salicylates has been researched along with Trypanosomiasis--African* in 2 studies
2 other study(ies) available for salicylates and Trypanosomiasis--African
| Article | Year |
|---|---|
Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase.
The zinc-metalloenzyme GlcNAc-PI de-N-acetylase is essential for the biosynthesis of mature GPI anchors and has been genetically validated in the bloodstream form of Trypanosoma brucei, which causes African sleeping sickness. We screened a focused library of zinc-binding fragments and identified salicylic hydroxamic acid as a GlcNAc-PI de-N-acetylase inhibitor with high ligand efficiency. This is the first small molecule inhibitor reported for the trypanosome GPI pathway. Investigating the structure activity relationship revealed that hydroxamic acid and 2-OH are essential for potency, and that substitution is tolerated at the 4- and 5-positions. Topics: Amidohydrolases; Humans; Hydroxamic Acids; Protein Binding; Salicylates; Small Molecule Libraries; Structure-Activity Relationship; Substrate Specificity; Trypanosoma brucei brucei; Trypanosomiasis, African; Zinc | 2014 |
The estimation of cerebrospinal-fluid protein in sleeping sickness: Sicard and Cantaloube's method and a sulphosalicylic-acid method.
Topics: Animals; Benzenesulfonates; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Salicylates; Trypanosomiasis; Trypanosomiasis, African | 1955 |