain 3 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 3 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection3.791
Corticosteroid Injection + Sham Pulsed Radiofrequency4.441

Change in Average Occipital Pain 6 Months After the Start of Treatment

The change in the numeric pain scale score from baseline to 6 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection4.312
Corticosteroid Injection + Sham Pulsed Radiofrequency4.765

Change in Average Occipital Pain 6 Weeks After the Start of Treatment

The change in the numeric pain scale score from baseline to 6 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection3.068
Corticosteroid Injection + Sham Pulsed Radiofrequency3.738

Change in Overall Average Headache Pain 2 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 2 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 2 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection3.392
Corticosteroid Injection + Sham Pulsed Radiofrequency4.220

Change in Overall Average Headache Pain 3 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 3 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection4.000
Corticosteroid Injection + Sham Pulsed Radiofrequency4.694

Change in Overall Average Headache Pain 6 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.761
Corticosteroid Injection + Sham Pulsed Radiofrequency7.556

Change in Overall Average Headache Pain 6 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection3.678
Corticosteroid Injection + Sham Pulsed Radiofrequency4.410

Change in Overall Worst Headache Pain 2 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 2 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 2 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection5.540
Corticosteroid Injection + Sham Pulsed Radiofrequency6.650

Change in Overall Worst Headache Pain 3 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 3 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.522
Corticosteroid Injection + Sham Pulsed Radiofrequency7.417

Change in Overall Worst Headache Pain 6 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.761
Corticosteroid Injection + Sham Pulsed Radiofrequency7.556

Change in Overall Worst Overall Headache Pain 6 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.583
Corticosteroid Injection + Sham Pulsed Radiofrequency6.825

Change in the Presence of Insomnia 3 Months After the Start of Treatment Measured Using the Athens Insomnia Scale.

This outcome will measure the participant's perceived improvement in sleep using the Athens Insomnia Scale. Scores in this scale can range from 0 to 24. 0 being the best possible outcome and 24 being the worst possible outcome. A score greater than or equal to 6 indicates a presence of insomnia. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection9.539
Corticosteroid Injection + Sham Pulsed Radiofrequency9.069

Change in the Presence of Insomnia 6 Months After the Start of Treatment Measured Using the Athens Insomnia Scale.

This outcome will measure the participant's perceived improvement in sleep using the Athens Insomnia Scale. Scores in this scale can range from 0 to 24. 0 being the best possible outcome and 24 being the worst possible outcome. A score greater than or equal to 6 indicates a presence of insomnia. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection9.256
Corticosteroid Injection + Sham Pulsed Radiofrequency9.431

Change in the Presence of Insomnia 6 Weeks After the Start of Treatment Measured Using the Athens Insomnia Scale.

This outcome will measure the participant's perceived improvement in sleep using the Athens Insomnia Scale. Scores in this scale can range from 0 to 24. 0 being the best possible outcome and 24 being the worst possible outcome. A score greater than or equal to 6 indicates a presence of insomnia. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection10.025
Corticosteroid Injection + Sham Pulsed Radiofrequency8.132

Change in the Severity of Depression 3 Months After the Start of Treatment Measured Using the Beck's Depression Inventory

This outcome will measure the change in severity of depression using the Beck's Depression Inventory. Scores in this inventory can range from 0 to 63. 0 being the best possible outcome and 63 being the worst possible outcome. A score between 14 and 19 indicates mild depression and a score greater than or equal 29 indicates severe depression. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection11.333
Corticosteroid Injection + Sham Pulsed Radiofrequency11.972

Change in the Severity of Depression 6 Months After the Start of Treatment Measured Using the Beck's Depression Inventory

This outcome will measure the change in severity of depression using the Beck's Depression Inventory. Scores in this inventory can range from 0 to 63. 0 being the best possible outcome and 63 being the worst possible outcome. A score between 14 and 19 indicates mild depression and a score greater than or equal 29 indicates severe depression. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection12.590
Corticosteroid Injection + Sham Pulsed Radiofrequency12.250

Change in the Severity of Depression 6 Weeks After the Start of Treatment Measured Using the Beck's Depression Inventory

This outcome will measure the change in severity of depression using the Beck's Depression Inventory. Scores in this inventory can range from 0 to 63. 0 being the best possible outcome and 63 being the worst possible outcome. A score between 14 and 19 indicates mild depression and a score greater than or equal 29 indicates severe depression. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection12.775
Corticosteroid Injection + Sham Pulsed Radiofrequency10.842

Change in Worst Occipital Pain 2 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 2 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 2 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection4.726
Corticosteroid Injection + Sham Pulsed Radiofrequency5.846

Change in Worst Occipital Pain 3 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 3 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection5.850
Corticosteroid Injection + Sham Pulsed Radiofrequency7.149

Change in Worst Occipital Pain 6 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.705
Corticosteroid Injection + Sham Pulsed Radiofrequency7.541

