salicylates and Urticaria

There is much (renewed) interest about the effects of salicylates on food intolerance, attention-deficit disorders, and cardiovascular disease. Current evidence for the efficacy of salicylate-elimination diets in the treatment of attention-deficit disorders and hyperactivity is weak, and further investigation is required on the relationship between salicylates and cardiovascular disease.

Topics: Asthma; Cardiovascular Diseases; Food; Food Analysis; Humans; Hyperkinesis; Pharmaceutical Preparations; Salicylates; Urticaria

Urticaria represents a wide variety of conditions characterized by urticarial papules, wheals, and angioedema. The number of potential causes of urticaria is legion, but a diligent search by careful history and examination is indicated. Laboratory testing depends upon the specific situation, but routine screening examinations are not cost effective. Histamine from mast cells plays an important role in urticaria. Multiple factors, such as aspirin and other nonsteroidal anti-inflammatory agents, direct histamine-releasing agents (including benzoates), tartrazine and other azo dyes, and perhaps blockers of beta 2-adrenergic activity and H2 receptors, adversely influence histamine release either directly or indirectly. Vasodilation is also detrimental. Treatment of both acute and chronic urticaria necessitates removal of the patient from aggravating factors as well as the cause of the outbreak (if one can be found), along with effective antihistaminic agents and perhaps beta 2-adrenergic agonists. Treatment of specific entities within the urticarial group is briefly outlined in this article.

Topics: Chronic Disease; Coloring Agents; Diet; Histamine Release; Humans; Physical Stimulation; Salicylates; Skin; Sunlight; Temperature; Urticaria; Vasculitis

Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Azathioprine; Cushing Syndrome; Cyclophosphamide; Drug Eruptions; Gold; Humans; Lichen Planus; Nail Diseases; Pemphigus; Penicillamine; Pigmentation Disorders; Pruritus; Purpura; Salicylates; Skin Neoplasms; Urticaria

Topics: Aspirin; Erythema; Erythema Multiforme; Humans; Psoriasis; Purpura; Salicylates; Skin Diseases; Urticaria

Topics: Anti-Bacterial Agents; Antitubercular Agents; Aspirin; Clinical Trials as Topic; Coloring Agents; Contraceptives, Oral; Drug Eruptions; Eczema; Erythema Multiforme; Humans; Placebos; Salicylates; Skin; Urticaria

Topics: Adolescent; Adult; Aged; Ambulatory Care; Arthritis, Rheumatoid; Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Follow-Up Studies; Humans; Male; Methods; Middle Aged; Ointments; Pharmaceutic Aids; Placebos; Salicylates; Urticaria

Topics: Aged; Humans; Male; Photosensitivity Disorders; Salicylates; Thromboembolism; Urticaria

Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Bismuth; Drug Hypersensitivity; Humans; Immunoglobulin E; Male; Organometallic Compounds; Reproducibility of Results; Salicylates; Skin Tests; United States; Urticaria

The binding of serum protein to salicylate was measured by a Sephadex batch method in the serum of 82 allergic individuals, 30 members of their families, and 24 normals. Subjects with the immediate types of allergy exhibited a significantly (p less than 0.001) increased binding ability corrected for albumin (Alb). The members of their families also showed significantly (p less than 0.005) elevated binding, but this was lower than in the allergic subjects themselves. The binding study with serum proteins fractionated with DEAE-Sephadex A-50 from both allergic and normal subjects using 14C-labeled salicylate showed that the salicylate molecule binds exclusively to Alb. No correlation was observed between the binding ability corrected for Alb and the serum Alb concentration in allergic and normal subjects. From the evidence obtained, there seems to be a certain underlying diathesis related to the Alb binding ability to endogenous inflammatory substances, which may back up the consequences of allergic reactions among allergic individuals.

Topics: Adolescent; Adult; Aged; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Humans; Hypersensitivity; Infant; Middle Aged; Prealbumin; Rheumatic Fever; Rhinitis, Allergic, Seasonal; Salicylates; Serum Albumin; Serum Globulins; Urticaria

2 patients with acute allergic contact dermatitis from 3-(aminomethyl)-pyridyl salicylate are described. Both patients were females with histories of urticaria and showed cross-sensitization to substances of the para group. Clinical manifestations included eczema, angioedema and respiratory effects. In 1 patient, airborne elicitation was suspected. A lymphocyte transformation test confirmed the allergy, with an extremely high response index. 35 normal controls were negative.

