salicylates and Nephritis--Interstitial

Non-steroidal anti-inflammatory agents ( NSAIA ) are increasingly used in clinical practice. They exert the majority of their therapeutic and adverse effects by inhibiting prostaglandin synthesis. A variety of clinically important side effects have been described following their administration. We review the renal complications, which include sodium retention, interference with the effectiveness of diuretics, impairment of water excretion, development of hyperkalemia, interference with the therapy of hypertension, and induction of at least four different forms of renal failure. The hemodynamic variety of renal failure and the side effects affecting fluid and electrolyte homeostasis are most likely to become manifest in the context of conditions leading to decreased renal perfusion. Guidelines for use of NSAIA , detection of patients at risk, and therapeutic approaches are provided.

Topics: Acute Kidney Injury; Adult; Aged; Anti-Inflammatory Agents; Blood Pressure; Female; Glomerulonephritis; Hemodynamics; Humans; Hyperkalemia; Hyponatremia; Kidney Diseases; Kidney Papillary Necrosis; Male; Middle Aged; Nephritis, Interstitial; Prostaglandin Antagonists; Prostaglandins; Risk; Salicylates; Water-Electrolyte Balance

Excessive percutaneous absorption of potentially toxic substances such as menthol and methyl salicylate may occur through local application of heat, such as the use of a heating pad. Menthol and methyl salicylate are found in nonprescription items and used for muscular and arthritic pains. This patient experienced full-thickness skin and muscle necrosis as well as persistent interstitial nephritis as a result of topical application of methyl salicylate and menthol followed by use of a heating pad, despite the manufacturer's warning against the use of heating pads.

Topics: Administration, Cutaneous; Drug Combinations; Hot Temperature; Humans; Male; Menthol; Middle Aged; Muscular Diseases; Necrosis; Nephritis, Interstitial; Salicylates; Skin Diseases, Vesiculobullous

To assess the effects of long-term aspirin ingestion on renal function, we studied all of the patients at the Massachusetts General Hospital Arthritis Clinic who had been taking aspirin continuously for ten or more years. Aspirin ingestion was documented by multiple, random, unannounced blood salicylate levels. Most of these 46 patients had seropositive rheumatoid arthritis. All creatinine and BUN levels were normal. Maximum recorded specific gravities were greater than 1.019 in 43 of 46 patients. These data suggest that long-term salicylate ingestion does not cause renal damage.

Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Creatinine; Female; History, 17th Century; Humans; Kidney; Kidney Diseases; Male; Nephritis, Interstitial; Proteinuria; Random Allocation; Salicylates; Time Factors

Topics: Acute Kidney Injury; Adult; Diflunisal; Humans; Male; Nephritis, Interstitial; Salicylates

Topics: Anti-Bacterial Agents; Humans; Nephritis, Interstitial; Salicylates

Topics: Acute Disease; Aged; Dermatitis, Exfoliative; Diflunisal; Female; Humans; Nephritis, Interstitial; Salicylates

Topics: Analgesics; Australia; Drug Combinations; Humans; Kidney Diseases; Kidney Papillary Necrosis; Nephritis, Interstitial; Nonprescription Drugs; Phenacetin; Salicylates; Substance-Related Disorders

Topics: Aged; Anti-Bacterial Agents; Contrast Media; Drug Tolerance; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Nephritis, Interstitial; Nephrosis; Phenacetin; Phenylbutazone; Salicylates; Substance-Related Disorders

Topics: Analgesics; Anemia; Creatinine; Female; Hemoglobinometry; Humans; Kidney Function Tests; Kidney Papillary Necrosis; Male; Middle Aged; Nephritis, Interstitial; Phenacetin; Prognosis; Salicylates; Substance-Related Disorders; Urinary Tract Infections

Topics: Adrenal Cortex Hormones; Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Female; Humans; Kidney Diseases; Kidney Papillary Necrosis; Male; Middle Aged; Nephritis, Interstitial; Phenacetin; Phenylbutazone; Pyelonephritis; Salicylates