salicylates and Pain--Postoperative

Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain, Postoperative; Propionates; Salicylates

Tenoxicam is an effective analgesic and anti-inflammatory agent for symptomatic treatment of various conditions. The purpose of this study was to evaluate clinically the effectiveness of prophylactic tenoxicam and prophylactic ibuprofen in reducing post-endodontic pain compared with placebo. A total of 48 patients consented to a double-blind, single dose, prophylactic oral administration of 20 mg of tenoxicam, 200 mg of ibuprofen, or a placebo before root canal treatment. The root canal treatment was performed in one visit. The patients registered their degree of discomfort on a 100-mm visual analog scale, immediately postoperative, and 6, 12, 24, 48 and 72 h after initiation of root canal treatment. The two-way ANOVA test and Tukey HSD post hoc test showed that in the 6-h period, both 20 mg of tenoxicam and 200 mg of ibuprofen provided significantly better pain relief than the placebo. Prophylactic administration of a single dose of 20 mg tenoxicam or 200 mg ibuprofen before RCT provides an effective reduction at 6 h (P < 0.05). Because of the advantages of tenoxicam, it may be useful as a prophylactic analgesic when post-endodontic pain is anticipated.

Topics: Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Calcium Hydroxide; Double-Blind Method; Female; Follow-Up Studies; Gutta-Percha; Humans; Ibuprofen; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Piroxicam; Placebos; Premedication; Root Canal Filling Materials; Root Canal Irrigants; Root Canal Preparation; Root Canal Therapy; Salicylates; Sodium Hypochlorite; Treatment Outcome; Young Adult

A clinical study using vital maxillary central incisors was performed to evaluate the incidence of postoperative pain after root canal treatment in one- or two-appointments using a calcium hydroxide-containing root canal sealer. No differences were observed between the two groups.

Topics: Adolescent; Adult; Calcium Hydroxide; Female; Gutta-Percha; Humans; Incidence; Incisor; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Root Canal Filling Materials; Root Canal Obturation; Salicylates; Time Factors; Treatment Outcome

The root canals of 588 consecutive nonsurgical patients with varying levels of pain were completely instrumented in 10 endodontic practices and 4 endodontic graduate programs. The participants were sequentially assigned to one of nine medications and a placebo. The severity of pain was assessed by the visual analog scale for 72 h following instrumentation. Among all of the parameters studied, three factors (preoperative pain, apprehension, and types of medication) were found to be significant in determining postinstrumentation pain. An association was found between the intensity of pre-and postoperative pain. As the intensity of preoperative pain increased, the chances for more severe postoperative pain increased (p < 0.0001). In addition, an association between the presence of apprehension before any treatment and postoperative pain was also noted (between 0.012 < p < 0.047). Examination of the time-effect curves for various medications in patients with no mild pain showed no statistical significant difference between the effectiveness of different medications and placebo. However, a multiple comparison of the effectiveness of various medications and placebo on patients in moderate and severe preoperative pain showed that ibuprofen, ketoprofen, erythromycin base, penicillin, and methylprednisolone plus penicillin were more effective than placebo within the first 48 h following complete instrumentation.

Topics: Acetaminophen; Adult; Analysis of Variance; Chi-Square Distribution; Codeine; Dental Anxiety; Erythromycin; Humans; Ibuprofen; Ketoprofen; Methylprednisolone; Pain Measurement; Pain, Postoperative; Penicillins; Regression Analysis; Root Canal Irrigants; Root Canal Therapy; Salicylates; Salicylic Acid; Surveys and Questionnaires; Time Factors; Toothache

This prospective study compared the effectiveness of nine medications and a placebo in controlling pain following obturation. A total of 588 patients who required root canal obturation were included. After obturation of root canals, each patient took one of the medications, salicylic acid (2 x 250 mg), acetaminophen (2 x 250 mg), ibuprofen (2 x 250 mg), ketoprofen (2 x 250 mg), acetaminophen (2 x 250 mg) plus codeine (2 x 250 mg), penicillin (2 x 250 mg), erythromycin base (2 x 250 mg), penicillin plus ibuprofen (2 x 250 mg), methylprednisolone (2 x 250 mg) plus penicillin (2 x 250 mg), or a placebo, every 6 h for 72 h. All medications were encapsulated in identical capsules. The patients registered their degree of discomfort on a visual analogue scale of 0 to 9. Statistical analysis of the data showed that the incidence of postoperative pain after obturation is lower than that following complete cleaning and shaping (5.83% versus 21.76%). In addition, there was no significant difference between the effectiveness of the various medications and placebo tablets in controlling postoperative pain following obturation.

