salicylates and Hyperlipidemias

We compared the COBAS(R) acetaminophen and salicylate assays (Roche Diagnostics) with the Stanbio GDS assays (Stanbio Laboratories) that are currently used in our laboratory with respect to interferences from hemolysis and lipemia.. Acetaminophen and salicylate were added into human serum with varying concentrations of hemoglobin or Intralipid to generate a range of acetaminophen and salicylate concentrations. Then the COBAS and GDS assays were used to measure the apparent drug concentrations; the H and L indices were measured to determine the extent of hemolysis and lipemia present in each specimen.. Both hemolysis and lipemia have less effect on the COBAS(R) acetaminophen and salicylate assays than on the GDS assays.. The COBAS assays for acetaminophen and salicylate are preferable to the current GDS assays in clinical toxicology laboratories.

Topics: Acetaminophen; Biological Assay; Hemolysis; Humans; Hyperlipidemias; Reproducibility of Results; Salicylates

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cardiomyopathies; Clinical Laboratory Techniques; False Positive Reactions; Humans; Hyperlipidemias; Hypothyroidism; Indicators and Reagents; Lipids; Male; Salicylates; Spectrophotometry, Ultraviolet

The practical importance of BSR and blood cell changes for the early recognition should not be overestimated. But every symptomless person with raised BSR should be examined very carefully, especially for occult hepatic diseases (active hepatitis, liver cirrhosis), for anaemias, leukaemias, malignant lymphomas and other malignant diseases. The practical use of the diagnosis of blood cell changes is the possible recognition of anaemias, leukaemias and malignant lymphomas.

Topics: Adrenal Cortex Hormones; Anemia; Blood Cell Count; Blood Sedimentation; Eosinophilia; Humans; Hyperlipidemias; Leukemia; Liver Diseases; Lymphoma; Multiple Myeloma; Parasitic Diseases; Salicylates

Topics: Adult; Aldosterone; Animals; Biological Transport; Caprylates; Centrifugation; Chickens; Cholesterol; Dicumarol; Digitoxin; Digoxin; Estradiol; Fatty Acids; Hormones; Humans; Hydrocortisone; Hyperlipidemias; Male; Pentobarbital; Pharmaceutical Preparations; Phenytoin; Protein Binding; Rabbits; Salicylates; Testosterone