salicylates and Warts

Viral warts are a common skin condition, which can range in severity from a minor nuisance that resolve spontaneously to a troublesome, chronic condition. Many different topical treatments are available.. To evaluate the efficacy of local treatments for cutaneous non-genital warts in healthy, immunocompetent adults and children.. We updated our searches of the following databases to May 2011: the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, MEDLINE (from 2005), EMBASE (from 2010), AMED (from 1985), LILACS (from 1982), and CINAHL (from 1981). We searched reference lists of articles and online trials registries for ongoing trials.. Randomised controlled trials (RCTs) of topical treatments for cutaneous non-genital warts.. Two authors independently selected trials and extracted data; a third author resolved any disagreements.. We included 85 trials involving a total of 8815 randomised participants (26 new studies were included in this update). There was a wide range of different treatments and a variety of trial designs. Many of the studies were judged to be at high risk of bias in one or more areas of trial design.Trials of salicylic acid (SA) versus placebo showed that the former significantly increased the chance of clearance of warts at all sites (RR (risk ratio) 1.56, 95% CI (confidence interval) 1.20 to 2.03). Subgroup analysis for different sites, hands (RR 2.67, 95% CI 1.43 to 5.01) and feet (RR 1.29, 95% CI 1.07 to 1.55), suggested it might be more effective for hands than feet.A meta-analysis of cryotherapy versus placebo for warts at all sites favoured neither intervention nor control (RR 1.45, 95% CI 0.65 to 3.23). Subgroup analysis for different sites, hands (RR 2.63, 95% CI 0.43 to 15.94) and feet (RR 0.90, 95% CI 0.26 to 3.07), again suggested better outcomes for hands than feet. One trial showed cryotherapy to be better than both placebo and SA, but only for hand warts.There was no significant difference in cure rates between cryotherapy at 2-, 3-, and 4-weekly intervals.Aggressive cryotherapy appeared more effective than gentle cryotherapy (RR 1.90, 95% CI 1.15 to 3.15), but with increased adverse effects.Meta-analysis did not demonstrate a significant difference in effectiveness between cryotherapy and SA at all sites (RR 1.23, 95% CI 0.88 to 1.71) or in subgroup analyses for hands and feet.Two trials with 328 participants showed that SA and cryotherapy combined appeared more effective than SA alone (RR 1.24, 95% CI 1.07 to 1.43).The benefit of intralesional bleomycin remains uncertain as the evidence was inconsistent. The most informative trial with 31 participants showed no significant difference in cure rate between bleomycin and saline injections (RR 1.28, 95% CI 0.92 to 1.78).Dinitrochlorobenzene was more than twice as effective as placebo in 2 trials with 80 participants (RR 2.12, 95% CI 1.38 to 3.26).Two trials of clear duct tape with 193 participants demonstrated no advantage over placebo (RR 1.43, 95% CI 0.51 to 4.05).We could not combine data from trials of the following treatments: intralesional 5-fluorouracil, topical zinc, silver nitrate (which demonstrated possible beneficial effects), topical 5-fluorouracil, pulsed dye laser, photodynamic therapy, 80% phenol, 5% imiquimod cream, intralesional antigen, and topical alpha-lactalbumin-oleic acid (wh. Data from two new trials comparing SA and cryotherapy have allowed a better appraisal of their effectiveness. The evidence remains more consistent for SA, but only shows a modest therapeutic effect. Overall, trials comparing cryotherapy with placebo showed no significant difference in effectiveness, but the same was also true for trials comparing cryotherapy with SA. Only one trial showed cryotherapy to be better than both SA and placebo, and this was only for hand warts. Adverse effects, such as pain, blistering, and scarring, were not consistently reported but are probably more common with cryotherapy.None of the other reviewed treatments appeared safer or more effective than SA and cryotherapy. Two trials of clear duct tape demonstrated no advantage over placebo. Dinitrochlorobenzene (and possibly other similar contact sensitisers) may be useful for the treatment of refractory warts.

