salicylates and Multiple-Myeloma

Ginkgolic acid C 17:1 (GAC 17:1) extracted from

Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Ginkgo biloba; Humans; Interleukin-6; Membrane Potential, Mitochondrial; Multiple Myeloma; Phosphorylation; Plant Extracts; Plant Leaves; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 6; PTEN Phosphohydrolase; Salicylates; STAT3 Transcription Factor

The present investigation was undertaken in order to elucidate the delayed reaction of Bence Jones proteins to sulfosalicylic acid. The author observed this interesting phenomenon in 2 of 32 untreated patients with multiple myeloma who excreted Bence Jones proteins. Their urine samples contained a large amount of Bence Jones proteins with alpha 2 mobility on electrophoresis, which is rarely encountered in urinary Bence Jones proteins. The delayed reaction may be linked, in part at least, to the chemical properties of Bence Jones proteins responsible for alpha 2 mobility.

Topics: Aged; Bence Jones Protein; Benzenesulfonates; False Negative Reactions; Humans; Male; Middle Aged; Multiple Myeloma; Salicylates; Time Factors

Topics: Aged; Benzenesulfonates; False Negative Reactions; Humans; Immunoglobulin kappa-Chains; Immunoglobulin Light Chains; Male; Multiple Myeloma; Proteinuria; Salicylates

The practical importance of BSR and blood cell changes for the early recognition should not be overestimated. But every symptomless person with raised BSR should be examined very carefully, especially for occult hepatic diseases (active hepatitis, liver cirrhosis), for anaemias, leukaemias, malignant lymphomas and other malignant diseases. The practical use of the diagnosis of blood cell changes is the possible recognition of anaemias, leukaemias and malignant lymphomas.

Topics: Adrenal Cortex Hormones; Anemia; Blood Cell Count; Blood Sedimentation; Eosinophilia; Humans; Hyperlipidemias; Leukemia; Liver Diseases; Lymphoma; Multiple Myeloma; Parasitic Diseases; Salicylates

The plasma protein binding of salicylate, a representative acidic drug, and of quinidine, a representative basic drug, has been studied in patients with multiple myeloma, a disease characterized by a profound alteration of the plasma protein pattern. Abnormal binding of salicylate was detected only in patients with high values of circulating abnormal protein. Plasma protein binding of quinidine was not altered in any of the patients studied.

Topics: Adult; Aged; Blood Proteins; Humans; Middle Aged; Multiple Myeloma; Protein Binding; Quinidine; Salicylates