salicylates and Headache

Topics: Analgesics; Arthritis, Rheumatoid; Aspirin; Headache; Humans; Ischemia; Kinetics; Neoplasms; Neuralgia; Phenacetin; Phenylbutazone; Salicylates; Time Factors; Wounds and Injuries

Sixty-four patients with proven ulcerative colitis who had been maintained on sulphasalazine as their sole form of treatment for a minimum period of one year were entered into a controlled trial of sulphasalazine versus dummy tablets for a period of six months. All the patients admitted were not only symptom-free but also showed no evidence of inflammation on sigmoidoscopy and rectal biopsy. A patient was judged to have relapsed when there was a recurrence of colitic symptoms accompanied by sigmoidoscopic and histological evidence of inflammation. The patients who received dummy tablets had more than four times the relapse rate of those receiving sulphasalazine. The results were similar in patients who had been on maintenance treatment with sulphasalazine for less than three years before entry into the trial and in those who had been on this treatment for more than three years. It is concluded that maintenance treatment of ulcerative colitis with sulphasalazine should be continued indefinitely unless contraindicated by side effects.

Topics: Biopsy; Blood Cell Count; Blood Sedimentation; Clinical Trials as Topic; Colitis, Ulcerative; Headache; Hemoglobins; Humans; Inflammation; Nausea; Placebos; Prednisolone; Psychology; Rectum; Remission, Spontaneous; Salicylates; Sigmoidoscopy; Sulfasalazine

For patients who have had a recent neurosurgical procedure, a visit to the emergency department for encephalopathy may automatically prompt a neurosurgical consult. We present a case of a patient with a history of Chiari malformation decompressed 6 months prior who presented with a 2-week history of slowly progressive altered mental status, headache and imbalance-symptoms consistent with her initial Chiari symptoms, so neurosurgery was consulted. Imaging showed no acute abnormality, but laboratory results revealed metabolic acidosis with high salicylate levels. When reporting medication use, this patient initially left out that she had been taking Goody's powder (845 mg aspirin) for headaches, and long-term use led to metabolic encephalopathy. Despite a recent history of surgery, it is important to keep the differential diagnosis broad especially when there are signs of metabolic derangement.

Topics: Acidosis; Aftercare; Arnold-Chiari Malformation; Brain; Brain Diseases; Diagnosis, Differential; Female; Headache; Humans; Infusions, Intravenous; Mental Disorders; Middle Aged; Neurosurgical Procedures; Salicylates; Sodium Bicarbonate; Tomography, X-Ray Computed; Treatment Outcome

Headache after administration of electroconvulsive therapy (ECT) is common, affecting approximately half of patients treated. Post-ECT headache is typically treated with acetaminophen or nonsteroidal anti-inflammatory drugs but occasionally requires agents such as sumatriptan, opioids, or β-blockers. We report on a patient whose severe post-ECT headaches responded completely to methyl salicylate ointment, applied to the area of his temporalis and masseter muscles. Topical methyl salicylate is generally well tolerated and may be a viable option for some patients with post-ECT headache.

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Depressive Disorder, Major; Electroconvulsive Therapy; Headache; Humans; Ketorolac; Male; Ointments; Salicylates; Stress Disorders, Post-Traumatic

Topics: Adult; Ceftriaxone; Diagnostic Errors; Female; Headache; Humans; Lyme Disease; Male; Meningitis, Aseptic; Physical Examination; Salicylates

Repetitive administration of therapeutic salicylate over 72 hours for amelioration of headache produced severe central nervous system manifestations in an adolescent. The simultaneous occurrence of bacterial meningitis was not promptly diagnosed. Treatment directed at correcting fluid and metabolic derangements of salicylism may have contributed to a morbid outcome.

Topics: Adolescent; Headache; Humans; Male; Meningitis, Pneumococcal; Salicylates

Topics: Aged; Diflunisal; Headache; Humans; Male; Melena; Ranitidine; Salicylates; Temporomandibular Joint Dysfunction Syndrome

Topics: Anti-Inflammatory Agents; Drug Eruptions; Dyspepsia; Headache; Humans; Peptic Ulcer; Phenylacetates; Propionates; Salicylates; Vertigo

Two and three Dow Cordis Hollow Fiber and Gambro Lundia artificial kidneys were used for high efficiency dialysis in large patients, intoxications, and for rapid ultrafiltration. BUN clearances of up to 240 ml/min were achieved. One episode of severe neuropathy occurred during high efficiency dialysis, and hypotensive episodes were more common. High efficiency dialysis has certain indications particularly in intoxication cases. However, because of possible side effects more experience is needed before its ultimate place in the treatment of uremia can be ascertained.

Topics: Barbiturates; Blood Urea Nitrogen; Body Weight; Calcium; Creatinine; Edema; Headache; Humans; Hypotension; Kidneys, Artificial; Nausea; Phenobarbital; Phenytoin; Poisoning; Primidone; Renal Dialysis; Salicylates; Substance-Related Disorders; Ultrafiltration; Uremia; Uric Acid

Topics: Audiometry; Cornea; Diagnosis, Differential; Electrocardiography; Female; Headache; Histamine; Humans; Indomethacin; Kininogens; Middle Aged; Migraine Disorders; Pulse; Salicylates; Vascular Headaches

Topics: Analgesics; Ascorbic Acid; Female; Headache; Humans; Male; Middle Aged; Rheumatic Diseases; Salicylates

Topics: Child; Eye Diseases; Female; Follow-Up Studies; Headache; Humans; Male; Migraine Disorders; Salicylates

Four patients who had ingested large amounts of phenacetin-salicylate medications were studied during a 12-month period. Renal failure had progressed slowly over a number of years. All patients took the drug because of psychogenic headache. Considerable skill was required to elicit the history of drug habituation. The major features of the nephropathy were multiple episodes of metabolic acidosis, minimal proteinuria, pyuria but no bacteriuria, and polyuria and polydipsia early in the course of drug ingestion. Papillary necrosis was not a prominent clinical feature of this series. Discontinuation of drug ingestion by one patient was associated with recovery of a considerable degree of renal function. Preliminary experimental evidence obtained in the dog suggests that salicylate impaired the efficiency of the counter-current multiplier by decreasing sodium transport in the ascending limb of Henle, and decreased the permeability to water of the distal convoluted and collecting tubule; phenacetin had no such effect.

Topics: Acidosis; Animals; Aspirin; Bacteriuria; Biological Transport; Caffeine; Codeine; Dogs; Drug Therapy; Headache; Humans; Kidney Diseases; Kidney Papillary Necrosis; Kidney Tubules; Metabolism; Neoplasm Recurrence, Local; Neoplasms; Phenacetin; Polyuria; Proteinuria; Pyuria; Salicylates; Sodium; Toxicology