salicylates and Infant--Newborn--Diseases

Salicylates have been the most widely studied of the nonnarcotic analgesics in pregnancy, and in the last 20 years evidence has accumulated indicating that their ingestion in pregnancy may have adverse effects on the mother and her child. Salicylates have been found to reduce the mean birth weight of the offspring in animal studies and in 1 human study. In the third trimester of pregnancy the maternal and fetal effects are mediated through the antiprostaglandin properties of salicylates and include prolongation of gestation and labor, increased blood loss at delivery, and increased perinatal mortality. Bleeding manifestations and withdrawal symptoms in newborn infants are associated with raised fetal blood salicylate levels. These effects of salicylates warrant routine antenatal urinary screening for salicylates in communities known to use them heavily. Adverse maternal or fetal effects form acetaminophen use in pregnancy have not been reported, but formal clinical or epidemiologic studies of its use have not been conducted.

Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Birth Weight; Chemical and Drug Induced Liver Injury; Female; Fetal Blood; Fetal Growth Retardation; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Liver; Obstetric Labor Complications; Pregnancy; Pregnancy, Prolonged; Retrospective Studies; Salicylates

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Anticoagulants; Antimetabolites; Antineoplastic Agents; Antithyroid Agents; Female; Fetal Diseases; Fetus; Hemolysis; Hormones; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregnancy; Reserpine; Salicylates; Thalidomide; Tolbutamide; Vitamin K

Topics: Adult; Chickenpox; Chickenpox Vaccine; Disease Transmission, Infectious; Female; Humans; Immunocompromised Host; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Salicylates; Vaccines, Attenuated

Impaired bilirubin-albumin binding (peroxidase method) was found in serum from a salicylate-toxic neonate. Bilirubin binding improved with serum dilution, indicating weak, competitive salicylate binding. The competitive effect of salicylate was much less than expected from calculations using data from the literature. This occurs because salicylate displaces bilirubin only from the primary bilirubin binding site, and the displaced bilirubin is buffered by secondary bilirubin binding sites. Binding data for salicylate and bilirubin are used to derive guidelines for the clinical management of jaundice in the salicylate-toxic neonate.

Topics: Bilirubin; Binding Sites; Binding, Competitive; Cesarean Section; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Diseases; Salicylates; Serum Albumin

Topics: Bilirubin; Binding Sites; Binding, Competitive; Caprylates; Fatty Acids, Nonesterified; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Infant, Newborn; Infant, Newborn, Diseases; Linoleic Acids; Protein Binding; Safflower Oil; Salicylates; Serum Albumin; Spectrum Analysis

This is a report of a 16-day-old, breast-fed infant who presented with metabolic acidosis and no history of drug ingestion. Salicylate intoxication was demonstrated as the probable cause of the acidosis.

Topics: Acidosis; Breast Feeding; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Milk, Human; Salicylates

Topics: Acetazolamide; Aspirin; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Salicylates

Sebaceous gland activity in the newborn and children is extensive at first in the epidermis, and later decreases owing to defective operation of the sweat glands, circulation changes, growth of the hair, and a predisposition to infection, for which significant treatment is required. In addition to the genetic "typus neurodermiticus", pharmaceutical, alimentary and respiratory allergens and psychological factors may play a part in the appearance of atopical dermatitis. Onset is usually in the 2nd to 6th month and the side of the face and the scalp are affected. The clinical picture varies considerably with age and includes sanious foci covered with scabs on the head and eczema flexurarum. Differences in family history, age and the location of sites will distinguish this form from seborrhoeic dermatitis. Gluteal dermitis is secondary to congestion caused by dampness, rugging and soaking, and the action of stools and urine (bacterial amniogenesis). The main complications of neonatal and infantile impetigo are: glomerulonephritis, exfoliative dermatitis, pulmonary abscess, pulmonitis and osteomyelitis; phlyctenular, serpiginous impetigo with large and small bullae is particularly important. Treatment of neonatal and infantile dermatosis must take account of the fact that increased reabsorption and congestion are contraindications for the local application of corticoids and preparations containing salicylic and boric acid.

Topics: Anti-Bacterial Agents; Child, Preschool; Dermatitis, Atopic; Dermatitis, Seborrheic; Diagnosis, Differential; Diet Therapy; Eczema; Humans; Hypnotics and Sedatives; Impetigo; Infant; Infant, Newborn; Infant, Newborn, Diseases; Neurodermatitis; Nystatin; Oils; Ointments; Salicylates; Skin Diseases

Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregnancy; Purpura; Salicylates

Topics: Blood Platelet Disorders; Female; Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregnancy; Salicylates

Topics: Brain Diseases; Female; Gliosis; Hippocampus; Humans; Hypothalamus; Infant; Infant, Newborn; Infant, Newborn, Diseases; Inferior Colliculi; Male; Maternal-Fetal Exchange; Medulla Oblongata; Neuroglia; Pregnancy; Reticular Formation; Salicylates; Thalamus

Topics: Blood; Blood Proteins; Epilepsy; Epilepsy, Tonic-Clonic; Female; Humans; Hyperbilirubinemia; In Vitro Techniques; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Phenytoin; Protein Binding; Salicylates; Serum Albumin; Umbilical Cord; Uremia

Topics: Aspirin; Blood Proteins; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregnancy; Protein Binding; Salicylates; Serum Albumin; Umbilical Cord

Topics: Child Abuse; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Salicylates; Seizures

Topics: Adrenal Cortex Hormones; Analgesics; Anthelmintics; Anti-Bacterial Agents; Barbiturates; Dermatologic Agents; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Hormones; Humans; Infant, Newborn; Infant, Newborn, Diseases; Malpractice; Pharmaceutical Preparations; Phenothiazines; Salicylates; Skin Manifestations; Sulfonamides

Topics: Analgesics; Analgesics, Non-Narcotic; Anemia; Anemia, Hemolytic; Antimalarials; Antipyretics; Erythroblastosis, Fetal; Female; Fetal Diseases; Glucosephosphate Dehydrogenase Deficiency; Glucosephosphates; Humans; Hyperbilirubinemia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Jaundice; Jaundice, Neonatal; Maternal-Fetal Exchange; North Carolina; Novobiocin; Pregnancy; Salicylates; Sulfisoxazole; Toxicology; Vitamin K

Topics: Blood Transfusion; Burns; Child; Chlorides; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infusions, Parenteral; Intestinal Obstruction; Kidney; Peritonitis; Potassium; Pyloric Stenosis; Salicylates; Sodium; Toxicology; Water; Water-Electrolyte Balance

Topics: Administration, Oral; Child; Eczema; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Salicylates; Sodium Salicylate