salicylates and Psoriasis

Itch is an important, but underestimated symptom in psoriasis. Many therapies are available for pruritus; however, few are effective for psoriatic itch. Antipruritic therapies that are potentially effective in psoriasis include coal tar products, topical corticosteroids, topical salicylates, menthol and pramoxine, capsaicin, phototherapy, vitamin D analogs, topical immunomodulators, methotrexate, oral mirtazapine, and biologics. Using these therapies can benefit psoriasis patients in the outpatient clinical setting.

Topics: Administration, Cutaneous; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipruritics; Capsaicin; Coal Tar; Emollients; Histamine H1 Antagonists; Humans; Immunologic Factors; Immunosuppressive Agents; Keratolytic Agents; Methotrexate; Mianserin; Mirtazapine; Morpholines; Phototherapy; Pruritus; Psoriasis; Quality of Life; Salicylates; Skin Care; Vitamin D

Topics: Administration, Topical; Anti-Inflammatory Agents; Antimetabolites; Aza Compounds; Glucocorticoids; Humans; Hydroxyurea; Methotrexate; Psoriasis; Salicylates; Tars; Uridine

Topics: Aspirin; Erythema; Erythema Multiforme; Humans; Psoriasis; Purpura; Salicylates; Skin Diseases; Urticaria

Topics: Anthracenes; Arsenic; Baths; Glucocorticoids; Humans; Mercury; Methotrexate; Psoriasis; Salicylates; Tars; Ultraviolet Therapy

Dandruff is a common scalp disorder affecting almost half of the post-pubertal population of any ethnicity and both genders. It is one of the major reasons for patients to consult a dermatologist and it is the cause of significant psychological and social distress.. The aim of this open study was to evaluate the benefit of a 4-week treatment with a shampoo containing 0.1% lipohydroxyacid (LHA) and 1.3% salicylic acid on the scalp condition and on the quality of life of 275 volunteers with seborrheic dermatitis (SD) (n = 226) or light-to-moderate scalp psoriasis (SP) (n = 49).. The clinical benefit of the treatment was assessed by scoring the following parameters, i.e., severity of the dermatosis, scaling, itching, excoriations, and superficial burning sensation. The impact on the quality of life was assessed using the Scalpdex, a questionnaire specially developed by Chen et al. for patients with scalp dermatitis, which includes 23 questions regarding the symptoms, functioning and emotions affected by scalp dermatosis.. The shampoo used in this study was well tolerated. After a 4-week treatment, dermatologists noticed a significant clinical improvement of all the scalp parameters evaluated (i.e., the composite lesional score was improved in 91% and 77% of the patients with SD or SP respectively). The symptoms, functioning and emotions scores of quality of life were also significantly improved in relation to the improvement of scalp condition.. This study not only allowed a better understanding of the SD and SP patient's profile but also demonstrated that the shampoo evaluated is a convenient, efficient, safe, and well-tolerated cosmetic treatment of SD and light-to-moderate SP improving greatly the quality of life of the treated patients.

Topics: Administration, Cutaneous; Adult; Chronic Disease; Dermatitis, Seborrheic; Female; Hair Preparations; Humans; Keratolytic Agents; Male; Middle Aged; Psoriasis; Quality of Life; Salicylates; Scalp Dermatoses; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome

Topics: Adolescent; Adult; Betamethasone; Child; Dermatitis, Atopic; Dermatologic Agents; Drug Combinations; Humans; Middle Aged; Ointments; Psoriasis; Remission Induction; Salicylates; Solutions; Time Factors

This double-blind randomized study was designed to compare the efficacy and safety of calcipotriol ointment (50 microg/g) with betamethasone dipropionate (64 mg/g) and salicylic acid (0.03 g/g) ointment in the treatment of nail bed psoriasis. Fifty-eight patients applied the given drug to the affected nails twice a day for 3-5 months, depending on clinical response. Efficacy was assessed monthly on the basis of nail thickness, measured in millimetres. Photographs of the treated nails were taken at baseline, and after 3 and 5 months. Tolerability was assessed at 3 and 5 months. In patients with fingernail psoriasis, after 3 months of treatment subungual hyperkeratosis was reduced from 2.3 +/- 0.1 mm (mean +/- SEM) to 1.5 +/- 0.1 mm (-26.5%) in the calcipotriol group and from 2.3 +/- 0.1 mm to 1.6 +/- 0.1 mm (-30.4%) in the betamethasone dipropionate and salicylic acid group [not significant (NS) between treatments, analysis of variance (ANOVA)]. After 5 months, responders showed a 49.2% reduction in hyperkeratosis in the calcipotriol group (from 2.8 +/- 0.1 mm to 1.4 +/- 0.2 mm) and 51.7% (from 2.1 +/- 0.1 mm to 1.0 +/- 0.1 mm) in the betamethasone dipropionate and salicylic acid group (P < 0.001 from baseline, NS between treatments, ANOVA). In patients with toenail psoriasis, after 3 months of treatment there was an overall reduction in hyperkeratosis from 2.6 +/- 0.1 mm to 2.1 +/- 0.1 mm (-20.1%) in the calcipotriol group and from 3.0 +/- 0.1 mm to 2.3 +/- 0.1 mm (-22. 9%) in the betamethasone dipropionate and salicylic acid group (P < 0.001 from baseline, NS between treatments, ANOVA). By the end of the fifth month there was a 40.7% reduction in hyperkeratosis in the calcipotriol group (from 2.1 +/- 0.1 mm to 1.2 +/- 0.1 mm) and 51.9% in the betamethasone dipropionate and salicylic acid group (from 2.7 +/- 0.1 mm to 1.3 +/- 0.1 mm; P < 0.0001 from baseline, NS between treatments, ANOVA). The results of the study show that calcipotriol is as effective as a combination of a topical steroid with salicylic acid in the treatment of nail psoriasis and represents a safe alternative in the topical treatment of nail psoriasis.

Topics: Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Dermatologic Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Nail Diseases; Ointments; Psoriasis; Salicylates

Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Dermatologic Agents; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Middle Aged; Patient Compliance; Psoriasis; Salicylates; Salicylic Acid; Treatment Outcome

Although cyclosporine has been found to be effective therapy for severe psoriasis, only limited data exist about efficacy and safety during long-term treatment with a low-dose regimen. Furthermore, little is known about the course of psoriasis after drug withdrawal.. Our purpose was to assess the results of long-term therapy with cyclosporine for severe psoriasis with particular regard to efficacy and safety, as well as the disease course after stopping treatment.. A multicenter study of 217 patients treated with 1.25, 2.5, or 5.0 mg/kg per day of cyclosporine was performed. Duration of treatment ranged from 6 to 30 months followed by a posttreatment period of 3 months. Efficacy was assessed by the Psoriasis Area and Severity Index and safety was monitored by clinical and laboratory investigations.. Patients with severe psoriasis showing a reduction in the Psoriasis Area and Severity Index of 75% with their individual dose of cyclosporine maintained clinical improvement during continuous maintenance therapy. Newly occurring side effects were less frequent during the maintenance phase than in the induction phase. After withdrawal of cyclosporine, worsening of psoriasis requiring antipsoriatic therapy was seen in about half of the patients.. Cyclosporine is effective for long-term therapy for severe psoriasis and does not lead to severe deterioration of the disease after drug withdrawal.

Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Creatinine; Cyclosporine; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Ointments; Psoriasis; Recurrence; Safety; Salicylates; Salicylic Acid; Time Factors; Triglycerides

Topics: Administration, Topical; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Dermatologic Agents; Drug Therapy, Combination; Glucocorticoids; Humans; Psoriasis; Salicylates; Salicylic Acid

Fifty patients having psoriasis were studied with a view to assess the efficacy of 'puvasol' (Oral psoralen with sun-rays exposure) alone and in combination with topical tar therapy and were placed in 2 groups, each group being consisted of 25 patients. At the end of 8 weeks, out of 25 patients (Group 1) receiving 'Puvasol' in combination with topital tar therapy 15 patients (60%) showed complete clearance, marked improvement of lesions were seen in 4 cases (16%) and deterioration in one case (4%). Out of 25 patients (Group I) receiving 'Puvasol' alone 8 cases (32%) showed complete clearance of lesions and 11 patients (44%) showed marked im-provement of lesions. It is found that topical tar therapy when used as an adjunct to 'Puvasol' was more effective than 'Puvasol' alone.

Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Chemotherapy, Adjuvant; Coal Tar; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Psoriasis; PUVA Therapy; Salicylates; Severity of Illness Index; Treatment Outcome

Salicylic acid has been widely used in the topical treatment of psoriasis. Chemically it is closely related to paraaminobenzoic acid. Following in vitro studies indicating that salicylic acid might exhibit relevant UVB absorption, we found that salicylic acid had a clinically pronounced filter effect when applied prior to UVB exposure. The duration of photoprotection after application was more than 12 h, sometimes exceeding 24 h. In a prospective, randomized, double-blind, left-right comparison study in patients with psoriasis between emollients with and without salicylic acid, salicylic acid was shown to decrease the clearing rate significantly.

Topics: Administration, Cutaneous; Adult; Aged; Chronic Disease; Double-Blind Method; Emollients; Erythema; Female; Humans; Infant, Newborn; Male; Middle Aged; Prospective Studies; Psoriasis; Salicylates; Salicylic Acid; Ultraviolet Therapy

Topics: Administration, Topical; Drug Evaluation; Emollients; Erythema; Humans; Ointment Bases; Psoriasis; Salicylates; Salicylic Acid; Ultraviolet Therapy

Psoriasis is difficult to manage in general practice, mainly because the standard treatments produce side effects, or are ineffective in both the short and long term. In recent years, the main topical therapies have included extracts of coal tar or dithranol. In a six-week within-patient trial, 23 patients applied two different treatments to the left and right halves of their bodies. A new preparation (Psorin, Thames Laboratories), containing relatively low concentrations of dithranol and crude coal tar, was significantly more effective and more acceptable than a refined alcoholic extract of coal tar with allantoin (Alphosyl, Stafford Miller Ltd).

Topics: Adolescent; Adult; Aged; Allantoin; Anthralin; Coal Tar; Dermatologic Agents; Drug Combinations; Drug Evaluation; Female; Humans; Male; Middle Aged; Psoriasis; Random Allocation; Salicylates

The relevance of salicylic acid in dithranol creams was evaluated in a double-blind study. Patients with chronic plaque psoriasis were treated using a short-contact schedule for dithranol on an outpatient basis. A left-right comparison was carried out between sites treated with either dithranol with 2% salicylic acid (D + S) or dithranol in the same base without salicylic acid (D-S). Clinical results were evaluated once a week using the psoriasis area severity index. In order to quantify the improvement, flow cytometric measurements were done using the monoclonal antibody Ks8.12, recognizing keratin 16 in normal and lesional epidermis. Simultaneously, relative DNA content was quantified which previously was described as a useful method to monitor a therapeutic effect. Both PASI scores and Ks8.12 binding decreased after 6 weeks treatment with D + S and D-S. However, percentages of cells in SG2M phases did not show a significant change. No significant difference was observed between sites treated with either D + S or D-S. Therefore we conclude that the addition of salicylic acid in a concentration of 2% does not enhance the efficacy of dithranol creams and we confirm that Ks8.12 is a useful quantitative marker for therapeutic efficacy.

Topics: Adolescent; Adult; Anthralin; DNA; Double-Blind Method; Erythema; Female; Flow Cytometry; Humans; Keratins; Male; Middle Aged; Ointments; Psoriasis; Randomized Controlled Trials as Topic; Salicylates; Salicylic Acid; Skin

Efficacy and tolerance of an alcoholic solution containing 0.64 mg betamethasone-dipropionate plus 20 mg salicylic acid (Diprosalic Solution) were compared with an alcoholic solution containing 0,64 mg betamethasone-dipropionate in a 3 week double blind study in 100 patients with psoriasis and other steroid-responsive dermatoses of dry nature, comprising scalp and other hairy and non-hairy areas of the body. This double blind study was followed by a 3 week open study in another 100 patients with similar diagnosis, using Diprosalic Solution only. Although the therapeutic results of the double blind study showed no significant differences between both treatment groups, distinct advantages of the drug containing salicylic acid could be clearly demonstrated, such as: 1. More rapid onset of action, 2. rapid clearing of scaling, pruritus and inflammation, 3. these advantages are in compliance with the fact that topically applied salicylic acid softens keratin, loosens cornified epithelium and desquamates the epidermis, making the underlying layers more accessible to the antiinflammatory steroid.

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Clinical Trials as Topic; Dermatitis; Dermatitis, Seborrheic; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Eczema; Female; Glucocorticoids; Humans; Male; Middle Aged; Psoriasis; Salicylates; Salicylic Acid

Forty adult out-patients with erythematous squamous dermatoses of the scalp were treated in this 21-day double-blind study with an alcohol base lotion containing either 0.05% betamethasone-17,21-dipropionate, 2% salicylic acid, 0.05% betamethasone-17,21-dipropionate + 2% salicylic acid or their respective placebo. The four treatments were assigned randomly to the patients according to a 2 x 2 orthogonal factorial design. Changes in severity of redness, scaling, pruritus and size of lesions were evaluated. Since very few patients presented with excoriation and lichenification, these symptoms could not be ascertained. Results were assessed for significance by covariance analysis where initial status was used as regressor. A potentiation of the betamethasone-17,21-dipropionate activity by salicylic acid was observed for scaling. An additive effect was noted for redness and pruritus. According to the physician's global evaluation, patients treated with the combination drug showed a better evolution than those treated with placebo. The results suggest that addition of a keratolytic agent enhances the corticosteroid effect in the treatment of erythematous squamous dermatoses.

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Betamethasone; Drug Combinations; Drug Evaluation; Drug Interactions; Drug Synergism; Female; Glucocorticoids; Humans; Male; Middle Aged; Psoriasis; Salicylates; Salicylic Acid; Scalp Dermatoses

Topics: Adrenal Cortex Hormones; Adult; Clinical Trials as Topic; Dermatitis; Drug Combinations; Eczema; Female; Flumethasone; Humans; Male; Middle Aged; Psoriasis; Salicylates; Skin Diseases

A double-blind, multiclinic, parallel, controlled study was conducted to compare the efficacy of two coal tar over-the-counter products, Oxipor VHC lotion and Tegrin lotion. The pooled analysis showed that both left and right sides of the body were comparable with respect to the initial severity of all clinical parameters including scaling, erythema, pruritus, crusting, and lesion elevations. Both test medications improved clinical symptoms significantly, but Oxipor VHC lotion was superior to Tegrin lotion in all clinical variables with the exception of crusting. Oxipor VHC was also significantly superior to Tegrin in terms of physicians' and patients' overall assessments.

Topics: Allantoin; Benzocaine; Clinical Trials as Topic; Coal Tar; Drug Combinations; Humans; Polysorbates; Psoriasis; Salicylates

A double-blind comparison was made between Diprosalic and Dermovate lotions in fifty-one patients with psoriasis of the scalp. Both preparations were highly effective. No significant difference in efficacy between the preparations could be demonstrated after 3 weeks treatment except for antipruritic effect, in this respect Diprosalic being superior to Dermovate. Only three patients (two in the Dermovate group, and one in the Diprosalic group) experienced minor adverse reactions. Plasma cortisol levels were determined in seventeen of the patients and no significant influence on the adrenal function could be shown on the part of either of the preparations.

