salicylates and Lupus-Erythematosus--Systemic

Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Autoimmune Diseases; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Myasthenia Gravis; Pemphigoid Gestationis; Polyarteritis Nodosa; Pregnancy; Pregnancy Complications; Salicylates; Scleroderma, Systemic; Thrombocytopenia; Thyroid Diseases

Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cryoglobulinemia; Felty Syndrome; Giant Cell Arteritis; Humans; Liver Diseases; Lupus Erythematosus, Systemic; Polymyalgia Rheumatica; Rheumatic Diseases; Rheumatic Fever; Salicylates; Scleroderma, Systemic; Sjogren's Syndrome; Vasculitis

Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Gold; Gout; Humans; Lupus Erythematosus, Systemic; Osteoarthritis; Penicillamine; Rheumatic Diseases; Salicylates; Spondylitis, Ankylosing; Vasculitis

Topics: Antigen-Antibody Reactions; Antimalarials; Diagnosis, Differential; Humans; Lupus Erythematosus, Systemic; Salicylates; Steroids

Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Reactions; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Epinephrine; Fever; Histamine H1 Antagonists; Humans; Jaundice; Lupus Erythematosus, Systemic; Prednisone; Salicylates; Serum Sickness; Skin Tests; Thrombocytopenia

Topics: Adrenal Cortex Hormones; Antimalarials; Antineoplastic Agents; Humans; Indomethacin; Lupus Erythematosus, Systemic; Salicylates

Topics: Animals; Autoantibodies; Cytokines; Disease Progression; Female; Glycosides; Inflammation; Lupus Erythematosus, Systemic; Mice; Mice, Inbred BALB C; Salicylates; Signal Transduction; Terpenes

A sudden hearing loss in a woman on aspirin has uncovered a frequently neglected toxicological parameter.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Progression; Female; Hearing Loss; Humans; Lupus Erythematosus, Systemic; Proteinuria; Salicylates; Tinnitus

Topics: Asthma; Bismuth; Female; Gastroesophageal Reflux; Humans; Lupus Erythematosus, Systemic; Middle Aged; Organometallic Compounds; Salicylates; Tongue Diseases

Activation and proliferation of lymphocytes requires the active signal transducer Ras. Activation of lymphocytes, associated with autoimmunity, may therefore be modified by S-farnesylthiosalicylic acid (FTS), a synthetic substance that detaches Ras from the inner cell membrane and induces its rapid degradation. The MRL/lpr mouse is a genetic model of a generalized autoimmune disease sharing many features and organ pathology with systemic lupus erythematosus (SLE) and the primary antiphospholipid syndrome (APS). The objective of the present study was to examine the effect of FTS on laboratory and clinical pathology in the MRL/lpr mouse. Female MRL/lpr (n = 50) and MRL/++ control (n = 35) mice were treated intraperitoneally with either FTS (5 mg/kg/day) or saline between 6 and 18 weeks of age. The mice were weighed, tested for proteinuria and lymphadenopathy, lymphocyte proliferation, antibodies, grip strength and behaviour in an open field. FTS treatment resulted in a 50% decrease in splenocyte proliferation to ConA, LPS and a disease specific antigen, beta(2)-glycoprotein-I, and in a significant decrease in serum antibody levels against cardiolipin and dsDNA. Proteinuria and grip strength were normalized and lymphadenopathy and postmortem lymph node and spleen weights were significantly reduced in FTS treated MRL/lpr mice. These findings indicate that modulation of Ras activation has a significant impact on the MRL/lpr model and may represent a new therapeutic approach for the treatment of systemic autoimmune diseases such as SLE and APS.