Change in Worst Occipital Pain 6 Weeks After the Start of Treatment

The change in the numeric pain scale score from baseline to 6 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection5.354
Corticosteroid Injection + Sham Pulsed Radiofrequency6.064

Disability Due to Headaches 3 Months After the Start of Treatment Measured Using the Headache Impact Scale

This outcome measures what the patient feels they cannot do because headaches. This outcome is measured using the Headache Impact Test. Scores in this test range from range from 36 to 78, with higher scores indicating greater negative impact. A score of less than 50 indicates minimal impact, while a score greater than or equal to 60 indicates headaches are severely impacting one's life. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection59.718
Corticosteroid Injection + Sham Pulsed Radiofrequency60.556

Disability Due to Headaches 6 Months After the Start of Treatment Measured Using the Headache Impact Scale

This outcome measures what the patient feels they cannot do because headaches. This outcome is measured using the Headache Impact Test. Scores in this test range from range from 36 to 78, with higher scores indicating greater negative impact. A score of less than 50 indicates minimal impact, while a score greater than or equal to 60 indicates headaches are severely impacting one's life. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection59.641
Corticosteroid Injection + Sham Pulsed Radiofrequency61.389

Disability Due to Headaches 6 Weeks After the Start of Treatment Measured Using the Headache Impact Scale

This outcome measures what the patient feels they cannot do because headaches. This outcome is measured using the Headache Impact Test. Scores in this test range from range from 36 to 78, with higher scores indicating greater negative impact. A score of less than 50 indicates minimal impact, while a score greater than or equal to 60 indicates headaches are severely impacting one's life. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection60.087
Corticosteroid Injection + Sham Pulsed Radiofrequency59.553

Severe Headache Frequency for Migraine Headaches 3 Months After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe migraine headaches in the week (7 days) prior to the 3 month follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection2.087
Corticosteroid Injection + Sham Pulsed Radiofrequency2.263

Severe Headache Frequency for Migraine Headaches 6 Months After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe migraine headaches in the week (7 days) prior to the 6 month follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection2.044
Corticosteroid Injection + Sham Pulsed Radiofrequency2.368

Severe Headache Frequency for Migraine Headaches 6 Weeks After the Start of Treatment Measured Asking the Number of Severe Headaches in the Past Week.

This outcome will measure the number of days the patient has severe migraine headaches in the week (7 days) prior to the 6 week follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection1.708
Corticosteroid Injection + Sham Pulsed Radiofrequency1.810

Severe Headache Frequency for Occipital Neuralgia Headaches 3 Months After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe occipital neuralgia headaches in the week (7 days) prior to the 6 week follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: 3 months

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection1.846
Corticosteroid Injection + Sham Pulsed Radiofrequency1.919

Severe Headache Frequency for Occipital Neuralgia Headaches 6 Months After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe occipital neuralgia headaches in the week (7 days) prior to the 6 week follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection2.128
Corticosteroid Injection + Sham Pulsed Radiofrequency2.162

Severe Headache Frequency for Occipital Neuralgia Headaches 6 Weeks After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe occipital neuralgia headaches in the week (7 days) prior to the 6 week follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection1.436
Corticosteroid Injection + Sham Pulsed Radiofrequency1.436

Reviews

3 reviews available for salicylic acid and Neuralgia

ArticleYear
[Scalp neuralgia and headache elicited by cranial superficial anatomical causes: supraorbital neuralgia, occipital neuralgia, and post-craniotomy headache].
    Rinsho shinkeigaku = Clinical neurology, 2014, Volume: 54, Issue:5

    Topics: Craniotomy; Decompression, Surgical; Headache; Humans; Neck Muscles; Neuralgia; Orbit; Peripheral Ne

2014
Occipital neuralgia manifesting as orofacial pain.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1995, Volume: 80, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Facial Pain; Female; Humans; Middle Aged;

1995
Occipital neuralgias: clinical recognition of a complicated headache. A case series and literature review.
    Journal of orofacial pain, 1997,Spring, Volume: 11, Issue:2

    Topics: Adult; Anesthetics, Local; Diagnosis, Differential; Facial Pain; Female; Follow-Up Studies; Headache

1997

Trials

2 trials available for salicylic acid and Neuralgia

ArticleYear
Skin and plasma levels of acetylsalicylic acid: a comparison between topical aspirin/diethyl ether mixture and oral aspirin in acute herpes zoster and postherpetic neuralgia.
    European journal of clinical pharmacology, 1998, Volume: 54, Issue:3

    Topics: Acute Disease; Administration, Oral; Administration, Topical; Aged; Analgesics; Anti-Inflammatory Ag

1998
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015

Other Studies

19 other studies available for salicylic acid and Neuralgia

ArticleYear
[Therapy of rheumatic, neuralgic and influenzal diseases in general practice].
    Medizinische Monatsschrift, 1953, Volume: 7, Issue:1

