Page last updated: 2024-10-17

salicylic acid and Hyperpigmentation

salicylic acid has been researched along with Hyperpigmentation in 28 studies

Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).

Hyperpigmentation: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.

Research Excerpts

ExcerptRelevanceReference
" We sought to determine the efficacy and safety of Jessner's solution (JS) in comparison with salicylic acid (SA) 30% in the management of acne vulgaris and postacne hyperpigmentation in patients with colored skin."9.34Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial. ( How, KN; Lim, PY; Shamsudin, N; Wan Ahmad Kammal, WSL, 2020)
"Comparing the therapeutic efficacy of TCA 25% peels with those of salicylic acid 30% in patients with acne vulgaris."9.20Trichloroacetic Acid Versus Salicylic Acid in the Treatment of Acne Vulgaris in Dark-Skinned Patients. ( Abdel Meguid, AM; Elaziz Ahmed Attallah, DA; Omar, H, 2015)
"Many clinicians have used glycolic acid (GA) peels for facial acne, scarring, and hyperpigmentation, mainly in lighter skin types."7.75Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study. ( Garg, VK; Sarkar, R; Sinha, S, 2009)
" No adverse reaction was reported in either group."7.30Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial. ( He, X; Li, S; Niu, YG; Steel, A; Wang, HT; Zhang, XS; Zhang, Z, 2023)
" Treatment had no significant adverse effects."6.74Effectiveness, safety, and effect on quality of life of topical salicylic acid peels for treatment of postinflammatory hyperpigmentation in dark skin. ( Alam, M; Boone, SL; Helenowski, I; Joshi, SS; Kundu, RV; Rademaker, A; West, DP; White, L; Yoo, S, 2009)
" We sought to determine the efficacy and safety of Jessner's solution (JS) in comparison with salicylic acid (SA) 30% in the management of acne vulgaris and postacne hyperpigmentation in patients with colored skin."5.34Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial. ( How, KN; Lim, PY; Shamsudin, N; Wan Ahmad Kammal, WSL, 2020)
"Comparing the therapeutic efficacy of TCA 25% peels with those of salicylic acid 30% in patients with acne vulgaris."5.20Trichloroacetic Acid Versus Salicylic Acid in the Treatment of Acne Vulgaris in Dark-Skinned Patients. ( Abdel Meguid, AM; Elaziz Ahmed Attallah, DA; Omar, H, 2015)
" Salicylic acid peel has effectiveness for both of acne and postinflammatory hyperpigmentation that are common in patients with skin of color."5.12Whitening effect of salicylic acid peels in Asian patients. ( Ahn, HH; Kim, IH, 2006)
"Many clinicians have used glycolic acid (GA) peels for facial acne, scarring, and hyperpigmentation, mainly in lighter skin types."3.75Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study. ( Garg, VK; Sarkar, R; Sinha, S, 2009)
"The results of this study suggest that superficial salicylic acid peels are both safe and efficacious for treatment of acne vulgaris, oily skin, textural changes, melasma, and post-inflammatory hyperpigmentation in patients with skin types V and VI."3.70The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. ( Grimes, PE, 1999)
" No adverse reaction was reported in either group."3.30Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial. ( He, X; Li, S; Niu, YG; Steel, A; Wang, HT; Zhang, XS; Zhang, Z, 2023)
" Treatment had no significant adverse effects."2.74Effectiveness, safety, and effect on quality of life of topical salicylic acid peels for treatment of postinflammatory hyperpigmentation in dark skin. ( Alam, M; Boone, SL; Helenowski, I; Joshi, SS; Kundu, RV; Rademaker, A; West, DP; White, L; Yoo, S, 2009)
"Hydroquinone 4% cream with 2% glycolic acid is safe and effective in improving photodamage on the neck and upper chest when used alone or in combination with salicylic acid peels."2.69Efficacy of hydroquinone cream (USP 4%) used alone or in combination with salicylic acid peels in improving photodamage on the neck and upper chest. ( Gladstone, HB; Jeffers, M; Moy, RL; Nguyen, SL; Ottomeyer, T; Williams, R; Wortzman, M, 2000)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.57)18.2507
2000's9 (32.14)29.6817
2010's13 (46.43)24.3611
2020's5 (17.86)2.80