Topics: Animals; Antiphospholipid Syndrome; Autoantibodies; Autoimmune Diseases; Farnesol; Female; In Vitro Techniques; Lupus Erythematosus, Systemic; Lymphatic Diseases; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred MRL lpr; ras Proteins; Salicylates

After a patient with a history of systemic lupus erythematosus in remission was given salsalate, all of her hematologic elements, especially leukocytes, profoundly decreased within hours, although the patient was receiving steroids. She had been challenged with salsalate at an earlier date, with a similar but less impressive drop in blood counts. Granulocytotoxic antibodies persisted during this episode in contrast to declining lymphocytotoxic and anti-native DNA antibodies that accompanied a remission of systemic lupus. This is the first case of this kind occurring with salsalate therapy and may have represented preformed antibodies induced by salsalate.

Topics: Adolescent; Antibodies; Antibody Affinity; Antilymphocyte Serum; Female; Granulocytes; Humans; Lupus Erythematosus, Systemic; Pancytopenia; Remission Induction; Salicylates

Topics: Bismuth; Humans; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Organometallic Compounds; Salicylates; Syphilis

Topics: Child; Cyclophosphamide; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Prednisone; Salicylates

Topics: Adult; Female; Humans; Lupus Erythematosus, Systemic; Prednisone; Pregnancy; Pregnancy Complications; Salicylates

The mechanism for aspirin-caused liver injury is not clear. Aspirin produces hepatotoxic reactions as a cumulative phenomenon, requiring days or weeks to develop. Patients with active rheumatic or collagen disease, as well as children, are especially susceptible. Blood levels of salicylate higher than 25 mg/dL are particularly likely to lead to hepatic injury. Levels lower than 15 mg/dL rarely do. The mechanism for acetaminophen liver damage is quite clear. It produces hepatic injury as a result of a large single overdose, usually suicidal in intent. Patients with acetaminophen blood levels higher than 300 mg/dL at four hours after intake are most likely to develop hepatic damage; when N-acetylcysteine is used within the first ten hours after ingestion of an overdose, the recovery rate is reported to be virtually 100%. The conditions of patients receiving long-term full doses of either aspirin or acetaminophen should be intermittently monitored for hepatic injury.

Topics: Acetaminophen; Adolescent; Adult; Alcoholism; Arthritis, Juvenile; Aspirin; Child; Female; Humans; Liver; Lupus Erythematosus, Systemic; Male; Salicylates

110 patients with various arthropathies, mostly rheumatoid arthritis, treated with salicylates, were investigated for the presence of signs of liver disease attributable to this drug. An increased serum alkaline phosphatase level was observed in 9 of 96 ASA-treated patients with rheumatoid arthritis. However, this alteration could not be related to the use of salicylates, nor to the ingestion of any other antirheumatic drug. The hyperphosphatasemia persisted during a three-year follow-up in five of the nine patients.

Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Arthritis; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Liver; Liver Function Tests; Lupus Erythematosus, Systemic; Male; Middle Aged; Salicylates

Topics: Adrenal Cortex Hormones; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Pregnancy; Remission, Spontaneous; Salicylates

Topics: Brain Neoplasms; Cerebrovascular Disorders; Dermatitis, Atopic; Humans; Lupus Erythematosus, Systemic; Orosomucoid; Polarography; Psoriasis; Salicylates

Topics: Aged; Azathioprine; Chloroquine; Cyclophosphamide; Diagnosis, Differential; Female; Glucocorticoids; Humans; Indomethacin; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Phenylbutazone; Prednisone; Salicylates; Sex Factors; Syndrome

The three principal syndromes of juvenile rheumatoid arthritis have distinctive features that aid in early diagnosis and can contribute to specificity of treatment. Guidelines are given for differentiating JRA from other disorders producing joint pain.