Topics: Aminopyridines; Analgesics; Dermatitis, Contact; Female; Humans; Lymphocyte Activation; Middle Aged; Patch Tests; Salicylates; Urticaria

A woman experienced exacerbations of bronchial asthma after taking aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatoid arthritis. On oral challenges, she developed an urticarial reaction after tartrazine; urticarial and bronchospastic reactions after salicylsalicylic acid; and urticarial and bronchospastic reactions after choline magnesium trisalicylate. Non-acetylated salicylates have been recommended for use in aspirin- and/or tartrazine-sensitive patients. The results of sensitivity studies of our patient indicates that such patients may also be sensitive to non-acetylated salicylates.

Topics: Albuterol; Arthritis, Rheumatoid; Asthma; Bronchial Spasm; Choline; Drug Combinations; Drug Hypersensitivity; Female; Humans; Middle Aged; Nasal Polyps; Salicylates; Tartrazine; Urticaria

Topics: Food Hypersensitivity; Humans; Salicylates; Urticaria

Topics: Chronic Disease; Food Additives; Humans; Salicylates; Sulfites; Tartrazine; Urticaria

Not only is urticaria a condition of disparate cause, but it also may be produced through the action of one or more of a long list of chemical mediators. This article discusses some of the accepted procedures in the evaluation of patients with urticaria, which includes not only categorization but also a search for the sources of aggravation and laboratory testing to confirm the clinical diagnosis. An example of a printed history form is included, which comprises questions that hopefully will help to identify aggravating factors as well as potential causes.

Topics: Angioedema; Aspirin; Cold Temperature; Coloring Agents; Dermatitis, Contact; Food Preservatives; Hot Temperature; Humans; Pressure; Salicylates; Sunlight; Tyramine; Urticaria; Vasculitis; Water; Yeasts

Urticaria and angio-oedema are a symptom complex covering a wide range of clinical disorders. Specific types are now well described, and it appears that many cases of idiopathic chronic urticaria which make up the vast majority of patients referred for assessment are due to intolerance to natural salicylates, preservatives and colouring agents. There is, therefore, an urgent need for legislation to enforce the clear identification of these chemicals in processed food and drugs.

Topics: Angioedema; Cold Temperature; Drug-Related Side Effects and Adverse Reactions; Food Coloring Agents; Food Preservatives; Histamine H2 Antagonists; Humans; Salicylates; Urticaria

Topics: Drug Hypersensitivity; Female; Food Additives; Food Coloring Agents; Food Hypersensitivity; Food Preservatives; Humans; Middle Aged; Salicylates; Urticaria

As the problem of chronic urticaria is frustrating both to the physician and patient, an attempt to study its aetiology was made. 100 cases of chronic urticaria was studied in 1979. Patients having daily urticaria for more than 6 weeks, were included. There were 52 males and 48 females. A detailed history of the pattern of urticaria, drugs, physical causes, diet and illnesses were asked for, followed by physical examination. Each were then screened through a Diagnostic Tray including basic haematological tests, urinalysis, stools analysis, physical allergy tests, food provocation battery and further special tests. 17 patients had physical urticaria, cold (6), pressure (5), delayed dermographism (1), cholinergic (4), solar (1). 4 patients had severe reactions with aspirin, one with tetracycline; one had undiagnosed thyrotoxicosis. 36 of all the patients had a positive test on provocation with the food battery: aspirin (13), preservatives (3), colour dyes (6), yeast (1) and others (15). It has been suggested that these are not the immediate cause but are aggravating factors. 48% of patients showed dermographism. The number of idiopathic cases about 77% is consistent with the findings of others. We feel that an attempt to exclude treatable causes has brought reassurance to many of the patients. Long term antihistamine therapy was given in these cases.