Topics: Administration, Topical; Adult; Bleomycin; Child; Cryotherapy; Dermatologic Agents; Dinitrochlorobenzene; Fluorouracil; Humans; Interferons; Photochemotherapy; Randomized Controlled Trials as Topic; Salicylates; Surgical Tape; Warts

Topics: Anti-Infective Agents; Combined Modality Therapy; Cymbopogon; Debridement; Female; Foot Dermatoses; Humans; Immunocompromised Host; Keratolytic Agents; Lavandula; Mentha piperita; Nonprescription Drugs; Oils, Volatile; Ovarian Neoplasms; Plant Oils; Recurrence; Salicylates; Salicylic Acid; Treatment Outcome; Warts

Viral warts are common and usually harmless but very troublesome. A very wide range of local treatments are used.. To assess the effects of different local treatments for cutaneous, non-genital warts in healthy people.. We searched the Cochrane Skin Group Specialised Register (March 2005), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 1, 2005), MEDLINE (1966 to March 2005), EMBASE (1980 to March 2005) and a number of other biomedical databases. The references of all trials and selected review articles were also searched. In addition, we contacted pharmaceutical companies involved in local treatments for warts and experts in the field. Randomised controlled trials of local treatments for cutaneous non-genital viral warts in immunocompetent (healthy) people.. Data was extracted and two authors independently selected the trials and assessed methodological quality.. Sixty trials were identified that fulfilled the criteria for inclusion. The evidence provided by these studies was generally weak due to poor methodology and reporting. In 21 trials with placebo groups that used participants as the unit of analysis, the average cure rate of placebo preparations was 27% (range 0 to 73%) after an average period of 15 weeks (range 4 to 24 weeks). The best available evidence was for simple topical treatments containing salicylic acid, which were clearly better than placebo. Data pooled from five placebo-controlled trials showed a cure rate of 117/160 (73%) compared with 78/162 (48%) in controls, which translates to a risk ratio of 1.60 (95% confidence interval 1.16 to 2.23), using a random effects model. Evidence for the absolute efficacy of cryotherapy was surprisingly lacking. Two trials comparing cryotherapy with salicylic acid and one comparing duct tape with cryotherapy showed no significant difference in efficacy. Evidence for the efficacy of the remaining treatments reviewed was limited.. There is a considerable lack of evidence on which to base the rational use of topical treatments for common warts. The reviewed trials are highly variable in method and quality. Cure rates with placebo preparations are variable but nevertheless considerable. There is certainly evidence that simple topical treatments containing salicylic acid have a therapeutic effect. There is less evidence for the efficacy of cryotherapy, but reasonable evidence that it is only of equivalent efficacy to simpler and safer treatments. The benefits and risks of topical dinitrochlorobenzene and 5-fluorouracil, intralesional bleomycin and interferons, photodynamic therapy and other miscellaneous treatments remain to be determined.

Topics: Administration, Topical; Bleomycin; Cryotherapy; Dermatologic Agents; Dinitrochlorobenzene; Fluorouracil; Humans; Interferons; Photochemotherapy; Randomized Controlled Trials as Topic; Salicylates; Warts

Cutaneous warts are a common presenting complaint in children and adolescents. Common, plantar, or flat warts are cutaneous manifestations of the human papillomavirus. The treatment of warts poses a therapeutic challenge for physicians. No single therapy has been proven effective at achieving complete remission in every patient. As a result, many different approaches to wart therapy exist. These approaches are discussed to demonstrate the evidence supporting common therapies and provide a guideline for physicians. Evidence supports the at-home use of topical salicylic acid and physician-administered cryotherapy. Intralesional immunotherapy for nongenital cutaneous warts may be an option for large or recalcitrant warts.

Topics: Administration, Topical; Clinical Trials as Topic; Cryosurgery; Dermatologic Agents; Evidence-Based Medicine; Humans; Salicylates; Skin Diseases; Warts

