salicylates has been researched along with Starvation* in 5 studies
5 other study(ies) available for salicylates and Starvation
| Article | Year |
|---|---|
Studies on the pharmacological bases of fetal toxicity of drugs (IV). Effect of endotoxin and starvation on serum protein binding of salicylic acid in pregnant rats.
Our previous paper reported that the fetotoxic effects of aspirin (ASA) were enhanced by bacterial endotoxin (LPS), and the effects of ASA were attributed to its major metabolite, salicylic acid (SA), as indicated by high SA concentrations in fetus and placenta. In order to clarify the mechanisms of the enhancement by LPS, serum total protein, albumin and free fatty acid (FFA) levels and SA-binding capacity of serum protein were investigated in pregnant rats. The following results were obtained: 1) FFA levels increased steadily after day 16 of pregnancy, and SA-binding capacity of serum protein decreased gradually after day 18, as the pregnancy proceeded to full term. 2) LPS injection decreased total protein and albumin levels in normal and starved rats on day 15 of pregnancy. 3) Starvation and/or LPS injection potentiated the increase of FFA level and reduced significantly SA-binding capacity of serum protein in the rats on day 15 of pregnancy. 4) Serum protein showing low SA-binding capacity from LPS-treated rats recovered normal SA-binding capacity when FFA was removed from serum protein by charcoal treatment. These data suggested the decrease of the SA-protein binding in serum by the increased level of FFA, an inhibitor of the binding, and the decreased level of albumin as a possible mechanism for the potentiation of the fetotoxicities of ASA by LPS. Topics: Animals; Aspirin; Blood Proteins; Endotoxins; Fatty Acids, Nonesterified; Female; Fetus; Pregnancy; Protein Binding; Rats; Rats, Inbred Strains; Salicylates; Serum Albumin; Starvation | 1983 |
Studies on growth hormone secretion. V. Influence of plasma free fatty acid levels.
Topics: Acetates; Animals; Blood Glucose; Epinephrine; Fatty Acids, Nonesterified; Female; Growth Hormone; Heparin; Homeostasis; Insulin; Male; Malonates; Nicotinic Acids; Propionates; Pyrazoles; Radioimmunoassay; Salicylates; Sheep; Starvation; Triglycerides; Vasopressins | 1973 |
Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, on the concentrations of hexose phosphates, nucleotides and inorganic phosphate in perfus
Topics: Acetoacetates; Adenine Nucleotides; Adenosine Triphosphate; Adrenalectomy; Animals; Diabetes Mellitus, Experimental; Dinitrophenols; Enzymes; Fatty Acids; Glucose; Heart; Hexosephosphates; Hydroxybutyrates; Hypophysectomy; Hypoxia; In Vitro Techniques; Perfusion; Phosphates; Phosphofructokinase-1; Pyruvates; Rats; Salicylates; Starvation | 1964 |
Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles.
Topics: Animals; Arabinose; Carbon Dioxide; Diabetes Mellitus, Experimental; Diaphragm; Fatty Acids; Glucose; Glycogen; Glycolysis; Heart; Hydroxybutyrates; Hypoxia; In Vitro Techniques; Muscles; Myocardium; Perfusion; Phosphofructokinase-1; Pyruvates; Rats; Salicylates; Starvation | 1964 |
Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation, on pyruvate metabolism and on lactate-pyruvate and L-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat h
Topics: Acetoacetates; Animals; Butyrates; Carbon Dioxide; Diabetes Mellitus, Experimental; Diaphragm; Fatty Acids; Glucose; Glycerophosphates; Heart; Hydroxybutyrates; Hypoxia; In Vitro Techniques; Ketone Bodies; Lactates; Muscles; Myocardium; NAD; Palmitic Acids; Perfusion; Phosphates; Pyruvates; Rats; Salicylates; Starvation | 1964 |