salicylates and Stevens-Johnson-Syndrome

The nonsteroidal anti-inflammatory drugs are one of the most commonly prescribed classes of drugs used in medical practice. This review discusses the diverse cutaneous reactions associated with nonsteroidal anti-inflammatory drugs. Adverse cutaneous reactions occur most frequently with benoxaprofen, piroxicam, sulindac, meclofenamate sodium, zomepirac sodium, and phenylbutazone. The most serious adverse cutaneous reactions, Stevens-Johnson syndrome and toxic epidermal necrolysis, appear to be most often associated with sulindac and phenylbutazone. Tolmetin and zomepirac sodium, two structurally similar pyrrole derivatives, have been associated with a disproportionate number of cases of anaphylactoid reactions. Among the currently marketed nonsteroidal anti-inflammatory drugs, piroxicam appears to have the highest rate of phototoxic reactions. This phototoxic eruption is most often vesiculobullous.

Topics: Acetates; Anti-Inflammatory Agents; Aspirin; Drug Eruptions; Humans; Ibuprofen; Indomethacin; ortho-Aminobenzoates; Piroxicam; Propionates; Pruritus; Pyrazoles; Pyrazolones; Salicylates; Skin; Skin Diseases; Stevens-Johnson Syndrome; Thiazines

Various nonsteroidal anti-inflammatory drugs are known to increase the risk of Stevens-Johnson syndrome and toxic epidermal necrolysis. The relationship between salicylate treatment and these conditions is not known.. A case-control study was conducted in four countries in Europe from 1989 to 1995.. Among 373 cases and 1720 controls, the multivariate relative risk estimate for any salicylate use in the previous week was 1.3 (95% confidence interval, 0.8-2.2); no statistically significant elevations were observed for single ingredient preparations or for salicylate-containing combination products.. Acetylsalicylic acid and other salicylates are not associated with a measurable increase in the risk of these rare but severe reactions.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Humans; Multivariate Analysis; Salicylates; Stevens-Johnson Syndrome

Topics: Adult; Diflunisal; Erythema Multiforme; Female; Humans; Middle Aged; Salicylates; Stevens-Johnson Syndrome

Topics: Adult; Analgesics; Female; Humans; Middle Aged; Salicylates; Stevens-Johnson Syndrome

Topics: Adolescent; Adult; Aged; Ampicillin; Analgesics; Anaphylaxis; Angioedema; Anti-Bacterial Agents; Barbiturates; Child; Child, Preschool; Dermatitis, Exfoliative; Drug Eruptions; Erythema; Exanthema; Female; Humans; Infant; Male; Middle Aged; Penicillins; Photosensitivity Disorders; Salicylates; Stevens-Johnson Syndrome; Sulfonamides; Urticaria

Topics: Aminopyrine; Angioedema; Anti-Bacterial Agents; Barbiturates; Dermatitis, Contact; Drug Hypersensitivity; Erythema; Erythema Multiforme; Erythema Nodosum; Exanthema; Humans; Hungary; Pertussis Vaccine; Purpura; Quinine; Salicylates; Smallpox Vaccine; Stevens-Johnson Syndrome; Sulfonamides; Tetanus Antitoxin; Tranquilizing Agents; Vaccinia

Topics: Adult; Diagnosis, Differential; Eye Manifestations; Female; Humans; Male; Salicylates; Stevens-Johnson Syndrome; Sulfanilamides

Topics: Aminopyrine; Boric Acids; Child; Child, Preschool; Chloramphenicol; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Penicillins; Salicylates; Stevens-Johnson Syndrome; Sulfonamides