salicylates and Mycoses

Topics: Anti-Bacterial Agents; Congenital Abnormalities; Conjunctiva; Diagnosis; Eye Diseases; Eye Neoplasms; Eyelids; Hemorrhage; Humans; Hydantoins; Infections; Irritants; Keratoconjunctivitis; Lacrimal Apparatus; Lacrimal Duct Obstruction; Mycoses; Pathology; Salicylates; Sulfonamides; Surgical Procedures, Operative; Therapeutics; Toxicology; Trachoma

A charge transfer complex of o-phenylenediamine (OPD) as donor with 3,5-dinitrosalicylic acid (DNSH) as acceptor, was synthesized and characterized by FTIR, (1)H NMR, (13)C NMR, mass spectroscopy, elemental analysis and X-ray crystallography. The structural investigations exhibit that the cation and anion are joined together by strong N(+)H⋯O(-) type hydrogen bonds and stoichiometry of CT complex was found to be 1:1. The CT (charge transfer) complex shows remarkable interaction with Calf thymus DNA, and the CT complex was also screened for its microbial activity such as antimicrobial and antifungal activities. A molecular frame work through H-bonding interactions via n→π(*) transitions between neighboring moieties is found which is responsible for high melting point of resulting CT complex. This has been attributed to the formation of 1:1 CT complex.

Topics: Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Cattle; Crystallography, X-Ray; DNA; Fungi; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Mycoses; Phenylenediamines; Salicylates; Spectroscopy, Fourier Transform Infrared

Erythema nodosum is the most common and, in its classic form, the most easily recognized cause of inflammatory nodules on the legs. It is characterized by inflammatory, tender, nonulcerating, nonscarring nodules that are typically multiple and bilateral. The rather characteristic clinical presentation can be attributable to one of many causes or associated with a wide spectrum of systemic diseases. Diagnosis, evaluation, and treatment are discussed.

Topics: Adrenal Cortex Hormones; Bacterial Infections; Bed Rest; Behcet Syndrome; Chlamydia Infections; Diagnosis, Differential; Erythema Nodosum; Humans; Mycoses; Prognosis; Salicylates; Sarcoidosis

Topics: Adult; Female; Humans; Male; Middle Aged; Mycoses; Salicylates; Skin Diseases; Thiazoles

Some substituted dihydroxybenzenes have been examined for suppression of the yeast-induced inflammatory reaction in the rat paw. This anti-inflammatory activity is greatest in those compounds derived from resorcinol and in particular the halogenated 5-methylresorcinols. The significance of the internuclear distance between the hydroxyl groups in the meta-position to each other in resorcinol and the importance of the enhanced activity due to the halogen atom(s) is discussed. In this series the toxicity and activity could not be divorced.

Topics: Anti-Inflammatory Agents; Benzene; Bromine; Inflammation; Mycoses; Pharmacology; Phenols; Rats; Research; Resorcinols; Salicylates

Topics: Antifungal Agents; Drug Combinations; Humans; Mycoses; Piperidines; Salicylanilides; Salicylates