salicylates and Thrombocytopenia

Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Autoimmune Diseases; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Myasthenia Gravis; Pemphigoid Gestationis; Polyarteritis Nodosa; Pregnancy; Pregnancy Complications; Salicylates; Scleroderma, Systemic; Thrombocytopenia; Thyroid Diseases

Topics: Albumins; Barbiturates; Carbon; Cellulose; Collodion; Creatinine; Embolism; Hemadsorption; Microscopy, Electron, Scanning; Poisoning; Salicylates; Thrombocytopenia; Uremia

Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Reactions; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Epinephrine; Fever; Histamine H1 Antagonists; Humans; Jaundice; Lupus Erythematosus, Systemic; Prednisone; Salicylates; Serum Sickness; Skin Tests; Thrombocytopenia

A 4-week, double-blind, controlled multi-centre study was carried out in 235 patients with active rheumatoid arthritis to compare the efficacy and tolerance of 500 mg or 1000 mg diflunisal per day administered once daily, in the evening, or in divided, twice daily dosage. The results showed that diflunisal given once daily was at least as effective as diflunisal given twice daily. Day pain, morning stiffness, average grip strength and erythrocyte sedimentation rate improved similarly in both groups. Significant differences favouring the once-daily regimen were observed for improvement in night pain, Ritchie index and overall assessments by patient and investigator. Adverse experiences were slightly more common in patients taking diflunisal once daily (24% vs 19%) but this difference was not significant. It is concluded, therefore, that diflunisal once-a-day is an alternative regimen for the treatment of rheumatoid arthritis. It is at least as effective as the twice-daily regimen and may provide additional convenience to the patient and potential enhancement of compliance.

Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Drug Administration Schedule; Drug Eruptions; Drug Tolerance; Female; Gastritis; Humans; Male; Melena; Middle Aged; Patient Compliance; Salicylates; Thrombocytopenia

Topics: Adult; Arthritis, Rheumatoid; Diflunisal; Humans; Male; Salicylates; Thrombocytopenia

The anticoagulant property of aspirin has long been appreciated. Recently, the physiologic mechanism has been identified and documented extensively. Despite the long-lasting inhibition of platelet function and clinically significant postoperative hemorrhage following aspirin use, few serious complications or fatalities are reported in the current literature. We report a case in which fatal hemorrhage resulted from minor trauma following massive salicylate ingestion. A review of the cyclo-oxygenase mechanism is presented.

Topics: Alcoholism; Aspirin; Death, Sudden; Hemorrhage; Humans; Lung Diseases; Male; Mediastinal Diseases; Middle Aged; Purpura; Salicylates; Thrombocytopenia; Wounds, Nonpenetrating

Topics: Animals; Arachidonic Acids; Aspirin; Blood Pressure; Bronchi; Guinea Pigs; In Vitro Techniques; Rabbits; Salicylates; Thrombocytopenia

In exudates of implanted sponges in rats, made thrombocytopenic by the administration of anti-platelet serum, there are significant reductions in the platelet and leucocyte counts and of the content of prostaglandin-like activity. It is concluded that platelets migrate into the developing sponge exudates, are the source of the prostaglandins and interact with complement to cause leucocyte migration. In normal animals the administration of indomethacin and sodium salicylate cause similar effects to thrombocytopenia whereas the injection of human plasma fraction affects only the leucocyte migration. One of the sites of the anti-inflammatory action of conventional non-steroidal drugs may be concerned with the migration of platelets into inflammatory lesions.

Topics: Animals; Blood Cell Count; Blood Platelets; Exudates and Transudates; Female; Immune Sera; Indomethacin; Inflammation; Leukocyte Count; Prostaglandins; Rats; Salicylates; Thrombocytopenia; Time Factors

Topics: Agranulocytosis; Ampicillin; Anaphylaxis; Animals; Anti-Bacterial Agents; Antigens; Autoradiography; Drug Eruptions; Drug Hypersensitivity; Humans; Immune Sera; Immunodiffusion; Immunoglobulin E; Iodine Isotopes; Penicillins; Pyrazoles; Salicylates; Skin Diseases; Sulfonamides; Swine; Thrombocytopenia; Urticaria

Topics: Child; Child, Preschool; Dehydration; Humans; Hypokalemia; Infant; Salicylates; Thrombocytopenia

Topics: Child; Child, Preschool; Dehydration; Humans; Hypersensitivity; Hypokalemia; Salicylates; Thrombocytopenia

Topics: Adsorption; Aldehydes; Animals; Capsules; Charcoal; Creatinine; Drug Compounding; Electrophoresis, Polyacrylamide Gel; Embolism; Gels; Glutaral; In Vitro Techniques; Methylmethacrylates; Microscopy, Electron, Scanning; Particle Size; Renal Dialysis; Salicylates; Serum Albumin, Bovine; Sheep; Thrombocytopenia