salicylates and Foreign-Body-Reaction

To evaluate the kinetics of the inflammatory tissue response to three root canal sealers using a physicochemical method for quantification of the enhanced vascular permeability and histopathological analysis.. Twenty-eight male Wistar rats randomly assigned to four groups according to the evaluation periods (1, 3, 7 and 14 days) were used to assess the vascular permeability and histopathological reaction to RoekoSeal, AH Plus and Sealapex (new formulation) sealers, using saline and Chloropercha as negative and positive controls, respectively. Seven rats were sacrificed per period. The biocompatibility of the sealers was evaluated spectrophotometrically and histopathologically.. At day 14, Sealapex produced significantly more inflammatory exudate than AH Plus and RoekoSeal (P < 0.05); however, there was no significant difference between AH Plus and RoekoSeal (P > 0.05). Sealapex (new formulation) was the most irritating sealer, producing severe inflammation with the presence of multinucleated giant cells. RoekoSeal was the most biocompatible sealer, producing the least amount of inflammatory exudate.. RoekoSeal root canal sealer was biocompatible when implanted in connective tissue.

Topics: Animals; Balsams; Calcium Hydroxide; Capillary Permeability; Dental Cements; Drug Combinations; Edema; Epoxy Resins; Foreign-Body Reaction; Gutta-Percha; Implants, Experimental; Inflammation; Injections, Subcutaneous; Male; Pilot Projects; Rats; Rats, Wistar; Root Canal Filling Materials; Salicylates; Statistics, Nonparametric; Time Factors; Zinc Oxide

To determine the flow characteristics and subcutaneous tissue reactions to five endodontic sealers.. The materials used were Procosol, AH26, Endomethasone, Sealapex and Endion. The sealers were prepared following the manufacturers' instructions, and 0.075 mL of each material was placed on a glass surface, which was then rotated 90 degrees. The samples were stored at 37 degrees C and 95% humidity. The displacement of the sealer was recorded by measuring the difference between its original position and the position recorded at 15 and 60 min. Three samples of each material were used. Two pockets were created in the back of Wistar rats, and one silicone tube, 1 mm in diameter and 1 cm in length, was implanted in each. One was filled with one of the materials under study, and the other empty tube was implanted as a control. Fourteen days after implantation, the animals were sacrificed, and samples of the skin containing the tubes were histologically processed. Histological and histomorphometric evaluations of the tissues adjacent to the open end of the tube were carried out the volume of tissue reaction was measured histomorphometrically according to standard stereological principles. Results were statistically analysed using analysis of variance and Duncan's test.. The highest flow values were obtained with Sealapex and AH26. Time significantly affected the flow and the material (P < (1001). Procosol and Endion produced the most severe histological reactions: these were outlined by fibrous tissue; AH26. Endomethasone and Sealapex produced reactions of smaller size and with more moderately defined limits.. The flow did not correlate with the degree of inflammatory response. Procosol and Endion produced the most severe tissue reactions, whereas Endomethasone, Sealapex and AH26 produced only minimum reactions.

Topics: Analysis of Variance; Animals; Bismuth; Calcium Hydroxide; Dexamethasone; Drug Combinations; Epoxy Resins; Fibroblasts; Foreign-Body Reaction; Formaldehyde; Glass Ionomer Cements; Hydrocortisone; Materials Testing; Rats; Rats, Wistar; Resins, Synthetic; Rheology; Root Canal Filling Materials; Salicylates; Silver; Skin; Statistics, Nonparametric; Thymol; Titanium; Viscosity; Zinc Oxide; Zinc Oxide-Eugenol Cement

Four root canal sealers (AH-26, Roth 811, CRCS, and Sealapex) were tested for tissue biocompatibility in rat connective tissue. Each sealer was placed in Teflon tubes and implanted subcutaneously in Wistar-Furth rats. The implants were removed after 7, 14, and 21 days, fixed, and histologically prepared for microscopical evaluation. Brain, liver, kidneys, and uterus were removed from the animals killed at the first experimental period (7 days) and analyzed for zinc and calcium concentration by flame atomic absorption spectrophotometry. In total, 100 specimens were examined. At the seventh day, the most irritant material was seen to be AH-26, but this inflammatory reaction decreased with time. Roth 811 and Sealapex caused moderate-to-severe inflammatory reaction, whereas CRCS caused mild to moderate. CRCS and Roth 811 induced redistribution of zinc, whereas AH-26 induced changes in calcium content in some organs.

Topics: Animals; Biocompatible Materials; Bismuth; Brain Chemistry; Calcium; Calcium Hydroxide; Connective Tissue; Drug Combinations; Epoxy Resins; Female; Foreign-Body Reaction; Kidney; Liver; Methenamine; Rats; Rats, Wistar; Root Canal Filling Materials; Salicylates; Silver; Tissue Distribution; Titanium; Uterus; Zinc; Zinc Oxide; Zinc Oxide-Eugenol Cement

Topics: Animals; Calcium Hydroxide; Foreign-Body Reaction; Materials Testing; Rats; Root Canal Filling Materials; Salicylates; Time Factors; Zinc Oxide-Eugenol Cement