salicylic acid has been researched along with Acne Vulgaris in 126 studies
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).
Acne Vulgaris: A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the efficacy of supramolecular salicylic acid combined with doxycycline on acne, totally 70 patients with acne treated in our dermatology department from May 2020 to May 2021 were enrolled and randomized (1:1) into control or experimental groups using the random number table method." | 9.69 | Efficacy of supramolecular salicylic acid in combination with doxycycline in the treatment of acne. ( Liu, Y; Long, T; Meng, Z; Shang, W; Yang, J, 2023) |
| "A dermocosmetic (DC) containing salicylic acid, niacinamide, and thermal spring water has been developed for the management of mild to moderate acne." | 9.69 | A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide. ( Demessant-Flavigny, A; Dréno, B; Kerob, D; Khammari, A; Seité, S, 2023) |
| " We sought to determine the efficacy and safety of Jessner's solution (JS) in comparison with salicylic acid (SA) 30% in the management of acne vulgaris and postacne hyperpigmentation in patients with colored skin." | 9.34 | Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial. ( How, KN; Lim, PY; Shamsudin, N; Wan Ahmad Kammal, WSL, 2020) |
| "Topical drugs for mild to moderate acne include adapalene (ADA) and benzoyl peroxide(BPO)." | 9.30 | Efficacy and safety of 2% supramolecular salicylic acid compared with 5% benzoyl peroxide/0.1% adapalene in the acne treatment: a randomized, split-face, open-label, single-center study. ( Chen, J; Lai, W; Xia, Y; Ye, C; Yin, S; Zeng, Q; Zheng, Y, 2019) |
| "5% salicylic acid (SA) solution that does not need to be neutralized in the treatment of acne vulgaris compared to the conventional peeling using Jessner's solution." | 9.27 | Comparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris. ( Dong Hyun, K; Dong Ju, H; In Jae, J; Lee, HJ; Yoon, MS, 2018) |
| "To evaluate the short-term effect of a benzoyl peroxide 3% gel on acne lesions." | 9.22 | Five-day study to judge the short-term effect of a benzoyl peroxide 3% gel on acne lesions. ( Draelos, ZD; Ertel, K; Rom, D, 2016) |
| "Comparing the therapeutic efficacy of TCA 25% peels with those of salicylic acid 30% in patients with acne vulgaris." | 9.20 | Trichloroacetic Acid Versus Salicylic Acid in the Treatment of Acne Vulgaris in Dark-Skinned Patients. ( Abdel Meguid, AM; Elaziz Ahmed Attallah, DA; Omar, H, 2015) |
| "To compare the therapeutic efficacy and tolerability of salicylic acid peels with those of Jessner's solution peels in patients with acne vulgaris." | 9.17 | Salicylic acid peels versus Jessner's solution for acne vulgaris: a comparative study. ( Bae, BG; Chung, KY; Lee, JH; Lee, KH; Lee, SH; Lee, SJ; Lee, YS; Park, CO; Shin, H, 2013) |
| "Benzoyl peroxide (BPO) is a widely used over-the-counter (OTC) topical acne treatment often used in combination with salicylic acid (SA) to achieve better comedone control than that achieved with BPO alone." | 9.17 | Evaluation of the efficacy, tolerability, and safety of an over-the-counter acne regimen containing benzoyl peroxide and salicylic acid in subjects with acne. ( Butners, V; Eastern, J; Green, LJ; Gwazdauskas, J; Kircik, LH, 2013) |
| "A proprietary topical blend of salicylic acid and highly purified sandalwood oil from Australia was used in this open-label study in adolescents and adults with mild to moderate facial acne." | 9.16 | Single-center, open-label study of a proprietary topical 0.5% salicylic acid-based treatment regimen containing sandalwood oil in adolescents and adults with mild to moderate acne. ( Levenson, C; Moy, RL; Rock, JA; So, JJ, 2012) |
| "Clindamycin phosphate (CDP), benzoyl peroxide (BPO) and salicylic acid (SA) are known to be effective acne therapy agents depending on their anti-inflammatory and comedolytic properties." | 9.16 | Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris. ( Akarsu, S; Fetil, E; Gül, E; Güneş, AT; Yücel, F, 2012) |
| "To compare lipohydroxyacid and salicylic acid peels in subjects with comedonal acne." | 9.15 | Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne. ( Bissonnette, R; Hamzavi, I; Levesque, A; Rougier, A; Seite, S, 2011) |
| " Participants with mild to moderate facial acne vulgaris were randomly assigned to 10 weeks' facial treatment with the 3-step acne system (proprietary salicylic acid cleanser 2% twice daily, proprietary salicylic acid toner 2% once daily, and solubilized BPO gel 5% twice daily) or with control cleanser twice daily plus clindamycin 1%-BPO 5% gel (jar formulation) twice daily." | 9.14 | A 3-step acne system containing solubilized benzoyl peroxide versus clindamycin-benzoyl peroxide. ( Del Rosso, JQ; Eichenfield, L; Parr, L; Shalita, A; Swinyer, L; Tanghetti, E; Thiboutot, D; Tschen, E, 2009) |
| "To compare the efficacy and tolerance of a lipophillic derivative of salicylic acid (lipo hydroxy acid or LHA) containing formulation and 5% benzoyl peroxide in subjects with acne vulgaris." | 9.14 | Randomized study comparing the efficacy and tolerance of a lipophillic hydroxy acid derivative of salicylic acid and 5% benzoyl peroxide in the treatment of facial acne vulgaris. ( Bissonnette, R; Bolduc, C; Maari, C; Nigen, S; Provost, N; Rougier, A; Seité, S, 2009) |
| "Salicylic acid peels have been introduced as a useful modality in acne treatment." | 9.10 | Salicylic acid peels for the treatment of acne vulgaris in Asian patients. ( Kim, IH; Lee, HS, 2003) |
| "The objective of the present work was to determine the relative bioavailability of salicylic acid (SA) after repeated (14-day) topical application to subjects who presented normal, acnegenic, or photodamaged facial skin." | 9.08 | Percutaneous absorption of salicylic acid after repeated (14-day) in vivo administration to normal, acnegenic or aged human skin. ( Davis, DA; Kraus, AL; Odio, MR; Olerich, M; Thompson, GA, 1997) |
| "To assess the effects of topical treatments (azelaic acid, salicylic acid, nicotinamide, zinc, alpha-hydroxy acid, and sulphur) for acne." | 9.05 | Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. ( Liu, GJ; Liu, H; Liu, L; Peinemann, F; Sang, H; Xia, J; Yu, H, 2020) |
| "The effects of topical azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid (alpha-hydroxy acid) for acne are unclear." | 9.05 | Evidence-based topical treatments (azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid) for acne: an abridged version of a Cochrane systematic review. ( Liu, G; Liu, H; Liu, L; Peinemann, F; Sang, H; Xia, J; Yu, H, 2020) |
| "2% CL, 5% BPO with salicylic acid (SA) preparation, and combination BPO/CL in acne lesion reduction." | 8.86 | Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne. ( Kimball, AB; Seidler, EM, 2010) |
| "Salicylic acid has been used as an anti-acne agent with its comedolytic property and antimicrobial activity." | 8.31 | Anti-acne activity of carnitine salicylate and magnolol through the regulation of exfoliation, lipogenesis, bacterial growth and inflammation. ( Kim, MS; Kwon, KC; Park, SW; Shin, YW; Song, YS; Won, JG, 2023) |
| "To evaluate the efficacy of topical 30% salicylic acid plus minocycline in moderate to severe acne." | 8.31 | Efficacy of topical 30% salicylic acid in combination with minocycline in moderate to severe acne. ( Liu, Y; Meng, Z; Xu, X; Yang, J, 2023) |
| "To study the efficacy of 30% supramolecular salicylic acid (SSA) in the treatment of acne, especially its effect on facial sebum secretion and the skin barrier." | 8.12 | 30% supramolecular salicylic acid peels effectively treats acne vulgaris and reduces facial sebum. ( Ariyawati, A; Chen, J; Chen, Y; Li, Y; Liu, L; Pu, Y; Shao, X; Wang, J; Zhang, L; Zhang, Y, 2022) |
| "The combination of salicylic acid-based chemical peel plus exfoliating home care treatment appears to be a very good strategy against acne." | 8.02 | Efficacy of a combined chemical peel and topical salicylic acid-based gel combination in the treatment of active acne. ( Calvisi, L, 2021) |
| "To assess the efficacy of a serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperpigmentation and controlling skin oiliness in Brazilian patients with acne vulgaris." | 8.02 | Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris. ( Campos, V; Correia, P; Gonçalves Júnior, JE; Kalil, C; Pitassi, L; Sant'Anna, B, 2021) |
| "A multicenter prospective observational study was carried out on patients with a diagnosis of mild comedonal-papular facial acne to provide new evidence on the clinical effectiveness, tolerability and acceptability of three salicylic acid-based products for the topical treatment of acne in the daily clinical practice." | 7.96 | Effectiveness of a combination of salicylic acid-based products for the treatment of mild comedonal-papular acne: a multicenter prospective observational study. ( Bettoli, V; Micali, G; Monfrecola, G; Veraldi, S, 2020) |
| "We designed a prospective study to assess the efficacy of our serum composed of glycolic and salicylic acid for patients suffering from mild to moderate inflammatory and cystic acne, rosacea, folliculitis, and keratosis pilaris." | 7.96 | Two is better than one: The combined effects of glycolic acid and salicylic acid on acne-related disorders. ( Haddad, L; Wiegmann, D, 2020) |
