salicylates and Muscular-Diseases

The purpose of this study was to determine the effects of ultrasound and phonophoresis using an anti-inflammatory-analgesic cream (trolamine salicylate) on delayed-onset muscle soreness (DOMS). Repeated eccentric contractions were used to induce DOMS in the elbow flexors of 40 college-aged women. Subjects were then assigned randomly to one of four groups: (1) group 1 (n = 10) received sham ultrasound using placebo cream, (2) group 2 (n = 10) received sham ultrasound using trolamine salicylate cream, (3) group 3 (n = 10) received ultrasound using placebo cream, and (4) group 4 (n = 10) received ultrasound using trolamine salicylate cream. Subjects were treated on 3 consecutive days. Muscle soreness and active elbow range of motion were assessed daily prior to each treatment. The subjects in group 3 experienced an increase in DOMS, whereas no increase in soreness was observed in the subjects in group 4. The authors concluded that ultrasound enhanced the development of DOMS but that this enhancement was offset by the anti-inflammatory-analgesic action of salicylate phonophoresis. These findings suggest that salicylate phonophoresis may be useful in clinical situations in which it is desirable to administer ultrasound without increasing inflammation.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Elbow Joint; Exercise; Female; Humans; Muscular Diseases; Pain Management; Phonophoresis; Range of Motion, Articular; Salicylates; Ultrasonic Therapy

In a double-blind, cross-over study of 90 patients with degenerative disease of the hip, knee, cervical or lumbar spine, and capsulitis of the shoulder the analgesic drug benorylate (either alone or in combination with chlormezanone, a muscle relaxant anxiolytic drug) favourably modified pain, stiffness, quality of sleep and ability to work. Chlormezanone significantly reduced the number of breaks in sleep. There was no significant difference in the number of patients reporting side-effects on each of the four treatments, but drowsiness occurred significantly more in the chlormezanone weeks. There appeared to be no advantage in adding chlormezanone in patients suffering from osteoarthritis of the hip or knee, lumbar spondylosis or capsulitis of the shoulder, but there was significant improvement in both pain relief and quality of sleep in those patients with neck pain.

Topics: Chlormezanone; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Humans; Joint Diseases; Muscular Diseases; Salicylates

Topics: Aged; Analgesics; Aspirin; Bone Diseases; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Joint Diseases; Lysine; Middle Aged; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Pain; Placebos; Salicylates; Stomach

Fosfosal or 2-phosphonoxybenzoic acid is a new analgesic drug, whose analgesic activity and side effects have been determined in a double blind clinical study in comparison with placebo. The study has been done with 60 outpatients, of both sexes, which suffered musculoskeletal and arthritic pains. Patients were treated with fosfosal or placebo for eight days. The daily dose of fosfosal was 1 gram three times a day, once every 6-8 hours. The results obtained show that fosfosal has a clear analgesic activity, statistically significant versus placebo in all the parameters that were measured: pain severity, activity impairment and insomnia. The overall evaluation of the group of patients treated with fosfosal showed a marked improvement with a difference statistically significant with respect to the control group treated with placebo (p less than 0.001). The distribution of results in the fosfosal treated group was as follows: poor, 1; regular, 8; good, 10 and excellent, 6. The distribution in the placebo group was as follows: poor, 15; regular, 3; good, 2 and excellent, 0. The marked analgesic activity, the absence of side effects and the excellent gastric tolerance suggest that fosfosal is a promising new analgesic drug useful for the treatment of painful syndromes of several etiologies.

Topics: Adult; Aged; Analgesics; Arthritis; Bone Diseases; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Pain; Salicylates

Excessive percutaneous absorption of potentially toxic substances such as menthol and methyl salicylate may occur through local application of heat, such as the use of a heating pad. Menthol and methyl salicylate are found in nonprescription items and used for muscular and arthritic pains. This patient experienced full-thickness skin and muscle necrosis as well as persistent interstitial nephritis as a result of topical application of methyl salicylate and menthol followed by use of a heating pad, despite the manufacturer's warning against the use of heating pads.