Topics: Acetaminophen; Adult; Aged; Analysis of Variance; Chi-Square Distribution; Codeine; Erythromycin; Female; Humans; Ibuprofen; Ketoprofen; Male; Methylprednisolone; Middle Aged; Pain Measurement; Pain, Postoperative; Penicillins; Prospective Studies; Regression Analysis; Root Canal Obturation; Salicylates; Salicylic Acid

A double-blind randomised cross-over study to compare 2 regimes of paracetamol and diflunisal for postoperative pain relief following 3rd molar surgery was designed. 35 patients received one of the regimes at one visit and the alternative at the other visit. Both drugs, namely a single dose of 500 mg of diflunisal given preoperatively or 2 doses of 1000 mg of paracetamol, given preoperatively and 4 h postoperatively, produced adequate pain relief, without the need for supplementary analgesics during the 10-h test period. The differences in the mean overall pain scores in the 2 regimes were not statistically significant.

Topics: Acetaminophen; Adult; Diflunisal; Double-Blind Method; Female; Humans; Male; Molar, Third; Pain, Postoperative; Premedication; Random Allocation; Salicylates; Time Factors; Tooth Extraction

The efficacy of a single pre-operative dose of benorylate (4 g) was determined in a double-blind, randomized, placebo-controlled parallel study in patients undergoing removal of a single impacted lower third molar. Patients treated with benorylate 4 g reported significantly less pain between 3-6 h after dosage than those treated with placebo. Overall pain scores at 6 h were significantly less in the benorylate group than the placebo group. However, overall pain scores at 12 h did not differ significantly between treatment groups. It is concluded from this study that a single dose of benorylate 4 g given immediately prior to the removal of an impacted lower third molar provides limited pain control during the postoperative period.

Topics: Acetaminophen; Adolescent; Adult; Double-Blind Method; Female; Humans; Male; Molar, Third; Pain, Postoperative; Random Allocation; Salicylates; Tooth Extraction; Tooth, Impacted

Despite the demonstrated therapeutic advantage of preoperatively administered nonsteroidal anti-inflammatory agents (NSAIAs) in suppressing postoperative pain, clinicians are reluctant to administer these drugs orally before surgical procedures performed using sedation or general anesthesia. Using a within-subject, crossover experimental design, this study compared the analgesic efficacies of an NSAIA, diflunisal 1,000 mg, administered either 30 minutes preoperatively or 30 minutes postoperatively to 20 patients undergoing the removal of impacted third molars. Pain intensity was assessed preoperatively and postoperatively for eight hours using category-rating and visual analog scales. Treatment with diflunisal 30 minutes after completion of surgery proved to be just as effective in suppressing postsurgical pain as presurgical administration. Administration of an NSAID in the immediate postoperative period may be indicated for optimum postoperative analgesia for patients in whom preoperative oral intake is contraindicated.

Topics: Adolescent; Adult; Diflunisal; Drug Administration Schedule; Female; Humans; Male; Molar, Third; Pain Measurement; Pain, Postoperative; Postoperative Period; Preanesthetic Medication; Random Allocation; Salicylates; Tooth Extraction; Tooth, Impacted

A randomized double-blind crossover design study using 25 patients requiring bilateral gingival flap surgery was completed. The effect of rinsing postsurgically three times daily with an antimicrobial mouthrinse or physiological saline on dental plaque formation, gingival inflammation, bleeding, wound healing, and patient comfort was evaluated at 7, 14 and 28 days. The antimicrobial rinse was statistically significantly 28.9% more effective than saline at seven days for reducing plaque. It was also significantly more effective for improving wound healing at day 7 as measured by edema (p less than 0.04). There were no significant differences in gingival index scores or bleeding at any time period. Use of an antimicrobial mouthrinse may be an effective aid in early healing of gingival flap surgery wounds.