| "5% salicylic acid (SA) and 4% D-panthenol (D-p) in the treatment of mild-moderate acne, comparing it with a previous formulation (ACNAID TM gel Cosmetic) containing 4% HPO, 0." | 7.83 | Efficacy and tolerability of a topical gel containing 3% hydrogen peroxide, 1.5% salicylic acid and 4% D-panthenol in the treatment of mild-moderate acne. ( Fabbrocini, G; Panariello, L, 2016) |
| "Retinoids (RC), alpha-hydroxy acids (AHA), and salicylic acid (BHA) treat acne through differing mechanisms of action." | 7.83 | Novel retinoid ester in combination with salicylic acid for the treatment of acne. ( Draelos, Z; Lewis, J; McHugh, L; Pellegrino, A; Popescu, L, 2016) |
| "We, the Food and Drug Administration (FDA), are issuing this final rule to include benzoyl peroxide as a generally recognized as safe and effective (GRASE) active ingredient in over-the-counter (OTC) topical acne drug products." | 7.76 | Classification of benzoyl peroxide as safe and effective and revision of labeling to drug facts format; topical acne drug products for over-the-counter human use; final rule. ( , 2010) |
| "Many clinicians have used glycolic acid (GA) peels for facial acne, scarring, and hyperpigmentation, mainly in lighter skin types." | 7.75 | Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study. ( Garg, VK; Sarkar, R; Sinha, S, 2009) |
| " No adverse reaction was reported in either group." | 7.30 | Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial. ( He, X; Li, S; Niu, YG; Steel, A; Wang, HT; Zhang, XS; Zhang, Z, 2023) |
| "Salicylic acid was found better in treating noninflammatory lesions, while MA had an upper hand in treating inflammatory lesions." | 6.94 | Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris. ( Dayal, S; Kalra, KD; Sahu, P, 2020) |
| "Salicylic acid (SA) peel is a well-established peeling agent for acne." | 6.84 | Jessner's solution vs. 30% salicylic acid peels: a comparative study of the efficacy and safety in mild-to-moderate acne vulgaris. ( Amrani, A; Dayal, S; Jain, VK; Sahu, P, 2017) |
| "The biggest hurdle in the treatment of acne vulgaris is patient non-compliance that is due in large part to poor tolerability to common acne medications." | 6.79 | Rapid treatment of mild acne with a novel skin care system containing 1% salicylic acid, 10% buffered glycolic acid, and botanical ingredients. ( Bhatia, AC; Jimenez, F, 2014) |
| "A dermocosmetic (DC) containing salicylic acid, niacinamide, and thermal spring water has been developed for the management of mild to moderate acne." | 5.69 | A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide. ( Demessant-Flavigny, A; Dréno, B; Kerob, D; Khammari, A; Seité, S, 2023) |
| "To determine the efficacy of supramolecular salicylic acid combined with doxycycline on acne, totally 70 patients with acne treated in our dermatology department from May 2020 to May 2021 were enrolled and randomized (1:1) into control or experimental groups using the random number table method." | 5.69 | Efficacy of supramolecular salicylic acid in combination with doxycycline in the treatment of acne. ( Liu, Y; Long, T; Meng, Z; Shang, W; Yang, J, 2023) |
| "One of the ways to treat acne is by using chemical peels." | 5.56 | A split-face comparative study to evaluate the efficacy of 50% pyruvic acid against a mixture of glycolic and salicylic acids in the treatment of acne vulgaris. ( Deda, A; Odrzywołek, W; Wilczyński, S; Zdrada, J, 2020) |
| "Acne vulgaris is a common and chronic skin disease that impacts on physical and psychological perceptions." | 5.56 | Efficacy and safety of a new topical gel formulation containing retinol encapsulated in glycospheres and hydroxypinacolone retinoate, an antimicrobial peptide, salicylic acid, glycolic acid and niacinamide for the treatment of mild acne: preliminary resul ( Annunziata, MC; Cinelli, E; Donnarumma, M; Fabbrocini, G; Milani, M; Villani, A, 2020) |
| "Acne vulgaris is a prevalent cutaneous disease characterized by a multifactorial pathogenic process including hyperseborrhea, inflammation, over-keratinization of follicular keratinocytes and Propionibacterium acnes (P acnes) overgrowth." | 5.51 | Salicylic acid treats acne vulgaris by suppressing AMPK/SREBP1 pathway in sebocytes. ( Cong, T; Du, D; He, G; Jiang, X; Li, X; Lu, J; Wen, X, 2019) |
| "Acne vulgaris is a disease of the sebaceous follicle which affects up to 90% of adolescent patients." | 5.43 | Combination therapy with hydrogen peroxide (4%), salicylic acid (0.5%) and D-panthenol (4%): efficacy and skyn tolerability in common acne vulgaris during sun exposure period. ( Capizzi, R; De Waure, C; Fossati, B; Frascione, P; Guerriero, C; Masini, F; Ricci, F, 2016) |
| " We sought to determine the efficacy and safety of Jessner's solution (JS) in comparison with salicylic acid (SA) 30% in the management of acne vulgaris and postacne hyperpigmentation in patients with colored skin." | 5.34 | Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial. ( How, KN; Lim, PY; Shamsudin, N; Wan Ahmad Kammal, WSL, 2020) |
| "Topical drugs for mild to moderate acne include adapalene (ADA) and benzoyl peroxide(BPO)." | 5.30 | Efficacy and safety of 2% supramolecular salicylic acid compared with 5% benzoyl peroxide/0.1% adapalene in the acne treatment: a randomized, split-face, open-label, single-center study. ( Chen, J; Lai, W; Xia, Y; Ye, C; Yin, S; Zeng, Q; Zheng, Y, 2019) |
| "5% salicylic acid (SA) solution that does not need to be neutralized in the treatment of acne vulgaris compared to the conventional peeling using Jessner's solution." | 5.27 | Comparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris. ( Dong Hyun, K; Dong Ju, H; In Jae, J; Lee, HJ; Yoon, MS, 2018) |
| "To evaluate the short-term effect of a benzoyl peroxide 3% gel on acne lesions." | 5.22 | Five-day study to judge the short-term effect of a benzoyl peroxide 3% gel on acne lesions. ( Draelos, ZD; Ertel, K; Rom, D, 2016) |
| "Comparing the therapeutic efficacy of TCA 25% peels with those of salicylic acid 30% in patients with acne vulgaris." | 5.20 | Trichloroacetic Acid Versus Salicylic Acid in the Treatment of Acne Vulgaris in Dark-Skinned Patients. ( Abdel Meguid, AM; Elaziz Ahmed Attallah, DA; Omar, H, 2015) |
| "To compare the therapeutic efficacy and tolerability of salicylic acid peels with those of Jessner's solution peels in patients with acne vulgaris." | 5.17 | Salicylic acid peels versus Jessner's solution for acne vulgaris: a comparative study. ( Bae, BG; Chung, KY; Lee, JH; Lee, KH; Lee, SH; Lee, SJ; Lee, YS; Park, CO; Shin, H, 2013) |
| "Benzoyl peroxide (BPO) is a widely used over-the-counter (OTC) topical acne treatment often used in combination with salicylic acid (SA) to achieve better comedone control than that achieved with BPO alone." | 5.17 | Evaluation of the efficacy, tolerability, and safety of an over-the-counter acne regimen containing benzoyl peroxide and salicylic acid in subjects with acne. ( Butners, V; Eastern, J; Green, LJ; Gwazdauskas, J; Kircik, LH, 2013) |
| "A proprietary topical blend of salicylic acid and highly purified sandalwood oil from Australia was used in this open-label study in adolescents and adults with mild to moderate facial acne." | 5.16 | Single-center, open-label study of a proprietary topical 0.5% salicylic acid-based treatment regimen containing sandalwood oil in adolescents and adults with mild to moderate acne. ( Levenson, C; Moy, RL; Rock, JA; So, JJ, 2012) |
| "To compare lipohydroxyacid and salicylic acid peels in subjects with comedonal acne." | 5.15 | Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne. ( Bissonnette, R; Hamzavi, I; Levesque, A; Rougier, A; Seite, S, 2011) |
| "This study evaluated the efficacy and tolerability of treating mild-to-moderate facial acne using a new, hand-held, light-emitting diode blue light device in conjunction with a foam cleanser containing 5% glycolic acid and 2% salicylic acid plus a skin rebuilding serum containing 1." | 5.15 | Evaluation of self-treatment of mild-to-moderate facial acne with a blue light treatment system. ( Dhawan, S; Wheeland, RG, 2011) |
| " Participants with mild to moderate facial acne vulgaris were randomly assigned to 10 weeks' facial treatment with the 3-step acne system (proprietary salicylic acid cleanser 2% twice daily, proprietary salicylic acid toner 2% once daily, and solubilized BPO gel 5% twice daily) or with control cleanser twice daily plus clindamycin 1%-BPO 5% gel (jar formulation) twice daily." | 5.14 | A 3-step acne system containing solubilized benzoyl peroxide versus clindamycin-benzoyl peroxide. ( Del Rosso, JQ; Eichenfield, L; Parr, L; Shalita, A; Swinyer, L; Tanghetti, E; Thiboutot, D; Tschen, E, 2009) |
| " Salicylic acid peel has effectiveness for both of acne and postinflammatory hyperpigmentation that are common in patients with skin of color." | 5.12 | Whitening effect of salicylic acid peels in Asian patients. ( Ahn, HH; Kim, IH, 2006) |
