Page last updated: 2024-10-17

salicylic acid and Anoxemia

salicylic acid has been researched along with Anoxemia in 30 studies

Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).

Research Excerpts

Excerpt	Relevance	Reference
"Hypercapnia was induced by applying gas mixtures with CO2 contents from 0 to 5, 10, 20 or 30% CO2 in O2."	1.30	Hypoxia- and hypercapnia-induced DC potential shifts in rat at the scalp and the skull are opposite in polarity to those at the cerebral cortex. ( Lehmenkühler, A; Pöppelmann, T; Richter, F, 1999)
"Nine men had male pattern baldness (Juri degree II or III), and nine were controls (no male pattern baldness)."	1.29	Transcutaneous PO2 of the scalp in male pattern baldness: a new piece to the puzzle. ( Fisher, DM; Goldman, BE; Ringler, SL, 1996)
"Therefore, the influence of hypoxemia on scalp blood flow was studied in four chronically catheterized fetal lambs of 125-135 days of gestation."	1.27	Red blood cell flow in the fetal scalp during hypoxemia in the chronic sheep experiment: a laser Doppler flow study. ( Aarnoudse, JG; Smits, TM; Zijlstra, WG, 1986)

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (56.67)	18.7374
1990's	7 (23.33)	18.2507
2000's	3 (10.00)	29.6817
2010's	2 (6.67)	24.3611
2020's	1 (3.33)	2.80

Authors

Authors	Studies
Avancini, G	1
Abreu, IN	1
Saldaña, MD	1
Mohamed, RS	1
Mazzafera, P	1
WALTNER, K	1
Khalid, MA	2
Ashraf, M	2
Piantadosi, CA	1
Zhang, J	1
Demchenko, IT	1
Delhaas, T	1
Andriessen, P	1
van Laar, JO	1
Vullings, R	1
Hermans, BJ	1
Niemarkt, HJ	1
Jellema, RK	1
Ophelders, DR	1
Wolfs, TG	1
Kramer, BW	1
Zwanenburg, A	1
Carré, JL	1
Suzuki, T	1
Paus, R	2
Andresen, JH	1
Saugstad, OD	1
Luttkus, AK	1
Norén, H	1
Stupin, JH	1
Blad, S	1
Arulkumaran, S	1
Erkkola, R	1
Hagberg, H	1
Lenstrup, C	1
Visser, GH	1
Tamazian, O	1
Yli, B	1
Rosén, KG	1
Dudenhausen, JW	1
Bodó, E	1
Kromminga, A	1
Funk, W	1
Laugsch, M	1
Duske, U	1
Jelkmann, W	1
Jansen, CA	1
Bass, FG	1
Lowe, KC	1
Nathanielsz, PW	1
Aarnoudse, JG	2
Oeseburg, B	1
Kwant, G	1
Huisjes, HJ	1
Zijlstra, WG	2
Germon, TJ	1
Kane, NM	1
Manara, AR	1
Nelson, RJ	1
Gershan, LA	1
Esterly, NB	1
Goldman, BE	1
Fisher, DM	1
Ringler, SL	1
Lehmenkühler, A	1
Richter, F	1
Pöppelmann, T	1
Wood, C	1
Staisch, K	1
Nuwayhid, B	1
Bauer, R	1
Welsh, L	1
Brinkman, CR	1
Smits, TM	1
Cohen, H	1
Seeds, AE	2
Escarcena, L	1
Vogtmann, C	1
Johnston, DI	1
Bloom, SR	1
Spurrett, B	1
Erdmann, W	1
Kunke, S	1
Heidenreich, J	1
Dempsey, W	1
Günther, H	1
Schäfer, H	1
Behrman, RE	2
Fisher, D	1
Paton, JB	1
Keller, J	1
Hobel, CJ	1
Gare, DJ	1
Shime, J	1
Paul, WM	1
Hoskins, M	1
Tatelbaum, RC	1
Rosen, MG	1

Clinical Trials (2)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized Trial of Fetal ECG ST Segment and T Wave Analysis as an Adjunct to Electronic Fetal Heart Rate Monitoring (STAN)[NCT01131260]		11,108 participants (Actual)	Interventional	2010-11-30	Completed
Use of Botulinum Toxin in the Treatment of Androgenic Alopecia[NCT05456087]	Phase 2	20 participants (Anticipated)	Interventional	2022-08-12	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Median Apgar Score at 5 Minutes

