salicylates and Granuloma

Topics: Adalimumab; Adrenal Cortex Hormones; Antibodies, Monoclonal, Humanized; Anus Diseases; Colonoscopy; Crohn Disease; Diagnosis, Differential; Drug Resistance; Edema; Female; Fissure in Ano; Follow-Up Studies; Giant Cells; Granuloma; Humans; Immunosuppressive Agents; Middle Aged; Recurrence; Salicylates; Skin Ulcer; Vulvar Diseases

We report an unusual case of pyogenic granuloma that appeared after the application of liquid nitrogen and 27 percent salicylic acid (Duoplant, Stiefel Inc.) to a verruca vulgaris. Only two cases of pyogenic granuloma following cryotherapy appear in the literature and pyogenic granuloma as a complication of salicylic acid application has not been documented.

Topics: Cryosurgery; Granuloma; Hand Dermatoses; Humans; Male; Middle Aged; Nitrogen; Salicylates; Salicylic Acid; Warts

Administration of the antioxidants 2(3)-tert-butyl-4-hydroxyanisole (BHA) or 5-(P-methoxyphenyl)-3H-1,2-dithiol-3-thione (ADT) to female CD-1 mice starting 4 weeks after infection with 70 cercariae of Schistosoma mansoni resulted in a decrease in the size of the inner fibrotic region of the hepatic granuloma. The cellular composition of the granuloma was not altered by treatment with these two compounds. The administration of the specific superoxide scavenger copper diisopropylsalicylate (CuDIPS) resulted in a similar decrease in granuloma size, suggesting a role of superoxide radicals in the granulomatous response.

Topics: Anethole Trithione; Animals; Anisoles; Antioxidants; Butylated Hydroxytoluene; Chemotaxis, Leukocyte; Female; Free Radicals; Granuloma; Inflammation; Liver Diseases, Parasitic; Mice; Ovum; Oxygen; Salicylates; Schistosoma mansoni; Schistosomiasis mansoni; Superoxides; Triglycerides

64Cu was administered in two anti-inflammatory formulations to normal rats and to rats with 2 forms of local inflammation, namely (a) an acute paw oedema (elicited with carrageenan) or (b) a chronic granulomatous response to an implanted irritant (Mycobacterium tuberculosis in a polyurethane sponge). The copper formulations used were (i) a slow release one consisting of Cu(II) salicylate applied dermally with ethanol/DMSO and (ii) short acting hydrophilic complex (Cu(I)Cu(II)-penicillamine)5- given subcutaneously. Three types of changes in copper biodistribution with these forms of inflammation were discerned based on determination of 64Cu and copper content in the following organs: inflammatory locus (foot or sponge implant), kidney, liver, spleen, adrenals, brain, blood, thymus, heart, and skin (site of application). The most evident changes were in the kidneys, liver, spleen, adrenals, thymus and serum from animals with chronic granulomatous inflammation. In contrast, a short term acute inflammatory stress (carrageenan paw oedema) had little effect. While copper D-penicillamine (applied subcutaneously) appeared to move as a bolus through the animals, the results with the percutaneous copper salicylate formulation are consistent with it providing a slow release source of copper(II). Exogenous 64Cu from both formulations was sequestered at inflammatory sites (relative to serum). This may partly explain how applied copper complexes can be anti-inflammatory.

Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Carrageenan; Copper; Edema; Granuloma; Inflammation; Injections, Subcutaneous; Male; Organometallic Compounds; Penicillamine; Radioisotopes; Rats; Rats, Inbred Lew; Salicylates; Tissue Distribution

A combination of indomethacin and diflunisal, a new salicylic acid derivative, when given to rats, gave a greater reduction in the size of permanganate induced granulomas and less gastric irritation, than either drug given alone.

Topics: Animals; Diflunisal; Drug Therapy, Combination; Granuloma; Indomethacin; Male; Rats; Salicylates; Stomach Diseases; Stomach Ulcer

In this work the authors are concerned with the study of different amounts of calcium in granulomas induced by permanganate and treated with Indomethacin only or with Indomethacin plus Diflunisal. Less calcium was found in granulomas of animals treated with Indomethacin plus Diflunisal.

Topics: Animals; Diflunisal; Drug Interactions; Granuloma; Indomethacin; Male; Potassium Permanganate; Rats; Salicylates; Spectrometry, Fluorescence; Stomach Diseases

In the present work it was determined the ability of non-steroidal anti-inflammatory drugs (Diflunisal and Indomethacin) to inhibit formation of "granuloma pouch" exudate induced in rats. This study shows that the combined administration of Diflunisal and Indomethacin exerts similar anti-inflammatory activity as the single drugs. There does not seem to be additive anti-inflammatory effects of the drugs in combination but, if anything, a weak antagonism. The association of the two compounds produces a reduced harmful effect on the gastric mucus.

