salicylates and Respiration-Disorders

There are limited data on modern intermittent hemodialysis (IHD) efficacy on salicylate elimination from topical poisoning.. A 54-year-old male sought treatment for dyspnea but was then diagnosed with salicylate toxicity from topical application of Dencorub Extra Strength Heat Gel® for 1 week. Each tube contained 100 g with 26 % methylsalicylate (26 g). Laboratory workup was remarkable for an elevated anion gap of 30 and salicylate concentration of 78.7 mg/dL [5.7 mmol/L (N < 0.4 mmol/L)]. Treatment with urinary alkalinization was followed by hemodialysis for 5 h. Extraction ratios were 0.44 with clearance rates of 78.5 mL/min. Salicylate concentrations fell rapidly following initiation of hemodialysis with no rebound observed.. Modern high flux IHD is an effective method of removing salicylates in the treatment of chronic topical poisoning.

Topics: Administration, Cutaneous; Antirheumatic Agents; Drug Overdose; Humans; Male; Middle Aged; Renal Dialysis; Respiration Disorders; Salicylates; Treatment Outcome

Methyl salicylate (oil of wintergreen) in the form of candy flavoring was ingested by a 21-month-old male infant who subsequently developed vomiting, lethargy, and hyperpnea. A "swallow" of the solution resulted in a serum salicylate concentration of 81 mg/dL six hours after ingestion. The infant was treated with parenteral fluids and sodium bicarbonate and he recovered rapidly. Hazards associated with salicylate use in this form include lack of parental awareness of the substance's toxic potential, the attractiveness of the candy-like odor, and the availability of the liquid in non-child-resistant packaging containing potentially lethal quantities.

Topics: Candy; Flavoring Agents; Humans; Infant; Male; Respiration Disorders; Salicylates; Sleep Stages; Vomiting

Topics: Animals; Arachidonic Acids; Cricetinae; Disease Models, Animal; Fibrinolytic Agents; Injections, Intravenous; Lung Diseases; Mice; Rabbits; Respiration Disorders; Salicylates; Thrombosis

Out of 14 cases of poisoning assumed to be due to dextropropoxyphene-containing drugs, propoxyphene and its main metabolite norpropoxyphene could be demonstrated in 11. The concentrations of the drugs were determined shortly after admission and then after 2, 4, 6 and 10 hours (in four cases also after 16 hours). The highest plasma concentration of propoxyphene, 0.74 mug/ml, was found in one case of fatal poisoning. Another patient with a plasma concentration of 0.51 mug/ml showed signs of severe respiratory depression but survived after respirator therapy. In the patients with lower plasma concentrations the poisoning had a benign course. In most cases the plasma concentration of norpropoxyphene exceeded that of propoxyphene even in the first blood sample.

Topics: Acidosis; Acute Disease; Adolescent; Adult; Arrhythmia, Sinus; Aspirin; Barbiturates; Dextropropoxyphene; Drug Combinations; Ethanol; Female; Humans; Male; Middle Aged; Respiration Disorders; Salicylates; Time Factors; Ventricular Fibrillation

Topics: Acetates; Benzoates; Camphor; Expectorants; Humans; Oils; Respiration Disorders; Respiratory System; Respiratory Tract Diseases; Salicylates

Topics: Pleurisy; Respiration Disorders; Salicylates; Sodium Salicylate