Topics: Adolescent; Adult; Candidiasis; Child, Preschool; Chronic Disease; Coloring Agents; Drug Hypersensitivity; Female; Food Additives; Food Hypersensitivity; Humans; Infections; Male; Physical Stimulation; Salicylates; Time Factors; Urticaria

The role played by dietary chemical factors in the pathogenesis of chronic idiopathic urticaria (CIU) was assessed in seventy-six patients by challenge Stable remission was first established by using an empirically established 'exclusion diet'. A diet modified to exclude those chemicals giving a positive response to challlenge was demonstrated to be of therapeutic value for time periods of up to 18 months. Re-testing twelve patients at 12 months indicated that most patients positive to salicylate or benzoate challenge retained this pattern of reactivity.

Topics: Adolescent; Adult; Aged; Benzoates; Child; Chronic Disease; Female; Humans; Male; Middle Aged; Penicillins; Remission, Spontaneous; Salicylates; Tartrazine; Urticaria; Yeast, Dried

Exclusion diets may have a practical place in determining the precipitating dietary factors in certain clinical conditions. We present an exclusion diet which is based on the exclusion of food commonly known to cause food allergies, and the exclusion of food which contains salicylates, benzoates, tartrazine, yeast, and penicillin. This provided a basis for challenge with these additives and natural chemicals. Preliminary information in urticaria suggests a use for this diet in some allergic conditions.

Topics: Australia; Benzoates; Chronic Disease; Diet; Humans; Salicylates; Tartrazine; Urticaria

Topics: Bacterial Infections; Cold Temperature; Dermatitis, Atopic; Drug Eruptions; Drug Hypersensitivity; Food Hypersensitivity; Histamine Release; Hot Temperature; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Insect Bites and Stings; Light; Respiratory Hypersensitivity; Salicylates; Urticaria; Virus Diseases

Topics: Allergens; Azo Compounds; Benzoates; Food Additives; Food Hypersensitivity; Humans; Salicylates; Urticaria; Yeasts

Topics: Allergens; Antigens, Fungal; Candida; Chronic Disease; Humans; Salicylates; Urticaria

Topics: Adolescent; Adult; Ampicillin; Drug Eruptions; Electrocardiography; Erythromycin; Female; Heart; Humans; Insect Bites and Stings; Male; Middle Aged; Salicylates; Urticaria

Topics: Diet; Humans; Salicylates; Urticaria

Topics: Diet; Diet Therapy; Humans; Methods; Salicylates; Urticaria

Topics: Agranulocytosis; Ampicillin; Anaphylaxis; Animals; Anti-Bacterial Agents; Antigens; Autoradiography; Drug Eruptions; Drug Hypersensitivity; Humans; Immune Sera; Immunodiffusion; Immunoglobulin E; Iodine Isotopes; Penicillins; Pyrazoles; Salicylates; Skin Diseases; Sulfonamides; Swine; Thrombocytopenia; Urticaria

Topics: Adolescent; Adult; Aged; Ampicillin; Analgesics; Anaphylaxis; Angioedema; Anti-Bacterial Agents; Barbiturates; Child; Child, Preschool; Dermatitis, Exfoliative; Drug Eruptions; Erythema; Exanthema; Female; Humans; Infant; Male; Middle Aged; Penicillins; Photosensitivity Disorders; Salicylates; Stevens-Johnson Syndrome; Sulfonamides; Urticaria

Topics: Acute Disease; Child; Humans; Hypersensitivity; Male; Rheumatic Fever; Salicylates; Stomach Ulcer; Urticaria

Topics: Acetone; Adolescent; Adult; Aged; Aminobenzoates; Benzophenones; Cinnamates; Dermatologic Agents; Female; Humans; Male; Middle Aged; Naphthoquinones; Petrolatum; Photosensitivity Disorders; Porphyrias; Salicylates; Spectrophotometry; Sunburn; Sunscreening Agents; Trioses; Urticaria; Xeroderma Pigmentosum

Topics: Cosmetics; Dermatitis, Contact; Humans; Phenothiazines; Photosensitivity Disorders; Salicylates; Skin Diseases; Soaps; Sulfonamides; Tetracycline; Urticaria