Viral warts caused by the human papilloma virus represent one of the most common diseases of the skin. Any area of skin can be affected although the hands and feet are by far the commonest sites. A very wide range of local treatments are available.. To assess the effects of different local treatments for cutaneous, non-genital warts in healthy people.. We searched the Cochrane Controlled Trials Register (January 2003), the Skin Group trials register (January 2003), MEDLINE (1966 to January 2003), EMBASE (1980 to January 2003) and a number of other key biomedical and health economics databases. In addition the cited references of all trials identified and key review articles were searched. Pharmaceutical companies involved in local treatments for warts and experts in the field were contacted. The most recent searches were carried. Randomised controlled trials of local treatments for cutaneous non-genital viral warts in immunocompetent human hosts were included.. Study selection and assessment of methodological quality were carried out by two independent reviewers.. Fifty two trials were identified which fulfilled the criteria for inclusion in the review. The evidence provided by these studies was generally weak because of poor methodology and reporting. In 17 trials with placebo groups that used participants as the unit of analysis the average cure rate of placebo preparations was 30% (range 0 to 73%) after an average period of 10 weeks (range 4 to 24 weeks). The best available evidence was for simple topical treatments containing salicylic acid, which are clearly better than placebo. Data pooled from six placebo-controlled trials show a cure rate of 144/191 (75%) compared with 89/185 (48%) in controls, odds ratio 3.91 (95% confidence interval 2.40 to 6.36), random effects model. Most of the bigger trials of cryotherapy studied different regimens rather than comparing cryotherapy with other treatments or placebo. Pooled data from two small trials that included cryotherapy and placebo or no treatment, showed no significant difference in cure rates. In two trials comparing cryotherapy with salicylic acid and one comparing duct tape with cryotherapy no significant difference in efficacy was demonstrated. There was no consistent evidence for the effectiveness of intralesional bleomycin. Four studies, using warts rather than individuals as the unit of analysis, had widely varying results which could not be meaningfully pooled. There was some evidence for the efficacy of dinitrochlorobenzene, a potent contact sensitizer. Pooled data from two small studies comparing dinitrochlorobenzene with placebo showed cure rates of 32/40 (80%) and 15/40 (38%) respectively, odds ratio 6.67 (95% confidence interval 2.44 to 18.23), random effects model. Only limited evidence was found for the efficacy of topical 5-fluorouracil, intralesional interferons and photodynamic therapy.Bleomycin, dinitrochlorobenzene, 5-fluorouracil, interferons and photodynamic therapy are potentially hazardous or toxic treatments.. There is a considerable lack of evidence on which to base the rational use of the local treatments for common warts. The reviewed trials are highly variable in method and quality. Cure rates with placebo preparations are variable but nevertheless considerable. There is certainly evidence that simple topical treatments containing salicylic acid have a therapeutic effect. There is less evidence for the efficacy of cryotherapy and some evidence that it is only of equivalent efficacy to simpler, safer treatments. Dinitrochlorobenzene appears to be effective but there were no statistically significant differences when compared with the safer, simpler and cheaper topical treatments containing salicylic acid. The benefits and risks of 5-fluorouracil, bleomycin, interferons and photodynamic therapy remain to be determined.

Topics: Administration, Topical; Bleomycin; Cryotherapy; Dinitrochlorobenzene; Fluorouracil; Humans; Interferons; Photochemotherapy; Randomized Controlled Trials as Topic; Salicylates; Warts

