salicylates and Rheumatic-Diseases

Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diflunisal; Humans; Rheumatic Diseases; Salicylates

Cutaneous reactions to medications probably represent the most common manifestation of drug reactions. The diversity of cutaneous eruptions produced by drugs provide a challenge in searching for the mechanisms producing the reaction. Many eruptions are due to a form of allergic hypersensitivity, while others may be idiosyncratic, due to a metabolic abnormality, or represent a cumulative phenomenon. This article discusses the diagnosis of drug-induced cutaneous reactions by reviewing specific drugs commonly used in rheumatologic therapy.

Topics: Acetates; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antimetabolites; Cyclosporins; Gold; Humans; ortho-Aminobenzoates; Penicillamine; Piroxicam; Propionates; Pyrazoles; Retinoids; Rheumatic Diseases; Salicylates; Skin Diseases

Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Azathioprine; Chloroquine; Cyclophosphamide; Drug Therapy, Combination; Felty Syndrome; Gold; Humans; Hydroxychloroquine; Immunosuppressive Agents; Leukapheresis; Lung Diseases; Lymphoid Tissue; Methotrexate; Penicillamine; Plasmapheresis; Radiotherapy; Rheumatic Diseases; Salicylates; Sjogren's Syndrome; Spinal Diseases; Vasculitis

A regular control of nonsteroidal anti-inflammatory drug (NSAID) plasma levels may be useful to avoid undesirable side-effects to monitor therapeutic progress to see if patients are complying with their prescription. Trying to establish a relationship between the plasma concentration of a drug and its clinical effects requires a few prerequisites which may or may not be fulfilled according to the NSAID (e.g. a drug acting by itself, a reversible action, no tolerance to the drug, a highly specific and sensitive enough analytical method of the drug, similar free drug concentrations in the plasma and at the receptor sites,...), the most important of them-which is also probably the most difficult to fulfil in the case of rheumatic diseases-being that the clinical effect of the drug must be easily measured. In fact, the evidence for a good correlation between clinical effects and drug plasma levels are very scarce in the field of NSAID. The best correlation was obtained with salicylates for which ranges of plasma concentrations needed for observing therapeutic effects in rheumatoid arthritis as well as in juvenile rheumatoid arthritis have been established. Similar correlations have been made for side effects such as tinnitus or headaches as well as for toxic manifestations of salicylism. However, many individual variations have been described and there is considerable overlap between therapeutic and toxic concentrations. According to different authors there are or there are no correlations between phenylbutazone plasma levels and either is therapeutic or its side-effects.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Anti-Inflammatory Agents; Binding Sites; Circadian Rhythm; Drug Administration Schedule; Humans; Hydrogen-Ion Concentration; Indomethacin; Kinetics; Phenylbutazone; Propionates; Prostaglandins; Rheumatic Diseases; Salicylates; Serum Albumin; Synovial Fluid

Drug effects on fetal physiology as well as possible teratogenesis need to be considered before prescribing for women of child-bearing age. All nonsteroidal anti-inflammatory drugs (NSAIDs), because of their suppression of prostaglandin synthesis, may prolong gestation and labour. Aspirin is also associated with an increased risk of ante- and post-partum haemorrhage. Indomethacin may be teratogenic in humans and like aspirin may induce pulmonary hypertension in the neonate. To reduce the physiological alterations induced by NSAIDs, short-half-life drugs such as ibuprofen, flurbiprofen or ketoprofen should be used at the maximally tolerable dosage interval. Gold salts and corticosteroids show little human evidence of teratogenicity although the largest possible dosage interval of gold should be used. D-Penicillamine may be teratogenic thus it should not be commenced during pregnancy and if a patient becomes pregnant whilst receiving the drug, it should be slowly withdrawn or the dosage reduced. 4-Aminoquinoline compounds are contra-indicated in pregnancy.

Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Chloroquine; Female; Fetal Diseases; Gold; Humans; Indomethacin; Infant, Newborn; Penicillamine; Pregnancy; Pregnancy Complications; Rheumatic Diseases; Salicylates

The pharmacologic properties, clinical efficacy and tolerability of the newer non-steroidal anti-rheumatic drugs are compared. Guidelines for a prescribing policy are given in which a safety-first approach is adopted. Propionic acid derivatives or newer drugs with similar properties are proposed as initial therapy to control symptoms of rheumatoid arthritis or osteoarthrosis. Special problems such as compliance in chronic disease, treatment of ulcer patients with anti-rheumatic drugs, therapy in the elderly, treatment for juvenile rheumatoid arthritis and treatment during pregnancy are considered.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbazoles; Chronic Disease; Diclofenac; Diflunisal; Humans; Indomethacin; ortho-Aminobenzoates; Osteoarthritis; Phenylbutazone; Piroxicam; Rheumatic Diseases; Salicylates; Thiazines; Tolmetin

Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cryoglobulinemia; Felty Syndrome; Giant Cell Arteritis; Humans; Liver Diseases; Lupus Erythematosus, Systemic; Polymyalgia Rheumatica; Rheumatic Diseases; Rheumatic Fever; Salicylates; Scleroderma, Systemic; Sjogren's Syndrome; Vasculitis

Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Indoles; ortho-Aminobenzoates; Propionates; Pyrazoles; Rheumatic Diseases; Salicylates

The pathophysiology, symptoms and drug treatment of rheumatic disease are reviewed. Antirheumatic drugs reviewed are salicylates (including aspirin, sodium salicylate, choline salicylate, choline magnesium salicylate, salsalate), phenylpropionic acid derivatives (fenoprofen, ibuprofen, naproxen), indole derivatives (sulindac, tolmetin and indomethacin), pyrazolone derivatives (phenylbutazone, oxyphenbutazone), gold compounds, penicillamine, antimalarials mefenamic acid, corticosteroids and immunosuppressives. Simple analgesic therapy (acetaminophen, aspirin, propoxyphene) is used in the early stage of the disease. As the disease progresses, aspirin remains the drug of choice for antiinflammatory activity but the phenylpropionic acid or indole derivatives may be preferred in patients unable to tolerate salicylates. If such nonsteroidal antiinflammatory agents are not effective, parenteral therapy with gold compounds or oral penicillamine usually is indicated. Indomethacin or phenylbutazone, then antimalarials, are resorted to next. Corticosteroids or immunosuppressives are reserved for patients who are unsuccessfully controlled or who have major side effects with the other drugs. Mefenamic acid occupies a very secondary place in rheumatoid arthritis treatment.