    Topics: Family Practice; General Practice; Humans; Influenza, Human; Neuralgia; Phenacetin; Rheumatic Diseas

1953
DTI of great occipital nerve neuropathy: an initial study in patients with cervicogenic headache.
    Clinical radiology, 2019, Volume: 74, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Diffusion Tensor Imaging; Feasibility Studies; Female; Humans; Male;

2019
Occipital neuralgia after scalp biopsy and curettage.
    The British journal of dermatology, 2015, Volume: 173, Issue:6

    Topics: Biopsy; Curettage; Female; Headache Disorders; Humans; Hypotrichosis; Middle Aged; Neuralgia; Scalp;

2015
Anatomical variations of the occipital nerves: implications for the treatment of chronic headaches.
    Plastic and reconstructive surgery, 2009, Volume: 124, Issue:5

    Topics: Cicatrix; Cranial Nerves; Decompression, Surgical; Headache Disorders; Humans; Neuralgia; Occipital

2009
Adiposis dolorosa of scalp presenting with severe headache: an unusual case.
    The journal of headache and pain, 2010, Volume: 11, Issue:6

    Topics: Adiposis Dolorosa; Diagnosis, Differential; Female; Headache Disorders; Humans; Middle Aged; Neuralg

2010
Experience in acupuncture treatment of occipital neuralgia.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2002, Volume: 22, Issue:3

    Topics: Acupuncture Therapy; Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Neuralgia; Occipita

2002
Occipital neuralgia as isolated symptom of an upper cervical cavernous angioma.
    Journal of neurology, 2002, Volume: 249, Issue:10

    Topics: Female; Hemangioma, Cavernous, Central Nervous System; Humans; Middle Aged; Neuralgia; Radiography;

2002
THE SURGICAL THERAPY OF CERTAIN OCCIPITAL HEADACHES.
    Plastic and reconstructive surgery, 1964, Volume: 33

    Topics: Headache; Humans; Neuralgia; Neurosurgery; Neurosurgical Procedures; Scalp; Surgical Procedures, Ope

1964
[Exeresis in occipital neuralgia].
    Neurochirurgia, 1983, Volume: 26, Issue:2

    Topics: Adult; Cervical Vertebrae; Cicatrix; Female; Headache; Humans; Male; Middle Aged; Neuralgia; Neuroma

1983
Treatment of occipital neuralgia.
    The Medical journal of Australia, 1980, Jul-26, Volume: 2, Issue:2

    Topics: Aged; Arteries; Cluster Headache; Humans; Ligation; Male; Neuralgia; Scalp

1980
Occipital neuralgia in a football player: a case report.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 1995, Volume: 5, Issue:4

    Topics: Adult; Anesthetics, Local; Bupivacaine; Cervical Plexus; Diagnosis, Differential; Football; Headache

1995
Treatment of occipital neuralgia by partial posterior rhizotomy at C1-3.
    Journal of neurosurgery, 1995, Volume: 82, Issue:4

    Topics: Adult; Cervical Vertebrae; Craniocerebral Trauma; Female; Follow-Up Studies; Humans; Laminectomy; Ma

1995
Occipital neuralgia: symptoms, diagnosis, and treatment.
    Practical periodontics and aesthetic dentistry : PPAD, 1996, Volume: 8, Issue:6

    Topics: Diagnosis, Differential; Facial Pain; Female; Headache; Humans; Male; Neuralgia; Scalp

1996
Sudden unconsciousness during a lesser occipital nerve block in a patient with the occipital bone defect.
    European journal of anaesthesiology, 2001, Volume: 18, Issue:12

    Topics: Anesthetics, Local; Craniotomy; Dura Mater; Headache Disorders; Humans; Male; Middle Aged; Nerve Blo

2001
Occipital neuralgia.
    The Journal of the American Osteopathic Association, 1977, Volume: 76, Issue:5

    Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Neck; Neuralgia; Scalp

1977
Periodic migrainous neuralgia associated with an arteriovenous malformation.
    Postgraduate medical journal, 1975, Volume: 51, Issue:597

    Topics: Adult; Arteriovenous Malformations; Humans; Male; Migraine Disorders; Neuralgia; Scalp

1975
51 cases of occipital neuralgia treated with acupuncture.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 1992, Volume: 12, Issue:3

    Topics: Acupuncture Points; Acupuncture Therapy; Adult; Female; Humans; Male; Middle Aged; Neuralgia; Occipi

1992
Myofascial pain may present clinically as occipital neuralgia.
    Neurosurgery, 1986, Volume: 19, Issue:4

    Topics: Adult; Diagnosis, Differential; Female; Headache; Humans; Male; Middle Aged; Myofascial Pain Syndrom

1986
A classification of headache.
    International ophthalmology clinics, 1970,Fall, Volume: 10, Issue:3

    Topics: Antidepressive Agents; Anxiety; Arteritis; Aspirin; Depression; Ergot Alkaloids; Facial Neuralgia; H

1970