Topics: Arthritis, Juvenile; Child; Diagnosis, Differential; Gold Sodium Thiomalate; Humans; IgA Vasculitis; Lupus Erythematosus, Systemic; Salicylates; Spondylitis, Ankylosing; Uveitis, Anterior

Four women with fever, arthromyalgias, pericarditis, pleural effusion, high erythrocyte sedimentation rates, and lymphopenia had mitochondrial antibodies in the serum in the absence of antinuclear antibody. Their illness lasted 5-12 weeks and the antibody test results became negative on remission. Absence of specific bacteriological findings, normal antistreptolysin O titres, resistance to antibiotics, and good response to steroids suggested that these cases represented a milder and less persistent form of the syndrome resembling systemic lupus erythematosus described by German authors.

Topics: Adult; Antibodies, Antinuclear; Autoantibodies; Blood Sedimentation; Diagnosis, Differential; Drug Resistance; Female; Humans; Lupus Erythematosus, Systemic; Mitochondria; Pericarditis; Pleural Effusion; Pneumonia; Prednisone; Salicylates

Topics: Adolescent; Adrenal Cortex Hormones; Ambulatory Care; Child; Female; Humans; Lupus Erythematosus, Systemic; Male; Methods; Moscow; Salicylates; Vitamins

Topics: Betamethasone; Chronic Disease; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Ointments; Salicylates

Topics: Adolescent; Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Brain; Child; Child, Preschool; Dermatomyositis; Electroencephalography; Female; Gold; Humans; Lupus Erythematosus, Systemic; Male; Phenylbutazone; Psoriasis; Salicylates; Scleroderma, Localized; Sex Factors

Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Behcet Syndrome; Chronic Disease; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Recurrence; Salicylates; Thromboangiitis Obliterans; Thrombophlebitis

Topics: Adrenal Cortex Hormones; Antimalarials; Chloroquine; Collagen Diseases; Humans; Lupus Erythematosus, Systemic; Physical Therapy Modalities; Salicylates

Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Biopsy; Connective Tissue; Dermatomyositis; Diphosphates; Gout; Humans; Hyperparathyroidism; Inflammation; Joint Diseases; Lupus Erythematosus, Systemic; Neutrophils; Polyarteritis Nodosa; Psoriasis; Rheumatoid Factor; Salicylates; Sarcoidosis; Spondylitis, Ankylosing; Synovial Fluid; Synovial Membrane; Uric Acid

Using a new in vitro method of measuring the chemotaxis of polymorphonuclear leukocytes from peripheral blood, a chemotactic index has been calculated. The mean chemotactic index of 320 in 24 patients with definite rheumatoid arthritis, was significantly less (P < 0.0005) than the mean of 555 in 24 normal controls matched for age and sex. The mean chemotactic index of 435 in eight patients with juvenile rheumatoid arthritis was also significantly less (P < 0.01) than that of 553 in similarly matched controls. The chemotactic index could not be correlated with age, sex, disease activity, drugs used in treatment, latex titer, immunoglobulin levels, or protein coating on the cells. However, there was a correlation between the chemotactic index and the serum complement B(1e)/B(1a) value (P < 0.01) in 17 patients with adult onset rheumatoid arthritis. Although the serum complement B(1e)/B(1a) values were within the normal range, the lowest chemotactic indices were associated with the lowest complement values. The chemotactic indices in three patients with severe connective tissue disease (seropositive rheumatoid arthritis, systemic lupus erythematosus, and polymyositis) returned to normal after 5 days' treatment with 60 mg of prednisolone per day. Incubation of the cells from patients with rheumatoid arthritis with hydrocortisone in vitro failed to alter the chemotactic indices. Prior incubation of normal cells with purified rheumatoid factor complexes, rheumatoid serum, or macromolecules of iron dextran impaired their chemotaxis. It is suggested that phagocytosis of complexes in vivo is a possible mechanism by which the chemotaxis of the polymorphonuclear leukocytes of patients with rheumatoid arthritis is impaired. This impairment in chemotaxis may explain the increased incidence of bacterial infection, both during life and as a cause of death in these patients.

Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Chemotaxis; Child; Complement System Proteins; Female; Humans; Hydrocortisone; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Latex Fixation Tests; Leukocytes; Lupus Erythematosus, Systemic; Male; Methods; Middle Aged; Myositis; Phagocytosis; Prednisolone; Rheumatoid Factor; Salicylates

Topics: Aldehydes; Blood Platelets; Catechols; Cell Membrane; Chloroquine; Colchicine; Collagen; Complement Fixation Tests; Complement Inactivator Proteins; Guaiacol; Humans; Latex Fixation Tests; Lupus Erythematosus, Systemic; ortho-Aminobenzoates; Phenylbutazone; Platelet Adhesiveness; Resorcinols; Salicylates; Silicones; Sodium; Sulfinpyrazone

Topics: Arthritis, Rheumatoid; Collagen Diseases; Humans; Lupus Erythematosus, Systemic; Prednisolone; Pyrazoles; Rheumatic Fever; Rheumatic Heart Disease; Salicylates; Scleroderma, Systemic; Triamcinolone

Topics: Adrenocorticotropic Hormone; Blood Urea Nitrogen; Chloroquine; Follow-Up Studies; Histological Techniques; Humans; Kidney; Kidney Function Tests; Lupus Erythematosus, Systemic; Nephritis; Prednisone; Prognosis; Proteinuria; Salicylates

Topics: Alkylating Agents; Antimalarials; Glucocorticoids; Humans; Immunosuppressive Agents; Indomethacin; Kidney Transplantation; Lupus Erythematosus, Systemic; Phenylbutazone; Prognosis; Rest; Salicylates; Sunlight; Thymectomy; Transplantation, Homologous

Topics: Alopecia Areata; Benzalkonium Compounds; Dermatologic Agents; Eczema; Humans; Keloid; Lichen Planus; Lupus Erythematosus, Systemic; Neurodermatitis; Pruritus Ani; Psoriasis; Salicylates; Scleroderma, Systemic; Skin Diseases; Triamcinolone

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Blindness; Cataract; Conjunctivitis; Diplopia; Drug Therapy; Edema; Eye Diseases; Eye Manifestations; Glaucoma; Gold; Humans; Iatrogenic Disease; Intraocular Pressure; Iridocyclitis; Iritis; Keratitis; Lupus Erythematosus, Systemic; Myopia; Rheumatic Diseases; Salicylates; Spondylitis; Spondylitis, Ankylosing; Toxicology; Uveitis

Topics: Adrenal Cortex Hormones; Antigen-Antibody Reactions; Antineoplastic Agents; Arthritis; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Drug Therapy; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Phenylbutazone; Salicylates; Toxicology

Topics: Adolescent; Agranulocytosis; Anemia; Anemia, Aplastic; Anti-Bacterial Agents; Bone Marrow; Bone Marrow Diseases; Codeine; Depression; Dextropropoxyphene; Drug Hypersensitivity; Drug Therapy; Hydroxychloroquine; Lupus Erythematosus, Systemic; Methenamine; Prednisolone; Salicylates; Sulfonamides; Toxicology

Topics: Adrenal Cortex Hormones; Antimalarials; Diagnosis; Female; Fluocinolone Acetonide; Iatrogenic Disease; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Prednisone; Pregnancy; Pregnancy Complications; Prognosis; Salicylates; Toxicology; Triamcinolone Acetonide

Topics: Arthritis; Arthritis, Rheumatoid; Blood Transfusion; Collagen Diseases; Connective Tissue; Cortisone; Humans; Lung Diseases; Lupus Erythematosus, Systemic; Pathology; Physical Therapy Modalities; Polyarteritis Nodosa; Radiography, Thoracic; Salicylates; Scleroderma, Systemic

Topics: Benzenesulfonates; Cholesterol; Diagnostic Tests, Routine; Lupus Erythematosus, Systemic; Salicylates; Sulfonic Acids

Topics: Humans; Lupus Erythematosus, Systemic; Salicylates; Sodium Salicylate