Viral warts caused by the human papilloma virus represent one of the most common diseases of the skin. Any area of skin can be affected although the hands and feet are by far the commonest sites. A very wide range of local treatments are available.. To assess the effects of different local treatments for cutaneous, non-genital warts in healthy people.. We searched the Cochrane Controlled Trials Register (March 1999), the Skin Group trials register (March 1999), MEDLINE (1966 to August 2000), EMBASE (1980 to August 2000) and a number of other key biomedical and health economics databases. In addition the cited references of all trials identified and key review articles were searched. Pharmaceutical companies involved in local treatments for warts and experts in the field were contacted.. Randomized controlled trials of local treatments for cutaneous non-genital viral warts in immunocompetent human hosts were included.. Study selection and assessment of methodological quality were carried out by two independent reviewers.. Forty-nine trials were identified which fulfilled the criteria for inclusion in the review. The evidence provided by these studies was generally weak because of poor methodology and reporting. In 17 trials with placebo groups that used participants as the unit of analysis the average cure rate of placebo preparations was 30% (range 0 to 73%) after an average period of 10 weeks (range 4 to 24 weeks). The best available evidence was for simple topical treatments containing salicylic acid, which are clearly better than placebo. Data pooled from six placebo-controlled trials show a cure rate of 144/191 (75%) compared with 89/185 (48%) in controls, odds ratio 3.91 (95% confidence interval 2.40 to 6.36), random effects model. Most of the bigger trials of cryotherapy studied different regimens rather than comparing cryotherapy with other treatments or placebo. Pooled data from two small trials that included cryotherapy and placebo or no treatment, showed no significant difference in cure rates. In two other trials comparing cryotherapy with salicylic acid no significant difference in efficacy was demonstrated. There was no consistent evidence for the effectiveness of intralesional bleomycin. Four studies, using warts rather than individuals as the unit of analysis, had widely varying results which could not be meaningfully pooled. There was some evidence for the efficacy of dinitrochlorobenzene, a potent contact sensitizer. Pooled data from two small studies comparing dinitrochlorobenzene with placebo showed cure rates of 32/40 (80%) and 17/40 (43%) respectively, odds ratio 5.42 (95% confidence interval 1.99 to 14.75), random effects model. Only limited evidence was found for the efficacy of topical 5-fluorouracil, intralesional interferons and photodynamic therapy. Bleomycin, dinitrochlorobenzene, 5-fluorouracil, interferons and photodynamic therapy are potentially hazardous or toxic treatments.. There is a considerable lack of evidence on which to base the rational use of the local treatments for common warts. The reviewed trials are highly variable in method and quality. Cure rates with placebo preparations are variable but nevertheless considerable. There is certainly evidence that simple topical treatments containing salicylic acid have a therapeutic effect. There is less evidence for the efficacy of cryotherapy and no convincing evidence that it is any more effective than simple topical treatments. Dinitrochlorobenzene appears to be effective but no more so than the safer, simpler and cheaper topical treatments containing salicylic acid. The benefits and risks of 5-fluorouracil, bleomycin, interferons and photodynamic therapy remain to be determined.

Topics: Administration, Topical; Bleomycin; Cryotherapy; Dinitrochlorobenzene; Fluorouracil; Humans; Interferons; Photochemotherapy; Randomized Controlled Trials as Topic; Salicylates; Warts

Common, plantar and flat warts are the primary classes of nongenital warts. Although spontaneous remission does occur, all warts should be treated to avoid spreading. Common warts often develop in the periungual region of the fingers. This type of wart generally can be removed with cryotherapy, topical application of salicylic acid or occlusive taping. Plantar warts are found over pressure points of the heel or metatarsal heads. They are also treated with cryotherapy or salicylic acid. Flat warts are commonly seen on the dorsum of the hands or on the face. These warts are best treated with topical retinoids. Immunotherapies are being developed.

Topics: Bismuth; Cryosurgery; Humans; Hypnosis; Immunotherapy; Retinoids; Salicylates; Salicylic Acid; Skin Diseases; Warts

Topics: Antiviral Agents; Bleomycin; Condylomata Acuminata; Cryosurgery; Dinitrofluorobenzene; Electrocoagulation; Female; Fluorouracil; Formaldehyde; Genital Diseases, Female; Genital Diseases, Male; Genital Neoplasms, Female; Genital Neoplasms, Male; Humans; Immunotherapy; Laser Therapy; Male; Podophyllin; Salicylates; Warts

Topics: Antiviral Agents; Bleomycin; Cryosurgery; Fluorouracil; Formaldehyde; Humans; Interferons; Papillomaviridae; Podophyllin; Psychotherapy; Retinoids; Salicylates; Salicylic Acid; Tumor Virus Infections; Warts; Wounds and Injuries

Several previous studies have yielded data showing that plantar and other cutaneous verrucae follow a more aggressive course in patients infected with human immunodeficiency virus (HIV) than in uninfected individuals. A pilot study was undertaken to identify trends in a sample population that would support this characterization of plantar verrucae in HIV+ patients and to determine whether there are differences in treatment response between HIV+ and HIV- patients. The results show that the HIV+ patients in the study presented with a significantly greater number and total area of lesions than did the HIV- patients. Furthermore, the HIV+ patients experienced a greater frequency of recurrence of their lesions following treatment with surgical curettage. These findings should provide the foundation for other extensive, multicenter studies to further characterize the treatment response of these lesions in HIV+ patients and to develop effective guidelines for their management.