| "The objective of the present work was to determine the relative bioavailability of salicylic acid (SA) after repeated (14-day) topical application to subjects who presented normal, acnegenic, or photodamaged facial skin." | 5.08 | Percutaneous absorption of salicylic acid after repeated (14-day) in vivo administration to normal, acnegenic or aged human skin. ( Davis, DA; Kraus, AL; Odio, MR; Olerich, M; Thompson, GA, 1997) |
| " In the present study, the sustainable rates of production of the 5 neutral lipid classes found on the skin surface (triglycerides + free fatty acids, wax esters, cholesterol, cholesterol esters, and squalene) were measured on the foreheads of acne patients before, during, and following treatment with 13-cis-retinoic acid, a drug which suppresses sebum production profoundly." | 5.05 | Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin. ( Benoit, AM; Downing, DT; Stewart, ME; Strauss, JS, 1984) |
| "The effects of topical azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid (alpha-hydroxy acid) for acne are unclear." | 5.05 | Evidence-based topical treatments (azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid) for acne: an abridged version of a Cochrane systematic review. ( Liu, G; Liu, H; Liu, L; Peinemann, F; Sang, H; Xia, J; Yu, H, 2020) |
| "To assess the effects of topical treatments (azelaic acid, salicylic acid, nicotinamide, zinc, alpha-hydroxy acid, and sulphur) for acne." | 5.05 | Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. ( Liu, GJ; Liu, H; Liu, L; Peinemann, F; Sang, H; Xia, J; Yu, H, 2020) |
| "2% CL, 5% BPO with salicylic acid (SA) preparation, and combination BPO/CL in acne lesion reduction." | 4.86 | Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne. ( Kimball, AB; Seidler, EM, 2010) |
| "Salicylic acid has been used as an anti-acne agent with its comedolytic property and antimicrobial activity." | 4.31 | Anti-acne activity of carnitine salicylate and magnolol through the regulation of exfoliation, lipogenesis, bacterial growth and inflammation. ( Kim, MS; Kwon, KC; Park, SW; Shin, YW; Song, YS; Won, JG, 2023) |
| "To evaluate the efficacy of topical 30% salicylic acid plus minocycline in moderate to severe acne." | 4.31 | Efficacy of topical 30% salicylic acid in combination with minocycline in moderate to severe acne. ( Liu, Y; Meng, Z; Xu, X; Yang, J, 2023) |
| "To quantitatively and qualitatively explore the lipid-modifying effect of the moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid (LDCS) in seborrhea participants with and without acne vulgaris (AV)." | 4.12 | Influence of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid on facial skin lipidome among seborrhea participants. ( Asawanonda, P; Kumtornrut, C; Noppakun, N; Paemanee, A; Pewlong, P; Pongpamorn, P; Sirikantaramas, S; Wongtada, C, 2022) |
| "To assess the efficacy of a serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperpigmentation and controlling skin oiliness in Brazilian patients with acne vulgaris." | 4.02 | Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris. ( Campos, V; Correia, P; Gonçalves Júnior, JE; Kalil, C; Pitassi, L; Sant'Anna, B, 2021) |
| "The combination of salicylic acid-based chemical peel plus exfoliating home care treatment appears to be a very good strategy against acne." | 4.02 | Efficacy of a combined chemical peel and topical salicylic acid-based gel combination in the treatment of active acne. ( Calvisi, L, 2021) |
| " Utilization patterns of six non-first-line topical acne medications (ie, azelaic acid, salicylic acid, glycolic acid, sulfur, resorcinol, and zinc) were compared and followed over time." | 4.02 | Trends in utilization of non-first-line topical acne medications among children, adolescents, and adults in the United States, 2012-2016. ( Afarideh, M; Davis, DMR; Hand, JL; Rodriguez Baisi, KE; Tollefson, MM, 2021) |
| "A multicenter prospective observational study was carried out on patients with a diagnosis of mild comedonal-papular facial acne to provide new evidence on the clinical effectiveness, tolerability and acceptability of three salicylic acid-based products for the topical treatment of acne in the daily clinical practice." | 3.96 | Effectiveness of a combination of salicylic acid-based products for the treatment of mild comedonal-papular acne: a multicenter prospective observational study. ( Bettoli, V; Micali, G; Monfrecola, G; Veraldi, S, 2020) |
| "We designed a prospective study to assess the efficacy of our serum composed of glycolic and salicylic acid for patients suffering from mild to moderate inflammatory and cystic acne, rosacea, folliculitis, and keratosis pilaris." | 3.96 | Two is better than one: The combined effects of glycolic acid and salicylic acid on acne-related disorders. ( Haddad, L; Wiegmann, D, 2020) |
| "Glycolic acid (GA) and salicylic acid (SA) peels have been used separately for acne treatment, not as a sequential peel." | 3.96 | Sequential peeling as a monotherapy for treatment of milder forms of acne vulgaris. ( El Aguizy, RMS; Mahmoud, SB; Sabry, D; Sobhi, RM; Zayed, AA, 2020) |
| "5% salicylic acid (SA) and 4% D-panthenol (D-p) in the treatment of mild-moderate acne, comparing it with a previous formulation (ACNAID TM gel Cosmetic) containing 4% HPO, 0." | 3.83 | Efficacy and tolerability of a topical gel containing 3% hydrogen peroxide, 1.5% salicylic acid and 4% D-panthenol in the treatment of mild-moderate acne. ( Fabbrocini, G; Panariello, L, 2016) |
| "New salicylic acid (SA)-loaded gels were developed using excipients made from renewable materials, and our goal was to improve drug permeation in the topical treatment of acne vulgaris." | 3.83 | Bio-based topical system for enhanced salicylic acid delivery: preparation and performance of gels. ( Gavini, E; Giunchedi, P; Langasco, R; Özer, Ö; Rassu, G; Spada, G; Tanriverdi, ST, 2016) |
| "Retinoids (RC), alpha-hydroxy acids (AHA), and salicylic acid (BHA) treat acne through differing mechanisms of action." | 3.83 | Novel retinoid ester in combination with salicylic acid for the treatment of acne. ( Draelos, Z; Lewis, J; McHugh, L; Pellegrino, A; Popescu, L, 2016) |
| "We, the Food and Drug Administration (FDA), are issuing this final rule to include benzoyl peroxide as a generally recognized as safe and effective (GRASE) active ingredient in over-the-counter (OTC) topical acne drug products." | 3.76 | Classification of benzoyl peroxide as safe and effective and revision of labeling to drug facts format; topical acne drug products for over-the-counter human use; final rule. ( , 2010) |
| "Many clinicians have used glycolic acid (GA) peels for facial acne, scarring, and hyperpigmentation, mainly in lighter skin types." | 3.75 | Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study. ( Garg, VK; Sarkar, R; Sinha, S, 2009) |
| "The results of this study suggest that superficial salicylic acid peels are both safe and efficacious for treatment of acne vulgaris, oily skin, textural changes, melasma, and post-inflammatory hyperpigmentation in patients with skin types V and VI." | 3.70 | The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. ( Grimes, PE, 1999) |
| " No adverse reaction was reported in either group." | 3.30 | Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial. ( He, X; Li, S; Niu, YG; Steel, A; Wang, HT; Zhang, XS; Zhang, Z, 2023) |
| "Multiple approaches are used to treat acne scars, but some are expensive, ineffective, and cause complications." | 3.11 | Combination treatment with 30% salicylic acid and fractional CO ( Chen, J; Chen, JY; Chen, YM; Liu, L; Pu, YH; Shao, XY; Zhang, LZ; Zhang, YJ, 2022) |
| "Salicylic acid (SA) peel is a well-established peeling agent for acne." | 2.84 | Jessner's solution vs. 30% salicylic acid peels: a comparative study of the efficacy and safety in mild-to-moderate acne vulgaris. ( Amrani, A; Dayal, S; Jain, VK; Sahu, P, 2017) |
| "The biggest hurdle in the treatment of acne vulgaris is patient non-compliance that is due in large part to poor tolerability to common acne medications." | 2.79 | Rapid treatment of mild acne with a novel skin care system containing 1% salicylic acid, 10% buffered glycolic acid, and botanical ingredients. ( Bhatia, AC; Jimenez, F, 2014) |
| "Acne vulgaris is a common dermatologic disease that most frequently affects adolescents and young adults." | 2.78 | Randomized, controlled, evaluator-blinded studies conducted to compare the efficacy and tolerability of 3 over-the-counter acne regimens in subjects with mild or moderate acne. ( Green, L; Gwazdauskas, J; Kircik, LH, 2013) |
| "Acne vulgaris affects approximately 9% of the population worldwide and approximately 85% of those aged 12 to 24 years." | 2.72 | Management of Acne Vulgaris: A Review. ( Eichenfield, DZ; Eichenfield, LF; Sprague, J, 2021) |
| "Acne is one of the most frequent skin disorders that occurs in puberty, but often adults also have acne." | 2.52 | [Use of organic acids in acne and skin discolorations therapy]. ( Kapuścińska, A; Nowak, I, 2015) |
