salicylates and Multiple-Sclerosis

salicylates has been researched along with Multiple-Sclerosis* in 1 studies

Other Studies

1 other study(ies) available for salicylates and Multiple-Sclerosis

Article	Year
Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice. Proceedings of the National Academy of Sciences of the United States of America, 2017, 08-08, Volume: 114, Issue:32 UV light suppresses experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS, in mice and may be responsible for the decreased incidence of MS in equatorial regions. To test this concept further, we applied commercially available sunblock preparations to mice before exposing them to UV radiation. Surprisingly, some of the sunblock preparations blocked EAE without UV radiation. Furthermore, various sunblock preparations had variable ability to suppress EAE. By examining the components of the most effective agents, we identified homosalate and octisalate as the components responsible for suppressing EAE. Thus, salates may be useful in stopping the progression of MS, and may provide new insight into mechanisms of controlling autoimmune disease. Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Salicylates; Sunscreening Agents; Ultraviolet Rays	2017

Article

Year

Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice.

Proceedings of the National Academy of Sciences of the United States of America, 2017, 08-08, Volume: 114, Issue:32

UV light suppresses experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS, in mice and may be responsible for the decreased incidence of MS in equatorial regions. To test this concept further, we applied commercially available sunblock preparations to mice before exposing them to UV radiation. Surprisingly, some of the sunblock preparations blocked EAE without UV radiation. Furthermore, various sunblock preparations had variable ability to suppress EAE. By examining the components of the most effective agents, we identified homosalate and octisalate as the components responsible for suppressing EAE. Thus, salates may be useful in stopping the progression of MS, and may provide new insight into mechanisms of controlling autoimmune disease.

Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Salicylates; Sunscreening Agents; Ultraviolet Rays

2017