salicylates and Pancreatitis

In the past, numerous reports on drugs probably causing acute pancreatitis have been published. However, most of these case reports were anecdotal with a lack of obvious evidence and did not present a comprehensive summary. Although drug-associated pancreatitis is rare, it is gaining increasing importance with the introduction of several potent new agents, i.e., anti-acquired immunodeficiency syndrome drugs. The following comprehensive review scrutinizes the evidence present in the world literature on drugs associated with acute or chronic pancreatitis and, based on this, categorizes in a definite, probable, or possible causality. In addition, explanations for the pathophysiological mechanisms are discussed.

Topics: Acute Disease; Anti-Bacterial Agents; Antineoplastic Agents; Antiviral Agents; Calcium; Chronic Disease; Diuretics; Humans; Immunosuppressive Agents; Pancreatitis; Salicylates; Steroids

We critically reviewed the English language literature pertaining to drug-induced pancreatitis and attempted to determine whether the reported association between each drug and pancreatitis was valid. The following drugs seem to cause pancreatitis: azathioprine, thiazides, sulfonamides, furosemide, estrogens, and tetracycline. Less convincing, but suggestive evidence exists for: 1-asparaginase, iatrogenic hypercalcemia, chlorthalidine, corticosteroids, ethacrynic acid, phenformin, and procainamide. Evidence implicating other drugs is either inadequate or contradictory. Little is known about the pathogenesis of drug-induced pancreatitis. Ethanol was not considered in this review.

Topics: Acetaminophen; Adrenal Cortex Hormones; Amphetamines; Asparaginase; Azathioprine; Chlorthalidone; Cholestyramine Resin; Cimetidine; Cyproheptadine; Dextropropoxyphene; Diazoxide; Diuretics; Estrogens; Ethacrynic Acid; Furosemide; Histamine; Humans; Hypercalcemia; Indomethacin; Isoniazid; Mercaptopurine; Narcotics; Pancreatitis; Phenformin; Procainamide; Rifampin; Salicylates; Sodium Chloride Symporter Inhibitors; Sulfonamides; Tetracycline

Topics: Altitude Sickness; Central Nervous System Diseases; Dextropropoxyphene; Drowning; Ethchlorvynol; Hemodynamics; Heroin; Humans; Lung; Oxygen; Pancreatitis; Pulmonary Edema; Respiratory Distress Syndrome; Respiratory Therapy; Salicylates; Smoke; Syndrome

Topics: Acute Disease; Anticholesteremic Agents; Atorvastatin; Drug Combinations; Heptanoic Acids; Humans; Male; Middle Aged; Pancreatitis; Pyrroles; Salicylates; Treatment Outcome

Topics: Amylases; Amylose; Chlorides; Hot Temperature; Humans; Isoenzymes; Pancreas; Pancreatitis; Salicylates; Salivary Glands; Trypsin

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aged; Cathartics; Chemical and Drug Induced Liver Injury; Cholestasis; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Iatrogenic Disease; Indomethacin; Insecticides; Pancreatitis; Peptic Ulcer; Phenylbutazone; Potassium Chloride; Reserpine; Salicylates; Thiazines

Topics: Amylases; Autoanalysis; Humans; Methods; Pancreatitis; Polysaccharides; Salicylates

Topics: Amylases; Blood Chemical Analysis; Chromatography; Clinical Enzyme Tests; Colorimetry; Diabetes Mellitus; Electrophoresis; gamma-Globulins; Glucose; Humans; Intestinal Obstruction; Liver Cirrhosis; Maltose; Pancreatitis; Salicylates; Starch

Topics: Aspirin; Humans; Lactates; Pancreatitis; Salicylates