| "Many clinicians use these peels in the treatment of acne and acne-prone oily skin." | 2.47 | Expert opinion: efficacy of superficial chemical peels in active acne management--what can we learn from the literature today? Evidence-based recommendations. ( Berson, DS; Cohen, JL; Dréno, B; Fischer, TC; Perosino, E; Poli, F; Rendon, MI; Roberts, WE; Starker, I; Viera, MS; Wang, B, 2011) |
| "Acne is the most common disease of the skin, yet only a fraction of acne sufferers are treated with prescription products by physicians." | 2.44 | Effective over-the-counter acne treatments. ( Bowe, WP; Shalita, AR, 2008) |
| "A requirement for developing successful treatments for postacne scarring is a greater understanding of its pathogenesis, variability among afflicted individuals, and the inflammatory mediators and immunology of the scarring process." | 2.44 | The management of postacne scarring. ( Baron, JA; Goodman, GJ, 2007) |
| " Reported and theoretical adverse effects from systemic exposure are detailed." | 2.42 | Topical acne drugs: review of clinical properties, systemic exposure, and safety. ( Akhavan, A; Bershad, S, 2003) |
| "Acne is a common problem in adolescents and young adults." | 2.41 | Topical therapy for acne. ( Russell, JJ, 2000) |
| "Acne vulgaris is a common and chronic skin disease that impacts on physical and psychological perceptions." | 1.56 | Efficacy and safety of a new topical gel formulation containing retinol encapsulated in glycospheres and hydroxypinacolone retinoate, an antimicrobial peptide, salicylic acid, glycolic acid and niacinamide for the treatment of mild acne: preliminary resul ( Annunziata, MC; Cinelli, E; Donnarumma, M; Fabbrocini, G; Milani, M; Villani, A, 2020) |
| "Acne is a disease unique to humans and is associated with sebaceous glands that are found at high density on the scalp, forehead and face." | 1.56 | Why do humans get acne? A hypothesis. ( Shannon, JF, 2020) |
| "Acne vulgaris is a disease of the sebaceous follicle which affects up to 90% of adolescent patients." | 1.43 | Combination therapy with hydrogen peroxide (4%), salicylic acid (0.5%) and D-panthenol (4%): efficacy and skyn tolerability in common acne vulgaris during sun exposure period. ( Capizzi, R; De Waure, C; Fossati, B; Frascione, P; Guerriero, C; Masini, F; Ricci, F, 2016) |
| "FPLA-salicylic acid filament was successfully printed as a nose-shape mask by FDM 3DP, but the PCL-salicylic acid filament was not." | 1.43 | 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems. ( Basit, AW; Det-Amornrat, U; Gaisford, S; Goyanes, A; Wang, J, 2016) |
| "Among dermatoses more specific to black subjects, scalp conditions were frequently seen in both adults (alopecia 7% of diagnoses) and children (tinea capitis 9." | 1.35 | [Presenting skin disorders in black Afro-Caribbean patients: a multicentre study conducted in the Paris region]. ( Arsouze, A; Bafounta, ML; Bourgeois-Droin, C; Cabotin, PP; Chaine, B; Dehen, L; Delebecque, C; Dubertret, L; Dupuy, A; Fitoussi, C; Kornfeld, S; Petit, A; Raynaud, E, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (22.22) | 18.7374 |
| 1990's | 4 (3.17) | 18.2507 |
| 2000's | 19 (15.08) | 29.6817 |
| 2010's | 43 (34.13) | 24.3611 |
| 2020's | 32 (25.40) | 2.80 |
| Authors | Studies |
|---|---|
| Kubo, I | 1 |
| Muroi, H | 1 |
| Kubo, A | 1 |
| Afarideh, M | 1 |
| Rodriguez Baisi, KE | 1 |
| Davis, DMR | 1 |
| Hand, JL | 1 |
| Tollefson, MM | 1 |
| Eichenfield, DZ | 1 |
| Sprague, J | 1 |
| Eichenfield, LF | 1 |
| Zhang, L | 2 |
| Shao, X | 1 |
| Chen, Y | 1 |
| Wang, J | 2 |
| Ariyawati, A | 1 |
| Zhang, Y | 1 |
| Chen, J | 4 |
| Liu, L | 4 |
| Pu, Y | 1 |
| Li, Y | 2 |
| Ye, D | 1 |
| Xue, H | 1 |
| Huang, S | 1 |
| He, S | 1 |
| Liu, J | 1 |
| Wang, Z | 1 |
| Zeng, W | 1 |
| Dixit, N | 1 |
| Jena, A | 1 |
| Panda, M | 1 |
| Debasmita, B | 1 |
| Ipsita, D | 1 |
| Zhang, YJ | 1 |
| Chen, YM | 1 |
| Shao, XY | 1 |
| Pu, YH | 1 |
| Zhang, LZ | 1 |
| Chen, JY | 1 |
| Li, W | 2 |
| Yu, Q | 1 |
| Shen, Z | 1 |
| Zhang, W | 1 |
| Li, C | 1 |
| Wongtada, C | 1 |
| Pewlong, P | 1 |
| Asawanonda, P | 1 |
| Noppakun, N | 1 |
| Pongpamorn, P | 1 |
| Paemanee, A | 1 |
| Sirikantaramas, S | 1 |
| Kumtornrut, C | 1 |
| Cretu, S | 1 |
| Dascalu, M | 1 |
| Salavastru, CM | 1 |
| Han, Q | 1 |
| Zeng, J | 1 |
| Liu, Y | 3 |
| Yin, J | 1 |
| Sun, P | 1 |
| Wu, Y | 1 |
| Li, S | 1 |
| He, X | 1 |
| Zhang, Z | 1 |
| Zhang, XS | 1 |
| Niu, YG | 1 |
| Steel, A | 1 |
| Wang, HT | 1 |
| Kwon, KC | 1 |
| Won, JG | 1 |
| Kim, MS | 1 |
| Shin, YW | 1 |
| Park, SW | 1 |
| Song, YS | 1 |
| Yang, J | 3 |
| Xu, X | 1 |
| Meng, Z | 2 |
| Long, T | 1 |
| Shang, W | 1 |
| Măgerușan, ȘE | 1 |
| Hancu, G | 1 |
| Rusu, A | 1 |
| Khammari, A | 1 |
| Demessant-Flavigny, A | 1 |
| Kerob, D | 1 |
| Seité, S | 3 |
| Dréno, B | 2 |
| Zayed, AA | 1 |
| Sobhi, RM | 1 |
| El Aguizy, RMS | 1 |
| Sabry, D | 1 |
| Mahmoud, SB | 1 |
| Dayal, S | 2 |
| Kalra, KD | 1 |
| Sahu, P | 2 |
| Zdrada, J | 2 |
| Odrzywołek, W | 2 |
| Deda, A | 2 |
| Wilczyński, S | 2 |
| Wiegmann, D | 1 |
| Haddad, L | 1 |
| Liu, H | 2 |
| Yu, H | 2 |
| Xia, J | 2 |
| Liu, GJ | 1 |
| Sang, H | 2 |
| Peinemann, F | 2 |
| How, KN | 1 |
| Lim, PY | 1 |
| Wan Ahmad Kammal, WSL | 1 |
| Shamsudin, N | 1 |
| Villani, A | 1 |
| Annunziata, MC | 1 |
| Cinelli, E | 1 |
| Donnarumma, M | 1 |
| Milani, M | 1 |
| Fabbrocini, G | 2 |
| Liu, G | 1 |
| Bettoli, V | 1 |
| Micali, G | 1 |
| Monfrecola, G | 1 |
| Veraldi, S | 1 |
| Błońska-Fajfrowska, B | 1 |
| Campos, V | 1 |
| Pitassi, L | 1 |
| Kalil, C | 1 |
| Gonçalves Júnior, JE | 1 |
| Sant'Anna, B | 1 |
| Correia, P | 1 |
| Tang, J | 1 |
| Zhang, C | 1 |
| Zhang, X | 1 |
| Chen, Q | 1 |
| Zhang, S | 1 |
| Chen, L | 1 |
| Wang, C | 1 |
| Calvisi, L | 1 |
| Thuangtong, R | 1 |
| Tangjaturonrusamee, C | 1 |
| Rattanaumpawan, P | 1 |
| Ditre, CM | 1 |
| In Jae, J | 1 |
| Dong Ju, H | 1 |
| Dong Hyun, K | 1 |
| Yoon, MS | 1 |
| Lee, HJ | 1 |
| Platsidaki, E | 1 |
| Balamoti, E | 1 |
| Kouris, A | 1 |
| Katsarou, A | 1 |
| Mylonakis, N | 1 |
| Vavouli, C | 1 |
| Kontochristopoulos, G | 1 |
| Tolino, E | 1 |
| Skroza, N | 1 |
| Mambrin, A | 1 |
| Bernardini, N | 1 |
| Zuber, S | 1 |
| Balduzzi, V | 1 |
| Marchesiello, A | 1 |
| Proietti, I | 1 |
| Potenza, C | 1 |
| Stringer, T | 1 |
| Nagler, A | 1 |
| Orlow, SJ | 1 |
| Oza, VS | 1 |
| Zheng, Y | 2 |
| Yin, S | 1 |
| Xia, Y | 2 |
| Ye, C | 2 |
| Zeng, Q | 1 |
| Lai, W | 2 |
| Nofal, E | 1 |
| Nofal, A | 1 |
| Gharib, K | 1 |
| Nasr, M | 1 |
| Abdelshafy, A | 1 |
| Elsaid, E | 1 |
| Kołodziejczak, A | 1 |
| Wieczorek, A | 1 |
| Rotsztejn, H | 2 |
| Lu, J | 1 |
| Cong, T | 1 |
| Wen, X | 1 |
| Li, X | 1 |
| Du, D | 1 |
| He, G | 1 |
| Jiang, X | 1 |
| Kircik, LH | 2 |
| Gwazdauskas, J | 2 |
| Butners, V | 1 |
| Eastern, J | 1 |
| Green, LJ | 1 |
| Marczyk, B | 1 |
| Mucha, P | 1 |
| Budzisz, E | 1 |
| Bhatia, AC | 1 |
| Jimenez, F | 1 |
| Ash, C | 1 |
| Harrison, A | 1 |
| Drew, S | 1 |
| Whittall, R | 1 |
| Kapuścińska, A | 1 |
| Nowak, I | 1 |
| Draelos, Z | 1 |
| Lewis, J | 1 |
| McHugh, L | 1 |
| Pellegrino, A | 1 |
| Popescu, L | 1 |
| Abdel Meguid, AM | 1 |
| Elaziz Ahmed Attallah, DA | 1 |
| Omar, H | 1 |
| Panariello, L | 1 |
| Ricci, F | 1 |
| Masini, F | 1 |
| Fossati, B | 1 |
| Frascione, P | 1 |
| De Waure, C | 1 |
| Capizzi, R | 1 |
| Guerriero, C | 1 |
| Goyanes, A | 1 |
| Det-Amornrat, U | 1 |
| Basit, AW | 1 |
| Gaisford, S | 1 |
| Bernhardt, MJ | 1 |
| Myntti, MF | 1 |
| Langasco, R | 1 |
| Spada, G | 1 |
| Tanriverdi, ST | 1 |
| Rassu, G | 1 |
| Giunchedi, P | 1 |
| Özer, Ö | 1 |
| Gavini, E | 1 |
| Draelos, ZD | 1 |
| Ertel, K | 1 |
| Rom, D | 1 |
| Amrani, A | 1 |
| Jain, VK | 1 |
| Alba, MN | 1 |
| Gerenutti, M | 1 |
| Yoshida, VM | 1 |
| Grotto, D | 1 |
| Bowe, WP | 2 |
| Shalita, AR | 4 |
| Kempiak, SJ | 1 |
| Uebelhoer, N | 1 |
| Garg, VK | 1 |
| Sinha, S | 1 |
| Sarkar, R | 1 |
| Bissonnette, R | 2 |
| Bolduc, C | 1 |
| Nigen, S | 1 |
| Provost, N | 1 |
| Maari, C | 1 |
| Rougier, A | 2 |
| Thiboutot, D | 1 |
| Eichenfield, L | 1 |
| Shalita, A | 1 |
| Del Rosso, JQ | 1 |
| Swinyer, L | 1 |
| Tanghetti, E | 1 |
| Tschen, E | 1 |
| Parr, L | 1 |
| Choi, YS | 1 |
| Suh, HS | 1 |
| Yoon, MY | 1 |
| Min, SU | 1 |
| Kim, JS | 1 |
| Jung, JY | 1 |
| Lee, DH | 1 |
| Suh, DH | 1 |
| Seidler, EM | 1 |
| Kimball, AB | 1 |
| Babayeva, L | 1 |
| Akarsu, S | 2 |
| Fetil, E | 2 |
| Güneş, AT | 2 |
| Cook, D | 1 |
| Krassas, G | 1 |
| Huang, T | 1 |
| Fischer, TC | 1 |
| Perosino, E | 1 |
| Poli, F | 1 |
| Viera, MS | 1 |
| Rendon, MI | 1 |
| Berson, DS | 1 |
| Cohen, JL | 1 |
| Roberts, WE | 1 |
| Starker, I | 1 |
| Wang, B | 1 |
| Wheeland, RG | 1 |
| Dhawan, S | 1 |
| Levesque, A | 1 |
| Hamzavi, I | 1 |
| Yücel, F | 1 |
| Gül, E | 1 |
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| Park, CO | 1 |
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| MALKINSON, FD | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Assessment of Clinical Trial Experiences of Patients With Acne[NCT05737758] | 500 participants (Anticipated) | Observational | 2024-03-31 | Not yet recruiting | |||