Topics: Anti-Inflammatory Agents; Antimalarials; Glucocorticoids; Gold; Humans; Immunosuppressive Agents; Indomethacin; Mefenamic Acid; Penicillamine; Phenylbutazone; Phenylpropionates; Rheumatic Diseases; Salicylates; Sulindac; Tolmetin

The results of experiments designed to test the validity of the hypothesis that the anti-inflammatory and anti-rheumatic actions of aspirin are due to the inhibition of prostaglandin synthetase activity are reviewed.

Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cyclooxygenase Inhibitors; Humans; Rheumatic Diseases; Salicylates

Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Gold; Gout; Humans; Lupus Erythematosus, Systemic; Osteoarthritis; Penicillamine; Rheumatic Diseases; Salicylates; Spondylitis, Ankylosing; Vasculitis

A review of the literature on the gastrointestinal side effects of the analgesic drugs has disclosed a disparity between generally held views and the scientific evidence. This is largely due to the paucity of large long term controlled trials since the cost of these is very high. The problems in mounting a large observational study with population controls are discussed against a backgrwound of exploratory work in Australia and New Zealand and the conclusion is reached that a comprehensive survey is needed. The difficulties in mounting such a survey are discussed.

Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Indomethacin; Male; Oxyphenbutazone; Peptic Ulcer; Phenylbutazone; Rheumatic Diseases; Salicylates; Stomach Diseases; Stomach Ulcer

Topics: Adrenal Cortex Hormones; Ambulatory Care; Antimalarials; Gold; Gout; Humans; Immunosuppressive Agents; Indomethacin; Injections, Intra-Articular; Muscle Relaxants, Central; ortho-Aminobenzoates; Phenylacetates; Phenylbutazone; Pyrazoles; Rheumatic Diseases; Salicylates; Tissue Extracts; Tranquilizing Agents

Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Drug Hypersensitivity; Gastric Mucosa; Gout; Humans; Phenacetin; Phenylbutazone; Rheumatic Diseases; Salicylates; Stomach Diseases

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis, Rheumatoid; Atrophy; Betamethasone; Drug Interactions; Glucocorticoids; History, 20th Century; Humans; Hydrocortisone; Infections; Injections, Intra-Articular; Joint Diseases; Methylprednisolone; Necrosis; Osteoporosis; Peptic Ulcer; Prednisolone; Prednisone; Rheumatic Diseases; Salicylates; Skin Diseases; Substance Withdrawal Syndrome; Synovitis; Triamcinolone; Vascular Diseases

Topics: Adrenal Cortex Hormones; Dimethyl Sulfoxide; Gold; Humans; Immunosuppressive Agents; Indomethacin; Phenylbutazone; Physical Therapy Modalities; Psychotherapy; Rheumatic Diseases; Salicylates

Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Dogs; Drug Hypersensitivity; Duodenal Ulcer; Esophageal Diseases; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Glucocorticoids; Humans; Hydrocortisone; Indomethacin; Intestinal Mucosa; Osteoarthritis; Penicillins; Phenylbutazone; Prednisolone; Rats; Rheumatic Diseases; Salicylates; Sodium Salicylate; Stomach Diseases; Stomach Ulcer; Streptomycin

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antimalarials; Gold; Humans; Indomethacin; Pyrazoles; Rheumatic Diseases; Salicylates

Topics: Aminopyrine; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antimalarials; Antipyrine; Camphor; Chloroquine; Dexamethasone; Esters; Flufenamic Acid; Glucocorticoids; Gold; Humans; Immunosuppressive Agents; Indomethacin; Mefenamic Acid; Methylprednisolone; Nicotinic Acids; Oils, Volatile; Oxyphenbutazone; Prednisolone; Prednisone; Rheumatic Diseases; Salicylates; Triamcinolone

Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis; Azathioprine; Chloroquine; Cyclophosphamide; Glucocorticoids; Humans; Immunosuppressive Agents; Indomethacin; Methotrexate; Nitrogen Mustard Compounds; Rheumatic Diseases; Salicylates

Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antigen-Antibody Reactions; Antipyretics; Biochemical Phenomena; Biochemistry; Blood Chemical Analysis; Hypersensitivity; Inflammation; Necrosis; Pharmacology; Phenylbutazone; Proteins; Rheumatic Diseases; Salicylates

Topics: Adrenal Cortex Hormones; Child; Drug Therapy; Electrocardiography; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Fever; Humans; Imidazoles; Infant; Influenza, Human; Male; Rheumatic Diseases; Salicylates

Enelbin-Rheuma-ointment and a reference ointment were compared with regard to effectiveness in a double-blind trial in 100 patients with gonarthrosis, osteoarthrosis of the spine and humeroscapular periarthropathy. Both ointments showed good results regarding spontaneous pain, pain on pressure and motion, reduction of mobility, swelling and muscular tension. The success of treatment was statistically significantly better in the Enelbin-Rheuma-ointment treated patients.

Topics: Double-Blind Method; Drug Combinations; Drug Evaluation; Ethylene Glycols; Eucalyptus; Heparin; Humans; Hydroxybenzoates; Oils, Volatile; Ointments; Plants, Medicinal; Rheumatic Diseases; Salicylates; Thymol; Vanillic Acid

Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Capsicum; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Histamine; Humans; Male; Middle Aged; Nicotinic Acids; Oils, Volatile; Ointments; Plants, Medicinal; Rheumatic Diseases; Salicylates

Topics: Administration, Topical; Anti-Inflammatory Agents; Clinical Trials as Topic; Ethylene Glycols; Female; Humans; Male; Ointments; Rheumatic Diseases; Salicylates

Topics: Acetanilides; Acetates; Anti-Inflammatory Agents; Humans; Rheumatic Diseases; Salicylates; Tinnitus

Topics: Clinical Trials as Topic; Female; Glucocorticoids; Glycosaminoglycans; Humans; Joint Diseases; Male; Rheumatic Diseases; Salicylates

Benorylate (4-acetamidophenyl 2-acetoxybenzoate) is a new esterified aspirin preparation whose antirheumatic properties are reported to be as good as those of aspirin. Gastrointestinal blood loss, measured with (51)Cr-labelled red cells, during benorylate therapy was compared with that during therapy with soluble aspirin in 15 subjects, a simplified crossover procedure being used. Mean blood loss during benorylate therapy was 1.7 ml/day which was significantly less than that during therapy with soluble aspirin (5.1 ml/day; P <0.001). In 12 of the 15 patients blood loss with benorylate was less than 2.5 ml/day. Benorylate appears to be a definite improvement on current formulations of aspirin and should be a useful drug for the treatment of patients with chronic rheumatic disorders.

