salicylates and Migraine-Disorders

Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ergotamine; Humans; Ibuprofen; Indoles; Migraine Disorders; Naproxen; ortho-Aminobenzoates; Oxazolidinones; Piperidines; Pyrrolidines; Salicylates; Sumatriptan; Triazoles; Tryptamines

Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Diclofenac; Drug Therapy, Combination; Ergotamine; Humans; Ibuprofen; Indoles; Migraine Disorders; Naproxen; ortho-Aminobenzoates; Oxazolidinones; Piperidines; Pyrrolidines; Salicylates; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines

Topics: Acute Disease; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Therapy, Combination; Humans; Migraine Disorders; Randomized Controlled Trials as Topic; Salicylates; Serotonin Receptor Agonists; Treatment Outcome

Topics: Acute Disease; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Therapy, Combination; Humans; Migraine Disorders; Salicylates; Serotonin Receptor Agonists

Twenty-one patients continued a double-blind crossover study to compare the prophylactic effect on migraine of propranolol and clonidine. The daily dosage of propranolol and clonidine was 160 mg and 100 microgram, respectively. Statistical analysis did not show any significant difference between the two drugs in respect to headache or nausea. The number of sickleave days and the use of symptomatic drugs were both less on propranolol treatment than on clonidine, but there was no statistically conclusive difference.

Topics: Adult; Clinical Trials as Topic; Clonidine; Double-Blind Method; Ergotamine; Female; Humans; Male; Middle Aged; Migraine Disorders; Propranolol; Salicylates

The objective of this study was to document the clinical characteristics of migraine and patterns of medication use in residents > or =15 years old in 12 Latin American urban communities.. Few large-scale population studies have established the symptoms and disability associated with migraine with or without aura in Latin American urban communities or the pattern of medication use in these regions.. In this study, subjects in 12 urban communities, from 6 Latin American countries, were surveyed with a validated face-to-face interview questionnaire based on International Headache Society criteria for migraine. The questionnaire was completed during face-to-face interviews with headache sufferers within selected households and included questions about migraine symptoms, migraine-related disability, and the use of health-care resources and medications to treat migraines.. Of the 8618 people available for screening, 62% suffered from headaches. Of individuals with migraine, 42% reported consulting a health-care professional about their headaches. Of the migraineurs, 94.2% reported moderate to severe pain. Associated symptoms of nausea or vomiting, photophobia, phonophobia, and osmophobia were common during migraine attacks in 30.3, 76.4, 85.1, and 47.7% of subjects, respectively. The majority of subjects suffered between one and eight migraines each month. Although no previous diagnosis of migraine was reported by 65% of headache sufferers, migraineurs lost an average of 8 days in the preceding 3 months in any of the following areas: school, work, household chores, and/or social, family, or leisure activities. The agents used most widely to treat migraine were paracetamol and salicylates, while nonsteroidal anti-inflammatory drugs, dypirone, and ergotamines were also commonly used. Medication use varied widely among countries, but was predominantly nonprescription.. Migraine is a common disorder in Latin American urban communities imposing significant burden on individuals, families, and communities. The magnitude of the impact and the range of activities affected by migraine are similar to those of previous reports in other regions. The preponderance of nonprescription medications and the scarcity of migraine-specific triptans from the study findings are especially striking.

Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Disabled Persons; Efficiency; Female; Humans; Latin America; Male; Middle Aged; Migraine Disorders; Salicylates; Urban Population

Topics: Adult; Female; Humans; Migraine Disorders; Recurrence; Respiratory Distress Syndrome; Salicylates

Food intolerant symptoms can have various causes, including enzyme deficiencies (of lactase or aldehyde dehydrogenase) and pharmacological effects (e.g., caffeine, salicylates). The irritable bowel syndrome can also be associated with intolerance to specific foods in some cases, but the mechanism is unclear. Immunological causes are less common but may explain the small bowel mucosal changes associated with gluten enteropathy, as well as the childhood enteropathy provoked by cow's milk or, rarely, by other foods. Food allergy of the more immediate and classical type is associated with reactions both within and outside the gastrointestinal tract. Where these include urticaria, asthma and eczema, immunoglobulin E antibodies are often demonstrable by skin or radioallergosorbent tests, but pseudo-allergic reactions can produce a similar clinical picture. Diagnosis of food intolerance depends on withdrawing the food concerned and assessing the response to a blind challenge. Objective ways of detecting subclinical reactions are also useful, including the detection of a mediator response involving prostaglandins, histamine or serotonin.