| A Multi-center, Double-blind, Vehicle-controlled Study to Evaluate the Clinical Effect of Daily Next Science™ Acne Gel (NAG) on Mild to Moderate Facial Acne[NCT02404285] | Phase 1/Phase 2 | 68 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study[NCT04490967] | Phase 4 | 30 participants (Anticipated) | Interventional | 2021-04-30 | Not yet recruiting | ||
| Comparing the Efficacy and Safety of Combined Glycolic Acid and Salicylic Acid Peel Versus Glycolic Acid Peel Alone in the Treatment of Melasma: A Split Face Study[NCT02812719] | Early Phase 1 | 0 participants (Actual) | Interventional | 2018-07-31 | Withdrawn (stopped due to Study did not receive funding and will not be implemented.) | ||
| Efficacy and Safety of Topical Metformin Emulgel Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: A Split Face Study[NCT05536193] | Phase 4 | 34 participants (Anticipated) | Interventional | 2022-09-10 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Percent change in number of Inflammatory lesions with daily use of NAG compared with vehicle after 12-weeks of use. (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | % change of inflammatory lesions count (Mean) |
|---|---|
| Vehicle | -27 |
| NAG (Next Science Acne Gel) | -44 |
Percent Change in Number of Non-inflammatory lesions (open and closed comedones) were counted after 12 weeks of either Vehicle of NAG treatment (NCT02404285)
Timeframe: 12 weeks
| Intervention | % Change Non-inflammatory lesion count (Mean) |
|---|---|
| Vehicle | -6.5 |
| NAG (Next Science Acne Gel) | -34.1 |
Change in Burning/Stinging scores with daily use of NAG compared with vehicle after 12-weeks. Treatment area evaluation scoring system ranges from 0-3, with 0 being Absent (none) and 3 being Severe (intense, marked presence). (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Average score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean after 12 Weeks | |
| NAG (Next Science Acne Gel) | 0 | 0.1 |
| Vehicle | .1 | 0 |
Change in Dryness score with daily use of NAG compared with vehicle after 12-weeks. Treatment area evaluation scoring system ranges from 0-3, with 0 being Absent (none) and 3 being Severe (intense, marked presence). (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Average score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean after 12 Weeks | |
| NAG (Next Science Acne Gel) | .3 | 0.1 |
| Vehicle | .3 | 0.3 |
Change in Edema scores with daily use of NAG compared with vehicle after 12-weeks. Treatment area evaluation scoring system ranges from 0-3, with 0 being Absent (none) and 3 being Severe (intense, marked presence). (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Average score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean after 12 Weeks | |
| NAG (Next Science Acne Gel) | 0.1 | 0 |
| Vehicle | .2 | 0.1 |
Change in Erosion scores with daily use of NAG compared with vehicle after 12-weeks. Treatment area evaluation scoring system ranges from 0-3, with 0 being Absent (none) and 3 being Severe (intense, marked presence). (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Average score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean after 12 Weeks | |
| NAG (Next Science Acne Gel) | 0 | 0 |
| Vehicle | 0 | 0 |
Change in Erythema (measure of redness) scores with daily use of NAG compared with vehicle after 12-weeks.Treatment area evaluation scoring system ranges from 0-3, with 0 being Absent (none) and 3 being Severe (intense, marked presence). (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Average Score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean after 12 weeks | |
| NAG (Next Science Acne Gel) | .5 | 0.3 |
| Vehicle | .5 | 0.4 |
Change in Itching scores with daily use of NAG compared with vehicle after 12-weeks. Treatment area evaluation scoring system ranges from 0-3, with 0 being Absent (none) and 3 being Severe (intense, marked presence). (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Average score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean at 12 Weeks | |
| NAG (Next Science Acne Gel) | .1 | 0 |
| Vehicle | .2 | 0 |
Change in Pain scores with daily use of NAG compared with vehicle after 12-weeks. Treatment area evaluation scoring system ranges from 0-3, with 0 being Absent (none) and 3 being Severe (intense, marked presence). (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Average score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean at 12 Weeks | |
| NAG (Next Science Acne Gel) | .1 | 0 |
| Vehicle | .1 | 0 |
Change in the subjects perception of their acne symptoms with daily use of NAG compared with vehicle after 12-weeks. At baseline and each subsequent visit, subjects completed the Acne-QoL form after being given verbal instructions by the study coordinator. The Acne QoL is a validated measure that contains 19 questions referring to the past week, organized into four areas: self-perception, role-social, role-emotional, and acne symptoms. Each question gauges how much acne affects the subject, with answers ranging from 0 (extremely) to 6 (not at all). Domain scores are calculated by taking the average scores within each domain, with high scores reflecting better QoL determination. The number of subjects with a negative score for each quality of life region was determined at each time-point. Those with a negative score, were those with a score of 3.5 or less, indicating that the disease was having a meaningful effect on their lives (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean at 12 Weeks | |
| NAG (Next Science Acne Gel) | 3.4 | 4.5 |
| Vehicle | 3.4 | 4.4 |
Change in Role-Emotional scores with daily use of NAG compared with vehicle after 12-weeks. At baseline and each subsequent visit, subjects completed the Acne-QoL form after being given verbal instructions by the study coordinator. The Acne QoL is a validated measure that contains 19 questions referring to the past week, organized into four areas: self-perception, role-social, role-emotional, and acne symptoms. Each question gauges how much acne affects the subject, with answers ranging from 0 (extremely) to 6 (not at all). Domain scores are calculated by taking the average scores within each domain, with high scores reflecting better QoL determination. The number of subjects with a negative score for each quality of life region was determined at each time-point. Those with a negative score, were those with a score of 3.5 or less, indicating that the disease was having a meaningful effect on their lives (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean at 12 Weeks | |
| NAG (Next Science Acne Gel) | 3.9 | 4.8 |
| Vehicle | 3.9 | 4.6 |
Change in subjects social response to their acne with daily use of NAG compared with vehicle after 12-weeks. At baseline and each subsequent visit, subjects completed the Acne-QoL form after being given verbal instructions by the study coordinator. The Acne QoL is a validated measure that contains 19 questions referring to the past week, organized into four areas: self-perception, role-social, role-emotional, and acne symptoms. Each question gauges how much acne affects the subject, with answers ranging from 0 (extremely) to 6 (not at all). Domain scores are calculated by taking the average scores within each domain, with high scores reflecting better QoL determination. The number of subjects with a negative score for each quality of life region was determined at each time-point. Those with a negative score, were those with a score of 3.5 or less, indicating that the disease was having a meaningful effect on their lives (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean at 12 Weeks | |
| NAG (Next Science Acne Gel) | 4.5 | 5.3 |
| Vehicle | 4.1 | 4.7 |
Change in Self Perception scores with daily use of NAG compared with vehicle after 12-weeks. The Acne Quality of Life (QoL) Questionnaire Form was used to determine the practical improvements in quality of life. The Acne-QoL form is a validated measure that contains 19 questions referring to the past week, organized into four area: self-perception, role-social, role-emotional, and acne symptoms. Each question gauges how much acne affects the subject, with answers ranging from 0 (extremely) to 6 (not at all). Domain scores are calculated by taking the average scores within each domain, with high scores reflecting better QoL determination. The number of subjects with a negative score for each quality of life region was determined at each time-point. Those with a negative score, were those with a score of 3.5 or less, indicating that the disease was having a meaningful effect on their lives. (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean at 12 Weeks | |
| NAG (Next Science Acne Gel) | 4.1 | 5.0 |
| Vehicle | 3.5 | 4.6 |
Change in Investigator Global Assessment (IGA) score (0-5) with daily use of NAG compared with vehicle after 12-weeks. IGA score is worse at 5, with improvement at lower scores (best at 0). (NCT02404285)
Timeframe: Baseline until 12 weeks
| Intervention | Score on a scale (Mean) | |
|---|---|---|
| Mean at Baseline | Mean after 12 Weeks | |
| NAG (Next Science Acne Gel) | 2.4 | 2.0 |
| Vehicle | 2.8 | 2.3 |
19 reviews available for salicylic acid and Acne Vulgaris
| Article | Year |
|---|---|
Management of Acne Vulgaris: A Review.
