salicylates and Peptic-Ulcer-Perforation

Topics: Adolescent; Adult; Aged; Carbenoxolone; Child; Female; Glycyrrhiza; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Peptic Ulcer Perforation; Plants, Medicinal; Salicylates; Sex Factors; Stomach Ulcer; Triterpenes

Topics: Analgesics; Duodenal Ulcer; Humans; Male; Peptic Ulcer Perforation; Salicylates

An analysis of 246 cases of perforated peptic ulcer, treated at the Royal Newcastle Hospital from 1964 to 1974, is presented. The incidence has fallen considerably over that period. The rising proportion of women has reached a plateau. A perforated peptic ulcer in an Australian women is still just as likely to be located in the stomach as in the duodenum. In men, however, 84% of perforations are pyloroduodenal. A perforated gastric ulcer is closely associated with the use of salicylate preparations. The mortality rate has remained steady at 15% over the last 30 years. It is significantly higher in women. There is a highly significant relationship between the mortality and (a) the duration of perforation; and (b) the size of the perforation, particularly if it is located in the stomach.

Topics: Adult; Aged; Analgesics; Australia; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Peptic Ulcer Perforation; Salicylates; Sex Factors; Stomach Ulcer

In a retrospective study of 195 patients with a perforated peptic ulcer 18 per cent of the patients had taken aspirin, phenylbutazone or corticosteroids during the period before the perforation. In a controlled prospective trial, 18 of 22 patients (82 per cent) had taken drugs known to be potentially harmful to the stomach. Aspirin was the drug mainly used. Thirteen of 22 patients had taken the drugs within 12 hours of the perforation, usually because of symptoms not related to the gastro-intestinal tract. Drug consumption and perforation of pre-pyloric ulcers were most closely associated; the latter applies particularly to female patients, who either had only a short history of upper gastro-intestinal dyspepsia or were asymptomatic.

Topics: Adrenal Cortex Hormones; Denmark; Drug Utilization; Female; Humans; Male; Peptic Ulcer Perforation; Phenylbutazone; Retrospective Studies; Salicylates; Sex Factors

Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Indomethacin; Male; Middle Aged; Peptic Ulcer Hemorrhage; Peptic Ulcer Perforation; Prednisone; Salicylates; Stomach Ulcer

Topics: Adolescent; Adrenal Cortex Hormones; Duodenal Ulcer; Endocarditis; Humans; Male; Peptic Ulcer Perforation; Salicylates