salicylates has been researched along with Silicosis* in 5 studies
5 other study(ies) available for salicylates and Silicosis
| Article | Year |
|---|---|
Hydroxyl radical production and lung injury in the rat following silica or titanium dioxide instillation in vivo.
The hydroxyl radical (.OH) is a highly reactive oxygen free radical that has been implicated as a cause of lung injury following exposure to silica and silicates. Despite evidence that silica generates .OH in vitro, there has been no previous demonstration of in vivo production of .OH after exposure to nonfibrous mineral oxide dusts. We tested the hypothesis that instillation of silica into rat lungs is associated with greater .OH production and acute lung inflammation in vivo relative to the instillation of a less toxic nonsilicate particle, titanium dioxide. The production of .OH in the lungs following dust instillation was measured using sodium salicylate as an .OH trap. Seven days after dust exposure, the rats were given intraperitoneal salicylate, the lungs isolated, and salicylate hydroxylation products (2,3- and 2,5-dihydroxybenzoic acid), reflecting .OH, were measured. There was significantly more 2,3-dihydroxybenzoic acid in silica-exposed lungs compared with lungs instilled with titanium dioxide. In addition, the instillation of silica into rat lungs in vivo was associated with a greater acute inflammatory response. We conclude that following in vivo exposure, silica stimulates greater .OH production relative to the less toxic particle, titanium dioxide. These differences in .OH generation correspond to disparities in acute lung inflammation. Topics: Animals; Bronchoalveolar Lavage Fluid; Dust; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Lung; Lung Injury; Organ Size; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Silicon Dioxide; Silicosis; Titanium | 1995 |
[Method of determination of polyvinylpyridine N-oxide in the urine and feces].
Topics: Animals; Filtration; Humans; Polyvinylpyridine N-Oxide; Polyvinyls; Rats; Salicylates; Silicosis | 1977 |
[Experimental studies on the treatment of silicosis].
Topics: Air Pollution; Animals; Humans; Rats; Salicylates; Silicon Dioxide; Silicosis | 1967 |
An experimental study of the pathogenesis of silicotic granuloma in the anterior eye chamber in rabbits and changes in its development induced by the action of A.C.T.H., insulin, combinations of both, and salicylates.
Topics: Adrenocorticotropic Hormone; Animals; Anterior Chamber; Granuloma; Insulin; Lagomorpha; Rabbits; Salicylates; Silicosis | 1957 |
[Effect of ACTH, insulin, their combinations, and salicyl on the development of salicotic granuloma in rabbits].
Topics: Adrenocorticotropic Hormone; Animals; Granuloma; Insulin; Rabbits; Salicylates; Silicosis | 1956 |