Topics: Acetanilides; Acetates; Adult; Aged; Analgesics; Chromium Isotopes; Chronic Disease; Clinical Trials as Topic; Feces; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Occult Blood; Rheumatic Diseases; Salicylates; Solubility

Topics: Arthritis, Rheumatoid; Benzoates; Brachial Plexus Neuritis; Clinical Trials as Topic; Drug Combinations; Glycols; Humans; Nicotinic Acids; Ointments; Osteoarthritis; Rheumatic Diseases; Salicylates; Skin Temperature; Thermography

Topics: Adult; Delayed-Action Preparations; Humans; Male; Rheumatic Diseases; Salicylates

Topics: Acute Disease; Arthritis, Rheumatoid; Bone Diseases; Clinical Trials as Topic; Drug Synergism; Humans; Osteoarthritis; Osteochondritis; Osteoporosis; Pain; Penicillins; Placebos; Pleurisy; Prednisolone; Rheumatic Diseases; Rheumatic Fever; Salicylates; Spondylitis

Topics: Clinical Trials as Topic; Humans; Nicotinic Acids; Parasympatholytics; Rheumatic Diseases; Salicylates

Topics: Advertising; History, 19th Century; History, 20th Century; Humans; Neuralgia; Rheumatic Diseases; Salicylates

The first clinical reports on the treatment of fever and pain with salicylate-containing natural willow bark remedies were made by the English clergyman Edward Stone in 1763. The pharmacologically active principles were isolated from natural sources by Italian, German and French scientists between 1826 and 1829. Salicylic acid was first synthesised by the German Gerland in 1852 and a year later the Frenchman Gerhardt synthesised acetylsalicylic acid. The first reports on the clinical use of salicylic acid in rheumatic disorders were made independently by the two German physicians Stricher and Reiss in 1876. Acetylsalicylic acid was rediscovered by Hoffmann in 1897 and by the turn of the century it had gained worldwide recognition in the treatment of pain and rheumatological disorders. Reports on adverse events relating to gastrointestinal intolerance and bleeding appeared early, but were largely neglected until the 1950s. Today, salicylates are still widely used as analgesic, antipyretic and anti-inflammatory drugs. New indications, such as thrombosis prophylaxis, have emerged during the last decades, and yet others are being explored.

Topics: Europe; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Palliative Care; Rheumatic Diseases; Salicylates

To evaluate how the nonsteroidal anti-inflammatory agent salsalate affects the results of routine thyroid function tests.. In a cohort of patients taking salsalate for various rheumatic conditions, thyroid function tests were performed with patients on and off the drug.. Primary care of ambulatory patients in a university medical center.. A convenience sample of 14 euthyroid subjects, none of whom was taking thyroid hormone or other medication recognized to alter thyroid function.. Treatment with therapeutic doses of salsalate for a mean period of 44 weeks.. Serum levels of thyroxine (T4), free T4, thyroid hormone binding ratio, free T4 index (the product of T4 and the thyroid hormone binding ratio), triiodothyronine, and thyrotropin.. Serum T4 dropped from a mean baseline level of 96.7 nmol/L off salsalate to 53.4 nmol/L on it (P less than .001), and the free T4 index showed a parallel decline from 85.9 to 50.4 (P less than .001), with both values falling into the hypothyroid range. Similarly, free T4 levels and total triiodothyronine concentrations were low in several patients treated with salsalate. Serum thyrotropin levels declined transiently, falling from a mean of 3.2 to 1.7 mU/L (P less than .02) in patients treated for less than 3 weeks. Patients treated for longer periods had levels comparable to baseline. Despite these changes in the thyroid function test results, all subjects remained clinically euthyroid.. Salsalate commonly produces abnormalities in routine thyroid function test results similar to those found in central hypothyroidism.

Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Female; Humans; Hypothyroidism; Male; Middle Aged; Rheumatic Diseases; Salicylates; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyroxine

Topics: Aged; Ear; Humans; Osteoporosis; Rheumatic Diseases; Salicylates; Salicylic Acid

Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondrocalcinosis; Female; Giant Cell Arteritis; Gout; Humans; Male; Middle Aged; Osteoarthritis; Osteoporosis; Rheumatic Diseases; Salicylates

Specific information concerning the use of nonsteroidal anti-inflammatory agents, salicylates, analgesics, remittive drugs, and other adjunctive treatments used for rheumatic diseases are addressed. Based on a good diagnosis, pharmacotherapy combined with other approaches can result in successful treatment of most cases of arthritis.

Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Aurothioglucose; Chloroquine; Colchicine; Gold Sodium Thiomalate; Humans; Hydroxychloroquine; Penicillamine; Prednisone; Rheumatic Diseases; Salicylates

Topics: Anti-Inflammatory Agents; Dinoprostone; Gastrointestinal Hemorrhage; Humans; Prostaglandins E; Rheumatic Diseases; Salicylates

Side effects of non-steroidal antirheumatic drugs (NSAD) may occur in any organ system, since the prostaglandins, the synthesis of which is inhibited by NSAD, play a role in numerous adverse cellular processes throughout the body. Besides these physiologic regulations there are adverse effects of NSAD, such as bone marrow aplasia, of unexplained etiology. The interactions of NSAD are of clinical relevance in drug types such as the salicylates, pyrazolons and fenamic acids (e.g. interactions with cumarin derivatives). The clinically relevant interactions of NSAD are discussed in detail.

Topics: Anemia, Aplastic; Anti-Inflammatory Agents, Non-Steroidal; Coumarins; Drug Interactions; Gastrointestinal Diseases; Humans; Indomethacin; Naproxen; ortho-Aminobenzoates; Phenylbutazone; Prostaglandins; Rheumatic Diseases; Salicylates; Stomach Ulcer

Topics: Adolescent; Adult; Aged; Choline; Humans; Middle Aged; Rheumatic Diseases; Salicylates

A high pressure liquid chromatographic method was used to measure the serum concentrations of salicylic, salicyluric and gentisic acids in patients receiving chronic acetylsalicylic acid therapy. There was good correlation between this method and the established colorimetric assay for salicylic acid. The concentration of gentisic and salicyluric acids were increased in patients older than 60 years. No correlation was found with sex, concomitant ingestion of other drugs, serum creatinine or serum albumin.

