salicylates and Stomatitis--Aphthous

Topics: Actihaemyl; Adult; Anti-Inflammatory Agents, Non-Steroidal; Choline; Chronic Disease; Drug Combinations; Female; Gels; Humans; Male; Middle Aged; Ointments; Recurrence; Remission Induction; Salicylates; Stomatitis, Aphthous; Stomatitis, Herpetic; Time Factors

Recurrent aphthous ulceration (RAU) remains a clinical problem for many patients. Efforts in prevention and/or treatment with prescription and nonprescription formulations have to date resulted in minimal success at best. A 6-month double-blind clinical study of 96 adults compared a commercially available antimicrobial mouthrinse (Listerine Antiseptic [LA], Warner-Lambert Co., Morris Plains, N.J.) and a hydroalcoholic control to evaluate the effects of vigorous twice-daily rinsing on the incidence, duration, and severity of RAU in persons prone to this disorder. LA rinse and the hydroalcoholic rinse resulted in a statistically significant reduction in the incidence of RAU occurrences from baseline. The duration of lesions and the severity of pain in subjects with ulcers during the treatment period were also significantly reduced in the LA rinse group of patients when compared with baseline. The hydroalcoholic rinse did not show a significant effect versus baseline for either severity or duration of the lesions. Rinsing therefore can be of clinical value in reducing the occurrence of RAU in susceptible patients, and LA rinse can be of significant additional value in decreasing the duration and severity of RAU.

Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Local; Double-Blind Method; Drug Combinations; Ethanol; Female; Humans; Longitudinal Studies; Male; Middle Aged; Mouthwashes; Pain Measurement; Recurrence; Salicylates; Stomatitis, Aphthous; Terpenes

Topics: Adult; Aged; Choline; Clinical Trials as Topic; Dry Socket; Female; Gels; Humans; Male; Middle Aged; Mouth Diseases; Pain; Salicylates; Stomatitis, Aphthous; Stomatitis, Denture

Evaluation of the clinical efficacy of the drug holisal» according to the results of domestic and foreign studies on modern methods for treatment of inflammatory diseases of the oral mucosa mouth and periodontium.. The study method was a comparative analysis of data obtained by various authors. The literature search was conducted on PubMed (www.ncbi.nlm.nih.gov), eLibrary (elibrary.ru) and ScienceDirect (www.sciencedirect.com).. The drug Cholisal reduces the duration of treatment, allows to increase the period of remission of the disease. It also promotes pain relief and accelerated mucosal epithelialization of the mouth mucosa.. Clinical studies of the drug Cholisal have shown that a wide range of its pharmacological action ensures the effectiveness of treatment of inflammatory diseases of the oral mucosa and periodontium by a combination of analgesic, antimicrobial, anti-inflammatory, and antifungal effects.. Оценка клинической эффективности применения препарата Холисал по результатам отечественных и зарубежных исследований, посвященных современным методам лечения воспалительных заболеваний слизистой оболочки полости рта и пародонта.. Методом изучения явился сравнительный анализ представленных публичных данных, полученных различными авторами. Проведен поиск литературы по базе PubMed (www.ncbi.nlm.nih.gov), eLibrary (elibrary.ru) и ScienceDirect (www.sciencedirect.com).. Препарат Холисал сокращает сроки лечения, позволяет увеличить период ремиссии заболевания. Способствует купированию болевого синдрома и ускоренной эпителизации слизистой оболочки рта.. Клинические исследования препарата Холисал показали, что широкий диапазон его фармакологического действия обеспечивает эффективность лечения воспалительных заболеваний слизистой оболочки полости рта и пародонта, когда одновременно требуется сочетание анальгезирующего, противомикробного, противовоспалительного, противогрибкового воздействий.

Topics: Humans; Mouth Mucosa; Periodontal Diseases; Periodontium; Salicylates; Stomatitis, Aphthous

Topics: Candidiasis, Oral; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Humans; Indomethacin; Mouth Diseases; Piperidines; Salicylamides; Salicylanilides; Salicylates; Stomatitis, Aphthous

Topics: Age Factors; Child; Child, Preschool; Choline; Humans; Infant; Ointments; Salicylates; Stomatitis, Aphthous; Time Factors

Topics: Administration, Oral; Adult; Choline; Female; Gels; Humans; Male; Quinolines; Salicylates; Stomatitis, Aphthous

Topics: Adolescent; Adult; Aged; Benzoates; Child; Female; Humans; Malates; Male; Middle Aged; Salicylates; Stomatitis, Aphthous