Topics: Anti-Inflammatory Agents; Betamethasone; Clobetasol; Drug Evaluation; Female; Humans; Hydrocortisone; Male; Psoriasis; Salicylates; Scalp Dermatoses; Suspensions

Topics: Adolescent; Adult; Aged; Anthracenes; Anthralin; Chronic Disease; Clinical Trials as Topic; Coal Tar; Drug Combinations; Female; Humans; Male; Middle Aged; Ointments; Psoriasis; Salicylates; Salicylic Acid; Urea

In an open study, 38 patients suffering from psoriasis of the scalp with various degrees of severity and duration, were treated for 4 weeks with a lotion containing 0.05% betamethasone 17, 21-dipropionate and 2% salicylic acid in a paraben-free vehicle containing isopropyl alcohol. The results showed agreement between the overall evaluation of response by patients and the physician using a 60 mm visual scale analogue. Marked relief of symptoms appeared after 1 week of treatment while clinical improvement appeared after 2 weeks. Slight degree of induration was present in 1 patient after 4 weeks of treatment, while 8 patients showed slight degree of scaling. After 2 weeks, excoriation disappeared in all the patients treated. Overall tolerance and cosmetic acceptability of the preparation were good.

Topics: Adolescent; Adult; Aged; Betamethasone; Clinical Trials as Topic; Dermatologic Agents; Drug Combinations; Female; Humans; Male; Middle Aged; Psoriasis; Salicylates; Salicylic Acid; Scalp Dermatoses; Time Factors

Three conventional treatments of scalp psoriasis were compared in a randomized, blind, uncontrolled clinical trial in 30 patients at a psoriasis day-care centre. Triple gel (the sequential application of Keralyt, Estar, and Topsyn gels), 10 percent salicylic acid in Sofsyn oil, and 10 percent salicylic acid in mineral oil were compared. There were no statistically significant differences among the three treatments in terms of clinical efficacy. Therefore, on the basis of lowest cost and highest patient acceptance, 10 percent salicylic acid in mineral oil is the preferred treatment.

Topics: Adult; Aged; Coal Tar; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Female; Fluocinonide; Gels; Humans; Male; Middle Aged; Mineral Oil; Polysorbates; Propylene Glycols; Psoriasis; Random Allocation; Salicylates

The percutaneous absorption of betamethasone-17, 21-dipropionate and salicylic acid was studied after one and two weeks' treatment of psoriaris and eczema. The treated areas varied between 8 and 41 dm2. No change in the plasma cortisol levels was detectable by the routinely used laboratory method. The treatment gave no detectable salicylate concentrations in plasma.

Topics: Administration, Topical; Adolescent; Adult; Aged; Betamethasone; Clinical Trials as Topic; Eczema; Female; Humans; Hydrocortisone; Male; Middle Aged; Psoriasis; Salicylates; Skin Absorption; Time Factors

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Trials as Topic; Dermatitis; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Ointments; Pregnadienetriols; Psoriasis; Salicylates

The potential hazards of repeated topical application of salicylic acid under occlusion to large areas of the body was evaluated by measuring the percutaneous absorption and serum salicylate concentrations in four patients with active psoriasis. Serum salicylate concentrations never exceeded 5 mg/100 ml in any of the patients, and although greater than 60 percent of the salicylic acid applied was absorbed, no evidence of accumulation or toxicity was observed. This form of treatment appears to present little potential hazard even in patients with extensive skin disease. Therapy could be hazardous for patients with impaired hepatic or renal function or for smaller children. The urinary excretory products of salicylate metabolism were compared following topical and intravenous salicylate administration to determine if the skin plays any part in the biotransformation of salicylate during percutaneous absorption. Our data are too limited and inconclusive to answer this question.

Topics: Administration, Topical; Clinical Trials as Topic; Creatinine; Humans; Injections, Intravenous; Occlusive Dressings; Psoriasis; Salicylates; Skin Absorption

Topics: 17-Hydroxycorticosteroids; Adolescent; Adult; Child; Clinical Trials as Topic; Coal Tar; Female; Humans; Male; Middle Aged; Occlusive Dressings; Ointments; Psoriasis; Salicylates

Topics: Anthracenes; Anti-Infective Agents, Local; Antifungal Agents; Chemistry, Pharmaceutical; Drug Interactions; Drug Synergism; Evaluation Studies as Topic; Humans; Oxides; Pharmaceutical Vehicles; Psoriasis; Salicylates; Zinc

Topics: Anthracenes; Benzoates; Chloroform; Color; Humans; Ointments; Oxides; Paraffin; Pharmaceutic Aids; Psoriasis; Salicylates; Solutions; Starch; Zinc

Topics: Baths; Epithelium; Humans; Mineral Oil; Psoriasis; Salicylates; Tars; Time Factors

Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity, limit their use and patient compliance. Development of retinoid analogues with minimal AEs would allow a broader and more compliant use.. To synthesise a novel molecule, bakuchiol salicylate (bakusylan), with a modulatory gene expression profile similar to retinoids, using as reference three prescription retinoids: tretinoin, tazarotene and adapalene.. We hypothesized that because bakuchiol salicylate has a structure entirely different from existing retinoids, there would be at least a partial uncoupling of AEs from the skin-normalizing activity of this retinoid. This hypothesis was tested at the transcriptional level in psoriatic cytokine-treated cultures of keratinocytes and organotypic skin substitutes, using DNA microarrays and custom PCR arrays.. Evaluation of the gene expression profile of bakuchiol salicylate revealed elimination of several components of the retinoid-like proinflammatory response and teratogenic signature, without a substantial loss of normalizing potential. A possible mechanism of action, consisting of keratinocyte desensitization to psoriatic cytokine signalling through inhibition of the signal transducer and regulator of transcription (STAT)1/3/interferon inflammatory signal transduction axis was also identified.. Bipartite materials obtained by merging two skin-active entities with specific, complementary bioactivities, such as bakuchiol and salicylic acid, may yield a new class of functional retinoids.

Topics: Cells, Cultured; Cytokines; Gene Expression; Gene Expression Profiling; Humans; Keratinocytes; Oligonucleotide Array Sequence Analysis; Phenols; Polymerase Chain Reaction; Psoriasis; Retinoids; Salicylates; Skin, Artificial

Thermal imaging has been utilised, both preclinically and clinically, as a tool for assessing inflammation. Psoriasis is a chronic inflammatory skin disease characterised by hyperkeratosis, dermal inflammatory infiltrate and increased angiogenesis. The aim of the present study was to assess the usefulness of thermography in psoriatic lesion regression after topical treatment with bee propolis, recognised as potent antioxidants and anti-inflammatory agents.. We monitored the inflammation process induced by irritants such as n-Hexyl salycilate (HXS) or Di-n-Propyl Disulfide (PPD) by histopatological assessment of the skin, thermographic scanning, total number of inflammatory cells in the peritoneal cavity, differential analysis of cells in the peritoneal cavity, macrophage spreading index, haematological and biochemical parameters, frequencies of micronucleated reticulocytes, lipid peroxidation and glutathione assay in the skin.. Topically applied ethanolic extract of propolis (EEP) with HXS or PPD reduced the lipid peroxidation in the skin and total number of inflammatory cells in the skin and peritoneal cavity, functional activity of macrophages, the number of micronuclei in mouse peripheral blood reticulocytes and enzymatic activity of ALP and AST.. These results demonstrate that topical application of EEP may improve psoriatic-like skin lesions by suppressing functional activity of macrophages and ROS production. Taken together, it is suggested that EEP can safely be utilised in the prevention of psoriasis-related inflammatory changes without causing any toxic effect.

Topics: Animals; Anti-Infective Agents; Antioxidants; Disulfides; Drug Evaluation, Preclinical; Glutathione; Lipid Peroxidation; Macrophages; Male; Mice; Micronucleus Tests; Oxidative Stress; Peritonitis; Propolis; Psoriasis; Salicylates; Thermography

(1) Plaque psoriasis is the most common form of psoriasis in children. Topical agents should be tried first, especially well-tolerated products such as emollients. Topical corticosteroids are sometimes useful during exacerbations but, given adverse effects, they should only be used for short periods; (2) UVB phototherapy is an option for extensive psoriasis refractory to local treatments, but it carries a long-term risk of skin cancer. Immunosuppressants have not been well assessed in this setting, but methotrexate has been better evaluated than the others.