Topics: Adult; Aged; Anti-Infective Agents, Local; Dental Plaque; Double-Blind Method; Drug Combinations; Female; Gingiva; Gingival Hemorrhage; Humans; Male; Middle Aged; Mouthwashes; Pain, Postoperative; Periodontitis; Random Allocation; Salicylates; Surgical Flaps; Terpenes; Wound Healing

The effectiveness of diflunisal as a preoperative medication to reduce pain following periodontal surgery was evaluated. Fifty patients were divided into two groups in a double-blind random manner: Group one received preoperative difunisal and Group two received preoperative placebo. The preoperative diflunisal group reported significantly less discomfort (P less than 0.05) than the preoperative placebo group and used rescue medication significantly less often (P less than 0.01). Therapeutic doses of diflunisal, given presurgically, are significantly more effective than placebo in limiting postoperative pain associated with periodontal surgery.

Topics: Adolescent; Adult; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Humans; Middle Aged; Pain, Postoperative; Periodontal Diseases; Placebos; Premedication; Random Allocation; Salicylates

A double-blind, randomized, parallel-group study compared the analgesic efficacy of a single oral dose of 500 mg diflunisal, 60 mg codeine, 500 mg diflunisal plus 60 mg codeine given as separate agents, and placebo in 161 patients with moderate to severe postoperative pain. Standard subjective measures were used to evaluate analgesia. Eight-hour sum of pain intensity differences and total pain relief scores for all active treatments were significantly better than were those for placebo (p less than 0.05). Diflunisal plus codeine performed the best followed by diflunisal, codeine, and placebo. Diflunisal plus codeine was better than placebo from 1 1/2 to 8 hours (p less than 0.01), better than codeine from 1 1/2 to 6 hours (p less than 0.05), and better than diflunisal alone from 1/2 to 1 1/2 hours (p less than 0.05) for most measures of analgesia. Factorial analysis demonstrated a significant early codeine effect and a significant diflunisal effect throughout. No significant treatment group differences were observed regarding adverse effects. Our data demonstrate that diflunisal plus codeine is generally well tolerated and provides analgesia superior to that of diflunisal or codeine alone in the treatment of moderate to severe postoperative pain.

Topics: Adult; Codeine; Diflunisal; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Pain, Postoperative; Salicylates; Time Factors

16 healthy patients requiring removal of bilateral symmetrically-impacted mandibular third molars participated in a double-blind randomised crossover trial to test the effectiveness of postoperative pain control using a long-acting anti-inflammatory agent (diflunisal) in combination with a long-acting local anaesthetic agent (bupivacaine). Results were compared to the more traditional method of using an oral analgesic with shorter duration of action (paracetamol with codeine) with lignocaine as the local anaesthetic. Using a visual analogue pain scale, patients reported that significantly reduced pain was experienced over the first 4 days postoperatively with the diflunisal/bupivacaine treatment and patient preference for this treatment was highly significant. This report represents the first such study of diflunisal used for an extended course in oral surgery with pain assessment over the same period. No significant side-effects or adverse reactions were encountered.

Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Codeine; Diflunisal; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Molar, Third; Pain Measurement; Pain, Postoperative; Random Allocation; Salicylates; Tooth Extraction; Tooth, Impacted

In a double blind study in Hong Kong Chinese, 250 mg of diflunisal, 500 mg of paracetamol or placebo were given for post-operative pain relief following 77 third molar surgical procedures. The intensity of pain was recorded on a visual analogue scale. The first and second doses of paracetamol reduced pain significantly more than placebo, while this was true only for the second dose of diflunisal. There was no significant difference in pain reduction with the first and second dose of paracetamol, when compared with the first and the second dose of diflunisal. In this study in Hong Kong Chinese, neither the dose nor the interval between ingestion of the analgesic tablets in patients, who needed analgesics for postoperative pain, were significantly different to that reported before in non-Chinese, in contrast to the popular belief that Chinese patients have higher pain thresholds. However, a higher proportion of Chinese than that reported in non-Chinese did not need any analgesics for relief of postoperative pain.

Topics: Acetaminophen; Adult; China; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Hong Kong; Humans; Male; Molar, Third; Pain, Postoperative; Placebos; Random Allocation; Salicylates; Tooth Extraction

A double-blind, completely randomized study was carried out on 169 patients to compare the analgesic efficacy and tolerability of diflunisal with that of Veralgin after surgical removal of impacted third molars. One group received 1000 mg diflunisal (Donobid, MSD) 2 h preoperatively and then 500 mg twice daily for 2.5 days, and the other group Veralgin (aminophenazon. 286 mg, barbital. 114 mg, aethylmorph. hydrochlorid. 20 mg, Orion), a fixed combination widely used in Finland, 1 tablet twice daily beginning 2 h prior to operation. Visual analogue scales were used to estimate pain. Diflunisal was found to be superior in relieving pain in the early postoperative period, the associated frequency of adverse clinical experiences was lower and the final evaluation of analgesic efficacy by both the patients and the investigators, was in its favour. The study confirms that postoperative pain after third molar surgery can be controlled well without the use of mainly centrally acting combination analgesics.

