salicylates and Osteoporosis

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis, Rheumatoid; Atrophy; Betamethasone; Drug Interactions; Glucocorticoids; History, 20th Century; Humans; Hydrocortisone; Infections; Injections, Intra-Articular; Joint Diseases; Methylprednisolone; Necrosis; Osteoporosis; Peptic Ulcer; Prednisolone; Prednisone; Rheumatic Diseases; Salicylates; Skin Diseases; Substance Withdrawal Syndrome; Synovitis; Triamcinolone; Vascular Diseases

Topics: Acute Disease; Arthritis, Rheumatoid; Bone Diseases; Clinical Trials as Topic; Drug Synergism; Humans; Osteoarthritis; Osteochondritis; Osteoporosis; Pain; Penicillins; Placebos; Pleurisy; Prednisolone; Rheumatic Diseases; Rheumatic Fever; Salicylates; Spondylitis

Osteoporosis is a form of osteolytic disease caused by an imbalance in bone homeostasis, with reductions in osteoblast bone formation, and augmented osteoclast formation and resorption resulting in reduced bone mass. Cajaninstilbene acid (CSA) is a natural compound derived from pigeon pea leaves. CSA possesses beneficial properties as an anti-inflammatory, antibacterial, antihepatitis, and anticancer agent; however, its potential to modulate bone homeostasis and osteoporosis has not been studied. We observed that CSA has the ability to suppress RANKL-mediated osteoclastogenesis, osteoclast marker gene expression, and bone resorption in a dose-dependent manner. Mechanistically, it was revealed that CSA attenuates RANKL-activated NF-κB and nuclear factor of activated T-cell pathways and inhibited phosphorylation of key signaling mediators c-Fos, V-ATPase-d2, and ERK. Moreover, in osteoclasts, CSA blocked RANKL-induced ROS activity as well as calcium oscillations. We further evaluated the therapeutic effect of CSA in a preclinical mouse model and showed that in vivo treatment of ovariectomized C57BL/6 mice with CSA protects the mice from osteoporotic bone loss. Thus, this study demonstrates that osteolytic bone diseases can potentially be treated by CSA.

Topics: Animals; Bone Resorption; Calcium; Gene Expression Regulation; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; RANK Ligand; Reactive Oxygen Species; Salicylates; Signal Transduction; Stilbenes

Topics: Aged; Ear; Humans; Osteoporosis; Rheumatic Diseases; Salicylates; Salicylic Acid

Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondrocalcinosis; Female; Giant Cell Arteritis; Gout; Humans; Male; Middle Aged; Osteoarthritis; Osteoporosis; Rheumatic Diseases; Salicylates

Topics: Adult; Aged; Biopsy; Bone Resorption; Female; Fractures, Spontaneous; Haversian System; Humans; Male; Middle Aged; Osteoporosis; Phenylbutazone; Radiotherapy; Ribs; Salicylates; Spinal Diseases; Spondylitis, Ankylosing; Tetracycline

Topics: Adult; Age Factors; Anemia; Bone Diseases; Bone Resorption; Calcium; Fluorides; Glucocorticoids; Hepatomegaly; Histamine; Histamine Release; Humans; Hydroxyproline; Male; Mast Cells; Opium; Osteoporosis; Peptic Ulcer; Phosphorus; Protein-Losing Enteropathies; Radiography; Salicylates; Serotonin; Sex Factors; Splenomegaly; Urticaria Pigmentosa