Topics: Adult; Age Factors; Aspirin; Humans; Middle Aged; Rheumatic Diseases; Salicylates

Topics: Drug Antagonism; Drug Synergism; Drug Therapy, Combination; Glucocorticoids; Humans; Rheumatic Diseases; Salicylates

Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Humans; Indoles; ortho-Aminobenzoates; Rheumatic Diseases; Salicylates

Our present array of nonsteroidal anti-inflammatory drugs (NSAIDs) provides many more avenues for the long-term management of rheumatic disease. Their clinical efficacy notwithstanding, these drugs possess significant iatrogenic potential. These risks are typified by aspirin side effects, basically gastrointestinal, hematologic, and thrombopathic. Most of the NSAIDs share these liabilities. However, there is now wider appreciation of recent findings that nonacetylated salicylates, particularly salsalate, provide the benefits of aspirin and other NSAIDs but not their dangers. Salsalate is a prototypic drug of this class; it is reviewed in detail with appropriate comment concerning its present and potential clinical contributions to antirheumatic therapy.

Topics: Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Humans; Intestinal Absorption; Kinetics; Middle Aged; Rheumatic Diseases; Salicylates

Topics: Animals; Arthritis, Rheumatoid; Copper; Drug Therapy, Combination; Humans; Rheumatic Diseases; Salicylates

Topics: Adrenal Cortex Hormones; Antimalarials; Aspirin; Azathioprine; Chloroquine; Cyclophosphamide; Gold; Humans; Hydroxychloroquine; Immunosuppressive Agents; Indomethacin; Penicillamine; Phenylbutazone; Phenylpropionates; Rheumatic Diseases; Salicylates; Sulindac; Tolmetin

Topics: Adult; Aged; Analgesics; Drug Combinations; Female; Gels; Heparin; Humans; Male; Menthol; Middle Aged; Rheumatic Diseases; Salicylates; Wounds, Nonpenetrating

Topics: Arthritis, Rheumatoid; Humans; Rheumatic Diseases; Salicylates

Topics: Anti-Inflammatory Agents; Humans; Indoles; ortho-Aminobenzoates; Propionates; Pyrazoles; Rheumatic Diseases; Salicylates

Topics: Drug Combinations; Drug Evaluation; Esters; Ethylene Glycols; Humans; Plant Extracts; Rheumatic Diseases; Salicylates

Topics: Adult; Aged; Choline; Drug Evaluation; Female; Humans; Male; Middle Aged; Rheumatic Diseases; Salicylates

Topics: Administration, Topical; Anti-Inflammatory Agents; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Pain; Placebos; Rheumatic Diseases; Salicylates; Terpenes

Topics: Baths; Humans; Nicotinic Acids; Rheumatic Diseases; Salicylates; Sulfur

Topics: Abortion, Spontaneous; Chloroquine; Female; Gold; Humans; Hyperbilirubinemia; Indomethacin; Penicillamine; Pregnancy; Rheumatic Diseases; Salicylates; Teratoma

N-acetyl-beta glucosaminidase (NAG) enzymuria was used as a marker of renal injury in patients with rheumatic disease. An elevated NAG level was particularly common in patients receiving gold or aspirin therapy. The multiplicity of drugs received and the unknown role of underlying disease in these patients led to a study in healthy volunteers. Customary therapeutic doses of aspirin, choline salicylate, ibuprofen, indomethacin and acetaminophen did not produce enzymuria. Large single doses of salicylates equivalent to 6 tablets of aspirin consistently did produce enzymuria. The size of the individual dose in relation to body weight was more important than the total daily dose. NAG enzymuria appears to be a sensitive tool for identifying potentially nephrotoxic drugs.

Topics: Acetaminophen; Acetylglucosaminidase; Adult; Anti-Inflammatory Agents; Aspirin; Gold; Hexosaminidases; Humans; Ibuprofen; Indomethacin; Kidney; Kidney Diseases; Lysosomes; Rheumatic Diseases; Salicylates

Topics: Adult; Aged; Drug Evaluation; Female; Humans; Male; Middle Aged; Rheumatic Diseases; Salicylates

This paper reviews the possibilities of interactions of drugs, used in the treatment of rheumatism in the elderly. Exspecially glycosides, antikoagulants, diuretics, uricosurics, salicylates, barbiturates and corticosteroides are discussed.

Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anti-Inflammatory Agents; Anticoagulants; Barbiturates; Cardiac Glycosides; Diuretics; Drug Interactions; Humans; Middle Aged; Rheumatic Diseases; Salicylates; Uricosuric Agents

This review presents a historical account of the treatment of rheumatoid and other degenerative diseases with copper complexes. Clinical data obtained from 1940 to 1971 are provided for about 1,500 patients with rheumatoid arthritis (acute or chronic), rheumatic fever, ankylosing spondylitis, staphlococcal spondylitis, gonococcal arthritis, chronic gouty arthritis, polyarticular synovitis, coxitis, disseminated spondylitis, arthritis with psoriasis, Reiter's syndrome, lupus erythematosus, sarcoidosis, arthrosis deformans, erythema nodosum, sciatica (with and without lumbar involvement), cervical spine-shoulder syndrome or lumbar spine syndrome. The drugs used in these studies were Dicuprene, Alcuprin, Cuprimyl, and Permalon, a copper-salicylate preparation. A detailed presentation of toxicities associated with the use of these copper complexes is included.

Topics: Anti-Inflammatory Agents; Copper; Drug Administration Schedule; History, 20th Century; Humans; Infusions, Parenteral; Injections, Intravenous; Rheumatic Diseases; Salicylates

Topics: Adult; Aged; Drug Combinations; Drug Evaluation; Drug Synergism; Ethylene Glycols; Female; Flufenamic Acid; Glycosaminoglycans; Humans; Male; Middle Aged; Nicotinic Acids; Ointments; Rheumatic Diseases; Salicylates

Almost every drug that is given to a pregnant woman can pass into the developing fetus and possibly cause harm. A well-founded corticoid therapy is not contra-indicated. The administration of pyrazole derivatives in considered largely unobjectionable. Damage has been observed very recently with salicylates. Also indometacin is not absolutely free from teratogenic effects. Harmful effects have not yet been seen with the rest of the preparations for symptomatic treatment. During treatment with the basic drugs: gold, D-penicillamine and chloroquine, pregnancy should be avoided. The administration of cytostatics during pregnancy and the lactation period is contraindicated. Departures from this rule are only permissible in severe systemic lupus erythematodes.

Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Azathioprine; Chloroquine; Female; Fetal Diseases; Gestational Age; Gold; Humans; Indomethacin; Infant, Newborn; Maternal-Fetal Exchange; Penicillamine; Pregnancy; Pregnancy Complications; Pyrazoles; Rheumatic Diseases; Salicylates

Topics: Administration, Topical; Adolescent; Adult; Aged; Drug Combinations; Drug Evaluation; Female; Gels; Heparin; Humans; Joint Diseases; Male; Middle Aged; Nicotinic Acids; Rheumatic Diseases; Salicylates; Sciatica

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Diethylamines; Drug Combinations; Drug Evaluation; Female; Heparin; Humans; Male; Middle Aged; Nicotinic Acids; Rheumatic Diseases; Salicylates

Topics: Deafness; Female; Humans; Male; Middle Aged; Rheumatic Diseases; Salicylates

52 outpatients with rheumatoid arthritis or osteoarthritis were given benorylate (as the 40% suspension) in doses of up to 8 g daily. Peroids of medication were varied but some patients were given the drug for nearly 2 years. Assessments of clinical progress were made at regular intervals by recording both subjective and objective measurements including duration of morning stiffness, grip strength, joint size. Laboratory investigations include renal function tests, liver function tests, blood picture and occult blood. No serious side effect, attributable to benorylate was reported and it was concluded that the drug is satisfactory for the long term treatment of rheumatic diseases.

Topics: Arthritis, Rheumatoid; Blood Sedimentation; Drug Evaluation; Dyspepsia; Humans; Nausea; Osteoarthritis; Rheumatic Diseases; Salicylates; Urea; Vomiting

Benorylate is obtained by esterification of acetylsalicylic acid and N-acetyl p-aminophenol (4-acetamidophenyl 2-acetoxybenzoate). Experimentally, this new product has been shown to be a good analgesic and anti-inflammatory agent. A clinical trial was carried out in order to study the efficacy, side effects and tolerance of this new product. In a group of 49 hospitalised patients aged from 20 to 70 years who were treated with this new product, 15 had ankylosing spondylitis, 11 had chronic progressive rheumatoid arthritis, 4 had Reiter's syndrome, 4 had psoriatic arthropathy, 8 had osteoarthrosis of the hip and 7 had various forms of rheumatism. The drug was administered orally in suspension form, initially three times per day, then twice, the total daily doses being 15 ml (6 g) or 20 ml (8 g). Treatment was regarded as effective in 62% of the cases, and of these 62%, 46% good and very good results were obtained. In 88% of the patients, tolerance was satisfactory and of these, it was excellent in 80%. Only in 2 cases did treatment have to be discontinued on account of side effects. From the biological point of view, uricaemia was significantly reduced in 7 patients, and in 6 patients uricuria increased. With regard to the level of salicylate in the blood assays showed that it is the same for 6 g benorylate and for 4 g aspirin. Benorylate has been shown to be an effective treatment for both inflammatory and degenerative rheumatic disorders. The results of its use can be compared with those obtained by acetylsalicylic acid, but is better tolerated. In addition, in chronic disorders it is better to have to take the product only twice per day.

Topics: Administration, Oral; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Male; Middle Aged; Osteoarthritis; Rheumatic Diseases; Salicylates

Topics: Drug Evaluation; Humans; Rheumatic Diseases; Salicylates

Benorylate (Benoral, Benortan) is the esterification product of paracetamol and acetylsalicylic acid. It has anti-inflammatory, analgesic and antipyretic properties. Benorylate is probably absorbed as the intact molecule which accounts for its good gastric tolerance. After absorption, benorylate is hydrolysed into its components, salicylate and paracetamol, which then follows the usual routes of metabolism. Benorylate per se is also found in inflamed tissue and several studies, both in vivo and in vitro, have shown that it probably has an anti-inflammatory action of its own. Pharmacokinetic studies have shown that a twice daily administration of benorylate should be sufficient for a therapeutic effect and this has been confirmed by its use in patients. Clinical studies have compared benorylate with aspirin, indomethacin, ibuprofen and phenylbutazone and have shown its value in rheumatoid arthritis, osteoarthrosis and other musculoskeletal conditions. The overall tolerance is excellent. Some minor gastric disturbances are reported from time to time, but these are less than with comparable doses of aspirin. Studies measuring occult blood loss in the stools have shown that this is not a significant problem with benorylate and that the majority of patients lose no more blood than the controls.

Topics: Anti-Inflammatory Agents; Drug Evaluation; Drug Packaging; Humans; Rheumatic Diseases; Salicylates

Topics: Anti-Inflammatory Agents; Fenoprofen; Flufenamic Acid; Humans; Ibuprofen; Ketoprofen; Mefenamic Acid; Naproxen; Penicillamine; Phenylacetates; Rheumatic Diseases; Salicylates

Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyclooxygenase Inhibitors; Depression, Chemical; Humans; Prostaglandins; Rheumatic Diseases; Salicylates

Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Rheumatic Diseases; Salicylates

Topics: Humans; Rheumatic Diseases; Salicylates

The objectives of nonspecific anti-inflammatory therapy are, for the most part, to relieve symptoms. In selected patients such therapy may also slow, prevent, or reverse the destructive effects of the inflammatory process. It is well to remember that none of the wide variety of anti-inflammatory agents is without some inherent toxicity, although some agents are obviously much more toxic than others. The physician prescribing these agents must keep in mind both the potential benefits and the potential risks attendant to their use. In this way he can balance potential benefit against potential risk and arrive at the most rational drug therapy for any given rheumatic disorder.

Topics: Adrenal Cortex Hormones; Alkylating Agents; Anti-Inflammatory Agents; Antimalarials; Aspirin; Colchicine; Gold; Humans; Indomethacin; Phenylbutazone; Rheumatic Diseases; Salicylates

Topics: Anti-Inflammatory Agents; Drug Interactions; Humans; Rheumatic Diseases; Salicylates

Topics: Anti-Inflammatory Agents; Aspirin; Blood Pressure; Humans; Hydrocortisone; Intestinal Absorption; Kallikreins; Oxidation-Reduction; Oxidative Phosphorylation; Pituitary-Adrenal System; Rheumatic Diseases; Salicylamides; Salicylates; Sodium Salicylate

Topics: Analgesics; Anti-Inflammatory Agents; Chloroquine; Dimethylamines; Drug Hypersensitivity; Gold; Humans; Immunosuppressive Agents; Indomethacin; Malonates; Mefenamic Acid; Penicillamine; Propionates; Prostaglandin Antagonists; Pyrazoles; Rheumatic Diseases; Salicylates; Steroids; Triazines

Topics: Anti-Inflammatory Agents; Benzoates; Brachial Plexus Neuritis; Drug Combinations; Ethanolamines; Humans; Inflammation; Joint Diseases; Muscular Diseases; Nicotinic Acids; Ointments; Periarthritis; Rheumatic Diseases; Salicylates