Topics: Adult; Aminopyrine; Barbital; Barbiturates; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Ethylmorphine; Female; Humans; Male; Molar, Third; Morphine Derivatives; Pain Measurement; Pain, Postoperative; Random Allocation; Salicylates; Tooth Extraction

Topics: Adult; Aspirin; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain, Postoperative; Random Allocation; Salicylates; Surgery, Oral

One hundred seventy-nine patients with asymptomatic or mildly symptomatic endodontic disease had single-visit therapy and were given either diflunisal (n = 94) or aspirin with codeine (n = 85) to control posttreatment pain. In this open-label, randomized study, diflunisal was judged superior to the aspirin-codeine combination in all major categories evaluated. Of patients receiving diflunisal, 93.6% needed the medication for only one day. In contrast, 77.7% of patients receiving aspirin with codeine needed the medication for only one day. Almost 64% of patients receiving diflunisal needed only one dose, while 32.9% of patients using aspirin with codeine needed only one dose. Four or more doses were required by 5.3% of patients receiving diflunisal and by 23.5% of patients receiving the aspirin-codeine combination. In patients receiving diflunisal, 20.2% experienced side effects. In contrast, 29.4% of patients receiving aspirin with codeine reported side effects. Thirty-five percent of patients receiving diflunisal rated the analgesic as excellent; 5.3% rated it as fair or poor. In contrast, 12.9% of patients receiving aspirin with codeine rated the analgesic combination as excellent; another 12.9% rated it as fair or poor. Diflunisal was found to be generally effective and well-tolerated, and superior to aspirin with codeine in the management of pain from endodontic treatment.

Topics: Adolescent; Adult; Aged; Aspirin; Codeine; Diflunisal; Drug Combinations; Female; Humans; Male; Middle Aged; Pain, Postoperative; Prospective Studies; Random Allocation; Root Canal Therapy; Salicylates; Time Factors

Topics: Adolescent; Adult; Aged; Aspirin; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Humans; Middle Aged; Mouth; Pain, Postoperative; Random Allocation; Salicylates; Time Factors

Topics: Adolescent; Adult; Clinical Trials as Topic; Diflunisal; Female; Humans; Male; Pain, Postoperative; Salicylates

In a single-dose, double-blind randomized study, the analgesic efficacy of suprofen 200, suprofen (alpha-methyl-4-(2-thienylcarbonyl)-benzene acetic acid; Suprol) 400 mg and diflunisal 750 mg capsules was determined in comparison to placebo capsules. A total of 130 patients participated in the study, all of them requiring analgesic treatment on the first post-operative day following meniscectomy. The treatment groups were homogeneous with respect to their demographic data. With the chosen pain model all active test substances were statistically significantly superior to placebo as far as pain intensity differences (SPID), pain relief (TOTPAR) and global evaluation of efficacy were concerned. Despite great differences in dosage and half-life, the active test substances must be regarded as equipment. Side effects were reported by 2 patients each in the diflunisal 750 mg and the placebo group, and by 1 patient treated with suprofen 200 mg.

Topics: Adolescent; Adult; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain, Postoperative; Phenylpropionates; Salicylates; Suprofen; Time Factors

Suprofen 200 mg and suprofen 400 mg were found to be as efficacious as diflunisal 750 mg in a single-dose, double-blind randomized study of 130 hospitalized patients with pain following meniscectomy. Pain intensity was measured using both an interval scale and a visual analogue scale. Pain indices derived from both scales as well as the physician's global evaluation were consistent in demonstrating that suprofen is an effective analgesic agent in the relief of moderate to severe pain following orthopedic surgery.