Topics: Collodion; Curettage; Dermatologic Agents; Drug Combinations; Foot Diseases; HIV Seronegativity; HIV Seropositivity; Humans; Lactates; Pilot Projects; Salicylates; San Francisco; Treatment Outcome; Warts

A clinical study was conducted to evaluate the efficacy of a new delivery system for administering salicylic acid for the treatment of verruca vulgaris. The study compared wart resolution among volunteers who used karaya gum patches. The cure rate was 69% for warts treated with patches containing salicylic acid, which was significantly higher (p less than 0.01) than for warts treated with control patches (35%).

Topics: Administration, Cutaneous; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Hand Dermatoses; Humans; Karaya Gum; Male; Placebos; Random Allocation; Salicylates; Salicylic Acid; Warts

Patients with common hand warts and simple plantar warts attending a general practice wart clinic in Northern Ireland were assigned to one of three treatment groups - liquid nitrogen applied weekly, daily application of wart paint (lactic acid one part, salicylic acid one part, collodion four parts), or a combination of the two. Combination therapy cured 87% of common hand warts over a six week period, and was significantly more effective than either agent used separately (P<0.05). The results for simple plantar warts were disappointing and no treatment regimen proved to be significantly better than any other. These treatments were cheap, compliance and tolerance were good, and the six month recurrence rate was minimal. Given the likelihood that warts will multiply if left untreated we would recommend early active treatment for this condition.

Topics: Adolescent; Child; Combined Modality Therapy; Cryosurgery; Female; Humans; Lactates; Lactic Acid; Male; Salicylates; Warts

Monochloroacetic acid crystals and 60% salicylic acid ointment was found to be more effective than placebo as a treatment for simple plantar warts in a double blind study on 57 patients. Nineteen (66%) patients in the active treatment group compared with five (18%) patients in the placebo group were cured after 6 weeks (P = 0.002). The active treatment was associated with a significantly higher cure rate 6 months after entry (P = 0.04). Treatments were well tolerated. IgG or IgM antibodies or both to human papilloma virus (HPV) types 1 or 2 or both were detected significantly more frequently in the actively treated group 6 weeks after entry (P = 0.0005). Twelve (50%) patients considered to be cured had no detectable secondary immune response. Our results suggest that cure does not depend primarily on the humoral system but rather on mechanical destruction of wart tissue, or occurs as a result of cell mediated immunity.

Topics: Acetates; Administration, Topical; Adolescent; Adult; Child; Female; Foot Diseases; Humans; Irritants; Male; Salicylates; Salicylic Acid; Warts

In order to investigate the efficacy of anthralin ( Anthraderm ) in the treatment of warts a randomized controlled trial was carried out in 72 patients. During a two-month period of treatment 56% were cured in the group treated with anthralin 2% ( Anthraderm ), evaluated at follow-up 2-9 months after finishing treatment, compared with 26% in the group treated with the comparative drug ( Verucid ). Anthralin 2% ( Anthraderm ) was found to have a significantly better effect, especially in the group of patients with warts solely on the hands.

Topics: Adolescent; Adult; Anthracenes; Anthralin; Child; Clinical Trials as Topic; Copper; Drug Combinations; Humans; Lactates; Lactic Acid; Middle Aged; Organometallic Compounds; Plant Extracts; Random Allocation; Salicylates; Skin Diseases; Warts

Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Creosote; Female; Humans; Male; Methylene Blue; Middle Aged; Photochemotherapy; Random Allocation; Salicylates; Skin Diseases; Warts