Topics: Acne Vulgaris; Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Anti-Bacterial Ag | 2021 |
A Comprehensive Bibliographic Review Concerning the Efficacy of Organic Acids for Chemical Peels Treating Acne Vulgaris.
Topics: Acne Vulgaris; Adolescent; Chemexfoliation; Humans; Keratolytic Agents; Salicylic Acid; Skin; Young | 2023 |
Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.
Topics: Acne Vulgaris; Adapalene; Adolescent; Adult; Anti-Bacterial Agents; Benzoyl Peroxide; Bias; Child; C | 2020 |
Evidence-based topical treatments (azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid) for acne: an abridged version of a Cochrane systematic review.
Topics: Acne Vulgaris; Administration, Cutaneous; Dermatologic Agents; Dicarboxylic Acids; Fruit; Glycolates | 2020 |
Clinical evidence for washing and cleansers in acne vulgaris: a systematic review.
Topics: Acne Vulgaris; Anti-Infective Agents, Local; Benzoyl Peroxide; Detergents; Face; Glycolates; Humans; | 2018 |
[Use of organic acids in acne and skin discolorations therapy].
Topics: Acne Vulgaris; Adolescent; Adult; Child; Dermatitis; Female; Glycolates; Gram-Positive Bacterial Inf | 2015 |
Drugs for acne.
Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Animals; Anti-Bacterial Agents; Dermat | 2016 |
Effective over-the-counter acne treatments.
Topics: Acne Vulgaris; Benzoyl Peroxide; Drug Therapy, Combination; Humans; Hydroxy Acids; Nonprescription D | 2008 |
Superficial chemical peels and microdermabrasion for acne vulgaris.
Topics: Acne Vulgaris; Dermabrasion; Glycolates; Humans; Keratolytic Agents; Salicylic Acid; Treatment Outco | 2008 |
Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne.
Topics: Acne Vulgaris; Administration, Topical; Benzoyl Peroxide; Clindamycin; Drug Combinations; Humans; Sa | 2010 |
Expert opinion: efficacy of superficial chemical peels in active acne management--what can we learn from the literature today? Evidence-based recommendations.
Topics: Acne Vulgaris; Chemexfoliation; Evidence-Based Medicine; Glycolates; Humans; Keratolytic Agents; Pyr | 2011 |
Topical acne drugs: review of clinical properties, systemic exposure, and safety.
Topics: Acne Vulgaris; Administration, Topical; Anti-Bacterial Agents; Benzoyl Peroxide; Dermatologic Agents | 2003 |
Therapy of acne.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Benzoyl Peroxide; Estrogens; Glucocorticoids; Humans; Salicyla | 1982 |
Topical therapy for acne.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Age | 2000 |
Topical therapy of acne.
Topics: Acne Vulgaris; Administration, Topical; Benzoyl Peroxide; Clindamycin; Dicarboxylic Acids; Erythromy | 1986 |
Androgens in women: Androgen-mediated skin disease and patient evaluation.
Topics: Acne Vulgaris; Adrenal Gland Neoplasms; Adrenal Glands; Alopecia; Androgens; Cholesterol; Endocrinol | 2019 |
Cutis verticis gyrata secondary to acne scleroticans capitis.
Topics: Acne Vulgaris; Adult; Humans; Male; Scalp; Scalp Dermatoses | 2004 |
The management of postacne scarring.
Topics: Acne Vulgaris; Cicatrix; Face; Humans; Keratolytic Agents; Scalp; Severity of Illness Index | 2007 |
Zinc and cutaneous inflammation.
Topics: Acne Vulgaris; Acrodermatitis; Animals; Antibody Formation; B-Lymphocytes; Cellulitis; Dermatitis; H | 1985 |
41 trials available for salicylic acid and Acne Vulgaris
| Article | Year |
|---|---|
A prospective, randomized, split-face study of concomitant administration of low-dose oral isotretinoin with 30% salicylic acid chemical peeling for the treatment of acne vulgaris in Asian population.
Topics: Acne Vulgaris; Administration, Oral; Dermatologic Agents; Erythema; Humans; Isotretinoin; Melanins; | 2022 |
Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda.
Topics: Acne Vulgaris; Adult; Chemexfoliation; Humans; Infant, Newborn; Isotretinoin; Prospective Studies; S | 2022 |
Combination treatment with 30% salicylic acid and fractional CO
Topics: Acne Vulgaris; Carbon Dioxide; Cicatrix; Humans; Lasers, Gas; Pain; Prospective Studies; Salicylic A | 2022 |
Efficacy and safety of a cream containing octyl salicylic acid, salicylic acid, linoleic acid, nicotinamide, and piroctone olamine combined with 5% benzoyl peroxide in the treatment of acne vulgaris: a randomized controlled study.
Topics: Acne Vulgaris; Benzoyl Peroxide; Drug Combinations; Ethanolamines; Gels; Humans; Linoleic Acid; Niac | 2022 |
Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial.
Topics: Acne Vulgaris; Adult; China; Humans; Hyperpigmentation; Salicylic Acid; Skin; Treatment Outcome | 2023 |
Efficacy of supramolecular salicylic acid in combination with doxycycline in the treatment of acne.
Topics: Acne Vulgaris; Administration, Oral; Doxycycline; Humans; Salicylic Acid | 2023 |
A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide.
Topics: Acne Vulgaris; Adapalene; Benzoyl Peroxide; Dermatologic Agents; Drug Combinations; Gels; Humans; Qu | 2023 |
Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris.
Topics: Acne Vulgaris; Adolescent; Chemexfoliation; Dose-Response Relationship, Drug; Face; Female; Humans; | 2020 |
Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial.
Topics: Acne Vulgaris; Adult; Chemexfoliation; Double-Blind Method; Drug Combinations; Ethanol; Facial Derma | 2020 |
Comparison of salicylic acid 30% peel and pneumatic broadband light in the treatment of mild to moderately severe facial acne vulgaris.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Facial Dermatoses; Female; Humans; Keratolytic Ag | 2017 |
Comparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris.
Topics: Acne Vulgaris; Adult; Chemexfoliation; Drug Combinations; Drug Therapy, Combination; Esthetics; Etha | 2018 |
Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment.
Topics: Acne Vulgaris; Administration, Oral; Adolescent; Adult; Child; Dermatologic Agents; Dietary Suppleme | 2018 |
Efficacy and safety of 2% supramolecular salicylic acid compared with 5% benzoyl peroxide/0.1% adapalene in the acne treatment: a randomized, split-face, open-label, single-center study.
Topics: Acne Vulgaris; Adapalene; Administration, Cutaneous; Adolescent; Adult; Benzoyl Peroxide; Dermatolog | 2019 |
Combination chemical peels are more effective than single chemical peel in treatment of mild-to-moderate acne vulgaris: A split face comparative clinical trial.
Topics: Acne Vulgaris; Adult; Analysis of Variance; Chemexfoliation; Drug Combinations; Drug Therapy, Combin | 2018 |
Evaluation of the efficacy, tolerability, and safety of an over-the-counter acne regimen containing benzoyl peroxide and salicylic acid in subjects with acne.
Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Benzoyl Peroxide; Dermatologic Agents; | 2013 |
Rapid treatment of mild acne with a novel skin care system containing 1% salicylic acid, 10% buffered glycolic acid, and botanical ingredients.
Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Child; Dermatologic Agents; Female; Gly | 2014 |
A randomized controlled study for the treatment of acne vulgaris using high-intensity 414 nm solid state diode arrays.
Topics: Acne Vulgaris; Adolescent; Adult; Combined Modality Therapy; Cosmetic Techniques; Double-Blind Metho | 2015 |
Trichloroacetic Acid Versus Salicylic Acid in the Treatment of Acne Vulgaris in Dark-Skinned Patients.
Topics: Acne Vulgaris; Chemexfoliation; Dermatitis, Exfoliative; Double-Blind Method; Erythema; Female; Huma | 2015 |
Topical Treatment With an Agent Disruptive to P. acnes Biofilm Provides Positive Therapeutic Response: Results of a Randomized Clinical Trial.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Anti-Bacterial Agents; Biofilms; Child; D | 2016 |
Five-day study to judge the short-term effect of a benzoyl peroxide 3% gel on acne lesions.
Topics: Acne Vulgaris; Adolescent; Adult; Benzoyl Peroxide; Child; Dermatologic Agents; Double-Blind Method; | 2016 |
Jessner's solution vs. 30% salicylic acid peels: a comparative study of the efficacy and safety in mild-to-moderate acne vulgaris.
Topics: Acne Vulgaris; Adolescent; Chemexfoliation; Drug Combinations; Ethanol; Facial Dermatoses; Female; H | 2017 |
Clinical comparison of salicylic acid peel and LED-Laser phototherapy for the treatment of Acne vulgaris in teenagers.
Topics: Acne Vulgaris; Adolescent; Chemexfoliation; Color; Female; Humans; Keratolytic Agents; Lasers, Semic | 2017 |
Randomized study comparing the efficacy and tolerance of a lipophillic hydroxy acid derivative of salicylic acid and 5% benzoyl peroxide in the treatment of facial acne vulgaris.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Analysis of Variance; Benzoyl Peroxide; D | 2009 |
A 3-step acne system containing solubilized benzoyl peroxide versus clindamycin-benzoyl peroxide.
Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Anti-Bacterial Agents; Benzoyl Peroxide | 2009 |
A study of the efficacy of cleansers for acne vulgaris.
Topics: Acne Vulgaris; Administration, Cutaneous; Adult; Detergents; Dicarboxylic Acids; Dose-Response Relat | 2010 |
Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Clindamycin; Dose-Response Relationship, | 2011 |
Evaluation of self-treatment of mild-to-moderate facial acne with a blue light treatment system.
Topics: Acne Vulgaris; Adult; Combined Modality Therapy; Dermatologic Agents; Dicarboxylic Acids; Drug Combi | 2011 |
Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne.
Topics: Acne Vulgaris; Administration, Topical; Adult; Chemexfoliation; Erythema; Face; Female; Humans; Kera | 2011 |
Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Benzoyl Peroxide; Clindamycin; Dermatolog | 2012 |
Salicylic acid peels versus Jessner's solution for acne vulgaris: a comparative study.
Topics: Acne Vulgaris; Adult; Chemexfoliation; Double-Blind Method; Drug Combinations; Ethanol; Face; Humans | 2013 |
Clinical evidence on the efficacy and safety of an antioxidant optimized 1.5% salicylic acid (SA) cream in the treatment of facial acne: an open, baseline-controlled clinical study.
Topics: Acne Vulgaris; Administration, Topical; Adult; Antioxidants; Evidence-Based Medicine; Female; Humans | 2013 |
Randomized, controlled, evaluator-blinded studies conducted to compare the efficacy and tolerability of 3 over-the-counter acne regimens in subjects with mild or moderate acne.
Topics: Acne Vulgaris; Adolescent; Adult; Asian People; Benzoyl Peroxide; Black People; Dermatologic Agents; | 2013 |
Single-center, open-label study of a proprietary topical 0.5% salicylic acid-based treatment regimen containing sandalwood oil in adolescents and adults with mild to moderate acne.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Drug Combinations; Endpoint Determination | 2012 |
Comparison of chloroxylenol 0.5% plus salicylic acid 2% cream and benzoyl peroxide 5% gel in the treatment of acne vulgaris: a randomized double-blind study.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Benzoyl Peroxide; Double-Blind Method; Dr | 2003 |
Salicylic acid peels for the treatment of acne vulgaris in Asian patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Humans; Keratolytic Agents; Korea; Salicylic Acid | 2003 |
Salicylic acid peels for the treatment of acne vulgaris in Asian patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Humans; Keratolytic Agents; Korea; Salicylic Acid | 2003 |
Salicylic acid peels for the treatment of acne vulgaris in Asian patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Humans; Keratolytic Agents; Korea; Salicylic Acid | 2003 |
Salicylic acid peels for the treatment of acne vulgaris in Asian patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Humans; Keratolytic Agents; Korea; Salicylic Acid | 2003 |
Salicylic acid peels for the treatment of acne vulgaris in Asian patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Humans; Keratolytic Agents; Korea; Salicylic Acid | 2003 |
Salicylic acid peels for the treatment of acne vulgaris in Asian patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Humans; Keratolytic Agents; Korea; Salicylic Acid | 2003 |
Salicylic acid peels for the treatment of acne vulgaris in Asian patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Humans; Keratolytic Agents; Korea; Salicylic Acid | 2003 |
Salicylic acid peels for the treatment of acne vulgaris in Asian patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Humans; Keratolytic Agents; Korea; Salicylic Acid | 2003 |
Salicylic acid peels for the treatment of acne vulgaris in Asian patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Humans; Keratolytic Agents; Korea; Salicylic Acid | 2003 |
Whitening effect of salicylic acid peels in Asian patients.
Topics: Acne Vulgaris; Adult; Asian People; Chemexfoliation; Colorimetry; Female; Humans; Hyperpigmentation; | 2006 |
Comparison of alpha- and beta-hydroxy acid chemical peels in the treatment of mild to moderately severe facial acne vulgaris.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Chemexfoliation; Double-Blind Method; Fac | 2008 |
Efficacy and tolerability of clindamycin phosphate and salicylic acid gel in the treatment of mild to moderate acne vulgaris.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Anti-Bacterial Agents; Clindamycin; Doubl | 2008 |
Treatment of mild and moderate acne vulgaris with salicylic acid in an alcohol-detergent vehicle.
Topics: Acne Vulgaris; Adolescent; Adult; Child; Clinical Trials as Topic; Detergents; Double-Blind Method; | 1981 |
Percutaneous absorption of salicylic acid after repeated (14-day) in vivo administration to normal, acnegenic or aged human skin.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aging; Area Under Curve; Biological Avail | 1997 |
Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin.
Topics: Acne Vulgaris; Adolescent; Adult; Cholesterol; Cholesterol Esters; Clinical Trials as Topic; Fatty A | 1984 |
66 other studies available for salicylic acid and Acne Vulgaris
| Article | Year |
|---|---|
Naturally occurring antiacne agents.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Fatty Alcohols; Membrane Fluidity; Microbial Sensitivity Tests | 1994 |
Trends in utilization of non-first-line topical acne medications among children, adolescents, and adults in the United States, 2012-2016.
Topics: Acne Vulgaris; Adolescent; Adult; Child; Health Care Surveys; Humans; Infant, Newborn; Salicylic Aci | 2021 |
30% supramolecular salicylic acid peels effectively treats acne vulgaris and reduces facial sebum.
Topics: Acne Vulgaris; Chemexfoliation; Cyclooxygenase 2; Humans; Salicylic Acid; Sebum | 2022 |
Influence of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid on facial skin lipidome among seborrhea participants.
Topics: Acne Vulgaris; Adapalene; Benzoyl Peroxide; Carnitine; Dermatitis, Seborrheic; Dermatologic Agents; | 2022 |
Acne care in health care providers during the COVID-19 pandemic: A national survey.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Benzoyl Peroxide; COVID-19; Cross-Sectional Studies; Dermatolo | 2022 |
Evaluation of 30% supramolecular salicylic acid followed by 1565-nm non-ablative fractional laser on facial acne and subsequent enlarged pores.
Topics: Acne Vulgaris; Cicatrix; Erythema; Humans; Lasers; Prospective Studies; Salicylic Acid; Treatment Ou | 2023 |
Anti-acne activity of carnitine salicylate and magnolol through the regulation of exfoliation, lipogenesis, bacterial growth and inflammation.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Carnitine; Humans; Inflammation; Lignans; Lipogenesis; Salicyl | 2023 |
Efficacy of topical 30% salicylic acid in combination with minocycline in moderate to severe acne.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Humans; Minocycline; Quality of Life; Retrospective Studies; S | 2023 |
Sequential peeling as a monotherapy for treatment of milder forms of acne vulgaris.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Female; Glycolates; Humans; Keratolytic Agents; M | 2020 |
A split-face comparative study to evaluate the efficacy of 50% pyruvic acid against a mixture of glycolic and salicylic acids in the treatment of acne vulgaris.
Topics: Acne Vulgaris; Chemexfoliation; Female; Glycols; Humans; Keratolytic Agents; Pyruvic Acid; Salicylic | 2020 |
Two is better than one: The combined effects of glycolic acid and salicylic acid on acne-related disorders.
Topics: Acne Vulgaris; Glycolates; Humans; Prospective Studies; Salicylic Acid; Treatment Outcome | 2020 |
Efficacy and safety of a new topical gel formulation containing retinol encapsulated in glycospheres and hydroxypinacolone retinoate, an antimicrobial peptide, salicylic acid, glycolic acid and niacinamide for the treatment of mild acne: preliminary resul
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Anti-Infective Agents; Female; Gels; Glyc | 2020 |
Effectiveness of a combination of salicylic acid-based products for the treatment of mild comedonal-papular acne: a multicenter prospective observational study.
Topics: Acne Vulgaris; Adult; Carbamide Peroxide; Dermatologic Agents; Drug Combinations; Facial Dermatoses; | 2020 |
Analysis of the effectiveness of chemical peelings in the treatment of acne vulgaris assessed using high-frequency ultrasound-A comparative study.
Topics: Acne Vulgaris; Chemexfoliation; Female; Humans; Salicylic Acid; Treatment Outcome; Ultrasonography | 2021 |
Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris.
Topics: Acne Vulgaris; Adolescent; Adult; Brazil; Citric Acid; Female; HEPES; Humans; Male; Prospective Stud | 2021 |
The factors influencing the unmet effects of alpha hydroxy acid peels on acne vulgaris: A single tertiary center experience.
Topics: Acne Vulgaris; Adult; Chemexfoliation; Female; Humans; Keratolytic Agents; Male; Retrospective Studi | 2021 |
Efficacy of a combined chemical peel and topical salicylic acid-based gel combination in the treatment of active acne.
Topics: Acne Vulgaris; Adolescent; Chemexfoliation; Female; Humans; Keratolytic Agents; Quality of Life; Sal | 2021 |
Bevacizumab-associated Sudden Onset of Multiple Monomorphic Comedones on the Scalp Successfully Treated with 30% Salicylic Acid Peels.
Topics: Acne Vulgaris; Angiogenesis Inhibitors; Bevacizumab; Humans; Keratolytic Agents; Male; Middle Aged; | 2017 |
The assessment of the effects of the combination of microdermabrasion and cavitation peeling in the therapy of seborrhoeic skin with visible symptoms of acne punctata.
Topics: Acne Vulgaris; Adult; Dermabrasion; Dermatitis, Seborrheic; Female; Humans; Salicylic Acid; Skin Phy | 2019 |
Salicylic acid treats acne vulgaris by suppressing AMPK/SREBP1 pathway in sebocytes.
Topics: Acne Vulgaris; AMP-Activated Protein Kinases; Apoptosis; Cell Line; Computational Biology; Down-Regu | 2019 |
Comparative study of the effect of 50% pyruvic and 30% salicylic peels on the skin lipid film in patients with acne vulgaris.
