salicylates and Tooth-Erosion

Longitudinal in vitro.. Previously extracted, caries free, human premolars were selected and prepared by gentle pumicing and coating in an acid-resistant nail-varnish save for an exposed enamel window on the buccal surface. Each was assigned to one of eight groups (six per group, 10 in positive control); positive control (citric acid, pH 2.7, F(-) 0 ppm), negative control (pH 7.0, F(-) 0 ppm) Listerine (pH 3.87, F(-) 0.021 ppm), Tesco Value (pH 6.05, F(-) 289.00 ppm), Tesco Total Care (pH 6.20, F(-) 313.84 ppm), Sainsbury's (pH 6.15, F(-) 365.75 ppm), Sensodyne (pH 6.12, F(-) 285.30 ppm) and Corsodyl (pH 5.65, F(-) 0 ppm). The titratable acid values (TAV) for each rinse were established using volume (ml) of 0.1 M NaOH to achieve pH 7. Fluoride values were obtained by ion selective electrode. The solutions were kept at 37 degrees C and gently agitated. Teeth were removed at hourly intervals for 15 h, air-dried and subjected to Quantitative Light-induced Fluorescence (QLF) examination by a blinded examiner and DeltaQ values recorded. At the conclusion of the study each of the positive control teeth and one from each other group were sectioned through the eroded lesion, ground and polished to 100 micrometers and subjected to transverse microradiography and DeltaZ recorded for validation.. TAVs were: Listerine 2.45 L > Sainsbury's 0.35 ml >Tesco Total Care 0.14 ml > Tesco Value 0.08 ml > Corsodyl 0.10 ml >Sensodyne 0.9 ml. DeltaQ increased over time for the positive control, (0 h 0.2, 10 h 95.2, 15 h 152.3). Negative controls remained stable. The increase in DeltaQ for each rinse after 15 h was Listerine (9.3(+/-7.2)), Corsodyl (1.5(+/-1.2)), Tesco Value (1.8(+/-1.2)), Tesco Total Care (1.4(+/-1.1)), Sainsbury's (3.4(+/-2.2)), Sensodyne (0.9(+/-1.6)). TMR confirmed the presence/absence of erosive lesions.. QLF effectively monitored erosion in the positive controls and lack of erosion in the NC. Only one mouthrinse (Listerine) caused any erosion compared to the negative control, but this was only significant after 14 h of continuous use.

Topics: Analysis of Variance; Anti-Infective Agents, Local; Chlorhexidine; Citric Acid; Dental Enamel; Drug Combinations; Fluorescence; Fluorides; Humans; Hydrogen-Ion Concentration; Image Processing, Computer-Assisted; Light; Microradiography; Mouthwashes; Oils, Volatile; Salicylates; Single-Blind Method; Temperature; Terpenes; Tooth Erosion

There are both anecdotal clinical and laboratory experimental data suggesting that low pH mouthrinses cause dental erosion. This evidence is particularly relevant to acidified sodium chlorite (ASC) formulations since they have plaque inhibitory properties comparable to chlorhexidine but without the well known local side effects.. Studies in situ and in vitro were planned to measure enamel erosion by low pH mouthrinses. The study in situ measured enamel erosion by ASC, essential oil and hexetidine mouthrinses over 15-day study periods. The study was a 5 treatment, single blind cross over design involving 15 healthy subjects using orange juice, as a drink, and water, as a rinse, as positive and negative controls respectively. 2 enamel specimens from unerupted human third molar teeth were placed in the palatal area of upper removable acrylic appliances which were worn from 9 a.m. to 5 p.m., Monday to Friday for 3 weeks. Rinses were used 2x daily and 250 ml volumes of orange juice were imbibed 4x daily. Enamel loss was determined by profilometry on days 5, 10 and 15. The study in vitro involved immersing specimens in the 4 test solutions together with a reduced acid ASC formulation for a period of 4 h under constant stirring; Enamel loss was measured by profilometry every hour.. Enamel loss was in situ progressive over time with the 3 rinses and orange juice but negligible with water. ASC produced similar erosion to orange juice and significantly more than the two proprietary rinses and water. The essential oil and hexetidine rinses produced similar erosion and significantly more than water. Enamel loss in vitro was progressive over time, and the order from low to high erosion was reduced acid ASC, ASC, Essential oil, and hexetidine mouthrinses and orange juice.. Based on the study in situ, it is recommended that low pH mouthrinses should not be considered for long term or continuous use and never as pre-brushing rinses. In view of the plaque inhibitory efficacy of ASC, short- to medium-term applications similar to those of chlorhexidine would be envisaged.

Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Beverages; Chlorides; Chlorine Compounds; Citrus; Cross-Over Studies; Dental Enamel; Dental Plaque; Disease Progression; Drug Combinations; Female; Follow-Up Studies; Hexetidine; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Mouthwashes; Oils, Volatile; Oxides; Salicylates; Single-Blind Method; Statistics as Topic; Statistics, Nonparametric; Terpenes; Tooth Erosion; Water

Patients, healthcare professionals, and health product manufacturers focus on the benefits that the use of a medicine or health product will bring rather than the potential side effects. A case of erosive tooth surface loss caused by the repeated and prolonged use of an acidic mouthrinse is reported. The adverse effects of health care products on the dentition and methods to minimise potential damage are discussed.

Topics: Anti-Infective Agents, Local; Chlorine; Dental Stress Analysis; Drug Combinations; Humans; Iodine; Male; Middle Aged; Mouthwashes; Phenols; Salicylates; Surveys and Questionnaires; Tooth Erosion

Topics: Drug Approval; Drug Combinations; Humans; Mouthwashes; Salicylates; Societies, Dental; Terpenes; Tooth Erosion; United Kingdom

Topics: Arthritis, Juvenile; Child, Preschool; Female; Humans; Mouth Diseases; Salicylates; Salicylic Acid; Tooth Erosion