salicylates and Sarcoma

Despite numerous scientific advances, cancer continues to be one of the main causes of death in the world. This situation has driven the search for promising molecules. Lichen substances have been widely described for their pharmacological potential.. The present study evaluated the antitumour potential of a depsidone isolated from. The molecule was isolated from the acetonic extract of the lichen and recrystallized in acetone. The macrophage J774, sarcoma-180 and MDA-MB-231 cell lines were used for the MTT cytotoxicity assay. The antitumor assay used a murine model (Swiss albino mice) with sarcoma-180. The animals were treated for seven consecutive days with doses of SAL (25 and 50 mg/kg) and 5-fluorouracil (20 mg/kg).. Its purity was determined using high-performance liquid chromatography (94%), and its structure was confirmed by H. The present results demonstrate the potential of salazinic acid as a tumour inhibition agent.

Topics: Animals; Antineoplastic Agents; Fluorouracil; Humans; Lichens; Mice; Salicylates; Sarcoma

Topics: Adolescent; Anorexia Nervosa; Child, Preschool; Diagnosis; Diagnosis, Differential; Dysautonomia, Familial; Female; Glomerular Filtration Rate; Humans; Infant; Intellectual Disability; Intestinal Polyps; Male; Osteoma; Ovarian Neoplasms; Poisoning; Salicylates; Sarcoma; Testicular Neoplasms; Uremia; Uterine Cervical Neoplasms; Vaginal Neoplasms; Wilms Tumor