Topics: Acitretin; Administration, Topical; Anthralin; Calcitriol; Child; Cyclosporine; Dermatologic Agents; Emollients; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Methotrexate; Nicotinic Acids; Plant Extracts; Psoriasis; Receptors, Tumor Necrosis Factor; Salicylates; Steroids; Tars; Treatment Outcome; Ultraviolet Therapy

Avarol is a marine sesquiterpenoid hydroquinone with anti-inflammatory and antipsoriatic properties. The aim of this study was to evaluate the in vitro and in vivo pharmacological behaviour of the derivative avarol-3'-thiosalicylate (TA) on some inflammatory parameters related to the pathogenesis of psoriasis.. Human neutrophils and monocytes as well as the human keratinocyte cell line HaCaT were used to study the effect of TA on oxidative stress, the arachidonic acid pathway, tumour necrosis factor-alpha (TNF-alpha) release and nuclear factor-kappaB (NF-kappaB) activation. All these parameters were also determined in vivo using the zymosan induced mouse air pouch model and the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced mouse epidermal hyperplasia model.. TA showed antioxidant properties in human neutrophils and in the hypoxanthine/xanthine oxidase assay. This compound reduced, in a concentration-dependent manner, leukotriene B(4), prostaglandin E(2) and TNF-alpha production in activated leukocytes. Oral and intrapouch administration of TA in the mouse air pouch model produced a dose-dependent reduction of all these inflammatory mediators. TA also inhibited secretory phospholipase A(2) activity and NF-kappaB DNA-binding in HaCaT keratinocytes. In TPA-induced mouse epidermal hyperplasia, topical administration of TA reduced oedema, leukocyte infiltration, eicosanoid levels and TNF-alpha in skin. In addition, interleukin (IL)-1beta and IL-2 production were also inhibited. Finally, TA was also capable of suppressing NF-kappaB nuclear translocation in vivo.. TA inhibited several key biomarkers up-regulated in the inflammatory response of psoriatic skin and this compound could be a promising antipsoriatic agent.

Topics: Animals; Antioxidants; Arachidonic Acid; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Hyperplasia; Inflammation Mediators; Keratinocytes; Mice; Monocytes; Neutrophils; NF-kappa B; Oxidative Stress; Protein Transport; Psoriasis; Salicylates; Sesquiterpenes; Tumor Necrosis Factor-alpha

We present an interesting case of salicylism arising from the use of methyl salicylate as part of a herbal skin cream for the treatment of psoriasis. A 40-year-old man became quite suddenly and acutely unwell after receiving treatment from an unregistered naturopath. Methyl salicylate (Oil of Wintergreen) is widely available in many over the counter topical analgesic preparations and Chinese medicated oils. Transcutaneous absorption of the methyl salicylate was enhanced in this case due to the abnormal areas of skin and use of an occlusive dressing. The presence of tinnitus, vomiting, tachypnoea and typical acid/base disturbance allowed a diagnosis of salicylate toxicity to be made. Our patient had decontaminated his skin prior to presentation, limiting the extent of toxicity and was successfully treated with rehydration and establishment of good urine flow.

Topics: Adult; Herbal Medicine; Humans; Male; Psoriasis; Salicylates; Skin Absorption

Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; HIV Infections; Humans; Male; Psoriasis; Salicylates; Skin Absorption

Whereas cochlear impairment after intravenous ingestions of salicylates is well known, reports of cochlear symptoms after topical application are quite rare. The extent of the ototoxic salicylate impact is increased by diabetes, renal insufficiency, and alcoholism.. This study presents a case report of a female patient who suffered a repeated, symmetric, pancochlear, reversible inner ear impairment after two treatments with salicylate containing ointment for psoriasis. The correlation of the salicylate therapy with the observed inner ear lesions is obvious due to the close interval between these incidences and to the audiologic criteria typical for salicylate intoxication.. Audiologic controls should be carried out during extended local application of salicylate containing ointment.

Topics: Adult; Audiometry, Pure-Tone; Auditory Threshold; Female; Hearing Loss, Sensorineural; Humans; Keratolytic Agents; Nystagmus, Physiologic; Ointments; Otoacoustic Emissions, Spontaneous; Psoriasis; Salicylates; Salicylic Acid; Tinnitus

A 36-year-old woman, hospitalized because of an exacerbation of psoriasis, developed fever, sudden deafness and severe metabolic acidosis after treatment with a 10% salicylic acid containing ointment for four days. The use of salicylic acid on large areas of inflamed skin enhances the risk of transcutaneous resorption and intoxication. High serum concentrations (> 300 mg/l) of salicylic acid deregulate the blood glucose metabolism and cause damage to the inner ear. After timely intervention such symptoms are largely reversible.

Topics: Acute Disease; Adult; Female; Hearing Loss, Sensorineural; Humans; Keratolytic Agents; Ointments; Psoriasis; Salicylates

Topical preparations are sometimes applied before phototherapy without consideration of their potential to block UVB.. Our purpose was to examine the ability of topical preparations to block UVB.. Volunteers pretreated with mineral oil, a clear liquid emollient, 5% crude coal tar, 6% salicylic acid ointment, emollient creams, and petrolatum underwent minimal erythema dose testing. Transmission of UVB through a clear film coated with the preparations was measured.. Tars and salicylic acid blocked UVB. Thick application of petrolatum and emollient creams can reduce transmission of UVB. Mineral oil and a clear liquid emollient did not significantly affect transmission or erythemogenicity of UVB.. Clear liquid emollient and mineral oil can be used before phototherapy. If not removed before phototherapy, preparations containing tar or salicylic acid, or thickly applied petrolatum or emollients, can block UVB and presumably reduce its efficacy in the treatment of psoriasis.

Topics: Administration, Cutaneous; Adolescent; Adult; Coal Tar; Emollients; Erythema; Humans; Lipids; Mineral Oil; Ointment Bases; Ointments; Petrolatum; Psoriasis; Salicylates; Salicylic Acid; Ultraviolet Rays; Ultraviolet Therapy

To evaluate the efficacy of ultraviolet B (UVB) phototherapy for the treatment of psoriasis in patients infected with human immunodeficiency virus (HIV), the response of 14 patients was compared to that of matched seronegative control individuals. All patients were evaluated prior to treatment (baseline) and after 21 treatments for the extent of total body surface area (TBSA) involvement and the quantification of scale, erythema, and thickness of plaques using a scale of 0 (absent) to 4 (severe). The only concomitant medication allowed was salicylic acid in petrolatum. The cumulative score for scale, erythema, and thickness improved 1.9 +/- 0.5 [mean +/- standard error of mean (SEM)] in the HIV group and 2.4 +/- 0.3 in controls. There was 40.9 +/- 7.3% reduction of TBSA involvement in the former and 38.4 +/- 7.6% reduction in the latter group. None of the differences was statistically significant. There was no statistically significant difference in the response to therapy among various stages of immunosuppression in the HIV group. There was also no deterioration of immune status in this group. UVB phototherapy is an effective treatment for psoriasis in patients infected with HIV. The response is identical to that of matched control individuals.

Topics: Administration, Cutaneous; Adult; Antiviral Agents; Body Surface Area; Case-Control Studies; CD4 Lymphocyte Count; Dermatitis, Exfoliative; Erythema; HIV Infections; HIV Seronegativity; Humans; Immunocompromised Host; Keratolytic Agents; Male; Psoriasis; Salicylates; Salicylic Acid; Ultraviolet Rays; Ultraviolet Therapy; Zidovudine

Involvement of various cytokines in psoriasis pathomechanisms has previously been reported.. To better define the relationship between the disease severity and interleukin-6 and tumour necrosis factor alpha skin levels, these two cytokines were measured in suction blister fluids obtained from involved and uninvolved skin areas of psoriatic patients treated with UVB, beta-methasone dipropionate and salicylic acid ointment.. Determinations were performed by ELISA in fluids obtained from 6 patients with the Kiistala method, every 1-2 weeks for at least 1 month.. During the observation period, all the patients showed disease improvement (median PASI score declined from 13.4 to 3.9) and significant decreases in the cytokine levels in all samples.. These results are in agreement with a functional involvement of these two cytokines in the pathogenesis of the disease and their possible use as follow-up markers.

Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Betamethasone; Blister; Combined Modality Therapy; Exudates and Transudates; Female; Follow-Up Studies; Glucocorticoids; Humans; Interleukin-6; Middle Aged; Ointments; Psoriasis; Salicylates; Salicylic Acid; Skin; Tumor Necrosis Factor-alpha; Ultraviolet Therapy

Topics: Adult; Aged; Aged, 80 and over; Betamethasone; Biomarkers; Combined Modality Therapy; Female; Humans; Interleukin-6; Middle Aged; Psoriasis; Salicylates; Salicylic Acid; Severity of Illness Index; Ultraviolet Therapy

Topics: Administration, Topical; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemia; Male; Psoriasis; Salicylates; Salicylic Acid

Topics: Adult; Contusions; Cyclosporine; Drug Combinations; Humans; Hyperemia; Male; Niacin; Ointments; Psoriasis; Salicylates; Skin

The authors describe a therapeutically well managed case of severe salicylate intoxication in a patient with psoriasis who treated himself with 40 percent salicylic ointment applied to approximately 41 percent of his body surface. Nineteen hours after the application of salicylic acid, his blood level of the agent was 6.04 mmol/liter. The patient underwent hemodialysis and was discharged after fourteen days in good general health.

Topics: Administration, Cutaneous; Adult; Drug Overdose; Humans; Male; Medication Errors; Ointments; Psoriasis; Renal Dialysis; Salicylates

We describe a case of severe refractory hypoglycemia secondary to topical salicylate intoxication. A 72-year-old man with psoriasis and end-stage renal disease was treated with a topical cream containing 10% salicylic acid. The patient presented with encephalopathy and subsequently developed hypoglycemia refractory to infusions of large amounts of glucose. A serum salicylate concentration was elevated at 3.2 mmol/L. Emergent hemodialysis was accompanied by rapid lowering of serum salicylate concentration and resolution of refractory hypoglycemia. Salicylate is well absorbed across normal and diseased skin. Salicylate markedly impairs gluconeogenesis and increases glucose utilization, resulting in hypoglycemia. To our knowledge, this is the first article on hypoglycemia due to the application of topical salicylate.

Topics: Administration, Cutaneous; Aged; Confusion; Gluconeogenesis; Humans; Hypoglycemia; Kidney Failure, Chronic; Male; Occlusive Dressings; Ointments; Psoriasis; Salicylates; Salicylic Acid; Skin Absorption

A young man with Becker's melanosis developed typical guttate psoriasis following an attack of tonsillitis. The psoriatic lesions spared the area of melanosis, suggesting that there may be local factors within an area of Becker's melanosis which inhibit the development of psoriasis.

Topics: Adolescent; Humans; Male; Melanosis; Psoriasis; Salicylates

Topics: Humans; Psoriasis; Salicylates; Salicylic Acid; Sunlight; Ultraviolet Rays

Water content of the epidermis was measured before and after a 3-h , 4-day, and 10-day treatment using 10% salicylic acid or 10% carbamide ointment. The measurement was performed using the Corneometer CM 420 from the firm "Schwarzhaupt Medizintechnik GmbH". Salicylic acid ointment was applied on one and carbamide ointment on the other back of the hand. Neither salicylic acid nor carbamide seem to influence significantly the water content of the healthy epidermis. In two patients with more severe hyperkeratosis carbamide increased the water content more than salicylic acid did.

Topics: Administration, Topical; Adult; Body Water; Dermatologic Agents; Female; Hand Dermatoses; Humans; Ichthyosis; Keratolytic Agents; Keratosis; Male; Psoriasis; Salicylates; Salicylic Acid; Skin; Urea

Topics: Dermatologic Agents; Drug Compounding; Emollients; Humans; Pharmaceutical Vehicles; Psoriasis; Salicylates; Salicylic Acid

Topics: Adenosine Triphosphatases; Animals; Anthralin; Coal Tar; Langerhans Cells; Mice; Mice, Inbred BALB C; Psoriasis; Pyrogallol; Salicylates; Salicylic Acid

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Child; Dexamethasone; Drug Combinations; Eczema; Female; Glucocorticoids; Humans; Male; Middle Aged; Ointments; Psoriasis; Salicylates

Topics: Administration, Topical; Anthralin; Humans; Indomethacin; Psoriasis; Salicylates; Salicylic Acid

Topics: Administration, Topical; Dermatitis; Dermatitis, Exfoliative; Drug-Related Side Effects and Adverse Reactions; Hexachlorocyclohexane; Humans; Mutagenicity Tests; Pharmaceutical Preparations; Psoriasis; Risk; Salicylates; Skin; Time Factors

One hundred and four patients with psoriasis, treated in regimen of Day Hospital, have been examined. The diagnosis was widespread plaque type psoriasis (67.3%), guttate psoriasis (18.3%) and nail psoriasis (1.0%). Furthermore psoriatic erythroderma has been observed in 2.9% and pustular psoriasis of Barber in 1.9%. 10% of the patients showed psoriatic arthritis. 71.2% of the patients have been successfully treated with UVB and PUVA irradiation therapy (respectively 86.6% and 70.0% of complete clearing or marked improvement). Etretinate and topical therapy were successful (respectively 67.0% and 70.0% of complete clearing or marked improvement). Day Hospital has proved to be the ideal regimen for the treatment and control of psoriatic patients.

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Benzenesulfonates; Child; Child, Preschool; Coal Tar; Day Care, Medical; Etretinate; Female; Glucocorticoids; Humans; Male; Middle Aged; Ointments; Psoriasis; PUVA Therapy; Salicylates; Ultraviolet Therapy

Topics: Drug Combinations; Humans; Propylene Glycols; Psoriasis; Salicylates; Scalp Dermatoses; Skin Absorption

The combination of different antipsoriatics or treatment regimens should increase the therapeutic effect and reduce the adverse reactions. The combination of dithranol and tar (cignolin-salicyl-vaseline + tar, CSVT) reduces dithranol erythema and increases the antipsoriatic effect. CSVT treatment is highly effective, but patients tend to accept it less than other treatment regimens. On the other hand, Goeckerman therapy (tar + UV irradiation) is more accepted but less effective. Combinations of dithranol with UV irradiation or with tar and UV irradiation (Ingram regimen) are not advantageous. Dithranol and Goeckerman therapy are relatively secure treatment regimens, as they have been applied for more than 50 years without knowledge of significant late defects. PUVA therapy, although highly effective, is not superior to dithranol therapy. Even though PUVA therapy is more easily accepted than dithranol treatment, PUVA therapy should be applied only in severe cases. The combinations of aromatic retinoid with (selective) UVB irradiation (ReSUP) or with PUVA therapy (RePUVA) are highly effective. Retinoids can reduce the UV doses and most likely limit the risk of late damage. For routine treatment, ReSUP is preferable to RePUVA therapy.