A series of eleven comparative wart treatment trials undertaken between 1969 and 1975 and involving 1802 patients is described. A method of coding provided groups of patients matched for age, type, number and duration of warts, within which treatments could be randomized. The variation in response to treatment was shown to be influenced significantly by these factors and the level of cure to depend on the proportions of the various response groups within the population under consideration. These proportions were found to vary geographically and at different periods. In all the trials the results were assessed at 12 weeks. In the treatment of hand warts, the percentage cure of patients treated with liquid nitrogen fell significantly from 75 to 40% when the interval between freezings was increased from 3 to 4 weeks. The average number of freezings required for a cure was 3-1 amongst all patients cured by 6 or less freezings at intervals of 2 or 3 weeks. In a two-centre trial there was no significant difference between the percentage cure of patients with hand warts treated with liquid nitrogen (69%) and of those applying a paint containing salicylic and lactic acids (SAL) (67%). Patients receiving both treatments concurrently did better (78%) but the difference was not found to be statistically significant. In the treatment of simple plantar warts the percentage cure for the SAL paint (84%) was found to compare favourably with that for a podophyllin treatment (81%). Only one of the patients cured by the paint in that trial was found to have had a recurrence after 6 months. The paint was found to be satisfactory for use under general practice conditions. Additions to the formula did not alter its effectiveness. In the treatment of mosaic plantar warts the overall percentage cure for the SAL paint in a series of comparative trials (1969-75) was 45%. In these trials it was compared directly with one or more other preparations. No differences were found between its efficacy and that of 10% buffered gluteraldehyde (47%), 40% benzalkonium chloride dibromide (Callusolve 40) (30%) and 5% 5-fluorouracil in dimethyl sulphoxide (53%). Only 25% of thirty-six patients treated with 5% idoxuridine in dimethylsulphoxide were cured. Throughout the trials approximately 30% of patients with hand warts, 20% of those with simple plantar warts and 50% of those with mosaic plantar warts were found to be resistant to treatment. The adoption of treatment with SAL paint for hand war

Topics: Benzalkonium Compounds; Clinical Trials as Topic; Cryosurgery; Drug Combinations; Fluorouracil; Follow-Up Studies; Glutaral; Humans; Idoxuridine; Lactates; Polyethylene Glycols; Salicylates; Time Factors; Warts

A double-blind study was carried out to compare the action of 5-fluorouracil and 10% salicylic acid varnish with that of a 10% salicylic acid varnish on common warts. Fifty per cent of the lesions disappeared with the combined preparation and only 4% with the varnish containing salicylic acid alone. The presence of warts on the hands of 45.8% of the female workers of a fowl slaughterhouse is described.

Topics: Abattoirs; Administration, Topical; Animals; Chickens; Clinical Trials as Topic; Drug Combinations; Female; Fluorouracil; Hand Dermatoses; Male; Occupational Diseases; Paint; Salicylates; Warts

Topics: Clinical Trials as Topic; Copper; Drug Combinations; Foot Dermatoses; Hand Dermatoses; Humans; Lactic Acid; Plant Extracts; Salicylates; Warts

Topics: Adolescent; Adult; Antibodies; Bromine; Child; Child, Preschool; Clinical Trials as Topic; Foot Diseases; Humans; Immunoglobulin G; Lactates; Podophyllin; Quaternary Ammonium Compounds; Salicylates; Warts

Topics: Administration, Topical; Female; Humans; Middle Aged; Nausea; Salicylates; Tinnitus; Warts

Topics: Administration, Cutaneous; Adolescent; Adult; Child; Child, Preschool; Dermatitis, Irritant; Dermatologic Agents; Facial Dermatoses; Female; Humans; Irritants; Ointments; Salicylates; Salicylic Acid; Tretinoin; Warts

Ten patients who presented with nonmosaic plantar warts were treated with a new polymeric matrix patch delivery system containing salicylic acid USP, 21 percent. Clinicians then assessed the potential value of this patch system in terms of efficacy, length of treatment time required, patient compliance, and tolerance.

Topics: Administration, Cutaneous; Foot Dermatoses; Humans; Polymers; Salicylates; Salicylic Acid; Warts

We report an unusual case of pyogenic granuloma that appeared after the application of liquid nitrogen and 27 percent salicylic acid (Duoplant, Stiefel Inc.) to a verruca vulgaris. Only two cases of pyogenic granuloma following cryotherapy appear in the literature and pyogenic granuloma as a complication of salicylic acid application has not been documented.

Topics: Cryosurgery; Granuloma; Hand Dermatoses; Humans; Male; Middle Aged; Nitrogen; Salicylates; Salicylic Acid; Warts

The authors describe two cases of allergic contact dermatitis to colophony included in the formulation of flexible collodion BP, the vehicle of a wart paint. Patch and repeated open application tests confirmed absence of contact allergy to other constituents. The patients were known to be allergic to various adhesive plasters. The use of flexible collodion USP, which does not contain colophony, is highly advisable whenever possible.