Topics: Acne Vulgaris; Adolescent; Cheek; Chemexfoliation; Chin; Female; Forehead; Humans; Lipids; Male; Pyr | 2014 |
Novel retinoid ester in combination with salicylic acid for the treatment of acne.
Topics: Acne Vulgaris; Adult; Anti-Infective Agents; Detergents; Drug Combinations; Female; Humans; Keratoly | 2016 |
Efficacy and tolerability of a topical gel containing 3% hydrogen peroxide, 1.5% salicylic acid and 4% D-panthenol in the treatment of mild-moderate acne.
Topics: Acne Vulgaris; Administration, Cutaneous; Dermatologic Agents; Drug Combinations; Female; Gels; Huma | 2016 |
Combination therapy with hydrogen peroxide (4%), salicylic acid (0.5%) and D-panthenol (4%): efficacy and skyn tolerability in common acne vulgaris during sun exposure period.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Anti-Infective Agents, Local; Child; Comb | 2016 |
3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems.
Topics: Acne Vulgaris; Administration, Cutaneous; Drug Delivery Systems; Drug Liberation; Drug Stability; Fe | 2016 |
Bio-based topical system for enhanced salicylic acid delivery: preparation and performance of gels.
Topics: Acne Vulgaris; Administration, Cutaneous; Administration, Topical; Adult; Chemistry, Pharmaceutical; | 2016 |
Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Cicatrix; Drug Combinations; Female; Glycolates; | 2009 |
Classification of benzoyl peroxide as safe and effective and revision of labeling to drug facts format; topical acne drug products for over-the-counter human use; final rule.
Topics: Acne Vulgaris; Administration, Topical; Animals; Benzoyl Peroxide; Carcinogenicity Tests; Carcinogen | 2010 |
Acne - best practice management.
Topics: Acne Vulgaris; Algorithms; Australia; Benchmarking; Dermatologic Agents; Education, Medical, Continu | 2010 |
Acne & rosacea: thinking outside the box.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Clindamycin; Female; Humans; Keratolytic Agents; Male; Plant O | 2012 |
Commentary: salicylic acid peels versus Jessner's solution peels for acne vulgaris: a comparative study.
Topics: Acne Vulgaris; Chemexfoliation; Drug Combinations; Ethanol; Humans; Keratolytic Agents; Lactic Acid; | 2013 |
Alternate media in the therapy of acne vulgaris.
Topics: Acne Vulgaris; Analgesics; Anilides; Humans; Hydrocortisone; Salicylic Acid; Sulfacetamide; Sulfur; | 1963 |
THE "NEGLECTED" PATIENT.
Topics: Acne Vulgaris; Adolescent; Humans; Salicylic Acid; Sulfur | 1963 |
TREATMENT OF ACNE VULGARIS.
Topics: Acne Vulgaris; Humans; Resorcinols; Salicylic Acid; Sulfur; Zinc | 1963 |
ACNE VULGARIS. EVALUATION OF A MEDICATED CLEANSING PAD.
Topics: Acne Vulgaris; Adolescent; Adult; Ethanol; Female; Hexachlorophene; Humans; Placebos; Salicylic Acid | 1964 |
DAYTIME SKIN CARE AND ACNE CONTROL.
Topics: Acne Vulgaris; Adolescent; Drug Therapy; Ethanol; Humans; Salicylic Acid; Skin Care; Solutions | 1964 |
[LOCAL TREATMENT OF ACNE VULGARIS].
Topics: Acne Vulgaris; Drug Therapy; Heterocyclic Compounds; Humans; Salicylic Acid | 1964 |
A "SELF-TINTING" SALICYLIC ACID AND PARACHLOROMETAXYLENOL LIQUID POWDER-BASE FOR ACNE THERAPY.
Topics: Acne Vulgaris; Biomedical Research; Cosmetics; Drug Therapy; Humans; Phenols; Placebos; Powders; Sal | 1965 |
IN VITRO STUDY OF ANTIBACTERIAL ACTION OF VARIOUS CHEMICALS ON CORYNEBACTERIUM ACNES.
Topics: Acne Vulgaris; Ammonium Compounds; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agen | 1965 |
[Enelbin maske, a successful new method of treatment of acne vulgaris and conglobata].
Topics: Acne Vulgaris; Drug Combinations; Heparin; Humans; Salicylates; Salicylic Acid; Thymol; Vanillic Aci | 1961 |
Salicylic acid peels in polyethylene glycol vehicle for the treatment of comedogenic acne in Japanese patients.
Topics: Acne Vulgaris; Adolescent; Adult; Chemexfoliation; Drug Carriers; Drug Combinations; Female; Follow- | 2008 |
Excellent clinical results with a new preparation for chemical peeling in acne: 30% salicylic acid in polyethylene glycol vehicle.
Topics: Acne Vulgaris; Adult; Aged; Aged, 80 and over; Animals; Chemexfoliation; Dermatologic Agents; Drug C | 2008 |
Antiacne products--no benzoyl peroxide.
Topics: Acne Vulgaris; Administration, Cutaneous; Humans; Nonprescription Drugs; Salicylates; Salicylic Acid | 1993 |
The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups.
Topics: Acne Vulgaris; Adult; Black People; Chemexfoliation; Drug Administration Schedule; Female; Hispanic | 1999 |
[Which acne? Which therapy?].
Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Anti-Bacterial Agents; Benzoyl Peroxide; Est | 1985 |
Rational therapy for acne vulgaris: an update on topical treatment.
Topics: Acne Vulgaris; Administration, Topical; Anti-Bacterial Agents; Benzoyl Peroxide; Drug Therapy, Combi | 1986 |
Aseptic Pustulosis of the Folds Successfully Treated with Methotrexate.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Female; Folliculitis; Humans; Methotrexate; Middle Aged; Scalp | 2022 |
Why do humans get acne? A hypothesis.
Topics: Acne Vulgaris; Adolescent; Androgens; Biofilms; Diet; Dystocia; Female; Hair Follicle; Head; Humans; | 2020 |
Combination of surgery and photodynamic therapy for the treatment of cystic acne of the scalp.
Topics: Acne Vulgaris; Humans; Photochemotherapy; Photosensitizing Agents; Scalp; Treatment Outcome; Wound H | 2020 |
Dissecting folliculitis (dissecting cellulitis) of the scalp: a 66-patient case series and proposal of classification.
Topics: Abscess; Acne Vulgaris; Adult; Alopecia; Cellulitis; Comorbidity; Female; Granulation Tissue; Humans | 2018 |
Sox9 facilitates proliferation, differentiation and lipogenesis in primary cultured human sebocytes.
Topics: Acne Vulgaris; Apoptosis; Cell Differentiation; Cell Proliferation; Epithelial Cells; Fluorescent An | 2017 |
Adrenomedullin: expression and possible role in human skin and hair growth.
Topics: Acne Vulgaris; Adrenomedullin; Blotting, Western; Calcitonin Receptor-Like Protein; Cells, Cultured; | 2003 |
[Folliculitis and Hoffmann's perifolliculitis abscedens; acne conglobata of the scalp].
Topics: Acne Vulgaris; Dermatitis; Disease; Folliculitis; Head; Humans; Scalp | 1954 |
[Presenting skin disorders in black Afro-Caribbean patients: a multicentre study conducted in the Paris region].
Topics: Acne Vulgaris; Adult; Africa; Black People; Child; Humans; Paris; Scalp; Scalp Dermatoses; Skin Dise | 2008 |
Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions.
Topics: Acne Vulgaris; beta-Defensins; Hair Follicle; Humans; Immunohistochemistry; In Situ Hybridization; R | 2001 |
Quantification of bacteria in isolated pilosebaceous follicles in normal skin.
Topics: Acne Vulgaris; Adult; Back; Bacteria; Calcium Chloride; Hair; Humans; Male; Middle Aged; Propionibac | 1975 |
Necrotizing lymphocytic folliculitis: the early lesion of acne necrotica (varioliformis).
Topics: Acne Vulgaris; Aged; Biopsy; Chronic Disease; Diagnosis, Differential; Female; Folliculitis; Humans; | 1987 |
Pathogenesis of acne vulgaris. I. Comedogenic properties of human sebum in external ear canal of the rabbit.
Topics: Acne Vulgaris; Adult; Animals; Child; Darier Disease; Ear Canal; Humans; Rabbits; Scalp; Sebum; Skin | 1968 |
Pathogenesis of acne vulgaris. II. Histopathology of comedones induced in the rabbit ear by human sebum.
Topics: Acne Vulgaris; Animals; Darier Disease; Ear Canal; Humans; Hyperplasia; Inflammation; Naphthalenes; | 1968 |
Location of bacterial skin flora.
Topics: Acne Vulgaris; Back; Face; Forearm; Hair; Humans; Leg; Microscopy, Electron; Neck; Scalp; Skin; Toes | 1969 |
Composition of human comedone lipids.
Topics: Acne Vulgaris; Adolescent; Adult; Alcohols; Chromatography, Thin Layer; Fatty Acids, Nonesterified; | 1970 |
Comedogenicity of human sebum.
Topics: Acne Vulgaris; Adult; Animals; Child; Child, Preschool; Ear Diseases; Epithelium; Fatty Acids; Fatty | 1970 |
Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin--a possible pathogenic factor in acne.
Topics: Acne Vulgaris; Biopsy; Chin; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; | 1971 |
The skin microflora in acne vulgaris.
Topics: Acne Vulgaris; Adolescent; Adult; Bacteria; Bacteriophages; Cheek; Fatty Acids, Nonesterified; Femal | 1974 |
Acne vulgaris: a treatable disease.
Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Adolescent; Anti-Bacterial Agents; Con | 1974 |
Corynebacterium acnes and other anaerobic diphtheroids from human skin.
Topics: Acne Vulgaris; Anaerobiosis; Axilla; Back; Bacteriophage Typing; Caseins; Cheek; Corynebacterium; De | 1974 |