The Apgar score is a simple method of quickly assessing the health and vital signs of a newborn baby created by and named after Dr. Virginia Apgar. Apgar testing assesses Appearance, Pulse, Grimace and Activity in a newborn and is typically done at one and five minutes after a baby is born, and it may be repeated at 10, 15, and 20 minutes if the score is low. The five criteria are each scored as 0, 1, or 2 (two being the best), and the total score is calculated by then adding the five values obtained. Agar scores of 0-3 are critically low, 4-6 are below normal, and indicate that the baby likely requires medical intervention, scores of 7+ are considered normal. The lower the Apgar score, the more alert the medical team should be to the possibility of the baby requiring intervention. Some components of the Apgar score are subjective, and there are cases in which a baby requires urgent medical treatment despite having a high Apgar score. (NCT01131260)
Timeframe: 5 minutes after Delivery

Intervention	score on a scale (Median)
Open Group	9
Masked Group	9

Median Duration of Labor Post-randomization

Duration of labor in hours after randomization through delivery (NCT01131260)
Timeframe: Onset of Labor through delivery

Intervention	Hours (Median)
Open Group	3.8
Masked Group	3.9

Median Length of Hospital Stay

Days of stay in the hospital (NCT01131260)
Timeframe: From admission to labor and delivery through hospital discharge

Intervention	Days (Median)
Open Group	2
Masked Group	2

Number of Infants Admitted to Special Care Nursery

Intermediate care nursery or neonatal intensive care (anything more than well-baby nursery) (NCT01131260)
Timeframe: Delivery and 1 month of age

Intervention	Participants (Count of Participants)
Open Group	498
Masked Group	470

Number of Infants Experiencing Neonatal Encephalopathy (Primary Outcome Component)

Neonatal encephalopathy experienced between delivery and discharge (NCT01131260)
Timeframe: Delivery through hospital discharge

Intervention	Participants (Count of Participants)
Open Group	4
Masked Group	5

Number of Infants Who Experienced Neonatal Seizure (Primary Outcome Component)

Number of infants who experienced Neonatal Seizure (NCT01131260)
Timeframe: Birth through hospital discharge

Intervention	Participants (Count of Participants)
Open Group	3
Masked Group	4

Number of Infants With a Major Congenital Malformation

Major congenital malformation (NCT01131260)
Timeframe: Delivery

Intervention	Participants (Count of Participants)
Open Group	38
Masked Group	23

Number of Infants With Apgar Score < = 3 at 5 Minutes (Primary Outcome Component)

Intervention	Participants (Count of Participants)
Open Group	17
Masked Group	6

Number of Infants With Meconium Aspiration Syndrome

Meconium aspiration syndrome (NCT01131260)
Timeframe: Delivery through discharge

Intervention	Participants (Count of Participants)
Open Group	20
Masked Group	20

Number of Infants With Umbilical-artery Blood pH < = 7.05 and Base Deficit in Extracellular Fluid > = 12 mmol/Liter (Primary Outcome Component)

Umbilical-artery blood pH < = 7.05 and base deficit in extracellular fluid > = 12 mmol/liter (NCT01131260)
Timeframe: Delivery

Intervention	Participants (Count of Participants)
Open Group	3
Masked Group	8

Number of Intrapartum Fetal Deaths (Primary Outcome Component)

Death of the fetus during the intrapartum period. (NCT01131260)
Timeframe: During labor and through delivery of the baby

Intervention	Participants (Count of Participants)
Open Group	0
Masked Group	0

Number of Neonatal Deaths (Primary Outcome Component)

Death of the newborn between delivery and1 month of age (NCT01131260)
Timeframe: Delivery through1 month of age

Intervention	Participants (Count of Participants)
Open Group	3
Masked Group	1

Number of Neonates Intubated for Ventilation at Delivery (Primary Outcome Component)

Neonatal intubation for ventilation in the delivery room (NCT01131260)
Timeframe: Delivery

Intervention	Participants (Count of Participants)
Open Group	42
Masked Group	27

Number of Neonates With Shoulder Dystocia During Delivery

Presence of shoulder dystocia during delivery (NCT01131260)
Timeframe: Delivery

Intervention	Participants (Count of Participants)
Open Group	141
Masked Group	158

Number of Participants Experiencing Postpartum Endometritis

Postpartum endometritis (NCT01131260)
Timeframe: Delivery through hospital discharge

Intervention	Participants (Count of Participants)
Open Group	71
Masked Group	88

Number of Participants Who Had a Postpartum Blood Transfusion

Blood transfusion from delivery and through hospital stay until discharge (NCT01131260)
Timeframe: Delivery through hospital discharge

Intervention	Participants (Count of Participants)
Open Group	80
Masked Group	74

Number of Participants With Chorioamnionitis

Chorioamnionitis (NCT01131260)
Timeframe: Any time from Randomization through Delivery

Intervention	Participants (Count of Participants)
Open Group	286
Masked Group	269