Topics: Aldehyde Dehydrogenase; Animals; Asthma; beta-Galactosidase; Cattle; Food Hypersensitivity; Humans; Migraine Disorders; Milk; Salicylates

46 migraine patients and 4 patients suffering from "nonmigrainous" vascular headache were treated with 250 mg salicylate daily for 2 months. Platelet aggregability before and under treatment was measured in all patients and in 10 controls. The results confirm platelet hyperaggregability in migraine patients and a reduction of aggregability under salicylate out provide no evidence of any significant clinical improvement, thus falsifying the hypothesis of migraine as a platelet aggregation disorder.

Topics: Adolescent; Adult; Aged; Aspirin; Female; Humans; Male; Middle Aged; Migraine Disorders; Platelet Aggregation; Salicylates; Salicylic Acid; Vascular Headaches

Plasma aspirin and salicylate levels were measured at intervals over a two hour period during migraine attacks in 10 subjects given 900 mg oral aspirin alone, in 10 subjects given 900 mg oral aspirin plus 10 mg oral metoclopramide, and in 10 subjects given 900 mg oral aspirin plus an intramuscular injection of 10 mg metoclopramide. Higher peak aspirin and salicylate levels occurred in patients given aspirin with metoclopramide. Aspirin tended to appear in plasma earlier in patients given aspirin with oral metoclopramide than in patients given aspirin alone, or aspirin with intramuscular metoclopramide. Patients given aspirin with oral metoclopramide tended to obtain better early pain relief than the other two treatment groups, though by one hour from dosage use of injected metoclopramide was also associated with better pain relief.

Topics: Adolescent; Adult; Aspirin; Drug Therapy, Combination; Female; Humans; Male; Metoclopramide; Middle Aged; Migraine Disorders; Salicylates; Time Factors

Topics: Audiometry; Cornea; Diagnosis, Differential; Electrocardiography; Female; Headache; Histamine; Humans; Indomethacin; Kininogens; Middle Aged; Migraine Disorders; Pulse; Salicylates; Vascular Headaches

Topics: Antiemetics; Autogenic Training; Ergotamine; Glucocorticoids; Humans; Hypnosis; Hypnotics and Sedatives; Migraine Disorders; Salicylates

Topics: Child; Eye Diseases; Female; Follow-Up Studies; Headache; Humans; Male; Migraine Disorders; Salicylates

The plasma levels of the urate-binding alpha(1)-alpha(2)-globulin, as determined by its urate-binding capacity, have been recorded in 19 individuals from two gouty kindreds. A significantly reduced binding capacity, accounting for 13-30% of the mean value obtained in healthy, unrelated control subjects, was found in all cases of gout and in the single case of essential hyperuricemia included in the present study. In addition, six apparently healthy members of one of these kindreds also exhibited this characteristic. The distribution of the characteristic in three subsequent generations from this kindred further supported the hypothesis that the reduced binding capacity was inherited as an autosomal trait for which affected subjects were heterozygous. Based on the present observation, the mechanisms of inheritance in primary gout are discussed with special emphasis on the possible cooperation of genetic and environmental factors.

Topics: Adult; Alpha-Globulins; Arthritis; Autoradiography; Chromatography, Gel; Epilepsy; Female; Gout; Heterozygote; Humans; Immunoelectrophoresis; Kidney; Male; Middle Aged; Migraine Disorders; Narcolepsy; Pedigree; Protein Binding; Puberty; Salicylates; Spectrophotometry; Uric Acid

Topics: Humans; Migraine Disorders; Salicylates