Topics: Adolescent; Adult; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Humans; Knee Joint; Male; Middle Aged; Pain, Postoperative; Phenylpropionates; Placebos; Random Allocation; Salicylates; Sex Factors; Suprofen

1 Soluble aspirin, 600 mg and 1200 mg, and placebo were compared in a double-blind, cross-over study in 12 patients with post-operative pain following removal of impacted lower third molars. 2 Significant analgesia after 600 mg aspirin occurred only at 45 min after administration, whereas significant analgesia after 1200 mg aspirin occurred from 45 to 240 min. The 1200 mg dose produced greater analgesia than the 600 mg dose and is to be recommended in clinical practice. 3 Plasma concentrations of salicylate and acetylsalicylate were measured after both doses. A significant correlation (rs = 0.876, P less than 0.01) was observed between analgesia and plasma salicylate concentration after 1200 mg aspirin.

Topics: Adult; Aspirin; Female; Half-Life; Humans; Kinetics; Male; Pain, Postoperative; Salicylates; Salicylic Acid; Tooth Extraction

Topics: Humans; Infusions, Parenteral; Pain, Postoperative; Salicylates

Topics: Adolescent; Adult; Aminophenols; Child; Chymotrypsin; Clinical Trials as Topic; Diflunisal; Drug Combinations; Female; Humans; Male; Pain, Postoperative; Salicylates; Tooth Extraction; Trypsin

Topics: Adolescent; Adult; Aspirin; Clinical Trials as Topic; Diflunisal; Female; Humans; Male; Middle Aged; Pain, Postoperative; Salicylates; Tooth Extraction; Tooth, Impacted

Diflunisal, 5-(2', 4'-difluorophenyl) -salicylic acid, has been shown in animal and human studies to possess pronounced analgesic and anti-inflammatory effects. The objective of the present investigation wa to compare the analgesic effect and safety of three doses of 500 mg diflunisal, given orally over 36 h, with placebo in the treatment of pain following surgical removal of impacted mandibular third molars. A total of 60 patients, 30 patients in each treatment group, participated in this double-blind, completely randomized study. The treatment groups were compared for demographic data, disease-related variables and pretreatment severity of pain. According to both the investigator's and the patient's overall evaluation of treatment efficacy on postoperative pain, diflunisal was significantly better than placebo (P less than 0.0001). Clinical adverse reactions were reported by seven patients (25%) in the diflunisal group compared to three patients (11%) in the control group. In two instances the adverse reactions were rated by the investigator to have been "unacceptable". The overall conclusion of this study is that diflunisal, compared to placebo, is a highly effective and well-tolerated analgesic in the treatment of postoperative pain following surgical removal of impacted mandibular third molars.

Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Middle Aged; Pain, Postoperative; Placebos; Salicylates; Tooth, Impacted

A single dose experiment was used to evaluate the analgesic effect of diflunisal, a new salicylic acid derivative. Three dose levels of diflunisal (125 mg, 250 mg, and 500 mg) were compared to one dose level of acetylsalicylic acid (ASA) (600 mg) and placebo. The maximal analgesis induced by 500 mg diflunisal was comparable to that of 600 mg ASA. The onset of action was slightly more rapid with ASA but the duration of the analgesic effect was far longer for diflunisal, extending beyond 8 hours after administration. Diflunisal is a promising drug for the treatment of post-operative pain because of its long-lasting effect.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Menisci, Tibial; Pain, Postoperative; Placebos; Salicylates

1. Seven hundred and forty patients complaining of pain after oral or orthopaedic surgery or episiotomy were studied in five single dose or short-term double-blind, controlled, randomized studies comparing efficacy and safety of diflunisal with that of acetylsalicylic acid, glafenin or placebo. 2. Diflunisal was found to be effective in relieving postoperative pain in 75-85% of patients. A twice day dosage schedule seems to be clinically adequate, 375 mg twice daily proving to be equally effective as glafenin 200 mg three times daily. No serious drug-related clinical or laboratory adverse experiences were encountered in any of the five studies.

Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Fluorobenzenes; Humans; Male; Middle Aged; Pain, Postoperative; Placebos; Salicylates; Time Factors

Pain is a multistep process that originates in the peripheral nervous system at the site of injury, is transmitted and processed within the central nervous system, and is perceived at the level of the cerebral cortex. Each of these steps in pain transmission is subject to intervention, with the possibility of reducing or blocking the nociceptive information to result in decreased pain. Based on knowledge of pain processes, dentists can use analgesic strategies to prevent or reduce pain.