Authors

AuthorsStudies
Liu, J1
Jiang, R1
Zhou, J1
Xu, X1
Sun, Z1
Li, J1
Chen, X1
Li, Z1
Yan, X1
Zhao, D1
Zheng, Z1
Sun, L1
Li, S1
He, X1
Zhang, Z1
Zhang, XS1
Niu, YG1
Steel, A1
Wang, HT1
Tsukahara, R1
Miyata, K1
Go, U1
Mitsuishi, T1
How, KN1
Lim, PY1
Wan Ahmad Kammal, WSL1
Shamsudin, N1
Vakirlis, E1
Theodosiou, G1
Lallas, A1
Apalla, Z1
Sotiriou, E1
Guarneri, C1
Tchernev, G1
Chokoeva, AA1
Ananiev, J1
Wollina, U1
Abdel Meguid, AM1
Elaziz Ahmed Attallah, DA1
Omar, H1
Shokeen, D1
Mohamed Ali, BM1
Gheida, SF1
El Mahdy, NA1
Sadek, SN1
Garg, VK1
Sinha, S1
Sarkar, R1
Joshi, SS1
Boone, SL1
Alam, M1
Yoo, S1
White, L1
Rademaker, A1
Helenowski, I1
West, DP1
Kundu, RV1
Dahl, A1
Yatskayer, M1
Raab, S1
Oresajo, C1
Taibjee, SM1
Cheung, ST1
Laube, S1
Lanigan, SW1
Ahn, HH1
Kim, IH1
Hexsel, D1
Arellano, I1
Rendon, M1
Grimes, PE1
Gladstone, HB1
Nguyen, SL1
Williams, R1
Ottomeyer, T1
Wortzman, M1
Jeffers, M1
Moy, RL1
Di Altobrando, A1
Tabanelli, M1
Crisanti, E1
Dika, E1
Patrizi, A1
Savoia, F1
Chan, C1
Magro, CM1
Pham, AK1
LeBlanc, RE1
Yan, S1
Barton, DT1
Pace, NC1
Chapman, MS1
Momtahen, S1
Ward, PD1
Miller, HL1
Shipman, AR1
Yeo, L1
Husain, E1
Rajpara, S1
Oza, VS1
Schulman, JM1
Mully, TW1
Ortiz, S1
Regula, CG1
Clarke, JT1
Lin, MY1
Chen, LJ1
Ma, L1
Wu, WY1
Xiang, LH1
Morris-Jones, R1
Creamer, D1
Selim, A1
Roider, E1
Schneider, J1
Flaig, MJ1
Ruzicka, T1
Kunte, C1
Berking, C1
Castori, M1
Scarciolla, O1
Morlino, S1
Manente, L1
Biscaglia, A1
Fragasso, A1
Grammatico, P1
Federici, S1
Griffiths, D1
Siberchicot, F1
Chateil, JF1
Gilbert, B1
Lacombe, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparing the Efficacy and Safety of Combined Glycolic Acid and Salicylic Acid Peel Versus Glycolic Acid Peel Alone in the Treatment of Melasma: A Split Face Study[NCT02812719]Early Phase 10 participants (Actual)Interventional2018-07-31Withdrawn (stopped due to Study did not receive funding and will not be implemented.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for salicylic acid and Hyperpigmentation

ArticleYear
Postinflammatory hyperpigmentation in patients with skin of color.
    Cutis, 2016, Volume: 97, Issue:1

    Topics: Chemexfoliation; Dermatitis; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Ethanol; Gl

