salicylates and Nutrition-Disorders

Topics: Acute Kidney Injury; Barbiturates; Blood Volume; Child; Child, Preschool; Costs and Cost Analysis; Heart Failure; Humans; Hyperkalemia; Hypocalcemia; Hypotension; Intestinal Obstruction; Intestinal Perforation; Kidney Failure, Chronic; Metabolic Diseases; Methods; Nutrition Disorders; Peritoneal Dialysis; Poisoning; Renal Dialysis; Salicylates; Time Factors

The serum protein binding of salicylic and salicyluric acid has been determined by ultrafiltration in 60 children after administration of oral salicylate. The children were classified according to nutritional status: well-nourished (n = 12), underweight (n = 12), marasmic (n = 17) marasmic-kwashiorkor (n = 7) and kwashiorkor (n = 12). Salicylic acid free fractions were 0.106 +/- 0.026, 0.114 +/- 0.069, 0.141 +/- 0.037, 0.285 +/- 0.279 and 0.438 +/- 0.190 in the five groups, respectively. Salicyluric acid free fractions were 0.184 +/- 0.057, 0.280 +/- 0.282, 0.236 +/- 0.114, 0.484 +/- 0.497 and 0.646 +/- 0.261, respectively. The degree of binding was dependent on serum albumin levels, ligand concentrations and non-esterified fatty acids (NEFA). The NEFA/albumin ratio ranged from 0.05 to 6.6. The fitting of a one-site Scatchard binding model to the collective data was improved when a decrease was allowed for in the number of binding sites in proportion to NEFA concentrations. Salicyluric acid binding could be fitted only when inhibition of the parent compound was included. Binding was not affected by age or sex. The major determinants of salicylate binding in sera from malnourished children have thus been identified.

Topics: Binding, Competitive; Blood Proteins; Child, Preschool; Chromatography, High Pressure Liquid; Fatty Acids, Nonesterified; Female; Hippurates; Humans; Kwashiorkor; Male; Nutrition Disorders; Protein Binding; Protein-Energy Malnutrition; Salicylates; Salicylic Acid; Serum Albumin

Topics: Humans; Kinetics; Nutrition Disorders; Salicylates

Topics: Adrenal Insufficiency; Carbohydrate Metabolism, Inborn Errors; Ethanol; Glycogen Storage Disease; Hormones, Ectopic; Humans; Hypoglycemia; Hypopituitarism; Insulin; Islets of Langerhans; Liver Diseases; Nutrition Disorders; Pancreatic Neoplasms; Salicylates; Sulfonylurea Compounds

Topics: Agglutination Tests; Anemia, Hypochromic; Antibodies; Antifungal Agents; Antigens; Candidiasis, Cutaneous; Candidiasis, Oral; Child; Child, Preschool; Chronic Disease; Female; Humans; Hypersensitivity, Delayed; Imidazoles; Iron; Male; Nutrition Disorders; Ointments; Pyridoxine; Salicylates; Trityl Compounds; Vitamin A

Topics: Aged; Feces; Female; Hemorrhage; Humans; Hypoprothrombinemias; Malabsorption Syndromes; Male; Nutrition Disorders; Salicylates