Topics: Adult; Collodion; Dermatitis, Contact; Female; Humans; Lactates; Lactic Acid; Patch Tests; Pharmaceutical Vehicles; Resins, Plant; Salicylates; Skin Diseases; Warts

Topics: Administration, Cutaneous; Adolescent; Adult; Antiviral Agents; Child; Female; Gels; Hand Dermatoses; Humans; Male; Middle Aged; Salicylates; Salicylic Acid; Warts

Topics: Foot Diseases; Humans; Ointments; Salicylates; Salicylic Acid; Warts

Treatment of common warts with topical keratolytic solutions is generally estimated to result in cure rates of 60% to 80% in 12 weeks. Problems with keratolytic solutions include irritation of surrounding normal skin and poor patient compliance. A product containing 26% salicylic acid in a novel polyacrylic vehicle was evaluated in 27 patients and found to cure or provide much improvement in 22 (81%) after only two weeks of treatment. This rapid response was accompanied by a low incidence of irritation. The results of this study suggest that high-potency salicylic acid promotes prompt resolution of warts, which may enhance patient compliance.

Topics: Administration, Topical; Adolescent; Adult; Female; Humans; Male; Pharmaceutical Vehicles; Salicylates; Warts

Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Collodion; Drug Combinations; Female; Follow-Up Studies; Hand Dermatoses; Humans; Lactates; Male; Middle Aged; Nitrogen; Recurrence; Salicylates; Sex Factors; Warts

Currently, 25 different types of human papillomavirus (HPV) are recognized, each responsible for a characteristic clinical manifestation of warts or wart-like lesions. Increasingly, evidence supports a close relationship between certain types of HPVs--5, 8, 14, 16, 18, and perhaps 6 and 11--and malignant transformation. Before therapy is initiated, the probability of spontaneous resolution must be considered. The discomfort and possible risks of treatment must be balanced against the patient's discomfort and pain. Possible modes of treatment include topical therapy, cryotherapy and surgery, intralesional injections, and immunotherapy.

Topics: Administration, Topical; Bleomycin; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cryosurgery; Female; Humans; Immunotherapy; Injections; Male; Papillomaviridae; Salicylates; Salicylic Acid; Skin Neoplasms; Tumor Virus Infections; Uterine Neoplasms; Warts

One hundred and twenty-one children with plantar warts were treated with a topical preparation containing salicylic acid, 30%; podophyllin, 5%; and cantharidin, 1%. One hundred patients or their families were reached 6 months to 1 year later. This treatment was effective in 81 cases.

Topics: Adolescent; Cantharidin; Child; Child, Preschool; Combined Modality Therapy; Debridement; Drug Therapy, Combination; Foot; Humans; Podophyllin; Salicylates; Salicylic Acid; Skin Diseases; Warts

Topics: Administration, Topical; Adult; Benzalkonium Compounds; Bleomycin; Child; Cryotherapy; Formaldehyde; Glutaral; Humans; Nitrogen; Podophyllin; Salicylates; Skin Diseases; Warts

Topics: Adult; Child; Cryosurgery; Female; Formaldehyde; Humans; Male; Podophyllin; Salicylates; Salicylic Acid; Warts

Topics: 1-Propanol; Humans; Immunity, Cellular; Immunoglobulin G; Papillomaviridae; Podophyllin; Salicylates; Warts

Patterns of regression in common warts were studied. Patients with multiple verrucae vulgaris lesions applied topical agents to the warts and were observed at regular intervals until the lesions disappeared. Regression took place without the warts turning black in all but one instance. All warts did not disappear simultaneously; some lesions persisted weeks after others had disappeared. Microscopic examination in five patients of a wart persisting after most had regressed demonstrated mononuclear cell infiltration, exocytosis, and degenerative epidermal changes. Failure to demonstrate cellular infiltration in regressing common warts in earlier studies was probably due to concentration on studying only warts that had turned black. The regression of some of the warts in patients with multiple common warts may serve as an indicator that involution is in progress. Utilization of this observation to recognize clinically the period of involution may make possible studies during the critical phase of the involutionary process.