Topics: Animals; Diflunisal; Disease Models, Animal; Gastric Mucosa; Granuloma; Indomethacin; Male; Rats; Salicylates; Stomach Diseases

Fendosal (HP 129) is one of a series of potent non-steroidal anti-inflammatory agents. Fendosal was compared with aspirin in several anti-inflammatory and analgesic bioassay procedures. Results indicate that fendosal has an anti-inflammatory activity 1.4 times greater than does aspirin in carrageenan-induced rat paw edema. Fendosal is 6.9 to 9.5 times more active than aspirin in the prophylactic and therapeutic adjuvant-induced polyarthritis models of chronic inflammation. The analgesic activity of fendosal is considered to be superior to that of aspirin, with the advantage of a prolonged duration of action. The gastric-irritating properties of fendosal are very low in comparison with those of aspirin. Fendosal has a much wider separation of effective and gastric-irritating doses than does aspirin.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Female; Granuloma; Hydroxybenzoates; Indoles; Rats; Salicylates

The binding activity of [3H]dexamethasone to the specific receptor was studied in the cytoplasmic fraction of a established fibroblast line derived from rat carrageenin granuloma in culture condition. Specific receptor to dexamethasone was demonstrated. Scatchard analysis revealed a single class of binding sites with a dissociation constant for [3H]dexamethasone of 3.64 - 10(-8) M and a concentration of binding sites of 0.825 pmol per mg cytosol protein. The number of cytoplasmic binding sites per cell was calculated at 1.15 - 10(5). Total binding activity to [3H]dexamethasone of the cytoplasmic fraction was enhanced when the cells were cultured in a medium containing salicylic acid was at 37 degrees C. The maximum enhancement was seen at the concentration of 10(-3)M and in 3h treatment of salicylic acid. This enhancement by salicylic acid was lost when cycloheximide was added to the culture medium at the same time. If salicyclic acid was added to the cell free system, it showed no effect on the binding activity. The other non-steroidal anti-inflammatory drugs; phenylbutazone and indomethacin,also enhanced the total binding activity to [3H]dexamethasone of the cytoplasmic fraction at the concentration of 2 - 10(-5) M and 2 - 10(-7) M, respectively.

Topics: Animals; Carrageenan; Cell Line; Cycloheximide; Cytosol; Dexamethasone; Fibroblasts; Granuloma; Indomethacin; Kinetics; Neoplasms, Experimental; Phenylbutazone; Rats; Receptors, Cell Surface; Salicylates

Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chelating Agents; Copper; Disease Models, Animal; Edema; Granuloma; Hydrocortisone; Lethal Dose 50; Mice; ortho-Aminobenzoates; Rats; Salicylates; Tryptophan; Ulcer

1. The effect of (4-acetamido-phenyl)-2-acetoxy-benzoate (benorilate, Benortan) on the inflammatory process was studied thermographically and histologically in cotton-pellet tests on rats. 2. Following implantation of the cotton-pellet, thermography shows a clear inhibition of the local inflammation due to treatment with benorilate. 3. Histological examination shows a corresponding influence of benorilate upon the proliferative phase of the inflammation. 4. The success of antiphlogistic therapy is in correlation with the time of medication.

Topics: Animals; Carrageenan; Gossypium; Granuloma; Inflammation; Male; Rats; Salicylates; Thermography

Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Asbestos; Dextrans; Disease Models, Animal; Drug Combinations; Edema; Evaluation Studies as Topic; Female; Formaldehyde; Granuloma; Indomethacin; Inflammation; Kaolin; Phenylbutazone; Prednisolone; Rats; Rats, Inbred Strains; Salicylates; Serotonin; Sodium Salicylate

Topics: Adrenalectomy; Aminopyrine; Animals; Anti-Inflammatory Agents; Capillary Permeability; Edema; Fever; Granuloma; Guinea Pigs; Hydrocortisone; Male; Mice; Morphine; Peritonitis; Phenylbutazone; Pyridines; Rabbits; Rats; Salicylates; Wound Healing

Topics: Animals; Anti-Inflammatory Agents; Betamethasone; Body Weight; Carrageenan; Collagen; Diet; Granuloma; Indomethacin; Injections, Subcutaneous; Male; Phenylbutazone; Rats; Salicylates

Topics: Alopecia Areata; Benzalkonium Compounds; Dermatitis, Seborrheic; Granuloma; Humans; Neurodermatitis; Paronychia; Salicylates; Skin Diseases; Triamcinolone Acetonide

Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Drug Synergism; Edema; Glycosaminoglycans; Granuloma; Male; Neoplasms, Experimental; Rats; Salicylates; Sulfuric Acids

Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Edema; Formaldehyde; Granuloma; Indoles; Inflammation; Pharmacology; Phenylbutazone; Rats; Research; Salicylates; Serotonin

Topics: Animals; Anti-Inflammatory Agents; Formaldehyde; Gossypium; Granuloma; Indomethacin; Inflammation; Male; Phenylbutazone; Rats; Salicylates

Topics: Adrenal Cortex Hormones; Connective Tissue; Granuloma; Humans; Inflammation; Prednisone; Salicylates; Sodium Salicylate; Turpentine

Topics: Adrenocorticotropic Hormone; Animals; Anterior Chamber; Granuloma; Insulin; Lagomorpha; Rabbits; Salicylates; Silicosis

Topics: Adrenocorticotropic Hormone; Animals; Granuloma; Insulin; Rabbits; Salicylates; Silicosis

Topics: Animals; Anterior Chamber; Eye Diseases; Granuloma; Rabbits; Salicylates; Silicon; Silicon Dioxide