Topics: Capsicum; Drug Combinations; Humans; Nicotinic Acids; Ointments; Plant Extracts; Plants, Medicinal; Rheumatic Diseases; Salicylates

Topics: Drug Combinations; Esters; Glycosaminoglycans; Humans; Nicotinic Acids; Ointments; ortho-Aminobenzoates; Rheumatic Diseases; Salicylates

Topics: Administration, Oral; Back Pain; Drug Tolerance; Humans; Injections, Intramuscular; Injections, Intravenous; Osteoarthritis; Rheumatic Diseases; Salicylates; Sciatica

Topics: Adrenal Glands; Contusions; Female; Gels; Glycosaminoglycans; Humans; Male; Rheumatic Diseases; Salicylates; Sprains and Strains; Sulfuric Acids; Tissue Extracts; Wounds and Injuries

Topics: Child; Erythromycin; Humans; Penicillin G; Recurrence; Rheumatic Diseases; Rheumatic Fever; Salicylates; Streptococcal Infections; Time Factors

Topics: Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents; Female; Humans; Prednisone; Rheumatic Diseases; Salicylates; Serum Albumin; Spectrum Analysis

Topics: Baths; Humans; Humic Substances; Mud Therapy; Rheumatic Diseases; Salicylates

Topics: Analgesics; Anti-Inflammatory Agents; Flufenamic Acid; Humans; Indomethacin; Mefenamic Acid; ortho-Aminobenzoates; Phenylbutazone; Rheumatic Diseases; Salicylates

Topics: Acetaminophen; Acetanilides; Acetates; Aspirin; Humans; Rheumatic Diseases; Salicylates

Topics: Adult; Back Pain; Brachial Plexus Neuritis; Female; Glycosaminoglycans; Humans; Male; Middle Aged; Ointments; ortho-Aminobenzoates; Reflex Sympathetic Dystrophy; Rheumatic Diseases; Salicylates; Sulfuric Acids

Topics: Adult; Aged; Aspirin; Chromium Isotopes; Erythrocytes; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Occult Blood; Rheumatic Diseases; Salicylates

Topics: Humans; Rheumatic Diseases; Salicylates

Topics: Gels; Humans; Nicotinic Acids; Rheumatic Diseases; Salicylates

Topics: Anti-Inflammatory Agents; Antigens; Antilymphocyte Serum; Arthritis, Rheumatoid; Chloroquine; Glucocorticoids; Gold; Humans; Indomethacin; Lymphocytes; Lysosomes; Rheumatic Diseases; Rheumatoid Factor; Salicylates

Topics: Drug Combinations; Evaluation Studies as Topic; Female; Humans; Indomethacin; Male; Rheumatic Diseases; Salicylates

Topics: Adolescent; Adult; Anemia, Hypochromic; Arthritis, Rheumatoid; Child; Female; Humans; Iron; Male; Middle Aged; Rheumatic Diseases; Salicylates

Topics: Analgesics; Ethylamines; Female; Humans; Male; Rheumatic Diseases; Salicylates; Sex Factors; Time Factors

Topics: Animals; Anti-Inflammatory Agents; Benzoates; Connective Tissue; Glycosaminoglycans; In Vitro Techniques; Rats; Rheumatic Diseases; Salicylates; Sulfates; Sulfur Isotopes

Topics: Adenosine Triphosphate; Analgesics; Animals; Anti-Inflammatory Agents; Central Nervous System; Chemical Phenomena; Chemistry; Connective Tissue; Edema; Flufenamic Acid; Glycosaminoglycans; Humans; Indomethacin; Mefenamic Acid; Oxyphenbutazone; Phenylbutazone; Pituitary-Adrenal System; Rats; Rheumatic Diseases; Salicylates

Topics: Adrenal Cortex Hormones; Analgesics; Anti-Inflammatory Agents; Antidepressive Agents; Arthritis, Reactive; Arthritis, Rheumatoid; Drug Synergism; Humans; Osteoarthritis; Rheumatic Diseases; Salicylates; Spondylitis, Ankylosing

Topics: Adrenal Cortex Hormones; Antimalarials; Antineoplastic Agents; Arthritis, Rheumatoid; Aspirin; Chronic Disease; Gold Colloid, Radioactive; Humans; Immunosuppressive Agents; Indomethacin; Pyrazoles; Rheumatic Diseases; Salicylates; Ultrasonic Therapy

Topics: Analgesics; Ascorbic Acid; Female; Headache; Humans; Male; Middle Aged; Rheumatic Diseases; Salicylates

Topics: Humans; Prednisone; Rheumatic Diseases; Salicylates

Topics: Adrenal Cortex Hormones; Humans; Pyrazoles; Rheumatic Diseases; Salicylates

Topics: Glycols; Histamine; Humans; Nicotinic Acids; Ointments; Pyrazoles; Rheumatic Diseases; Salicylates

Topics: Adolescent; Age Factors; Anti-Bacterial Agents; Child; Child, Preschool; Female; Humans; Male; Poland; Rheumatic Diseases; Rheumatic Fever; Rheumatic Heart Disease; Salicylates; Sex Factors; Steroids

Topics: Adolescent; Adult; Aged; Child; Emulsions; Humans; Menthol; Middle Aged; Nicotinic Acids; Ointments; Rheumatic Diseases; Salicylates

Topics: Analgesics; Animals; Anti-Bacterial Agents; Chloroquine; Drug-Related Side Effects and Adverse Reactions; Glucocorticoids; Gold; Guinea Pigs; Humans; Rabbits; Rats; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Adrenal Cortex Hormones; Ambulatory Care; Arthritis, Rheumatoid; Chloroquine; Chronic Disease; Family Practice; Gold; Gout; Humans; Mineral Waters; Physical Therapy Modalities; Prednisone; Rheumatic Diseases; Salicylates; Spondylitis, Ankylosing

Topics: Adolescent; Adult; Glucuronates; Humans; Male; Rheumatic Diseases; Salicylates; Sodium Salicylate

Topics: Adult; Anti-Bacterial Agents; Humans; Military Personnel; Naval Medicine; Rheumatic Diseases; Salicylates; Sulfonamides; USSR

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Blindness; Cataract; Conjunctivitis; Diplopia; Drug Therapy; Edema; Eye Diseases; Eye Manifestations; Glaucoma; Gold; Humans; Iatrogenic Disease; Intraocular Pressure; Iridocyclitis; Iritis; Keratitis; Lupus Erythematosus, Systemic; Myopia; Rheumatic Diseases; Salicylates; Spondylitis; Spondylitis, Ankylosing; Toxicology; Uveitis