Number of Participants With Primary Composite Outcome

Composite primary outcome of intrapartum fetal death, neonatal death, Apgar score <=3 at 5 minutes, neonatal seizure, umbilical artery blood pH <= 7.05 with base deficit >=12 mmol/L in extra-cellular fluid, intubation for ventilation at delivery, neonatal encelphalopathy (NCT01131260)
Timeframe: From Delivery through 1 month of age

Intervention	Participants (Count of Participants)
Open Group	52
Masked Group	40

Number of Participants With an Indication for Forceps or Vacuum Delivery

Indication for delivery by forceps or vacuum (NCT01131260)
Timeframe: During labor through delivery

Intervention	Participants (Count of Participants)
	Fetal indication	Dystocia	Other
Masked Group	218	101	8
Open Group	225	95	9

Reviews

3 reviews available for salicylic acid and Anoxemia

Article	Year
Biochemical monitoring by fetal blood sampling. Clinical anesthesia, 1974, Volume: 10, Issue:2 Topics: Abscess; Anesthetics, Local; Blood; Blood Gas Analysis; Blood Specimen Collection; Female; Fetal Dis	1974
Prevention and correction of fetal acidosis and hypoxia. Clinical obstetrics and gynecology, 1974, Volume: 17, Issue:3 Topics: Acidosis; Amniotic Fluid; Bicarbonates; Birth Weight; Carbon Dioxide; Estriol; Female; Fetal Disease	1974
In utero disease and the newborn infant. Advances in pediatrics, 1970, Volume: 17 Topics: Acid-Base Equilibrium; Acidosis; Amniotic Fluid; Animals; Bilirubin; Birth Weight; Electrocardiograp	1970