Topics: Anthracenes; Anthralin; Combined Modality Therapy; Drug Therapy, Combination; Glucocorticoids; Humans; Psoriasis; PUVA Therapy; Retinoids; Risk; Salicylates; Salicylic Acid; Tars; Ultraviolet Therapy

A total of 315 psoriasis patients were treated on the basis of short-contact "minutes" therapy: 230 with 0.1-3% dithranol-2% salicylic acid-white soft vaseline (DSV) for 10-20 min daily; 85 patients in left-right comparison with modified therapeutic schemes. The object was to study the influence of concentration, contact time, psoriasis type, self-treatment at home, frequency of application, ointment base, and the admixture of corticosteroids on the efficacy of "minutes therapy." The clearing quotient for the individual psoriasis types was varied; it reached on an average 75% with a treatment period of 29.4 days. Even lower dithranol concentrations below 1% proved efficacious with part of the patients. Self-treatment at home and irregular applications diminished the efficacy. Neither prolongation of the contact time to 1 hr nor the addition of corticosteroids to dithranol did anything to improve the therapy results. The relapse-free period averaged 3.9 months. Undesirable irritation was avoided to a great extent by adjustment of the treatment intensity to individual tolerances. The simultaneous application of dithranol and corticosteroids did not hinder or diminish the dithranol erythema. For additional safety, a preliminary test treatment can be confined to a limited area for 1 week. Fortunately, the staining due to dithranol brown can be reliably removed from certain textiles and from the bath tub or shower cabin by the use of hypochlorite.

Topics: Anthracenes; Anthralin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Glucocorticoids; Humans; Petrolatum; Psoriasis; Recurrence; Salicylates; Salicylic Acid

The effect of ultraviolet-A (UV-A) irradiation in combination with 'short contact' dithranol treatment was studied in ten patients with chronic plaque psoriasis. Increasing concentrations of dithranol were applied daily to the psoriatic plaques on both sides of the body. One side was irradiated with UV-A daily. There was no difference in the rate of clearance between the two sides. The effectiveness of 'short contact' dithranol was confirmed.

Topics: Adolescent; Adult; Anthracenes; Anthralin; Chronic Disease; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Middle Aged; Psoriasis; Salicylates; Ultraviolet Therapy

Addition of crude coal tar to the standard therapy in Cologne since 1937 - dithranol and salicylic acid in white petrolatum - reveals less cutaneous irritation; the duration of therapy is shortened.

Topics: Adolescent; Adult; Anthracenes; Anthralin; Coal Tar; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Petrolatum; Psoriasis; Salicylates; Salicylic Acid; Skin

The initial stimulation of DNA-synthesis after application of dithranol as single agent is completely inhibited by addition of tar. The autoradiographic analyse indicates that the good clinical effect of the new antipsoriatic therapy with TCSV may be due to suppression of dithranol-caused irritation by tar. But, restored cytokinetic values do not correspond to clinical remission of psoriasis.

Topics: Adolescent; Adult; Anthracenes; Anthralin; Autoradiography; Drug Combinations; Female; Humans; Kinetics; Male; Middle Aged; Petrolatum; Psoriasis; Salicylates; Tars

As shown in bilateral comparison studies addition of crude coal tar (T) to standard antipsoriatic therapy with dithranol and salicylic acid in white petrolatum (CVS) diminished the dithranol-irritation; consequently, accelerated application of increasing dithranol-concentrations shortened the duration of TCSV -therapy.

Topics: Adult; Anthracenes; Anthralin; Coal Tar; Dermatologic Agents; Drug Combinations; Female; Humans; Male; Petrolatum; Psoriasis; Salicylates; Wound Healing

Topics: Anthracenes; Anthralin; Coal Tar; Dermatologic Agents; Dose-Response Relationship, Drug; Drug Combinations; Erythema; Humans; Male; Petrolatum; Psoriasis; Salicylates

Eight known antipsoriatic drugs of diverse structures were tested on the basis of their structural similarity with arachidonic acid and known inhibitors of lipoxygenase. A correlation was observed between their antipsoriatic activity and lipoxygenase inhibition suggesting that a common underlying mechanism of action might be involved.

Topics: Anthralin; Arachidonate Lipoxygenases; Etretinate; Glycine max; Lipoxygenase Inhibitors; Mycophenolic Acid; Psoriasis; Resorcinols; Salicylates; Tretinoin

Topics: Anthralin; Etretinate; Humans; Methotrexate; Psoriasis; PUVA Therapy; Salicylates

A multicentric open study was conducted to evaluate the efficacy and safety of betamethasone dipropionate and salicylic acid lotion in 86 patients with psoriasis or other steroid-responsive dermatoses of nonscalp body areas. Medication was applied to affected areas for 14 to 31 days. Patients were evaluated weekly. Within 14 to 21 days of therapy, there were favorable results in 68/86 (79%) patients. A complete clearing or marked improvement of signs and symptoms was achieved in 78/86 (91%) patients; improvement occurred in 7/86 (8%). Treatment failed in one (1%) patient. Three transient adverse reactions were reported.

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Child; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Eczema; Female; Glucocorticoids; Humans; Male; Middle Aged; Psoriasis; Salicylates; Salicylic Acid; Skin Diseases

Topics: Anthracenes; Anthralin; Chemistry, Pharmaceutical; Humans; Paraffin; Psoriasis; Salicylates; Salicylic Acid; Solvents; Starch; Zinc Oxide

The topical treatment of active chronic psoriasis can be achieved as effectively with 0,1% dithranol + 17% urea as with triamcinolone acetonite 0,1%. Compared with salicylic acid + dithranol preparations, the latter when combined with urea show a delayed clinical response, but less side effects. UVB in combination with the dithranol/urea preparation seems to be more efficient, without an increment of adverse effects. It would appear than an addition of urea offers an acceptable and effective alternative to salicylic acid.

Topics: Adolescent; Adult; Anthracenes; Anthralin; Drug Combinations; Female; Humans; Male; Middle Aged; Phototherapy; Psoriasis; Salicylates; Triamcinolone Acetonide; Urea

Topics: Adult; Aged; Candidiasis, Cutaneous; Dermatitis, Contact; Drug Combinations; Drug Eruptions; Eczema; Female; Humans; Irritants; Lactates; Lactic Acid; Male; Oils; Petrolatum; Phenols; Psoriasis; Rosaniline Dyes; Salicylates

Topics: Humans; Male; Middle Aged; Ointments; Psoriasis; Salicylates

Topics: Adult; Anthracenes; Anthralin; Female; Humans; Petrolatum; Psoriasis; Salicylates; Tars; Ultraviolet Therapy

Topics: Anthracenes; Anthralin; Chemistry, Pharmaceutical; Coal Tar; Dermatologic Agents; Drug Combinations; Humans; Nitrogen Mustard Compounds; Psoriasis; Salicylates

Classical topical therapy has been largely displaced by the development of up-to-date drugs and advances in the galenic field. Serious objections have even been leveled against some older drugs and others are no longer current in spite of their good efficacy (e.g. dyes) because less discriminatory drugs can be substituted for them. The fundamental principles of classical topical therapy are still as valid as ever (inherent action of the base). However, many of the active principles of the prechemotherapeutic era have meanwhile been superseded as for example boric acid, mercury, desquamative pastes, sulfur among others. In contrast to this, topical applications such as dithranol, salicylic acid, coal tar and a few others still belong to the permanent stock of dermatological topical therapy.

Topics: Administration, Topical; Anthralin; Balsams; Coal Tar; Humans; Psoriasis; Salicylates; Skin Diseases

Polyamine metabolism is important in cell proliferation and may play a role in the epidermal cell hyperproliferation of psoriasis. We have determined changes in polyamine levels in skin and urine accompanying clinical improvement in psoriasis following topical therapy. Nine hospitalized patients were examined at the beginning and end of their courses of treatment. Skin biopsy specimens and portions of 24-hour urine collections were analyzed for polyamines with a modified automatic amino acid analyzer. Treatment resulted in lower cutaneous levels of putrescine (by 50%, P less than .05), spermidine (by 24%, P less than .05), and spermine (by 35%, P less than .005), and lower urinary levels of spermidine (by 20%, P less than .025) and spermine (by 35%, P less than .025). These results suggest that in psoriasis, the skin significantly contributes to the levels of spermidine and spermine in systemic fluids. Topical therapy may reduce epidermal cell proliferation in psoriasis by lowering polyamine levels.

