salicylates and Hypercalcemia

We critically reviewed the English language literature pertaining to drug-induced pancreatitis and attempted to determine whether the reported association between each drug and pancreatitis was valid. The following drugs seem to cause pancreatitis: azathioprine, thiazides, sulfonamides, furosemide, estrogens, and tetracycline. Less convincing, but suggestive evidence exists for: 1-asparaginase, iatrogenic hypercalcemia, chlorthalidine, corticosteroids, ethacrynic acid, phenformin, and procainamide. Evidence implicating other drugs is either inadequate or contradictory. Little is known about the pathogenesis of drug-induced pancreatitis. Ethanol was not considered in this review.

Topics: Acetaminophen; Adrenal Cortex Hormones; Amphetamines; Asparaginase; Azathioprine; Chlorthalidone; Cholestyramine Resin; Cimetidine; Cyproheptadine; Dextropropoxyphene; Diazoxide; Diuretics; Estrogens; Ethacrynic Acid; Furosemide; Histamine; Humans; Hypercalcemia; Indomethacin; Isoniazid; Mercaptopurine; Narcotics; Pancreatitis; Phenformin; Procainamide; Rifampin; Salicylates; Sodium Chloride Symporter Inhibitors; Sulfonamides; Tetracycline

Pregnant and non pregnant rats were fed diets with different Mg content and treated with 5 oral doses of 300 mg/kg salicylic acid for 5 consecutive days or from day 16 to 20 of gestation. One day after the final dosage, serum Mg and Ca concentrations were measured by atomic absorption spectrophotometry. In maternal rats, salicylate caused a strong decrease of serum Ca with increasing serum Mg concentrations (r = -0.8706). In fetal and nonpregnant adult female rats, serum Ca was not significantly decreased by salicylate with increasing serum Mg concentrations. However, the hypocalcemic effect of salicylate was found when nonpregnant young growing rats were fed a Ca-deficient diet.

Topics: Animals; Diet; Drug Interactions; Female; Hypercalcemia; Magnesium; Pregnancy; Pregnancy Complications; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid

Topics: Bismuth; Diarrhea; Humans; Hypercalcemia; Organometallic Compounds; Risk; Salicylates; Travel

Topics: Alkalosis; Anatomy; Carbonic Anhydrases; Diuretics; Electrolytes; Estrogens; Humans; Hypercalcemia; Hypokalemia; Hyponatremia; Milk; Organomercury Compounds; Salicylates; Sodium; Spironolactone; Vitamin D; Water; Water-Electrolyte Balance

Topics: Anabolic Agents; Biochemical Phenomena; Biochemistry; Calcium; Calcium, Dietary; Diet; Edetic Acid; Hyaluronoglucosaminidase; Hydrogen-Ion Concentration; Hypercalcemia; Immobilization; Inositol; Kidney Calculi; Lithiasis; Paralysis; Paraplegia; Pathology; Poliomyelitis; Salicylates; Steroids; Urine