salicylates and Herpes-Simplex

Infections in neonates with herpes simplex virus 1 (HSV-1) following circumcision due to Metzitzah Be'Peh (MBP) performed by a Mohel occur each year in small numbers. One solution to this problem is the use of a mucus extractor device instead of MBP, which has been authorized by some rabbis. Yet, using a mucus extractor remains controversial among ultra-Orthodox Jews; thus, creating a need for additional solutions.. To seek to reduce HSV-1 infection of neonates due to MBP.. We tested several oral rinse solutions for their ability to destroy virus infectivity following incubation for 30 seconds and using plaque reduction assays.. Corsodyl, Decapinol, and Listerine® all destroyed plaques formation of spiked virus, while Gengigel and Tantum Verde were found to be less effective. We focused specifically on Listerine® due to its efficacy in eliminating contagious HSV-1 from saliva after a 30-second oral rinse. Five different products of Listerine® reduced the infectivity of a spiked virus by more than 4 orders of magnitude in 30 seconds. We also showed that Listerine (up to 7% v/v) can stay in the mouth but did not harm living cells and therefore will not cause any damage to the injured tissue.. Significant reduction in cases of infection with HSV-1 due to MBP can be achieved if Mohalim consistently adopt the practice of careful mouth washing with Listerine® just before performing MBP.

Topics: Anti-Infective Agents, Local; Circumcision, Male; Clergy; Drug Combinations; Herpes Simplex; Herpesvirus 1, Human; Humans; Infant, Newborn; Judaism; Male; Morpholines; Mouthwashes; Salicylates; Terpenes

Chemical peel and dermabrasion are traditional, well-proven methods for the rejuvenation of the skin. The medium-depth trichloroacetic acid peel and the deep phenol peel offer distinct advantages and disadvantages and are discussed in detail in this article. The management of complications associated with both peel techniques is also discussed. Regional dermabrasion is an effective adjunct to facial rejuvenative surgery, such as face lift and blepharoplasty. Full-face dermabrasion and spot or local dermabrasion are most often used in the treatment of facial scarring. The technique of dermabrasion is discussed as well as its indications and postoperative care. Results are shown for both dermabrasion and peel.

Topics: Administration, Topical; Chemexfoliation; Cicatrix, Hypertrophic; Dermabrasion; Dermatologic Surgical Procedures; Drug Combinations; Ethanol; Face; Herpes Simplex; Humans; Hyperpigmentation; Keratolytic Agents; Lactic Acid; Patient Selection; Phenols; Rejuvenation; Resorcinols; Salicylates; Skin; Skin Aging; Trichloroacetic Acid; Virus Activation