2016
Spontaneous Hair Repigmentation in an 80-Year-Old Man: A Case of Melanoma-Associated Hair Repigmentation and Review of the Literature.
    The American Journal of dermatopathology, 2019, Volume: 41, Issue:9

    Topics: Aged, 80 and over; Biopsy, Needle; Hair Color; Hair Follicle; Humans; Hyperpigmentation; Immunohisto

2019

Trials

9 trials available for salicylic acid and Hyperpigmentation

ArticleYear
Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:9

    Topics: Acne Vulgaris; Adult; China; Humans; Hyperpigmentation; Salicylic Acid; Skin; Treatment Outcome

2023
Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial.
    International journal of dermatology, 2020, Volume: 59, Issue:7

    Topics: Acne Vulgaris; Adult; Chemexfoliation; Double-Blind Method; Drug Combinations; Ethanol; Facial Derma

2020
Trichloroacetic Acid Versus Salicylic Acid in the Treatment of Acne Vulgaris in Dark-Skinned Patients.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2015, Volume: 41, Issue:12

    Topics: Acne Vulgaris; Chemexfoliation; Dermatitis, Exfoliative; Double-Blind Method; Erythema; Female; Huma

2015
Evaluation of salicylic acid peeling in comparison with topical tretinoin in the treatment of postinflammatory hyperpigmentation.
    Journal of cosmetic dermatology, 2017, Volume: 16, Issue:1

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Chemexfoliation; Child; Combined Modality Therap

2017
Effectiveness, safety, and effect on quality of life of topical salicylic acid peels for treatment of postinflammatory hyperpigmentation in dark skin.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35, Issue:4

    Topics: Administration, Topical; Adult; Chemexfoliation; Female; Humans; Hyperpigmentation; Inflammation; Ke

2009
Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone.
    Journal of drugs in dermatology : JDD, 2013, Volume: 12, Issue:1

    Topics: Adult; Aged; Chemistry, Pharmaceutical; Double-Blind Method; Ellagic Acid; Ethnicity; Face; Female;

2013
Controlled study of excimer and pulsed dye lasers in the treatment of psoriasis.
    The British journal of dermatology, 2005, Volume: 153, Issue:5

    Topics: Adult; Aged; Combined Modality Therapy; Female; Humans; Hyperpigmentation; Keratolytic Agents; Laser

2005
Whitening effect of salicylic acid peels in Asian patients.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2006, Volume: 32, Issue:3

    Topics: Acne Vulgaris; Adult; Asian People; Chemexfoliation; Colorimetry; Female; Humans; Hyperpigmentation;

2006
Efficacy of hydroquinone cream (USP 4%) used alone or in combination with salicylic acid peels in improving photodamage on the neck and upper chest.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2000, Volume: 26, Issue:4

    Topics: Chemexfoliation; Female; Glycolates; Humans; Hydroquinones; Hyperpigmentation; Keratolytic Agents; M

2000

Other Studies

17 other studies available for salicylic acid and Hyperpigmentation

ArticleYear
Salicylic acid in ginseng root alleviates skin hyperpigmentation disorders by inhibiting melanogenesis and melanosome transport.
    European journal of pharmacology, 2021, Nov-05, Volume: 910

    Topics: alpha-MSH; Animals; Calcium; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Hy

2021
Combined therapies of oral retinoid and topical salicylic acid in recalcitrant pigmented warts of a child.
    The Journal of dermatology, 2020, Volume: 47, Issue:5

    Topics: Administration, Cutaneous; Administration, Oral; Alphapapillomavirus; Biopsy; Child; Drug Resistance

2020
Terra firma-forme dermatosis: Differential diagnosis and response to salicylic acid therapy.
    Pediatric dermatology, 2019, Volume: 36, Issue:4

    Topics: Administration, Topical; Child; Dermoscopy; Diagnosis, Differential; Exanthema; Female; Humans; Hype

