salicylates and Xerostomia

To compare measures of dry mouth following extended use of an alcohol-based mouthrinse (LISTERINE Antiseptic [LA]) and a non-alcohol-based mouthrinse (Crest Pro-Health Rinse [CPH]) on healthy adults with "normal" salivary flow.. This single-site, randomized, observer-blinded, parallel study compared unstimulated whole salivary flow and perceived dryness following daily use at weeks 4 and 12 versus baseline. Noninferiority, between-treatment flow comparisons (0.15 mL/min margin), and between-treatment comparisons of the mean Bluestone Mouthfeel Questionnaire (BMQ) visual analog scale scores were made using analysis of covariance.. Measures of dry mouth were comparable between mouthrinses, as demonstrated by both noninferiority of LA versus CPH flow (P < .001) and no significant differences between groups in the BMQ measures at 4 or 12 weeks.. Extended use of an alcohol-based mouthrinse is no more likely to cause reduction in salivary flow or perceived dryness in individuals with normal salivary flow compared with a non-alcohol-based mouthrinse (CPH).

Topics: Adult; Cetylpyridinium; Drug Combinations; Female; Humans; Male; Mouthwashes; Salicylates; Salivation; Surveys and Questionnaires; Terpenes; Xerostomia

To determine if 2 commercial mouthrinses, 1 alcohol-based and 1 nonalcohol-based, affect salivary flow and symptoms of dry mouth in nonxerostomic adults.. This observer-blinded, randomized, crossover pilot study involved 20 adults. The primary endpoints of interest were whole salivary flow rates and the perceived mouth dryness VAS scores following 1 week of use. ANOVA was used to determine differences in these endpoints between groups, and ANCOVA was used to control for any variation in baseline flow rates and VAS scores (P <.05).. There were no significant differences between groups at baseline. After 1 week of mouthrinse use, ANOVA and ANCOVA of combined data (before and after crossover) revealed no significant differences in either flow rates or VAS scores between groups (P >.05).. There were no differences in objective or subjective measures of mouth dryness between alcohol- and nonalcohol-containing mouthrinses after 1 week in nonxerostomic subjects.

Topics: Adult; Alcohols; Drug Combinations; Epidemiologic Methods; Female; Humans; Male; Mouthwashes; Salicylates; Salivation; Terpenes; Xerostomia

To assess the irritation potential of an essential oil-containing mouthrinse (Listerine Antiseptic) in a population with objectively documented xerostomia (hyposalivation) using an exaggerated-exposure clinical model.. Following a baseline oral soft tissue examination, 19 qualifying female subjects with a mean age of 61 years and a mean unstimulated baseline salivary flow of 0.06 mL/min were randomly assigned either the essential oil mouthrinse or a negative control rinse. They rinsed under supervision with 20 ml of their assigned rinse for 30 seconds and 5 minutes later a second salivary flow rate was determined. They then rinsed unsupervised with 20 ml for 30 seconds three times daily for the next 14 days, and received soft tissue examinations on days 7 and 14. After a 1-week interim period, subjects switched to the alternate rinse and the examination and rinsing regimens were repeated during the subsequent 2 weeks.. The oral irritation potential of the essential oil mouthrinse was minimal. Oral mucosal abnormalities attributable to the test rinses were seen in only 2 subjects, both at the 7-day examination. These subjects were both using the essential oil mouthrinse. The abnormalities consisted of an asymptomatic "whitish slough" which was readily wiped off leaving a normal appearing, non-erythematous mucosa. In both subjects, the oral mucosa appeared normal at the 14-day examination.

Topics: Aged; Analysis of Variance; Cross-Over Studies; Dental Plaque; Drug Combinations; Female; Humans; Middle Aged; Mouth Mucosa; Mouthwashes; Oils, Volatile; Probability; Salicylates; Saliva; Secretory Rate; Single-Blind Method; Terpenes; Xerostomia

Topics: Anti-Infective Agents, Local; Biofilms; Cetylpyridinium; Chlorhexidine; Chlorine Compounds; Dental Caries; Dental Hygienists; Drug Combinations; Evidence-Based Dentistry; Female; Gingival Hemorrhage; Humans; Mouthwashes; Oxides; Patient Participation; Patient Preference; Professional-Patient Relations; Salicylates; Terpenes; Xerostomia; Young Adult

Topics: Chewing Gum; Drug Combinations; Humans; Mouthwashes; Salicylates; Terpenes; Xerostomia

Dental health professionals are being asked to care for a growing number and range of medically compromised patients living with chronic health problems. Although tooth loss overall has declined in the United States, millions of persons, particularly those of more advanced age, still require treatment for the edentulous condition. Particular challenges are faced when this oral state is combined with a complex medical history. The primary learning objective for this case is to increase your general knowledge of and skills in the dental management of the complete denture patient with a dry mouth.

Topics: Adhesives; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dental Care for Chronically Ill; Denture Retention; Denture, Complete; Drug Interactions; Humans; Male; Methotrexate; Mouth, Edentulous; Patient Education as Topic; Prednisone; Salicylates; Xerostomia