Topics: Administration, Topical; Adolescent; Adult; Collodion; Dermatologic Agents; Drug Combinations; Ethanol; Female; Humans; Lactates; Male; Propylene Glycols; Salicylates; Skin; Skin Diseases; Warts

Topics: Administration, Topical; Collodion; Humans; Salicylates; Warts

Topics: Aldehydes; Collodion; Drug Combinations; Glutaral; Humans; Lactates; Salicylates; Warts

Topics: Cryosurgery; Fluorouracil; Formaldehyde; Humans; Idoxuridine; Immunotherapy; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllum; Salicylates; Warts

Depigmented haloes developed around involuting flat warts in two patients whose warts were treated with a 6% salicylic acid-propylene glycol gel formulation. The clinical picture was indistinguishable from that seen in halo naevus.

Topics: Adolescent; Adult; Female; Humans; Propylene Glycols; Salicylates; Skin Diseases; Skin Pigmentation; Warts

Topics: Adult; Female; Foot Deformities, Acquired; Foot Diseases; Humans; Middle Aged; Salicylates; Silver Nitrate; Toes; Warts

Topics: Anus Neoplasms; Condylomata Acuminata; Formaldehyde; Genitalia; Humans; Immunotherapy; Nitrogen; Podophyllin; Salicylates; Skin Diseases, Infectious; Warts

Warts are common skin lesions caused by a papova virus. Their clinical appearance is variable. There is no definitive therapy. Therapy must be individually modified to get the best result with the least discomfort to the patient. Most warts will spontaneously resolve after an average of two years, so any therapy that has serious side effects or results in scarring should not be used. New modes of therapy, particularly immunotherapy, look promising but are still in the experimental stage.

Topics: Adolescent; Adult; Child; Child, Preschool; Cryosurgery; Humans; Nitrates; Nitrogen; Papillomaviridae; Phenols; Podophyllin; Polyomaviridae; Psychotherapy; Salicylates; Silver Nitrate; Trichloroacetic Acid; Warts

Topics: Administration, Topical; Child; Cicatrix; Facial Injuries; Female; Humans; Lactates; Salicylates; Warts

We report two patients who developed allergic eczematous contact dermatitis to a salacid plaster used to treat plantar warts. Both patients were subsequently shown to be allergic to dehydroabietic acid, a resin contained in the plaster.

Topics: Child; Dermatitis, Contact; Female; Foot Diseases; Humans; Salicylates; Warts

Warts that don't regress frequently have wart cell specific immune globulin M(IgM), but no wart virus specific Immune Globulin M (IgM) in the circulatory system. Warts that regress spontaneously have multiple circulating antibodies-wart cell specific IgM, IgG, and IgA. When the antibodies of IgG class appear in the circulation, the warts will commonly disappear. Topical application of cell toxic, irritant materials will elicit discernible amounts of virus specific IgM and IgG. Those B Cells which produce IgG have a "computer bank memory" and IgG should be recalled if wart virus antigen reappears as a result of reinfection. Therefore, persistent, consistent, topical application of irritant modalities to warts that will cause them to regress and disappear, should confer immunity on the individual through the production of wart virus specific IgG. Over a seven-year span 150 cases of wart were cleared in our office by an irritant method. In that group of cases there were eight recurrences. Two cases cleared spontaneously within two weeks, and four cleared with an acute inflammatory response within a few days of reirritation.

Topics: Adolescent; Adult; Arsenic; Child; Humans; Immunoglobulin G; Immunoglobulin M; Potassium; Recurrence; Salicylates; Warts

Topics: Adolescent; Adult; Antigens; Cell Migration Inhibition; Cryosurgery; Formaldehyde; Humans; Immunity, Cellular; In Vitro Techniques; Leukocytes; Microscopy, Electron; Salicylates; Warts

Topics: Disinfectants; Foot; Humans; Keratosis; Microscopy, Electron; Nitrogen; Papillomaviridae; Recurrence; Salicylates; Warts

Topics: Callosities; Caustics; Humans; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllum; Salicylates; Warts

Topics: Benzoates; Cryosurgery; Foot Diseases; Hand; Humans; Lanolin; Occlusive Dressings; Ointments; Salicylates; Warts

Topics: Adolescent; Cautery; Child; England; Family Practice; General Practice; Humans; Podophyllin; Podophyllum; Salicylates; Silver Nitrate; Statistics as Topic; Trichloroacetic Acid; Warts

Topics: Dry Ice; Foot Diseases; Humans; Ointments; Salicylates; Warts