Topics: Administration, Topical; Adrenal Cortex Hormones; Adult; Aged; Anthralin; Female; Humans; Male; Middle Aged; Polyamines; Psoriasis; Putrescine; Salicylates; Skin; Spermidine; Spermine

Topics: Administration, Topical; Humans; Psoriasis; Salicylates; Skin Absorption; Time Factors

Topics: Anthracenes; Anthralin; Humans; Psoriasis; Salicylates; Tars

The combination of 0.02% flumetasone pivalate and 1% salicylic acid in a water-alcohol solution (Locasalen) is a novel therapeutic for topical treatment of the hairy scalp and also for the cosmetically acceptable treatment of other skin areas, that is, exposed skin. An investigation was carried out in 6 patients with psoriasis capitis and 6 control subjects in order to determine whether the use of Locasalen Tincture on the hairy scalp leads to percutaneous absorption of the corticosteroid and the salicylic acid. In the patients with psoriasis a few slight transient changes in biochemical-endocrinological parameters were observed, but not in the control subjects. However, these changes remained within the normal, non-pathological range so that they are of no clinical consequence. Percutaneous absorption of salicylic acid was not observed in either patient group.

Topics: Administration, Topical; Drug Combinations; Flumethasone; Humans; Hydrocortisone; Male; Psoriasis; Salicylates; Skin Absorption; Solutions

Topics: Administration, Topical; Adolescent; Adult; Aged; Anthracenes; Anthralin; Child; Child, Preschool; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Psoriasis; Salicylates

Topics: Brain Neoplasms; Cerebrovascular Disorders; Dermatitis, Atopic; Humans; Lupus Erythematosus, Systemic; Orosomucoid; Polarography; Psoriasis; Salicylates

Topics: Anthralin; Humans; Photochemotherapy; Psoriasis; Salicylates; Tars; Ultraviolet Therapy

Topics: Administration, Topical; Adrenal Cortex Hormones; Humans; Methotrexate; Psoriasis; Salicylates; Tars

Fifty patients with refractory psoriasis were treated with a combined method consisting in the application of occlusive dressings with Locacorten Tar ointment at night and of 'open' treatment (without occlusive dressings) with Locasalen ointment during the day. The aim of this trial was to obtain the benefit of the occlusive-dressing method without having to hospitalize the patients. The mean time required for the eradication of psoriatic scales was 3.46 days, while that needed for complete recovery was 14 days. The results clearly indicated that this combined approach has all the advantages of occlusives dressings but allows the patient greater freedom during the day. The very good effect of the treatment is also attributable to the triple action obtained with this combination: the anti-epidermoplastic effect of flumethasone pivalate, the squamolytic effect of salicylic acid, and the keratoplastic action of the tar compound.

Topics: Adolescent; Adult; Aged; Ambulatory Care; Child; Female; Flumethasone; Humans; Male; Middle Aged; Occlusive Dressings; Ointments; Psoriasis; Salicylates; Tars; Time Factors

Topics: Dermatitis; Dermatitis, Seborrheic; Drug Combinations; Drug Evaluation; Humans; Pregnadienetriols; Psoriasis; Salicylates; Solutions

Topics: Anthracenes; Anthralin; Drug Prescriptions; Drug Synergism; Drug Therapy, Combination; Germany, West; Humans; Ointments; Petrolatum; Psoriasis; Salicylates

Topics: Administration, Oral; Administration, Topical; Fever; Humans; Nausea; Psoriasis; Salicylates; Vertigo

Topics: Adolescent; Adult; Aged; Anthralin; Child; Child, Preschool; Female; Hospitalization; Humans; Infant; Male; Methods; Middle Aged; Psoriasis; Salicylates; Sulfur; Ultraviolet Rays

Topics: Administration, Topical; Anti-Inflammatory Agents; Dermatitis; Dermatitis, Seborrheic; Dermatologic Agents; Drug Prescriptions; Eczema; Female; Humans; Hydrocortisone; Male; Neomycin; Ointment Bases; Psoriasis; Salicylates; Skin Diseases; Sulfur; Tetracycline

Salicylic acid in the therapeutic concentrations from 0.5 to 10% does not affect the rate of proliferation of psoriatic epidermal cells. In 18 patients suffering from psoriasis the H3-I (H3-thymidine labelling index) was determined using autoradiographic in vitro labelling techniques. In 12 of these patients double-labelling with C14-and H3-thymidine was used to determine the H3-I, the DNA-synthesis time (ts) and the duration of the cell-cycle (tc). No significant changes were observed following external application of salicyclic acid in white Vaseline in concentrations of 0.5, 2 and 10% for one week.

Topics: Autoradiography; Carbon Radioisotopes; Cell Division; Cell Movement; DNA; Drug Combinations; Drug Interactions; Female; Humans; In Vitro Techniques; Male; Ointments; Oxides; Psoriasis; Salicylates; Skin; Thymidine; Time Factors; Tritium; Zinc

Topics: Adrenal Cortex Hormones; Anthralin; Humans; Liver; Methotrexate; Nitrogen Mustard Compounds; Ointments; Psoriasis; Salicylates; Ultraviolet Rays

Topical treatment of a number of out-patients with psoriasis vulgaris resulted in reduced induration and diminished thickness of the layer of scales but complete involution was not obtained. A sequential photographic study of the macroscopic appearance of the lesions over a 3-month period of treatment revealed that artificially produced excoriations and a horny layer without scales were prominent features. The view is put forward that the cutaneous reaction to the injury probably elicited by the excoriations, together with an unsatisfactory treatment, may give rise to tissue changes which counteract the effect of topical treatment.

Topics: Administration, Topical; Female; Humans; Male; Psoriasis; Salicylates; Skin; Steroids, Fluorinated; Time Factors; Wound Healing

The uncontrolled, long-term (18 months), widespread (almost 3/4 total body skin surface), application of a concentrated (10%) salicylic acid ointment in a 62 year old psoriatic female led to chronic percutaneous salicylism. Salicylic acid levels in the urine (200 mg %) and serum (223 mg %), the highest values ever recorded in this type of intoxication, contrasted with the discrete clinical picture. The acute and chronic percutaneous salicylism is discussed with a review of the literature. It is warned against the uncontrolled use of topicals containing salicylic acid.

Topics: Administration, Topical; Chronic Disease; Female; Half-Life; Humans; Kinetics; Middle Aged; Ointments; Psoriasis; Salicylates; Self Medication

Topics: Acne Keloid; Administration, Topical; Alopecia Areata; Anti-Inflammatory Agents; Dermatitis, Seborrheic; Drug Combinations; Drug Evaluation; Fluocortolone; Glucocorticoids; Humans; Pantothenic Acid; Pregnadienediols; Psoriasis; Salicylates; Scalp Dermatoses; Solutions

Topics: Adrenocorticotropic Hormone; Alopecia; Betamethasone; Dermatitis, Seborrheic; Detergents; Eczema; Female; Hair; Hexachlorophene; Humans; Impetigo; Lice Infestations; Lichen Planus; Male; Psoriasis; Pyridinium Compounds; Salicylates; Scalp Dermatoses; Selenium; Skin Neoplasms; Sulfur; Tinea Capitis

Topics: Anthracenes; Anti-Infective Agents, Local; Catalysis; Chemical Phenomena; Chemistry; Drug Combinations; Drug Interactions; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Ointments; Oxides; Pharmaceutical Vehicles; Psoriasis; Salicylates; Solutions; Solvents; Zinc

Topics: Anthracenes; Drug Combinations; Glucosephosphate Dehydrogenase; Humans; Psoriasis; Salicylates; Sodium Salicylate; Zinc

Topics: Adolescent; Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Brain; Child; Child, Preschool; Dermatomyositis; Electroencephalography; Female; Gold; Humans; Lupus Erythematosus, Systemic; Male; Phenylbutazone; Psoriasis; Salicylates; Scleroderma, Localized; Sex Factors

