salicylates and Peripheral-Vascular-Diseases

Many clinical trials have shown the effectiveness of platelet-antiaggregant drugs in the treatment of obliterative peripheral arteriopathy, both locally and in the system, by improving the claudication symptoms and by preventing major cardiovascular events. In this study we evaluated the effectiveness of a 24-week treatment with triflusal, a comparatively new inhibitor of platelet aggregation, in patients affected by chronic peripheral arteriopathy, comparing twice-daily oral doses of 300 mg triflusal with twice-daily placebo doses. The percentages of successes (defined as a 40% increase of total walking distance over the basal control) were 63.6% in the triflusal group (35/55 patients) and 22.5% in the placebo group (14/62 patients). Patients treated with triflusal showed a more important increase in total walking distance and in pain-free walking distance over the basal values than those treated with placebo, together with an improvement of the symptomatology correlated with claudication. Moreover, in the triflusal group there was an increase in the peak-flow recorded through strain-gauge plethysmography. In conclusion, triflusal significantly increased both the distance which could be walked and the clinical symptoms, presumably by improving microperfusion.

Topics: Adult; Aged; Chronic Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Salicylates

Ginkgo biloba possesses fruits that have caused numerous cases of allergic contact dermatitis. Low amounts of the ginkgolic acids occur in the leaves as well.. Leaf extracts are used to treat cerebrovascular and peripheral vascular disorders. The question arises whether skin hypersensitivity reactions may be adverse effects because the pharmaceutical preparations contain low amounts of ginkgolic acids.. Guinea pigs were sensitized experimentally with pure ginkgolic acids as well as with leaf extracts containing approximately 1,000 ppm of ginkgolic acids.. The guinea pigs could be sensitized successfully with the pure ginkgolic acids. The animals could not be sensitized with the leaf extract.. Leaf extracts of Ginkgo biloba taken orally or given by infusion to treat diffuse cerebral disturbances can be considered safe, even when they might contain up to 1,000 ppm of the sensitizing ginkgolic acids.

Topics: Administration, Oral; Allergens; Animals; Cerebrovascular Disorders; Dermatitis, Allergic Contact; Dermatitis, Irritant; Disease Models, Animal; Female; Ginkgo biloba; Guinea Pigs; Immunization; Infusions, Intravenous; Peripheral Vascular Diseases; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Salicylates

Topics: Anticoagulants; Cardiovascular Diseases; Peripheral Vascular Diseases; Salicylates; Vascular Diseases

Topics: Aesculus; Balneology; Fagaceae; Peripheral Vascular Diseases; Salicylates; Vascular Diseases