Topics: Administration, Cutaneous; Drug Combinations; Hot Temperature; Humans; Male; Menthol; Middle Aged; Muscular Diseases; Necrosis; Nephritis, Interstitial; Salicylates; Skin Diseases, Vesiculobullous

Topics: Administration, Topical; Adult; Bone Diseases; Drug Combinations; Female; Humans; Iontophoresis; Male; Muscular Diseases; Nicotinic Acids; Plant Extracts; Salicylamides; Salicylates

A young women ingested large amounts of different analgesics, mainly salicylate and paracetamol. On admission about 17 hours later, clearly toxic serum levels of both drugs were demonstrated. She was comatose with respiratory failure for 5 days. During the first day there was a period of several hours of therapy-resistant hyperthermia. A severe bleeding tendency was probably related to profound coagulation defects. Persistingly elevated serum levels of ASAT and ALAT for two weeks were presumably caused by a toxic effect of paracetamol on the liver. When consciousness was regained, widespread pareses of skeletal muscles, predominantly of the lower limbs, were demonstrated. These were related to extensive rhabdomyolysis as evidenced by extremely elevated serums levels of CPK for 6 weeks, and by muscle necrosis in biopsy specimens. There was a gradual improvement, but walking disturbances were still present after one year. The hyperthermia was probably related to the cerebral effects of salicylates or the combination of multiple drugs. The rhabdomyolysis might be related to a deleterious effect of hyperthermia on the muscles or to an effect of paracetamol on the skeletal muscles similar to that which might occur in the myocardium, or to a combination of these mechanisms.

Topics: Acetaminophen; Adult; Female; Fever; Humans; Muscles; Muscular Diseases; Myoglobinuria; Necrosis; Salicylates; Suicide, Attempted

An open study was carried out in general practice to assess the analgesic effectiveness, tolerance and side-effects of salsalate when given at a dosage of 3 g per day for 6 weeks. Sixty-six patients who were known long-term analgesic users were treated: they included 16 with active inflammatory disease of rheumatoid type, 20 with degenerative joint disease, and 27 with other musculo-skeletal conditions. Three patients were withdrawn during the study because of gastro-intestinal upset. Assessments, using rating scale scores, were made pre-trial and at 2-weekly intervals of joint pain, other musculo-skeletal pain, and duration of morning stiffness. The results showed that there was marked improvement in joint pain and morning stiffness, particularly in those patients with inflammatory joint disease. Improvement in musculo-skeletal discomfort was less evident. Side-effects were reported on 24 occasions, the most frequent being dyspepsia. Faecal occult blood tests showed that there were 7 patients with probable blood loss during treatment, 4 of them, however, had no other clinical signs or symptoms of gastrointestinal intolerance.

Topics: Bone Diseases; Chronic Disease; Female; Humans; Male; Middle Aged; Muscular Diseases; Occult Blood; Pain; Salicylates

Topics: Anti-Inflammatory Agents; Benzoates; Brachial Plexus Neuritis; Drug Combinations; Ethanolamines; Humans; Inflammation; Joint Diseases; Muscular Diseases; Nicotinic Acids; Ointments; Periarthritis; Rheumatic Diseases; Salicylates

Topics: Adolescent; Adult; Aged; Boric Acids; Female; Hematoma; Heparin; Humans; Joint Diseases; Male; Middle Aged; Muscular Diseases; Oils, Volatile; Ointments; Orthopedics; Outpatient Clinics, Hospital; Phlebitis; Salicylates

Topics: Bone Diseases; Glycosaminoglycans; Humans; Muscular Diseases; Salicylates; Tissue Extracts

Topics: Anthracosilicosis; Hemorrhage; Humans; Kidney Diseases; Lung Diseases; Muscular Diseases; Penicillins; Radiography, Thoracic; Salicylates; Scleroderma, Systemic; Vitamin E