Other Studies

27 other studies available for salicylic acid and Anoxemia

Article	Year
Induction of pilocarpine formation in jaborandi leaves by salicylic acid and methyljasmonate. Phytochemistry, 2003, Volume: 63, Issue:2 Topics: Acetates; Cyclopentanes; Dose-Response Relationship, Drug; Hypoxia; Oxylipins; Pilocarpine; Pilocarp	2003
[Hypoxia-like phenomena caused by salicylic acid]. Arzneimittel-Forschung, 1959, Volume: 9 Topics: Humans; Hypoxia; Salicylates; Salicylic Acid	1959
Direct detection of endogenous hydroxyl radical production in cultured adult cardiomyocytes during anoxia and reoxygenation. Is the hydroxyl radical really the most damaging radical species? Circulation research, 1993, Volume: 72, Issue:4 Topics: Animals; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Free Radicals; Horseradish Pero	1993
Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat. Free radical biology & medicine, 1997, Volume: 22, Issue:4 Topics: Animals; Carbon Monoxide Poisoning; Cerebrovascular Circulation; Hemoglobins; Hippocampus; Hydroxybe	1997
Maximal .OH production is seen upon reoxygenation of viable anoxic cultured cardiomyocytes but not of compromised cells. The American journal of cardiovascular pathology, 1992, Volume: 4, Issue:3 Topics: Animals; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Free Radicals; Horseradish Pero	1992
Why -aVF can be used in STAN as a proxy for scalp electrode-derived signal; reply to comments by Kjellmer et al. PloS one, 2019, Volume: 14, Issue:8 Topics: Animals; Electrocardiography; Electrodes; Female; Fetus; Humans; Hypoxia; Pregnancy; Scalp; Sheep; U	2019
Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-) organs? Experimental dermatology, 2020, Volume: 29, Issue:3 Topics: Anemia; Animals; Apoptosis; Bowman Capsule; Cell Differentiation; Erythropoietin; Hair; Hair Follicl	2020
50 Years Ago in The Journal of Pediatrics: Acid-Base Monitoring of the Fetus during Labor with Blood Obtained from the Scalp. The Journal of pediatrics, 2019, Volume: 208 Topics: Acid-Base Equilibrium; Acidosis; Blood Specimen Collection; Female; Fetal Diseases; Fetal Monitoring	2019
Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to CTG. A multi-center, observational study. Journal of perinatal medicine, 2004, Volume: 32, Issue:6 Topics: Acidosis; Cardiotocography; Electrocardiography; Europe; Female; Fetal Blood; Hospitals, University;	2004
Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007, Volume: 21, Issue:12 Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cyclophosphamide; Erythropoietin; Gene Expres	2007
Comparison of continuous transcutaneous and continuous intravascular PO2 measurement in fetal sheep. American journal of obstetrics and gynecology, 1980, Nov-15, Volume: 138, Issue:6 Topics: Animals; Carbon Dioxide; Carotid Arteries; Female; Fetus; Hydrogen-Ion Concentration; Hypoxia; Oxime	1980
Continuous measurement of scalp tissue oxygen tension and carotid arterial oxygen tension in the fetal lamb. Biology of the neonate, 1980, Volume: 38, Issue:1-2 Topics: Animals; Carotid Arteries; Fetus; Heart Rate; Hypoxia; Microelectrodes; Oxygen; Partial Pressure; Sc	1980
Near-infrared spectroscopy in adults: effects of extracranial ischaemia and intracranial hypoxia on estimation of cerebral oxygenation. British journal of anaesthesia, 1994, Volume: 73, Issue:4 Topics: Adult; Cerebrovascular Circulation; Exercise; Female; Humans; Hypoxia; Ischemia; Male; Middle Aged;	1994
Scarring alopecia in neonates as a consequence of hypoxaemia-hypoperfusion. Archives of disease in childhood, 1993, Volume: 68, Issue:5 Spec No Topics: Acidosis; Alopecia; Extracorporeal Membrane Oxygenation; Female; Humans; Hypoxia; Infant, Newborn; M	1993
Transcutaneous PO2 of the scalp in male pattern baldness: a new piece to the puzzle. Plastic and reconstructive surgery, 1996, Volume: 97, Issue:6 Topics: Adolescent; Adult; Alopecia; Blood Gas Monitoring, Transcutaneous; Frontal Bone; Hair; Humans; Hypox	1996
Hypoxia- and hypercapnia-induced DC potential shifts in rat at the scalp and the skull are opposite in polarity to those at the cerebral cortex. Neuroscience letters, 1999, Jul-30, Volume: 270, Issue:2 Topics: Animals; Cerebral Cortex; Electrophysiology; Hypercapnia; Hypoxia; Male; Rats; Rats, Wistar; Scalp;	1999
Fetal scalp sampling: its place in management. Seminars in perinatology, 1978, Volume: 2, Issue:2 Topics: Acidosis; Apgar Score; Blood Specimen Collection; Delivery, Obstetric; Estriol; Female; Fetal Blood;	1978
Continuous Fetal Scalp and Carotid Artery Oxygen Tension Monitoring in the Sheep. Obstetrics and gynecology, 1976, Volume: 47, Issue:5 Topics: Animals; Carotid Arteries; Electrocardiography; Electrodes, Implanted; Female; Fetal Distress; Fetal	1976
Red blood cell flow in the fetal scalp during hypoxemia in the chronic sheep experiment: a laser Doppler flow study. Pediatric research, 1986, Volume: 20, Issue:5 Topics: Animals; Erythrocytes; Female; Fetal Diseases; Hypoxia; Lasers; Pregnancy; Regional Blood Flow; Rheo	1986
[Correlations between placental transfusion and blood viscosity in newborn infants]. Zentralblatt fur Gynakologie, 1972, Nov-11, Volume: 94, Issue:45 Topics: Blood Viscosity; Cesarean Section; Female; Hematocrit; Humans; Hypoxia; Infant, Newborn; Labor, Obst	1972
Plasma glucagon levels in the term human infant and effect of hypoxia. Archives of disease in childhood, 1973, Volume: 48, Issue:6 Topics: Blood; Blood Glucose; Cesarean Section; Delivery, Obstetric; Female; Fetal Diseases; Glucagon; Human	1973
Intensive care of the high risk foetus in labour. Anaesthesia and intensive care, 1973, Volume: 1, Issue:5 Topics: Blood Chemical Analysis; Electrocardiography; Female; Fetal Diseases; Fetal Heart; Heart Function Te	1973
Clinical experiences with clap electrodes in fetal scalp for simultaneous pO2 and ECG-registration. Advances in experimental medicine and biology, 1973, Volume: 37 Topics: Electrocardiography; Electrodes; Evaluation Studies as Topic; Female; Fetus; Heart Rate; Humans; Hyp	1973
Intrapartum clinical assessment of fetal distress. American journal of obstetrics and gynecology, 1971, Jun-01, Volume: 110, Issue:3 Topics: Acidosis; Apgar Score; Blood Specimen Collection; Bradycardia; Carbon Dioxide; Delivery, Obstetric;	1971
Oxygen administration during labor. American journal of obstetrics and gynecology, 1969, Nov-15, Volume: 105, Issue:6 Topics: Carbon Dioxide; Female; Fetal Diseases; Humans; Hydrogen-Ion Concentration; Hypoxia; Obstetric Labor	1969
Applicability and acceptability of fetal scalp blood sampling technic. Obstetrics and gynecology, 1968, Volume: 32, Issue:2 Topics: Acid-Base Equilibrium; Blood Specimen Collection; Female; Fetal Diseases; Fetus; Humans; Hypoxia; Me	1968
Acid-base monitoring of the fetus during labor with blood obtained from the scalp. The Journal of pediatrics, 1969, Volume: 74, Issue:5 Topics: Acid-Base Equilibrium; Acidosis; Blood; Blood Specimen Collection; Female; Fetal Diseases; Humans; H	1969