Topics: Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Cortex; Facial Pain; Humans; Nerve Fibers; Neurogenic Inflammation; Nociceptors; Oral Surgical Procedures; Pain; Pain, Postoperative; Salicylates; Trigeminal Caudal Nucleus

Topics: Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Humans; Infant; Ketorolac; Pain; Pain, Postoperative; Premedication; Propionates; Salicylates; Tolmetin

Topics: Adult; Bupivacaine; Diflunisal; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lidocaine; Male; Molar, Third; Pain, Postoperative; Salicylates

In this study, 40 postarthroscopy patients were treated with either diflunisal or acetaminophen with codeine to control postoperative pain. In comparing these two drugs, better known as Dolobid and Tylenol #3, the results were comparable, though acetaminophen with codeine seemed to have a more rapid onset of action. Diflunisal provided better continuity of analgesia and less frequent dosing.

Topics: Acetaminophen; Adolescent; Adult; Analgesia; Codeine; Diflunisal; Drug Combinations; Female; Humans; Knee Joint; Male; Pain, Postoperative; Salicylates

Topics: Adolescent; Adult; Aged; Aminopyrine; Anti-Inflammatory Agents; Bone and Bones; Child; Dipyrone; Female; Humans; Imidazoles; Male; Middle Aged; Pain, Postoperative; Pyrazolones; Salicylates

Topics: Acetaminophen; Analgesics; Dental Care; Drug Combinations; Humans; Pain; Pain, Postoperative; Pyrazoles; Pyrazolones; Salicylates

The analgesics taken by patients after oral and periodontal surgery were noted over a three day observation period. Analgesic consumption matched closely the pain experience. The efficacy of self-prescribed analgesics was extrapolated from the pain scores obtained in the first 12 hours after surgery, and overall, the apparent efficacy appears poor. However, those patients who reported taking aspirin recorded significantly less pain than those who took either paracetamol or combination analgesics. Analgesic efficacy was not related to dose, although a significant correlation was noted between the number of paracetamol tablets taken and pain severity.

Topics: Adult; Analgesics; Aniline Compounds; Drug Combinations; Female; Humans; Male; Mouth; Pain, Postoperative; Periodontium; Salicylates; Time Factors; Tooth Extraction

Topics: Adolescent; Adult; Aged; Child; Diflunisal; Humans; Middle Aged; Mouth; Pain, Postoperative; Periapical Diseases; Salicylates; Tooth Extraction

Topics: Adolescent; Adult; Diflunisal; Female; Humans; Male; Middle Aged; Pain, Postoperative; Placebos; Salicylates; Tooth Extraction

Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dental Care; Drug Combinations; Humans; Pain, Postoperative; Phenacetin; Salicylates

Topics: Acetaminophen; Adult; Aged; Diflunisal; Double-Blind Method; Female; Humans; Male; Middle Aged; Molar, Third; Pain, Postoperative; Salicylates; Time Factors; Tooth Extraction; Tooth, Impacted

Topics: Acetaminophen; Adolescent; Adult; Aged; Anesthesia, Dental; Anesthesia, General; Caffeine; Codeine; Diflunisal; Drug Combinations; Female; Humans; Male; Middle Aged; Pain, Postoperative; Salicylates; Tooth Extraction

Topics: Adolescent; Adult; Diflunisal; Humans; Middle Aged; Orthognathic Surgical Procedures; Pain, Postoperative; Salicylates

Topics: Adult; Aged; Diflunisal; Female; Humans; Male; Mandibular Neoplasms; Maxillary Neoplasms; Middle Aged; Mouth Neoplasms; Pain, Postoperative; Salicylates

An open study was carried out in 196 consecutive patients who had undergone orthopaedic (103) or gynaecological (93) surgical procedures to assess the effectiveness and tolerability of a single dose of 500 mg diflunisal in the relief of postoperative pain. Diflunisal was given when patients first complained of pain, and pain severity before and at intervals up to 6 hours after the dose was assessed using a 10-point analogue scale. The results showed that diflunisal was both prompt and prolonged in its effect. No pain was reported after 1 hour in 138 (71%) of the 196 patients, and after 6 hours only 13 (7%) still reported some pain. Diflunisal was equally as effective in the two groups. Side-effects were reported in 13 (7%) patients but these were ones commonly found in the post-operative situation.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Female; Humans; Male; Middle Aged; Pain, Postoperative; Salicylates; Time Factors

Topics: Analgesia; Anesthesia, Local; Community Health Services; Humans; Pain; Pain, Postoperative; Salicylates; Substance-Related Disorders; Terminal Care