Topics: Administration, Topical; Chronic Disease; Dermatologic Agents; Drug Combinations; Female; Humans; Hydrocortisone; Male; Ointments; Petrolatum; Psoriasis; Salicylates; Time Factors

Topics: Administration, Topical; Adrenal Cortex Hormones; Adult; Ambulatory Care; Betamethasone; Female; Follow-Up Studies; Home Nursing; Hospitalization; Humans; Male; Prognosis; Psoriasis; Remission, Spontaneous; Salicylates; Tars; Time Factors; Ultraviolet Therapy

Topics: Adult; Anthracenes; Antisepsis; Arthritis, Reactive; Coal Tar; Demeclocycline; Humans; Male; Phenylbutazone; Psoriasis; Salicylates

Topics: Adult; Autoradiography; Carbon Isotopes; DNA; Humans; Male; Middle Aged; Mitosis; ortho-Aminobenzoates; Psoriasis; Salicylates; Skin; Time Factors; Tritium

Topics: Anthracenes; Chemical Phenomena; Chemistry; Chloroform; Drug Stability; Hydrogen-Ion Concentration; Ointments; Oxides; Pharmaceutical Vehicles; Psoriasis; Salicylates; Solutions; Zinc

Topics: Adolescent; Child; Child, Preschool; Eczema; Humans; Ointments; Psoriasis; Salicylates

Topics: Administration, Oral; Adult; Arthritis; Arthritis, Rheumatoid; Aspirin; Bursitis; Humans; Middle Aged; Osteoarthritis; Psoriasis; Salicylates; Synovial Fluid; Synovitis; Time Factors

Topics: Anthracenes; Baths; Castor Oil; Coal Tar; Drug Combinations; Humans; Psoriasis; Salicylates

Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Biopsy; Connective Tissue; Dermatomyositis; Diphosphates; Gout; Humans; Hyperparathyroidism; Inflammation; Joint Diseases; Lupus Erythematosus, Systemic; Neutrophils; Polyarteritis Nodosa; Psoriasis; Rheumatoid Factor; Salicylates; Sarcoidosis; Spondylitis, Ankylosing; Synovial Fluid; Synovial Membrane; Uric Acid

Topics: Adolescent; Adult; Aged; Climate; Climatotherapy; Evaluation Studies as Topic; Follow-Up Studies; Health Resorts; Humans; Middle Aged; Periodicity; Psoriasis; Recurrence; Salicylates; Seasons; Sunlight; Time Factors; Yugoslavia

Topics: Adult; Antimalarials; Biopsy; Humans; Lupus Erythematosus, Discoid; Male; Prednisone; Psoriasis; Salicylates; Skin; Wounds and Injuries

Topics: Adolescent; Adult; Aged; Climate; Climatotherapy; Evaluation Studies as Topic; Follow-Up Studies; Health Resorts; Humans; Middle Aged; Psoriasis; Recurrence; Salicylates; Sunlight; Time Factors; Yugoslavia

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Benzalkonium Compounds; Dermatitis; Female; Humans; Hydrocortisone; Male; Psoriasis; Salicylates; Skin Diseases; Solutions; Triamcinolone Acetonide

Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Drug Combinations; Female; Follow-Up Studies; Humans; Infant; Male; Middle Aged; Ointments; ortho-Aminobenzoates; Petrolatum; Psoriasis; Remission, Spontaneous; Salicylates; Sex Factors; Time Factors

Topics: Coal Tar; Flumethasone; Humans; Ointments; Psoriasis; Salicylates

Topics: Fusidic Acid; Humans; Psoriasis; Salicylates

Topics: Adult; Aged; Chronic Disease; Dermatitis, Atopic; Dermatitis, Contact; Drug Synergism; Eczema; Female; Flumethasone; Fluorine; Glucocorticoids; Humans; Lupus Erythematosus, Discoid; Male; Middle Aged; Ointments; Pregnanes; Psoriasis; Salicylates

Topics: Adrenal Cortex Hormones; Anthraquinones; Betamethasone; Coal Tar; Ergocalciferols; Humans; Mercury; Ointments; ortho-Aminobenzoates; Psoriasis; Salicylates; Sulfur; Triamcinolone

Topics: Adolescent; Adult; Aged; Anthracenes; Female; Humans; Male; Methods; Middle Aged; Ointments; Petrolatum; Psoriasis; Salicylates

Topics: Adult; Child; Coal Tar; Dermatitis, Exfoliative; Flumethasone; Fluorine; Glucocorticoids; Humans; Male; Middle Aged; Occlusive Dressings; Pregnanes; Psoriasis; Salicylates

Topics: Adult; Aged; Anthracenes; Anti-Infective Agents, Local; Dermatologic Agents; Female; Fluorouracil; Humans; Male; Middle Aged; Ointments; Psoriasis; Pyrogallol; Salicylates; Skin; Tars

Topics: Adolescent; Adult; Female; Humans; Male; Methods; Ointments; Psoriasis; Retrospective Studies; Salicylates; Synephrine; Ultraviolet Therapy

Topics: Adult; Brain Diseases; Humans; Male; Meninges; Neurologic Manifestations; Psoriasis; Salicylates

Topics: Aged; Carcinoma, Basal Cell; Female; Humans; Petrolatum; Photosensitivity Disorders; Psoriasis; Salicylates; Skin Neoplasms; Time Factors; Xeroderma Pigmentosum

Topics: Flumethasone; Glucocorticoids; Humans; Pregnanetriol; Psoriasis; Salicylates; Tars

Topics: Adolescent; Adrenal Cortex Hormones; Aspirin; Female; Folic Acid; Humans; Iodides; Iron; Male; Middle Aged; Potassium Iodide; Psoriasis; Salicylates; Tetrahydrofolate Dehydrogenase

Topics: Adolescent; Adult; Aged; Coal Tar; Dermatitis; Dermatologic Agents; Drug Eruptions; Eczema; Female; Flumethasone; Fluorine; Glucocorticoids; Humans; Lichen Planus; Male; Middle Aged; Pregnanes; Psoriasis; Salicylates

Topics: Anti-Inflammatory Agents; Drug Synergism; Flumethasone; Glucocorticoids; Humans; Psoriasis; Salicylates; Tars

Topics: Humans; Male; Middle Aged; Ointments; Psoriasis; Salicylates

Topics: Coal Tar; Flumethasone; Glucocorticoids; Humans; Psoriasis; Salicylates

Topics: Alopecia Areata; Benzalkonium Compounds; Dermatologic Agents; Eczema; Humans; Keloid; Lichen Planus; Lupus Erythematosus, Systemic; Neurodermatitis; Pruritus Ani; Psoriasis; Salicylates; Scleroderma, Systemic; Skin Diseases; Triamcinolone

Topics: Eczema; Flumethasone; Humans; Paramethasone; Psoriasis; Salicylates; Tars; Ultraviolet Rays

Topics: Adrenal Cortex Hormones; Anthracenes; Anti-Infective Agents; Humans; Ointments; Psoriasis; Salicylates; Tars

Topics: Arthritis; Colitis, Ulcerative; Humans; Male; Middle Aged; Psoriasis; Salicylates

Topics: Adolescent; Adult; Anthracenes; Antifungal Agents; Female; Humans; Male; Middle Aged; Psoriasis; Salicylates

Topics: Adrenal Cortex Hormones; Anthracenes; Anti-Infective Agents, Local; Fluocinolone Acetonide; Flurandrenolone; Humans; Mercury; Psoriasis; Salicylates; Tars; Triamcinolone

Topics: Aspirin; Betula; Chemical Phenomena; Chemistry; Child; Drug Hypersensitivity; Drug Tolerance; Pollen; Psoriasis; Research; Salicylates; Toxicology

Topics: Adjuvants, Immunologic; Adjuvants, Pharmaceutic; Cinnamates; Geriatrics; Humans; Ointments; Psoriasis; Salicylates; Salicylic Acid; Uric Acid

Topics: Humans; Psoriasis; Salicylates; Tars