Topics: Adolescent; Adrenocorticotropic Hormone; Arthritis, Juvenile; Child; Cortisone; Diagnosis, Differential; Drug Hypersensitivity; Drug Therapy; Humans; Osteomyelitis; Pathology; Purpura; Rest; Rheumatic Diseases; Rheumatic Fever; Salicylates; Streptococcal Infections; Tonsillitis

Topics: Drug Therapy; Rheumatic Diseases; Salicylates

Topics: Arthritis; Arthritis, Rheumatoid; Circadian Rhythm; Drug Therapy; Humans; Inflammation; Joint Diseases; Pain; Rheumatic Diseases; Salicylates; Toxicology

Topics: Adrenal Cortex Hormones; Gastric Juice; Liver; Pancreatic Juice; Phenylbutazone; Rheumatic Diseases; Salicylates

Topics: Arthritis; Camphor; Fatty Acids; Fatty Acids, Essential; Humans; Liniments; Niacin; Nicotinic Acids; Ointments; Rheumatic Diseases; Salicylates

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Antimalarials; Arthritis; Arthritis, Rheumatoid; Gold; Gout; Humans; Pyrazoles; Rheumatic Diseases; Rheumatic Fever; Salicylates; Spondylitis; Spondylitis, Ankylosing; Uricosuric Agents

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antirheumatic Agents; Ascorbic Acid; Dermatologic Agents; Drug Therapy; Humans; Penicillin G Benzathine; Rheumatic Diseases; Rutin; Salicylates

Topics: Adrenal Cortex Hormones; Aminopyrine; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Chloroquine; Drug Therapy; Gold; Humans; Prednisone; Pyrazoles; Rheumatic Diseases; Rheumatic Fever; Salicylates; Toxicology

Topics: Humans; Liver Diseases; Rheumatic Diseases; Rheumatic Fever; Salicylates; Toxicology

Topics: Blood Proteins; Child; Cortisone; Dexamethasone; Humans; Prednisolone; Rheumatic Diseases; Rheumatic Fever; Salicylates; Steroids; Triamcinolone; Water-Electrolyte Balance

Topics: Anti-Allergic Agents; Aspirin; Guaifenesin; Histamine H1 Antagonists; Humans; Rheumatic Diseases; Salicylates

Topics: Adrenal Cortex Hormones; Drug Combinations; Humans; Rheumatic Diseases; Rheumatology; Salicylates

Topics: Adrenal Cortex Hormones; Aminopyrine; Antipyrine; Humans; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Antistreptolysin; Deoxyribonuclease I; Humans; Hyaluronoglucosaminidase; Neurology; Phenylbutazone; Rheumatic Diseases; Salicylates; Streptodornase and Streptokinase; Streptokinase

Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Connective Tissue; Humans; Inflammation; Phenylbutazone; Rheumatic Diseases; Salicylates

Topics: Antirheumatic Agents; Chloroquine; Connective Tissue; Humans; Hydrocortisone; Phenylbutazone; Quinolines; Rheumatic Diseases; Salicylates

Topics: Rheumatic Diseases; Salicylates

Topics: Rheumatic Diseases; Salicylates

Topics: Adrenal Cortex Hormones; Myocarditis; Rheumatic Diseases; Rheumatic Fever; Rheumatic Heart Disease; Salicylates

Topics: Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Antirheumatic Agents; Humans; Rheumatic Diseases; Salicylates

Topics: Adrenal Cortex Hormones; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Adrenal Cortex Hormones; Hormones; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Adrenocorticotropic Hormone; Antirheumatic Agents; Cortisone; Humans; Phenylbutazone; Rheumatic Diseases; Salicylates; Vision, Ocular

Topics: Bee Venoms; Liniments; Rheumatic Diseases; Salicylates; Salicylic Acid; Venoms

Topics: Choline; Drug Combinations; Rheumatic Diseases; Salicylates

Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Azoles; Chloroquine; Humans; Rheumatic Diseases; Salicylates

Topics: Adrenocorticotropic Hormone; Cortisone; Heparin; Immune Tolerance; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Acids; Baths; Drug Combinations; Humans; Humic Substances; Rheumatic Diseases; Salicylates; Salicylic Acid

Topics: Adrenal Cortex; Rheumatic Diseases; Salicylates

Topics: Rheumatic Diseases; Salicylates; Salicylic Acid

Topics: Adrenal Cortex Hormones; Humans; Phenylbutazone; Rheumatic Diseases; Rheumatic Fever; Salicylanilides; Salicylates

Topics: Combined Modality Therapy; Manipulation, Osteopathic; Radiotherapy; Rheumatic Diseases; Salicylates; X-Rays

Topics: Benzenesulfonates; Liver Function Tests; Rheumatic Diseases; Salicylates

Topics: Bee Venoms; Bees; Ointments; Rheumatic Diseases; Salicylates

Topics: Analgesics; Inflammation; Ion Exchange Resins; Resins, Synthetic; Rheumatic Diseases; Salicylates; Salicylic Acid

Topics: Rheumatic Diseases; Salicylates

Topics: Iodides; Iodine; Rheumatic Diseases; Rheumatology; Salicylates

Topics: Adrenal Cortex Hormones; Antacids; Arthritis; Ascorbic Acid; Aspirin; General Practice; Humans; Prednisone; Rheumatic Diseases; Salicylates; Vitamins

Topics: Brain; Brain Diseases; Humans; Rheumatic Diseases; Rheumatic Fever; Salicylates; Sodium Salicylate

Topics: Humans; Injections, Intradermal; Pain; Procaine; Rheumatic Diseases; Salicylates

Topics: Arthritis; Arthritis, Rheumatoid; Humans; Osteoarthritis; Rheumatic Diseases; Salicylates

Topics: Buffers; Humans; Prednisolone; Rheumatic Diseases; Salicylates; Steroids

Topics: Aminopyrine; Analgesics; Humans; Rheumatic Diseases; Salicylamides; Salicylates

Topics: Adrenocorticotropic Hormone; Cortisone; Penicillins; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Adrenal Cortex; Rheumatic Diseases; Salicylates

Topics: Rheumatic Diseases; Salicylates

Topics: Desoxycorticosterone; Rheumatic Diseases; Salicylates

Topics: Ascomycota; Bulgaria; Communication; Heart Diseases; Humans; Rheumatic Diseases; Rheumatic Heart Disease; Salicylates

Topics: Analgesics; Antirheumatic Agents; Rheumatic Diseases; Salicylamides; Salicylates

Topics: 17-Hydroxycorticosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Blood; Humans; Poisoning; Rheumatic Diseases; Salicylates

