salicylates and Peripheral-Nervous-System-Diseases

In this study, we wanted to extend our investigation of the efficacy of fish oil with or without salsalate on vascular and neural complications using a type 2 diabetic rat model. Four weeks after the onset of hyperglycemia, diabetic rats were treated via the diet with 3 different amounts of menhaden oil with or without salsalate for 12 weeks. Afterwards, vascular reactivity of epineurial arterioles and neuropathy-related endpoints were examined. The addition of salsalate to high-fat diets enriched with 10% or 25% kcal of menhaden oil protected vascular reactivity to acetylcholine and calcium gene-related peptide, motor and sensory nerve conduction velocity, thermal nociception, intraepidermal nerve fiber density, and cornea sensitivity to a greater extent than 10% or 25% menhaden oil alone. Vascular and neural function was maximally protected with diet containing 45% kcal as menhaden oil, and adding salsalate did not provide any additional benefit. Salsalate alone in the high-fat diet of diabetic rats provided minimal protection/improvement of vascular and neural dysfunction. These studies imply that dietary salsalate in combination with lower amounts of menhaden oil can provide greater benefit toward diabetes-induced vascular and neural impairment than menhaden oil alone.

Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet; Diet, Fat-Restricted; Diet, High-Fat; Disease Models, Animal; Fish Oils; Male; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Salicylates; Sciatic Nerve

Topics: Acute Kidney Injury; Adult; Benzoates; Burns, Electric; Humans; Malates; Male; Necrosis; Ointments; Paralysis; Peripheral Nervous System Diseases; Radial Nerve; Salicylates

Topics: Arteriosclerosis Obliterans; Humans; Peripheral Nervous System Diseases; Salicylates; Ulcer