2019
[10-year-old boy with blackish brown skin alterations].
    Deutsche medizinische Wochenschrift (1946), 2014, Volume: 139, Issue:50

    Topics: 2-Propanol; Child; Chronic Disease; Dermatitis; Diagnosis, Differential; Ethanol; Humans; Hyperpigme

2014
Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35, Issue:1

    Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Cicatrix; Drug Combinations; Female; Glycolates;

2009
Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation.
    The British journal of dermatology, 2006, Volume: 156 Suppl 1

    Topics: Administration, Topical; Drug Therapy, Combination; Facial Dermatoses; Fluocinolone Acetonide; Gluco

2006
The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1999, Volume: 25, Issue:1

    Topics: Acne Vulgaris; Adult; Black People; Chemexfoliation; Drug Administration Schedule; Female; Hispanic

1999
Oral mucosal hyperpigmentation in a patient with a previous diagnosis of melanoma of the scalp.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2020, Volume: 18, Issue:10

    Topics: Aged; Humans; Hyperpigmentation; Male; Melanoma; Mouth Mucosa; Scalp; Skin Neoplasms

2020
A case of repigmentation and curling of hair on acitretin therapy.
    Clinical and experimental dermatology, 2014, Volume: 39, Issue:1

    Topics: Acitretin; Hair; Hair Color; Hair Diseases; Humans; Hyperpigmentation; Keratolytic Agents; Male; Mid

2014
Poliosis circumscripta unmasking a scalp melanoma.
    Clinical and experimental dermatology, 2015, Volume: 40, Issue:8

    Topics: Adult; Hair Diseases; Head and Neck Neoplasms; Humans; Hyperpigmentation; Male; Melanoma; Scalp; Ski

2015
A case of hair re-pigmentation from a scalp melanoma.
    Dermatology online journal, 2015, Jul-15, Volume: 21, Issue:7

    Topics: Biopsy, Needle; Diagnosis, Differential; Female; Hair; Hair Follicle; Humans; Hyperpigmentation; Imm

2015
JAAD Grand Rounds quiz. Woman with hyperpigmented plaque and alopecia.
    Journal of the American Academy of Dermatology, 2009, Volume: 61, Issue:1

    Topics: Adult; Alopecia; Diagnosis, Differential; Female; Forehead; Humans; Hyperpigmentation; Scalp; Sclero

2009
Generalized reticulated hyperpigmentation induced by lichen planus.
    Clinical and experimental dermatology, 2009, Volume: 34, Issue:8

    Topics: Aged; Diagnosis, Differential; Female; Foot Dermatoses; Hand Dermatoses; Humans; Hyperpigmentation;

2009
A clinically challenging pigmented lesion on the scalp.
    Clinical and experimental dermatology, 2010, Volume: 35, Issue:4

    Topics: Biopsy; Head and Neck Neoplasms; Humans; Hyperpigmentation; Male; Middle Aged; Neoplasms, Adnexal an

2010
Hypopigmentation in the sites of regressed melanoma metastases after successful dacarbazine therapy.
    International journal of dermatology, 2012, Volume: 51, Issue:9

    Topics: Antineoplastic Agents, Alkylating; Dacarbazine; Forearm; Head and Neck Neoplasms; Humans; Hyperpigme

2012
Whorled hairless nevus of the scalp, linear hyperpigmentation, and telangiectatic nevi of the lower limbs: a novel variant of the "phacomatosis complex".
    American journal of medical genetics. Part A, 2012, Volume: 158A, Issue:2

    Topics: Child; Hamartoma; Hemangioma; Humans; Hyperpigmentation; Lower Extremity Deformities, Congenital; Ma

2012
Oculo-ectodermal syndrome: a new tumour predisposition syndrome.
    Clinical dysmorphology, 2004, Volume: 13, Issue:2

    Topics: Alopecia; Child, Preschool; Female; Follow-Up Studies; Genetic Predisposition to Disease; Granuloma,

2004