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Blood; Potassium; Rheumatic Diseases; Rheumatic Fever; Salicylates; Sodium; Sodium Salicylate; Steroids; Urine

Topics: Dairy Products; Musculoskeletal Pain; Rheumatic Diseases; Salicylates

Topics: Capillary Permeability; Humans; Rheumatic Diseases; Salicylates; Sodium Salicylate

Topics: Rheumatic Diseases; Rheumatology; Salicylates

Topics: Adrenal Glands; Astemizole; Histamine; Ion Exchange; Iontophoresis; Rheumatic Diseases; Salicylates; Salicylic Acid

Topics: Acids; Arthritis; Cinnamates; Humans; Pain; Rheumatic Diseases; Salicylates; Sodium

Topics: 4-Aminobenzoic Acid; Rheumatic Diseases; Salicylates

Topics: Cardiomyopathies; Disease; Heart; Heart Diseases; Joint Diseases; Myocardium; Rheumatic Diseases; Salicylates; Sodium Salicylate

Topics: Abdomen; Disease; Gastrointestinal Diseases; Rheumatic Diseases; Salicylates

Topics: Blood Coagulation Factors; Heparin; Humans; Hyaluronoglucosaminidase; In Vitro Techniques; Rheumatic Diseases; Salicylates; Staining and Labeling

Topics: Aminosalicylic Acid; Rheumatic Diseases; Salicylates; Sodium Salicylate

Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Camphor; Humans; Rheumatic Diseases; Salicylates

Topics: Gentisates; Injections; Rheumatic Diseases; Salicylates

Topics: Analgesics; Anthelmintics; Rheumatic Diseases; Salicylates

Topics: Rheumatic Diseases; Salicylates; Salicylic Acid

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Carbohydrate Metabolism; Electrolytes; Humans; Leukocyte Count; Minerals; Rheumatic Diseases; Salicylates; Sodium Salicylate; Uric Acid

Topics: Appendicitis; Focal Infection; Humans; Rheumatic Diseases; Salicylates; Thyroiditis

Topics: Analgesics; Anthelmintics; Humans; Rheumatic Diseases; Salicylates

Topics: Administration, Rectal; Rheumatic Diseases; Salicylamides; Salicylates; Sciatica

Topics: Clinical Laboratory Techniques; Rheumatic Diseases; Salicylates

Topics: Analgesics; General Practice; Humans; Rheumatic Diseases; Salicylates

Topics: Hematology; Hemorrhage; Hemorrhagic Disorders; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Analgesics; Rheumatic Diseases; Salicylamides; Salicylates

Topics: Anthelmintics; Rheumatic Diseases; Salicylamides; Salicylates; Salicylic Acid

Topics: Adrenal Glands; Adrenocorticotropic Hormone; Analgesics; Antirheumatic Agents; Biomedical Research; Eosinophils; Gentisates; Leukocyte Count; Rheumatic Diseases; Salicylates

Topics: Benzamides; Humans; Rheumatic Diseases; Salicylates; Syndrome

Topics: Antirheumatic Agents; Rheumatic Diseases; Salicylates

Topics: Child; Humans; Poisoning; Rheumatic Diseases; Salicylates

Topics: Ascorbic Acid; Neuralgia; Rheumatic Diseases; Salicylates; Succinates; Vitamins

Topics: Copper; Humans; Organometallic Compounds; Rheumatic Diseases; Salicylates; Sodium; Sodium Salicylate

Topics: Humans; IgA Vasculitis; Purpura; Rheumatic Diseases; Salicylates

Topics: Humans; Rheumatic Diseases; Salicylates

Topics: Pantothenic Acid; Rheumatic Diseases; Salicylates

Topics: Adrenocorticotropic Hormone; Cortisone; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Blood Sedimentation; Erythrocytes; Hematologic Tests; Humans; In Vitro Techniques; Research; Rheumatic Diseases; Salicylates; Sodium Salicylate

Topics: Aminosalicylic Acid; Child; Humans; Infant; Rheumatic Diseases; Salicylates; Sodium Salicylate

Topics: Rheumatic Diseases; Salicylates

Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Coal Tar; Cortisone; Humans; Rheumatic Diseases; Salicylates

Topics: Rheumatic Diseases; Salicylates

Topics: Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Analgesics; Humans; Rheumatic Diseases; Salicylates

Topics: Child; Endocarditis; Epiphyses; Humans; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Rheumatic Diseases; Salicylates

Topics: Bridged-Ring Compounds; Cyclohexanes; Rheumatic Diseases; Salicylates

Topics: Administration, Rectal; Rheumatic Diseases; Salicylates

Topics: Rheumatic Diseases; Salicylates

Topics: Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Hematologic Tests; In Vitro Techniques; Research; Rheumatic Diseases; Salicylates; Sodium Salicylate

Topics: Humans; Hydroxybenzoates; Rheumatic Diseases; Salicylates; Salicylic Acid

Topics: 4-Aminobenzoic Acid; Arthritis; Arthritis, Rheumatoid; Rheumatic Diseases; Salicylates

Topics: Hyaluronoglucosaminidase; Rheumatic Diseases; Salicylates; Skin

Topics: Rheumatic Diseases; Salicylates; Sodium Salicylate

Topics: Rheumatic Diseases; Salicylates; Vitamin A; Vitamin K; Vitamins

Topics: Rheumatic Diseases; Salicylates; Sodium Salicylate; Thiamine

Topics: Rheumatic Diseases; Rheumatic Fever; Salicylamides; Salicylates

Topics: Aminosalicylic Acid; Rheumatic Diseases; Salicylates

Topics: Aminosalicylic Acid; Aminosalicylic Acids; Lymph Nodes; Rheumatic Diseases; Salicylates; Tuberculosis; Tuberculosis, Lymph Node

Topics: Blood; Rheumatic Diseases; Salicylates

Topics: Enema; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Rheumatic Diseases; Salicylates

Topics: Hemorrhage; Plasma; Rheumatic Diseases; Salicylates

Topics: Humans; Hyaluronoglucosaminidase; Rheumatic Diseases; Salicylates

Topics: Hyaluronoglucosaminidase; Rheumatic Diseases; Salicylates; Sulfadiazine

Topics: Arthritis; Humans; Rheumatic Diseases; Rheumatic Fever; Salicylates

Topics: Ascorbic Acid; Humans; Rheumatic Diseases; Rheumatic Fever; Salicylates; Vitamin A; Vitamin K; Vitamins

Topics: Ascorbic Acid; Humans; Rheumatic Diseases; Rheumatic Fever; Salicylates; Urine; Vitamin A; Vitamin K; Vitamins