salicylates and Foot-Diseases

Several previous studies have yielded data showing that plantar and other cutaneous verrucae follow a more aggressive course in patients infected with human immunodeficiency virus (HIV) than in uninfected individuals. A pilot study was undertaken to identify trends in a sample population that would support this characterization of plantar verrucae in HIV+ patients and to determine whether there are differences in treatment response between HIV+ and HIV- patients. The results show that the HIV+ patients in the study presented with a significantly greater number and total area of lesions than did the HIV- patients. Furthermore, the HIV+ patients experienced a greater frequency of recurrence of their lesions following treatment with surgical curettage. These findings should provide the foundation for other extensive, multicenter studies to further characterize the treatment response of these lesions in HIV+ patients and to develop effective guidelines for their management.

Topics: Collodion; Curettage; Dermatologic Agents; Drug Combinations; Foot Diseases; HIV Seronegativity; HIV Seropositivity; Humans; Lactates; Pilot Projects; Salicylates; San Francisco; Treatment Outcome; Warts

Monochloroacetic acid crystals and 60% salicylic acid ointment was found to be more effective than placebo as a treatment for simple plantar warts in a double blind study on 57 patients. Nineteen (66%) patients in the active treatment group compared with five (18%) patients in the placebo group were cured after 6 weeks (P = 0.002). The active treatment was associated with a significantly higher cure rate 6 months after entry (P = 0.04). Treatments were well tolerated. IgG or IgM antibodies or both to human papilloma virus (HPV) types 1 or 2 or both were detected significantly more frequently in the actively treated group 6 weeks after entry (P = 0.0005). Twelve (50%) patients considered to be cured had no detectable secondary immune response. Our results suggest that cure does not depend primarily on the humoral system but rather on mechanical destruction of wart tissue, or occurs as a result of cell mediated immunity.

Topics: Acetates; Administration, Topical; Adolescent; Adult; Child; Female; Foot Diseases; Humans; Irritants; Male; Salicylates; Salicylic Acid; Warts

Topics: Adolescent; Adult; Antibodies; Bromine; Child; Child, Preschool; Clinical Trials as Topic; Foot Diseases; Humans; Immunoglobulin G; Lactates; Podophyllin; Quaternary Ammonium Compounds; Salicylates; Warts

Topics: Foot Diseases; Humans; Ointments; Salicylates; Salicylic Acid; Warts

Topics: Adult; Female; Foot Deformities, Acquired; Foot Diseases; Humans; Middle Aged; Salicylates; Silver Nitrate; Toes; Warts

We report two patients who developed allergic eczematous contact dermatitis to a salacid plaster used to treat plantar warts. Both patients were subsequently shown to be allergic to dehydroabietic acid, a resin contained in the plaster.

Topics: Child; Dermatitis, Contact; Female; Foot Diseases; Humans; Salicylates; Warts

Topics: Benzoates; Cryosurgery; Foot Diseases; Hand; Humans; Lanolin; Occlusive Dressings; Ointments; Salicylates; Warts

Topics: Dry Ice; Foot Diseases; Humans; Ointments; Salicylates; Warts