salicylates and Malabsorption-Syndromes

Diarrhea is a common clinical feature of inflammatory bowel diseases and may be accompanied by abdominal pain, urgency, and fecal incontinence. The pathophysiology of diarrhea in these diseases is complex, but defective absorption of salt and water by the inflamed bowel is the most important mechanism involved. In addition to inflammation secondary to the disease, diarrhea may arise from a variety of other conditions. It is important to differentiate the pathophysiologic mechanisms involved in the diarrhea in the individual patient to provide the appropriate therapy. This article reviews microscopic colitis, ulcerative colitis, and Crohn's disease, focusing on diarrhea.

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidiarrheals; Bacterial Infections; Biopsy; Bismuth; Blood Cell Count; Blood Chemical Analysis; Body Water; Breath Tests; Budesonide; Cholestyramine Resin; Colitis, Microscopic; Diarrhea; Drug-Related Side Effects and Adverse Reactions; Endoscopy, Gastrointestinal; Feces; Glucocorticoids; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Intestinal Absorption; Intestinal Fistula; Intestinal Mucosa; Intestines; Ion Transport; Malabsorption Syndromes; Medical History Taking; Mesalamine; Organometallic Compounds; Physical Examination; Postoperative Complications; Prednisolone; Salicylates; Sodium; Tumor Necrosis Factor-alpha

Topics: Bismuth; Body Water; Breath Tests; Child, Preschool; Chronic Disease; Diagnosis, Differential; Diarrhea, Infantile; Dicyclomine; Dietary Carbohydrates; Fruit; Gastrointestinal Motility; Humans; Infant; Infant, Newborn; Intestinal Diseases, Parasitic; Lactose Intolerance; Loperamide; Malabsorption Syndromes; Myoelectric Complex, Migrating; Organometallic Compounds; Salicylates

Topics: Aminosalicylic Acids; Anticonvulsants; Biological Transport; Blood Glucose; Celiac Disease; Cholesterol; Colchicine; Folic Acid; Glucose; Humans; Intestinal Absorption; Intestine, Small; Malabsorption Syndromes; Neomycin; Pharmaceutical Preparations; Phenformin; Phenylbutazone; Salicylates; Vitamin B 12; Xylose

Salicylate intolerance is defined as a nonspecific antigen-induced pseudo-allergic hypersensitivity reaction which can occur upon contact of an organism with salicylic acid, its derivatives or other related organic or inorganic acids of similar chemical structure. Since the effects of nonsteroidal anti-inflammatory drugs (NSAID) intolerance are by no means always severe or life-endangering but may just as well present as oligosymptomatic or local disorders (e.g. abdominal pain, diarrhea, we decided to evaluate the characteristics of patients with salicylate intolerance on the basis of gastroenterological case material of Medical Department I of Erlangen University. On the basis of the findings from the Erlangen interdisciplinary data register of chronic inflammatory gastrointestinal disease, the signs and symptoms of NSAID intolerance were found to constitute a diagnosis of great practical import to clinical medicine (allergology, dermatology, immunology, other disorders etc.) including gastroenterology. For approx. 2-7% of all patients with inflammatory bowel syndrome and food allergies this poses a new diagnostic and therapeutic challenge which may concern physicians from any of the disciplines involved. When presented with patients with chronic active disease who are suffering from these symptoms one should, therefore, in future give greater thought to the possibility of salicylate intolerance, all the more as there are meaningful dietetic, diagnostic and therapeutic options available for these persons.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis, Ulcerative; Crohn Disease; Diet; Drug Hypersensitivity; Food Hypersensitivity; Gastrointestinal Diseases; Humans; Irritable Bowel Syndrome; Lower Gastrointestinal Tract; Malabsorption Syndromes; Mesalamine; Salicylates

Topics: Adult; Atrophy; Chloramphenicol; Cycloserine; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Isoniazid; Malabsorption Syndromes; Male; Middle Aged; Quinine; Salicylates; Sulfisoxazole

Topics: Aged; Feces; Female; Hemorrhage; Humans; Hypoprothrombinemias; Malabsorption Syndromes; Male; Nutrition Disorders; Salicylates

Topics: Adrenal Cortex Hormones; Bone Resorption; Calcitonin; Calcium; Female; Fluorides; Humans; Malabsorption Syndromes; Middle Aged; Osteitis Deformans; Pain; Pelvis; Phosphates; Radiography; Salicylates; Sodium