salicylates and Hand-Dermatoses

Thirty-five patients with dermatophyte onychomycosis caused by Trichophyton rubrum, T. mentagrophytes var. granulosum, T. tonsurans and Epidermophyton floccosum were examined before treatment and 27 of these patients were examined again when they came to the control check up 3 months after completion of treatment. The immunological investigations, including evaluation of immunological competence, were performed in vivo through the determination of lymphoid cell immunophenotype by a flow cytometry technique. The quantitative composition of basic lymphocyte subpopulations and natural killer cells in the peripheral blood of 35 patients before the treatment was compared with a control group of 20 individuals. Statistically significant differences in the percentages of CD3+ T lymphocytes (P<0.05), T helper lymphocytes (CD4+) (P<0.05) and activated T lymphocytes (CD3+/HLA-DR+) (P<0.05) were obtained. In the control check-up examinations of 27 patients 3 months after completion of treatment, in comparison with the control group of 20 healthy individuals, highly statistically significant differences in percehtages of T lymphocytes (CD3+) (P<0.001) and T helper lymphocytes (CD4+) (P<0.01) were obtained. In five of these 27 patients the treatment resulted in failure. Comparing the group of 22 recovered patients with these five patients in whom the treatment result was failure, the only statistically significant difference obtained before as well as after the treatment was in B lymphocytes (CD19+) percentage (P<0.05). The results obtained confirm that impairments of the patients' cellular immunity are crucial factors influencing the course and results of treatment in dermatophyte onychomycosis.

Topics: Antifungal Agents; Antigens, CD19; CD3 Complex; CD4 Antigens; Epidermophyton; Foot Dermatoses; Hand Dermatoses; HLA-DR Antigens; Humans; Itraconazole; Killer Cells, Natural; Lymphocyte Count; Lymphocyte Subsets; Naphthalenes; Onychomycosis; Salicylates; Terbinafine; Trichophyton

A clinical study was conducted to evaluate the efficacy of a new delivery system for administering salicylic acid for the treatment of verruca vulgaris. The study compared wart resolution among volunteers who used karaya gum patches. The cure rate was 69% for warts treated with patches containing salicylic acid, which was significantly higher (p less than 0.01) than for warts treated with control patches (35%).

Topics: Administration, Cutaneous; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Hand Dermatoses; Humans; Karaya Gum; Male; Placebos; Random Allocation; Salicylates; Salicylic Acid; Warts

A double-blind study was carried out to compare the action of 5-fluorouracil and 10% salicylic acid varnish with that of a 10% salicylic acid varnish on common warts. Fifty per cent of the lesions disappeared with the combined preparation and only 4% with the varnish containing salicylic acid alone. The presence of warts on the hands of 45.8% of the female workers of a fowl slaughterhouse is described.

Topics: Abattoirs; Administration, Topical; Animals; Chickens; Clinical Trials as Topic; Drug Combinations; Female; Fluorouracil; Hand Dermatoses; Male; Occupational Diseases; Paint; Salicylates; Warts

Topics: Clinical Trials as Topic; Copper; Drug Combinations; Foot Dermatoses; Hand Dermatoses; Humans; Lactic Acid; Plant Extracts; Salicylates; Warts

Topics: Anacardic Acids; Brazil; Case-Control Studies; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Hand Dermatoses; Humans; Plants, Toxic; Resorcinols; Salicylates

Topics: Adolescent; Castor Oil; Collodion; Dermatitis, Contact; Dermatologic Agents; Drug Combinations; Drug Eruptions; Female; Hand Dermatoses; Humans; Lactates; Resins, Plant; Salicylates; Tars

A methyl salicylate-buffered, croton oil-containing 50% salicylic acid ointment peel, following pretreatment with topical tretinoin and localized 20% trichloroacetic acid, is extremely effective for removal of lentigines, pigmented keratoses, and actinically damaged skin from the dorsum of the hands and forearms. The ease of application, uniform results, decreased risk of scarring, and one-time application of this peel, in comparison with other methods used for treatment of these aging-skin changes, warrants consideration by the dermatologic surgeon.

Topics: Aged; Bandages; Chemexfoliation; Dermatitis, Seborrheic; Female; Forearm; Hand Dermatoses; Humans; Keratosis; Lentigo; Ointments; Pigmentation Disorders; Salicylates; Salicylic Acid; Tretinoin; Trichloroacetic Acid

We report an unusual case of pyogenic granuloma that appeared after the application of liquid nitrogen and 27 percent salicylic acid (Duoplant, Stiefel Inc.) to a verruca vulgaris. Only two cases of pyogenic granuloma following cryotherapy appear in the literature and pyogenic granuloma as a complication of salicylic acid application has not been documented.

Topics: Cryosurgery; Granuloma; Hand Dermatoses; Humans; Male; Middle Aged; Nitrogen; Salicylates; Salicylic Acid; Warts

Topics: Administration, Cutaneous; Adolescent; Adult; Antiviral Agents; Child; Female; Gels; Hand Dermatoses; Humans; Male; Middle Aged; Salicylates; Salicylic Acid; Warts

Topics: Diflunisal; Female; Foot Dermatoses; Hand Dermatoses; Humans; Lichen Planus; Middle Aged; Photosensitivity Disorders; Salicylates

Water content of the epidermis was measured before and after a 3-h , 4-day, and 10-day treatment using 10% salicylic acid or 10% carbamide ointment. The measurement was performed using the Corneometer CM 420 from the firm "Schwarzhaupt Medizintechnik GmbH". Salicylic acid ointment was applied on one and carbamide ointment on the other back of the hand. Neither salicylic acid nor carbamide seem to influence significantly the water content of the healthy epidermis. In two patients with more severe hyperkeratosis carbamide increased the water content more than salicylic acid did.

Topics: Administration, Topical; Adult; Body Water; Dermatologic Agents; Female; Hand Dermatoses; Humans; Ichthyosis; Keratolytic Agents; Keratosis; Male; Psoriasis; Salicylates; Salicylic Acid; Skin; Urea

Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Collodion; Drug Combinations; Female; Follow-Up Studies; Hand Dermatoses; Humans; Lactates; Male; Middle Aged; Nitrogen; Recurrence; Salicylates; Sex Factors; Warts

Topics: Administration, Topical; Adult; Aged; Dichloroacetic Acid; Female; Foot Dermatoses; Hand Dermatoses; Humans; Male; Middle Aged; Nail Diseases; Ointments; Onychomycosis; Salicylates; Sulfur

Topics: Adolescent; Adult; Ambulatory Care; Animals; Bees; Benzoates; Cryosurgery; Dimethyl Sulfoxide; Drug Combinations; Foot Dermatoses; Hand Dermatoses; Humans; Iodine; Lanolin; Middle Aged; Nitrogen; Onychomycosis; Salicylates; Waxes

Topics: Adolescent; Adult; Aged; Antifungal Agents; Dimethyl Sulfoxide; Female; Foot Dermatoses; Hand Dermatoses; Humans; Hydroxyquinolines; Middle Aged; Onychomycosis; Oxyquinoline; Salicylates; Solutions

Topics: Fluocinonide; Hand Dermatoses; Humans; Propylene Glycols; Salicylates

Topics: Adult; Female; Hand Dermatoses; Humans; Mitosporic Fungi; Salicylates; Skin; Tinea